Aliases for ZNF90 Gene

Aliases for ZNF90 Gene

  • Zinc Finger Protein 90 2 3 4 5
  • Zinc Finger Protein HTF9 3 4
  • HTF9 2 3
  • Zinc Finger Protein 90 (HTF9) 2
  • ZNF90 5

External Ids for ZNF90 Gene

Previous GeneCards Identifiers for ZNF90 Gene

  • GC19P020725
  • GC19P020580
  • GC19P020034
  • GC19P020073
  • GC19P020049
  • GC19P020076
  • GC19U900566
  • GC19P019977
  • GC19P020188
  • GC19P020079
  • GC19P020518
  • GC19P020660
  • GC19P020838
  • GC19P022273
  • GC19P020274
  • GC19P020271
  • GC19P020379

Summaries for ZNF90 Gene

GeneCards Summary for ZNF90 Gene

ZNF90 (Zinc Finger Protein 90) is a Protein Coding gene. Diseases associated with ZNF90 include Chromosome 15Q13.3 Deletion Syndrome. Among its related pathways are Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and structural constituent of ribosome. An important paralog of this gene is ZNF93.

UniProtKB/Swiss-Prot Summary for ZNF90 Gene

Additional gene information for ZNF90 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF90 Gene

Genomics for ZNF90 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF90 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF90 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF90

Top Transcription factor binding sites by QIAGEN in the ZNF90 gene promoter:
  • AML1a
  • Cart-1
  • COMP1
  • Evi-1
  • FOXO1
  • FOXO1a
  • FOXO3
  • FOXO3a
  • FOXO3b

Genomic Locations for ZNF90 Gene

Genomic Locations for ZNF90 Gene
chr19:20,077,994-20,127,090
(GRCh38/hg38)
Size:
49,097 bases
Orientation:
Plus strand
chr19:20,188,803-20,237,885
(GRCh37/hg19)
Size:
49,083 bases
Orientation:
Plus strand

Genomic View for ZNF90 Gene

Genes around ZNF90 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF90 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF90 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF90 Gene

Proteins for ZNF90 Gene

  • Protein details for ZNF90 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q03938-ZNF90_HUMAN
    Recommended name:
    Zinc finger protein 90
    Protein Accession:
    Q03938
    Secondary Accessions:
    • B9EH87

    Protein attributes for ZNF90 Gene

    Size:
    601 amino acids
    Molecular mass:
    69058 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF90 Gene

Post-translational modifications for ZNF90 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF90 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF90 Gene

Domains & Families for ZNF90 Gene

Gene Families for ZNF90 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF90 Gene

InterPro:
Blocks:
  • KRAB box
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF90 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein HTF9 (ZNF90_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q03938

UniProtKB/Swiss-Prot:

ZNF90_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF90: view

Function for ZNF90 Gene

Molecular function for ZNF90 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
GENATLAS Biochemistry:
zinc finger protein 90 (HTF9),KRAB subfamily

Phenotypes From GWAS Catalog for ZNF90 Gene

Gene Ontology (GO) - Molecular Function for ZNF90 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IBA 21873635
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity NAS 2023909
GO:0008270 zinc ion binding NAS 2023909
genes like me logo Genes that share ontologies with ZNF90: view
genes like me logo Genes that share phenotypes with ZNF90: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF90

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF90 Gene

Localization for ZNF90 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF90 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF90 gene
Compartment Confidence
nucleus 4
cytosol 2
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF90 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IBA 21873635
genes like me logo Genes that share ontologies with ZNF90: view

Pathways & Interactions for ZNF90 Gene

PathCards logo

SuperPathways for ZNF90 Gene

genes like me logo Genes that share pathways with ZNF90: view

Pathways by source for ZNF90 Gene

1 KEGG pathway for ZNF90 Gene

Interacting Proteins for ZNF90 Gene

Gene Ontology (GO) - Biological Process for ZNF90 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA,IBA 21873635
genes like me logo Genes that share ontologies with ZNF90: view

No data available for SIGNOR curated interactions for ZNF90 Gene

Drugs & Compounds for ZNF90 Gene

No Compound Related Data Available

Transcripts for ZNF90 Gene

mRNA/cDNA for ZNF90 Gene

1 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF90

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF90 Gene

No ASD Table

Relevant External Links for ZNF90 Gene

GeneLoc Exon Structure for
ZNF90

Expression for ZNF90 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF90 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF90 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF90

