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Aliases for ZNF879 Gene

Aliases for ZNF879 Gene

  • Zinc Finger Protein 879 2 3 5
  • DKFZp686E2433 3

External Ids for ZNF879 Gene

Previous GeneCards Identifiers for ZNF879 Gene

  • GC05P178384
  • GC05P178450
  • GC05P173177

Summaries for ZNF879 Gene

Entrez Gene Summary for ZNF879 Gene

  • This gene encodes a kruppel-associated box-containing zinc finger protein (KRAB-ZFP). The encoded protein contains an N-terminal kruppel-associated box (KRAB) domain and thirteen C-terminal C2H2-type zinc finger domains. The KRAB-ZFPs represent the largest family of mammalian transcriptional repressors, which function through the recruitment of the nuclear co-factor KRAB-Associated Protein 1 (KAP1), to engage histone modifiers and induce heterochromatin formation. [provided by RefSeq, Jul 2017]

GeneCards Summary for ZNF879 Gene

ZNF879 (Zinc Finger Protein 879) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA binding transcription factor activity. An important paralog of this gene is ZNF470.

UniProtKB/Swiss-Prot for ZNF879 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF879 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF879 Gene

Genomics for ZNF879 Gene

GeneHancer (GH) Regulatory Elements for ZNF879 Gene

Promoters and enhancers for ZNF879 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05I179023 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 578 +0.1 69 1.6 ATF1 SIN3A ZNF2 YY1 ETS1 ZNF213 ZNF302 ELK1 ZNF143 ATF7 ZNF879 ZNF354C RN7SKP150 ZNF354B ZNF454 LOC100996419 MRNIP ENSG00000254035 ZFP2 GRM6
GH05I179619 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 62.5 +598.5 598541 6.1 CLOCK MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 HNRNPH1 MAML1 MRNIP ZNF879 RUFY1 ZFP2 GRM6 ZNF354C LOC100996419 ENSG00000254035
GH05I178203 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 46.9 -814.0 -813988 12.3 HDGF PKNOX1 SMAD1 ARNT ZFP64 ARID4B NEUROD1 SIN3A DMAP1 ZNF2 HNRNPAB ENSG00000247679 FAM193B ZNF879 LOC202181 ZNF354C ZFP2 ENSG00000254035 ZNF454 CLK4
GH05I179696 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 25.4 +675.2 675213 4.9 CLOCK FEZF1 DMAP1 IRF4 YY1 SLC30A9 E2F8 ZNF143 SP3 NFYC CANX GC05M179696 MAML1 HNRNPH1 ZNF354B RUFY1 MRNIP ZNF879 LOC101928445 ADAMTS2
GH05I179549 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 27.7 +526.9 526930 3.1 ARNT SIN3A ZNF2 YY1 POLR2B ZNF766 MXD4 REST ZNF592 KAT8 RUFY1 LOC105377762 ZNF354C HNRNPH1 MRNIP ZNF879 MAML1 LOC105377763 CNOT6 PRDX2P3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF879 on UCSC Golden Path with GeneCards custom track

Genomic Locations for ZNF879 Gene

Genomic Locations for ZNF879 Gene
chr5:179,023,732-179,035,064
(GRCh38/hg38)
Size:
11,333 bases
Orientation:
Plus strand
chr5:178,450,753-178,462,065
(GRCh37/hg19)

Genomic View for ZNF879 Gene

Genes around ZNF879 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF879 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF879 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF879 Gene

Proteins for ZNF879 Gene

  • Protein details for ZNF879 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    B4DU55-ZN879_HUMAN
    Recommended name:
    Zinc finger protein 879
    Protein Accession:
    B4DU55

    Protein attributes for ZNF879 Gene

    Size:
    563 amino acids
    Molecular mass:
    64577 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF879 Gene

Post-translational modifications for ZNF879 Gene

No Post-translational modifications

No data available for DME Specific Peptides for ZNF879 Gene

Domains & Families for ZNF879 Gene

Gene Families for ZNF879 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF879 Gene

Suggested Antigen Peptide Sequences for ZNF879 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

B4DU55

UniProtKB/Swiss-Prot:

