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Aliases for ZNF888 Gene

Aliases for ZNF888 Gene

  • Zinc Finger Protein 888 2 3 5
  • CTD-2331H12.6 3

External Ids for ZNF888 Gene

Previous GeneCards Identifiers for ZNF888 Gene

  • GC19M053410

Summaries for ZNF888 Gene

GeneCards Summary for ZNF888 Gene

ZNF888 (Zinc Finger Protein 888) is a Protein Coding gene. An important paralog of this gene is ZNF28.

UniProtKB/Swiss-Prot for ZNF888 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF888 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF888 Gene

Genomics for ZNF888 Gene

GeneHancer (GH) Regulatory Elements for ZNF888 Gene

Promoters and enhancers for ZNF888 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I052922 Promoter/Enhancer 1.9 FANTOM5 Ensembl ENCODE dbSUPER 550.8 -0.1 -74 3 PKNOX1 ATF1 SMAD1 ARID4B SIN3A BRCA1 POLR2B ZNF766 GLIS2 E2F8 ENSG00000269646 ZNF888 ZNF701 ZNF600 ZNF808 ZNF845 ENSG00000268970 ENSG00000269001 ZNF816 ZNF137P
GH19I053864 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10 -945.4 -945433 9.8 HDGF FOXA2 MLX ZFP64 ARID4B NEUROD1 SIN3A DMAP1 ZBTB7B SLC30A9 MYADM LOC105372457 ENSG00000269001 ZNF845 ZNF765 ZNF816 LENG8 ENSG00000235681 ZNF813 TPM3P6
GH19I052137 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 10 +783.8 783849 3.3 PKNOX1 FOXA2 SMAD1 ARNT ARID4B SIN3A DMAP1 YY1 POLR2B E2F8 ZNF616 ZNF137P ZNF160 ZNF808 ENSG00000268970 ZNF600 ZNF350 ZNF816 ZNF836 ZNF577
GH19I053893 Enhancer 0.7 ENCODE 10 -969.7 -969701 0.2 SUZ12 ZNF76 DEAF1 ETS1 ZNF766 ZNF143 CHD2 THAP11 AFF1 ZNF197 ENSG00000269001 ZNF845 ZNF765 ZNF816 LENG8 ENSG00000235681 ZNF813 TPM3P6 ZNF160 LENG8-AS1
GH19I052934 Enhancer 1.4 Ensembl ENCODE dbSUPER 0.4 -14.3 -14301 5.9 PKNOX1 FOXA2 ARNT ZNF766 CBX5 E2F8 JUNB REST ZNF592 MEF2D ZNF816 ENSG00000268225 ZNF83 ZNF321P ZNF888 ENSG00000283088 ZNF816-ZNF321P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF888 on UCSC Golden Path with GeneCards custom track

Genomic Locations for ZNF888 Gene

Genomic Locations for ZNF888 Gene
chr19:52,904,417-52,923,481
(GRCh38/hg38)
Size:
19,065 bases
Orientation:
Minus strand
chr19:53,408,210-53,426,723
(GRCh37/hg19)

Genomic View for ZNF888 Gene

Genes around ZNF888 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF888 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF888 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF888 Gene

Proteins for ZNF888 Gene

  • Protein details for ZNF888 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0CJ79-ZN888_HUMAN
    Recommended name:
    Zinc finger protein 888
    Protein Accession:
    P0CJ79

    Protein attributes for ZNF888 Gene

    Size:
    500 amino acids
    Molecular mass:
    58727 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF888 Gene

Post-translational modifications for ZNF888 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF888 Gene

No data available for DME Specific Peptides for ZNF888 Gene

Domains & Families for ZNF888 Gene

Gene Families for ZNF888 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ZNF888 Gene

Suggested Antigen Peptide Sequences for ZNF888 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P0CJ79

UniProtKB/Swiss-Prot:

ZN888_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF888: view

Function for ZNF888 Gene

Molecular function for ZNF888 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF888 Gene

Gene Ontology (GO) - Molecular Function for ZNF888 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF888: view

Phenotypes for ZNF888 Gene

GenomeRNAi human phenotypes for ZNF888:
genes like me logo Genes that share phenotypes with ZNF888: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZNF888 Gene

Localization for ZNF888 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF888 Gene

Gene Ontology (GO) - Cellular Components for ZNF888 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF888: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for ZNF888 Gene

Pathways & Interactions for ZNF888 Gene

SuperPathways for ZNF888 Gene

No Data Available

Interacting Proteins for ZNF888 Gene

Gene Ontology (GO) - Biological Process for ZNF888 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA,IEA --
genes like me logo Genes that share ontologies with ZNF888: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF888 Gene

Drugs & Compounds for ZNF888 Gene

No Compound Related Data Available

Transcripts for ZNF888 Gene

mRNA/cDNA for ZNF888 Gene

(5) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF888 Gene

No ASD Table

Relevant External Links for ZNF888 Gene

GeneLoc Exon Structure for
ZNF888
ECgene alternative splicing isoforms for
ZNF888

Expression for ZNF888 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF888 Gene

mRNA differential expression in normal tissues according to GTEx for ZNF888 Gene

This gene is overexpressed in Bladder (x7.3).

Protein differential expression in normal tissues from HIPED for ZNF888 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (52.8) and Amniocyte (16.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF888 Gene



Protein tissue co-expression partners for ZNF888 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF888 Gene:

ZNF888
genes like me logo Genes that share expression patterns with ZNF888: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF888 Gene

Orthologs for ZNF888 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for ZNF888 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC456268 33
  • 95.44 (n)
Species where no ortholog for ZNF888 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF888 Gene

ENSEMBL:
Gene Tree for ZNF888 (if available)
TreeFam:
Gene Tree for ZNF888 (if available)

Paralogs for ZNF888 Gene

(539) SIMAP similar genes for ZNF888 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ZNF888: view

Variants for ZNF888 Gene

Sequence variations from dbSNP and Humsavar for ZNF888 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000120090 -- 52,917,083(-) T/C intron_variant
rs1000335476 -- 52,906,884(-) G/A coding_sequence_variant, missense_variant
rs1000693172 -- 52,926,911(-) A/G genic_upstream_transcript_variant, intron_variant
rs1000751805 -- 52,926,754(-) G/A genic_upstream_transcript_variant, intron_variant
rs1000805951 -- 52,928,079(-) C/G genic_upstream_transcript_variant, intron_variant

Additional Variant Information for ZNF888 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF888

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for ZNF888 Gene

Disorders for ZNF888 Gene

Additional Disease Information for ZNF888

No disorders were found for ZNF888 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF888 Gene

Publications for ZNF888 Gene

  1. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 3 4 58
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for ZNF888 Gene

Sources for ZNF888 Gene

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