SOURCE GeneReport for Unigene cluster for ZNF90 Gene:

Hs.55304

Evidence on tissue expression from TISSUES for ZNF90 Gene

  • Nervous system(3.1)
genes like me logo Genes that share expression patterns with ZNF90: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF90 Gene

Orthologs for ZNF90 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF90 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZNF90 30 31
  • 99.22 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia -- 31
  • 53 (a)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 47 (a)
ManyToMany
-- 31
  • 41 (a)
ManyToMany
Dog
(Canis familiaris)
Mammalia -- 31
  • 38 (a)
OneToMany
Mouse
(Mus musculus)
Mammalia Zfp386 31
  • 33 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 54 (a)
ManyToMany
-- 31
  • 47 (a)
ManyToMany
-- 31
  • 39 (a)
ManyToMany
-- 31
  • 39 (a)
ManyToMany
-- 31
  • 36 (a)
ManyToMany
-- 31
  • 35 (a)
ManyToMany
-- 31
  • 35 (a)
ManyToMany
-- 31
  • 30 (a)
ManyToMany
Fruit Fly
(Drosophila melanogaster)
Insecta CG4046 32
  • 82 (a)
Worm
(Caenorhabditis elegans)
Secernentea rps-16 32
  • 72 (a)
Species where no ortholog for ZNF90 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Zebrafish (Danio rerio)

Evolution for ZNF90 Gene

ENSEMBL:
Gene Tree for ZNF90 (if available)
TreeFam:
Gene Tree for ZNF90 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF90: view image

Paralogs for ZNF90 Gene

Paralogs for ZNF90 Gene

(510) SIMAP similar genes for ZNF90 Gene using alignment to 3 proteins:

  • ZNF90_HUMAN
  • F8WBQ5_HUMAN
  • F8WDJ7_HUMAN
genes like me logo Genes that share paralogs with ZNF90: view

Variants for ZNF90 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF90 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
710765 Benign: not provided 20,117,920(+) G/A SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for ZNF90 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF90 Gene

Variant ID Type Subtype PubMed ID
dgv3456n100 CNV gain 25217958
dgv3457n100 CNV gain 25217958
dgv509e201 CNV deletion 23290073
dgv6303n54 CNV loss 21841781
dgv630e199 CNV deletion 23128226
esv2718296 CNV deletion 23290073
esv2718298 CNV deletion 23290073
esv2718300 CNV deletion 23290073
esv2758748 CNV gain 17122850
esv34357 CNV gain 17911159
esv3643866 CNV loss 21293372
esv3643868 CNV loss 21293372
nsv1057107 CNV gain 25217958
nsv1059188 CNV loss 25217958
nsv1061846 CNV loss 25217958
nsv519535 CNV gain 19592680
nsv578804 CNV gain 21841781
nsv578805 CNV gain 21841781
nsv817820 CNV gain 17921354
nsv963020 CNV duplication 23825009

Variation tolerance for ZNF90 Gene

Residual Variation Intolerance Score: 80.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.11; 80.56% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF90 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF90

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF90 Gene

Disorders for ZNF90 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZNF90 Gene - From: DISEASES

Disorder Aliases PubMed IDs
chromosome 15q13.3 deletion syndrome
  • chromosome 15q13.3 microdeletion syndrome
- elite association - COSMIC cancer census association via MalaCards
Search ZNF90 in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with ZNF90: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF90 Gene

Publications for ZNF90 Gene

  1. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PMID: 15146197) Brandenberger R … Stanton LW (Nature biotechnology 2004) 3 4
  2. Clustered organization of homologous KRAB zinc-finger genes with enhanced expression in human T lymphoid cells. (PMID: 8467795) Bellefroid EJ … Szpirer C (The EMBO journal 1993) 2 3
  3. The evolutionarily conserved Krüppel-associated box domain defines a subfamily of eukaryotic multifingered proteins. (PMID: 2023909) Bellefroid EJ … Martial JA (Proceedings of the National Academy of Sciences of the United States of America 1991) 3 4
  4. The polyproline-motif of S6K2: eIF5A translational dependence and importance for protein-protein interactions. (PMID: 30320934) Meneguello L … Luchessi AD (Journal of cellular biochemistry 2019) 3
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for ZNF90 Gene

Sources for ZNF90 Gene