ZN879_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF879: view

Function for ZNF879 Gene

Molecular function for ZNF879 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF879 Gene

Gene Ontology (GO) - Molecular Function for ZNF879 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF879: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZNF879 Gene

Localization for ZNF879 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF879 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF879 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF879 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF879: view

Pathways & Interactions for ZNF879 Gene

SuperPathways for ZNF879 Gene

No Data Available

Interacting Proteins for ZNF879 Gene

Gene Ontology (GO) - Biological Process for ZNF879 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA,IEA --
genes like me logo Genes that share ontologies with ZNF879: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF879 Gene

Drugs & Compounds for ZNF879 Gene

No Compound Related Data Available

Transcripts for ZNF879 Gene

mRNA/cDNA for ZNF879 Gene

(7) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF879 Gene

Zinc finger protein 879:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF879 Gene

No ASD Table

Relevant External Links for ZNF879 Gene

GeneLoc Exon Structure for
ZNF879
ECgene alternative splicing isoforms for
ZNF879

Expression for ZNF879 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF879 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF879 Gene:

ZNF879

SOURCE GeneReport for Unigene cluster for ZNF879 Gene:

Hs.445740
genes like me logo Genes that share expression patterns with ZNF879: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF879 Gene

Orthologs for ZNF879 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF879 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF879 33 34
  • 99.41 (n)
dog
(Canis familiaris)
Mammalia ZNF879 34
  • 90 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF879 33 34
  • 88.73 (n)
rat
(Rattus norvegicus)
Mammalia Zfp879 33
  • 80.18 (n)
mouse
(Mus musculus)
Mammalia Zfp879 33 16 34
  • 79.77 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 49 (a)
OneToMany
Species where no ortholog for ZNF879 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF879 Gene

ENSEMBL:
Gene Tree for ZNF879 (if available)
TreeFam:
Gene Tree for ZNF879 (if available)

Paralogs for ZNF879 Gene

(516) SIMAP similar genes for ZNF879 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for ZNF879 Gene

genes like me logo Genes that share paralogs with ZNF879: view

Variants for ZNF879 Gene

Sequence variations from dbSNP and Humsavar for ZNF879 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000106398 -- 179,034,687(+) A/G downstream_transcript_variant
rs1000264654 -- 179,023,172(+) A/G upstream_transcript_variant
rs1000716792 -- 179,024,722(+) A/G 5_prime_UTR_variant, intron_variant
rs1000850498 -- 179,033,774(+) C/T 3_prime_UTR_variant
rs1001345262 -- 179,034,006(+) G/A 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF879 Gene

Variant ID Type Subtype PubMed ID
nsv1120062 OTHER inversion 24896259
nsv1033597 CNV gain 25217958
nsv1027487 CNV gain 25217958
dgv5845n100 CNV gain 25217958

Variation tolerance for ZNF879 Gene

Gene Damage Index Score: 6.71; 78.65% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF879 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF879

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF879 Gene

Disorders for ZNF879 Gene

Additional Disease Information for ZNF879

No disorders were found for ZNF879 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF879 Gene

Publications for ZNF879 Gene

  1. KRAB zinc-finger proteins contribute to the evolution of gene regulatory networks. (PMID: 28273063) Imbeault M … Trono D (Nature 2017) 3 58
  2. Evolution of KRAB-containing zinc finger proteins and their roles in species evolution. (PMID: 27867147) Wang J … Tian CY (Yi chuan = Hereditas 2016) 3 58
  3. Zinc fingers function cooperatively with KRAB domain for nuclear localization of KRAB-containing zinc finger proteins. (PMID: 24647005) Wang W … Li W (PloS one 2014) 3 58
  4. Kruppel-associated box (KRAB) proteins in the adaptive immune system. (PMID: 24699165) Santoni de Sio FR (Nucleus (Austin, Tex.) 2014) 3 58
  5. Cys2His2 zinc finger protein family: classification, functions, and major members. (PMID: 22803940) Razin SV … Kantidze OL (Biochemistry. Biokhimiia 2012) 3 58

Products for ZNF879 Gene

Sources for ZNF879 Gene

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