ZNF880 Gene (Protein Coding)

Zinc Finger Protein 880

GC19P052369
GIFtS:
24
See more...

Aliases for ZNF880 Gene

Aliases for ZNF880 Gene

  • Zinc Finger Protein 880 2 3 4 5
  • Zinc Finger Protein LOC400713 3
  • ZNF880 5

External Ids for ZNF880 Gene

Previous GeneCards Identifiers for ZNF880 Gene

  • GC19P057568
  • GC19P052873
  • GC19P049203

Summaries for ZNF880 Gene

GeneCards Summary for ZNF880 Gene

ZNF880 (Zinc Finger Protein 880) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA-binding transcription factor activity. An important paralog of this gene is ZNF528.

Additional gene information for ZNF880 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF880 Gene

Genomics for ZNF880 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for ZNF880 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH19J052369 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE CraniofacialAtlas 267.2 +0.2 184 2.2 NR2C1 ETS1 POLR2A ELF1 ZNF610 SIN3A GABPA SP2 MAX TAF1 ZNF880 HSALNG0127311 ZNF528-AS1 ENSG00000277977 ZNF528
GH19J052368 Promoter 0.3 EPDnew 250.7 -1.0 -972 0.1 HSALNG0127311 ZNF880 ENSG00000269535 ZNF610
GH19J051926 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 18.5 -442.4 -442416 3 FEZF1 CEBPA SIX5 NR2C1 MNT IKZF1 ETS1 ZFP64 ZNF217 CTCF ZNF613 HSALNG0127271 lnc-ZNF613-3 ZNF615 ZNF611 ZNF649 ENSG00000269483 ZNF577 ZNF880 ZNF83
GH19J052733 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 10.4 +365.0 365026 3.5 TBP CEBPA NR2C1 IKZF1 SMAD5 ETS1 MBD2 POLR2A CTCF ELF1 ZNF611 ZNF83 HSALNG0127343 lnc-ZNF611-5 ZNF613 ZNF137P ENSG00000268970 ZNF701 ZNF577 ENSG00000269001
GH19J052026 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 10.4 -341.8 -341804 3.4 CHD2 TBP ZBTB10 MXD4 FEZF1 CEBPA SIX5 NR2C1 MNT BRCA1 ZNF614 piR-36887-012 ZNF841 ZNF137P ENSG00000268970 ZNF701 ZNF613 ZNF611 ZNF836 ZNF28
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF880 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF880

Genomic Locations for ZNF880 Gene

Latest Assembly
chr19:52,369,917-52,395,874
(GRCh38/hg38)
Size:
25,958 bases
Orientation:
Plus strand

Previous Assembly
chr19:52,873,176-52,889,048
(GRCh37/hg19 by Entrez Gene)
Size:
15,873 bases
Orientation:
Plus strand

chr19:52,873,170-52,889,048
(GRCh37/hg19 by Ensembl)
Size:
15,879 bases
Orientation:
Plus strand

Genomic View for ZNF880 Gene

Genes around ZNF880 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF880 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF880 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for ZNF880 Gene

Proteins for ZNF880 Gene

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  • Protein details for ZNF880 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6PDB4-ZN880_HUMAN
    Recommended name:
    Zinc finger protein 880
    Protein Accession:
    Q6PDB4
    Secondary Accessions:
    • B4DNA6

    Protein attributes for ZNF880 Gene

    Size:
    577 amino acids
    Molecular mass:
    66762 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF880 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF880 Gene

Post-translational modifications for ZNF880 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF880 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF880 Gene

Domains & Families for ZNF880 Gene

Gene Families for ZNF880 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF880 Gene

InterPro:
Blocks:
  • KRAB box
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF880 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 880 (ZN880_HUMAN)
genes like me logo Genes that share domains with ZNF880: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ZNF880 Gene

Function for ZNF880 Gene

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  4. Inhibitory RNAs for research
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  6. Cell Lines for research

Phenotypes From GWAS Catalog for ZNF880 Gene

Gene Ontology (GO) - Molecular Function for ZNF880 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IBA 21873635
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific IBA 21873635
GO:0003676 nucleic acid binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF880: view
genes like me logo Genes that share phenotypes with ZNF880: view

