Aliases for ZNF891 Gene

Aliases for ZNF891 Gene

  • Zinc Finger Protein 891 2 3 4 5
  • HCG1646157 3
  • ZNF891 5

External Ids for ZNF891 Gene

Previous GeneCards Identifiers for ZNF891 Gene

  • GC12M133698
  • GC12M130476

Summaries for ZNF891 Gene

GeneCards Summary for ZNF891 Gene

ZNF891 (Zinc Finger Protein 891) is a Protein Coding gene. Among its related pathways are Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZFP90.

UniProtKB/Swiss-Prot Summary for ZNF891 Gene

Additional gene information for ZNF891 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF891 Gene

Genomics for ZNF891 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF891 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF891 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF891

Genomic Locations for ZNF891 Gene

Genomic Locations for ZNF891 Gene
chr12:133,106,817-133,130,473
(GRCh38/hg38)
Size:
23,657 bases
Orientation:
Minus strand
chr12:133,694,740-133,707,059
(GRCh37/hg19)
Size:
12,320 bases
Orientation:
Minus strand

Genomic View for ZNF891 Gene

Genes around ZNF891 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF891 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF891 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF891 Gene

Proteins for ZNF891 Gene

  • Protein details for ZNF891 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A8MT65-ZN891_HUMAN
    Recommended name:
    Zinc finger protein 891
    Protein Accession:
    A8MT65

    Protein attributes for ZNF891 Gene

    Size:
    544 amino acids
    Molecular mass:
    63592 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BC017932; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

neXtProt entry for ZNF891 Gene

Post-translational modifications for ZNF891 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF891 Gene

No data available for DME Specific Peptides for ZNF891 Gene

Domains & Families for ZNF891 Gene

Gene Families for ZNF891 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF891 Gene

Suggested Antigen Peptide Sequences for ZNF891 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 891 (ZN891_HUMAN)

Graphical View of Domain Structure for InterPro Entry

A8MT65

UniProtKB/Swiss-Prot:

ZN891_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF891: view

Function for ZNF891 Gene

Molecular function for ZNF891 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF891 Gene

Gene Ontology (GO) - Molecular Function for ZNF891 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity IBA 21873635
GO:0043565 sequence-specific DNA binding IBA 21873635
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF891: view
genes like me logo Genes that share phenotypes with ZNF891: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF891

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF891 Gene

Localization for ZNF891 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF891 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF891 gene
Compartment Confidence
nucleus 4
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF891 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
genes like me logo Genes that share ontologies with ZNF891: view

Pathways & Interactions for ZNF891 Gene

PathCards logo

SuperPathways for ZNF891 Gene

genes like me logo Genes that share pathways with ZNF891: view

Pathways by source for ZNF891 Gene

1 KEGG pathway for ZNF891 Gene

Gene Ontology (GO) - Biological Process for ZNF891 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF891: view

No data available for SIGNOR curated interactions for ZNF891 Gene

Drugs & Compounds for ZNF891 Gene

No Compound Related Data Available

Transcripts for ZNF891 Gene

mRNA/cDNA for ZNF891 Gene

1 REFSEQ mRNAs :
3 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF891

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF891 Gene

No ASD Table

Relevant External Links for ZNF891 Gene

GeneLoc Exon Structure for
ZNF891

Expression for ZNF891 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF891 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZNF891 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF891

genes like me logo Genes that share expression patterns with ZNF891: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF891 Gene

Orthologs for ZNF891 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF891 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LOC100610530 30
  • 99.51 (n)
ZNF891 31
  • 99 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia LOC100125388 30
  • 82 (n)
ZNF891 31
  • 40 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 47 (a)
ManyToMany
-- 31
  • 41 (a)
ManyToMany
-- 31
  • 40 (a)
ManyToMany
-- 31
  • 33 (a)
ManyToMany
-- 31
  • 33 (a)
ManyToMany
-- 31
  • 31 (a)
ManyToMany
Mouse
(Mus musculus)
Mammalia 2410141K09Rik 31
  • 35 (a)
ManyToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 27 (a)
OneToMany
Zebrafish
(Danio rerio)
Actinopterygii ZNF557 31
  • 21 (a)
OneToMany
Species where no ortholog for ZNF891 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for ZNF891 Gene

ENSEMBL:
Gene Tree for ZNF891 (if available)
TreeFam:
Gene Tree for ZNF891 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF891: view image

Paralogs for ZNF891 Gene

(461) SIMAP similar genes for ZNF891 Gene using alignment to 1 proteins:

  • ZN891_HUMAN
genes like me logo Genes that share paralogs with ZNF891: view

Variants for ZNF891 Gene

Additional dbSNP identifiers (rs#s) for ZNF891 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF891 Gene

Variant ID Type Subtype PubMed ID
dgv1590n100 CNV gain 25217958
dgv1592n100 CNV gain 25217958
dgv1593n100 CNV gain 25217958
dgv1594n100 CNV gain 25217958
dgv1595n100 CNV gain 25217958
dgv1596n100 CNV gain 25217958
dgv220n27 CNV gain 19166990
dgv3060n54 CNV gain 21841781
dgv534e212 CNV gain 25503493
esv27162 CNV gain+loss 19812545
esv2759923 CNV loss 17122850
esv2760921 CNV gain 21179565
esv2763014 CNV gain 21179565
esv3631326 CNV loss 21293372
esv3631327 CNV gain 21293372
esv3631328 CNV gain 21293372
nsv1054203 CNV gain 25217958
nsv455818 CNV loss 19166990
nsv470337 CNV loss 18288195
nsv518970 CNV gain 19592680
nsv561145 CNV gain 21841781
nsv561148 CNV loss 21841781
nsv975544 CNV duplication 23825009

Variation tolerance for ZNF891 Gene

Gene Damage Index Score: 7.20; 80.95% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF891 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF891

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF891 Gene

Disorders for ZNF891 Gene

No disorders were found for ZNF891 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF891 Gene

Publications for ZNF891 Gene

  1. The finished DNA sequence of human chromosome 12. (PMID: 16541075) Scherer SE … Baylor College of Medicine Human Genome Sequencing Center Sequence Production Team (Nature 2006) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  3. VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. (PMID: 29507755) Yue Y … Liu J (Cell discovery 2018) 3
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3

Products for ZNF891 Gene

Sources for ZNF891 Gene