This gene encodes a kruppel-associated box-containing zinc finger protein (KRAB-ZFP). The encoded protein contains an N-terminal kruppel-associated box (KRAB) domain and thirteen C-terminal C2H2-type zinc finger domains. The KRAB-ZFPs represent the largest family of mammalian transcriptional repressors, which function through the recruitment of the nuclear co-factor KRAB-Associ... See more...

Aliases for ZNF879 Gene

Aliases for ZNF879 Gene

  • Zinc Finger Protein 879 2 3 4 5
  • DKFZp686E2433 2 3
  • ZNF879 5

External Ids for ZNF879 Gene

Previous GeneCards Identifiers for ZNF879 Gene

  • GC05P178384
  • GC05P178450
  • GC05P173177

Summaries for ZNF879 Gene

Entrez Gene Summary for ZNF879 Gene

  • This gene encodes a kruppel-associated box-containing zinc finger protein (KRAB-ZFP). The encoded protein contains an N-terminal kruppel-associated box (KRAB) domain and thirteen C-terminal C2H2-type zinc finger domains. The KRAB-ZFPs represent the largest family of mammalian transcriptional repressors, which function through the recruitment of the nuclear co-factor KRAB-Associated Protein 1 (KAP1), to engage histone modifiers and induce heterochromatin formation. [provided by RefSeq, Jul 2017]

GeneCards Summary for ZNF879 Gene

ZNF879 (Zinc Finger Protein 879) is a Protein Coding gene. Among its related pathways are Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA-binding transcription factor activity. An important paralog of this gene is ZNF354B.

UniProtKB/Swiss-Prot Summary for ZNF879 Gene

Additional gene information for ZNF879 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF879 Gene

Genomics for ZNF879 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF879 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF879 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF879

Genomic Locations for ZNF879 Gene

Genomic Locations for ZNF879 Gene
chr5:179,023,759-179,035,064
(GRCh38/hg38)
Size:
11,306 bases
Orientation:
Plus strand
chr5:178,450,753-178,462,065
(GRCh37/hg19)
Size:
11,313 bases
Orientation:
Plus strand

Genomic View for ZNF879 Gene

Genes around ZNF879 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF879 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF879 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF879 Gene

Proteins for ZNF879 Gene

  • Protein details for ZNF879 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    B4DU55-ZN879_HUMAN
    Recommended name:
    Zinc finger protein 879
    Protein Accession:
    B4DU55

    Protein attributes for ZNF879 Gene

    Size:
    563 amino acids
    Molecular mass:
    64577 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF879 Gene

Post-translational modifications for ZNF879 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF879 Gene

Domains & Families for ZNF879 Gene

Gene Families for ZNF879 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF879 Gene

Suggested Antigen Peptide Sequences for ZNF879 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 879 (ZN879_HUMAN)

Graphical View of Domain Structure for InterPro Entry

B4DU55

UniProtKB/Swiss-Prot:

ZN879_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF879: view

Function for ZNF879 Gene

Molecular function for ZNF879 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF879 Gene

Gene Ontology (GO) - Molecular Function for ZNF879 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF879: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF879

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZNF879 Gene

Localization for ZNF879 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF879 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF879 gene
Compartment Confidence
nucleus 4
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF879 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF879: view

Pathways & Interactions for ZNF879 Gene

PathCards logo

SuperPathways for ZNF879 Gene

genes like me logo Genes that share pathways with ZNF879: view

Pathways by source for ZNF879 Gene

1 KEGG pathway for ZNF879 Gene

Gene Ontology (GO) - Biological Process for ZNF879 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF879: view

No data available for SIGNOR curated interactions for ZNF879 Gene

Drugs & Compounds for ZNF879 Gene

No Compound Related Data Available

Transcripts for ZNF879 Gene

mRNA/cDNA for ZNF879 Gene

4 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF879

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF879 Gene

No ASD Table

Relevant External Links for ZNF879 Gene

GeneLoc Exon Structure for
ZNF879

Expression for ZNF879 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF879 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF879

SOURCE GeneReport for Unigene cluster for ZNF879 Gene:

Hs.445740
genes like me logo Genes that share expression patterns with ZNF879: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF879 Gene

Orthologs for ZNF879 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF879 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZNF879 30 31
  • 99.41 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ZNF879 31
  • 90 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia ZNF879 30 31
  • 88.73 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Zfp879 30
  • 80.18 (n)
Mouse
(Mus musculus)
Mammalia Zfp879 30 17 31
  • 79.77 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 49 (a)
OneToMany
Species where no ortholog for ZNF879 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ZNF879 Gene

ENSEMBL:
Gene Tree for ZNF879 (if available)
TreeFam:
Gene Tree for ZNF879 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF879: view image

Paralogs for ZNF879 Gene

Paralogs for ZNF879 Gene

(516) SIMAP similar genes for ZNF879 Gene using alignment to 4 proteins:

  • ZN879_HUMAN
  • E5RGZ8_HUMAN
  • E5RI37_HUMAN
  • E5RJY9_HUMAN

Pseudogenes.org Pseudogenes for ZNF879 Gene

genes like me logo Genes that share paralogs with ZNF879: view

Variants for ZNF879 Gene

Additional dbSNP identifiers (rs#s) for ZNF879 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF879 Gene

Variant ID Type Subtype PubMed ID
dgv5845n100 CNV gain 25217958
nsv1027487 CNV gain 25217958
nsv1033597 CNV gain 25217958
nsv1120062 OTHER inversion 24896259

Variation tolerance for ZNF879 Gene

Gene Damage Index Score: 6.71; 78.65% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF879 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF879

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF879 Gene

Disorders for ZNF879 Gene

No disorders were found for ZNF879 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF879 Gene

Publications for ZNF879 Gene

  1. KRAB zinc-finger proteins contribute to the evolution of gene regulatory networks. (PMID: 28273063) Imbeault M … Trono D (Nature 2017) 3
  2. Evolution of KRAB-containing zinc finger proteins and their roles in species evolution. (PMID: 27867147) Wang J … Tian CY (Yi chuan = Hereditas 2016) 3
  3. Zinc fingers function cooperatively with KRAB domain for nuclear localization of KRAB-containing zinc finger proteins. (PMID: 24647005) Wang W … Li W (PloS one 2014) 3
  4. Kruppel-associated box (KRAB) proteins in the adaptive immune system. (PMID: 24699165) Santoni de Sio FR (Nucleus (Austin, Tex.) 2014) 3
  5. Cys2His2 zinc finger protein family: classification, functions, and major members. (PMID: 22803940) Razin SV … Kantidze OL (Biochemistry. Biokhimiia 2012) 3

Products for ZNF879 Gene

Sources for ZNF879 Gene