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF880

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZNF880 Gene

Localization for ZNF880 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF880 gene
Compartment Confidence
nucleus 4
mitochondrion 1
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Intermediate filaments (2)
  • Nucleoli fibrillar center (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF880 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
genes like me logo Genes that share ontologies with ZNF880: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ZNF880 Gene

Pathways & Interactions for ZNF880 Gene

PathCards logo

SuperPathways for ZNF880 Gene

No Data Available

Interacting Proteins for ZNF880 Gene

STRING Interaction Network Preview (showing top 5 STRING interactants - click image to see top 25)
STRING Interaction Network
Selected Interacting proteins: ENSP00000406318 for ZNF880 Gene via STRING

GPS-Prot Interaction Network for ZNF880

Gene Ontology (GO) - Biological Process for ZNF880 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IBA 21873635
genes like me logo Genes that share ontologies with ZNF880: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF880 Gene

Drugs & Compounds for ZNF880 Gene

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  1. Drug products for research
No Compound Related Data Available

Transcripts for ZNF880 Gene

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mRNA/cDNA for ZNF880 Gene

1 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF880

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF880 Gene

No ASD Table

Relevant External Links for ZNF880 Gene

GeneLoc Exon Structure for
ZNF880

Expression for ZNF880 Gene

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mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF880 Gene

mRNA expression in normal human tissues for ZNF880 Gene
mRNA expression by GTEx for ZNF880 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF880

SOURCE GeneReport for Unigene cluster for ZNF880 Gene:

Hs.502314

Evidence on tissue expression from TISSUES for ZNF880 Gene

  • Heart(4.3)
genes like me logo Genes that share expression patterns with ZNF880: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF880 Gene

Orthologs for ZNF880 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF880 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia ZNF880 30
  • 90.24 (n)
-- 31
  • 79 (a)
 ManyToMany
Dog
(Canis familiaris)
 Mammalia -- 31
  • 48 (a)
 ManyToMany
Cow
(Bos Taurus)
 Mammalia -- 31
  • 31 (a)
 ManyToMany
Species where no ortholog for ZNF880 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ZNF880 Gene

ENSEMBL:
Gene Tree for ZNF880 (if available)
TreeFam:
Gene Tree for ZNF880 (if available)

Paralogs for ZNF880 Gene

Paralogs for ZNF880 Gene

(539) SIMAP similar genes for ZNF880 Gene using alignment to 3 proteins:

  • ZN880_HUMAN
  • F5H026_HUMAN
  • M0R0M5_HUMAN

Pseudogenes.org Pseudogenes for ZNF880 Gene

genes like me logo Genes that share paralogs with ZNF880: view

Variants for ZNF880 Gene

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dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for ZNF880 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for ZNF880 Gene

Variant ID Type Subtype PubMed ID
dgv1806n106 CNV deletion 24896259
dgv596n67 CNV loss 20364138
dgv6524n54 CNV loss 21841781
dgv6525n54 CNV loss 21841781
dgv657e199 CNV deletion 23128226
esv2718781 CNV deletion 23290073
esv2750580 CNV loss 17666407
esv28637 CNV loss 19812545
esv32843 CNV loss 17666407
esv3556562 CNV deletion 23714750
esv3644692 CNV loss 21293372
nsv1109210 CNV deletion 24896259
nsv1110930 OTHER inversion 24896259
nsv1140251 OTHER inversion 24896259
nsv2536 CNV deletion 18451855
nsv476454 CNV novel sequence insertion 20440878
nsv507900 OTHER sequence alteration 20534489
nsv511613 CNV loss 21212237
nsv512590 CNV loss 21212237
nsv521079 CNV loss 19592680
nsv580011 CNV loss 21841781
nsv828615 CNV loss 20364138
nsv833873 CNV gain 17160897
nsv956570 CNV deletion 24416366
nsv978839 CNV duplication 23825009

Variation tolerance for ZNF880 Gene

Residual Variation Intolerance Score: 93.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.00; 92.06% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF880 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF880

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF880 Gene

Disorders for ZNF880 Gene

Additional Disease Information for ZNF880

Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform

No disorders were found for ZNF880 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF880 Gene

Publications for ZNF880 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  3. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3

ExternalLinks

View latest publications for ZNF880 gene in Mastermind

Products for ZNF880 Gene

Sources for ZNF880 Gene