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Aliases for ZNF878 Gene

Aliases for ZNF878 Gene

  • Zinc Finger Protein 878 2 3 4 5

External Ids for ZNF878 Gene

Previous GeneCards Identifiers for ZNF878 Gene

  • GC19M012017
  • GC19M012154
  • GC19M011728

Summaries for ZNF878 Gene

GeneCards Summary for ZNF878 Gene

ZNF878 (Zinc Finger Protein 878) is a Protein Coding gene. Among its related pathways are Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF14.

UniProtKB/Swiss-Prot for ZNF878 Gene

Additional gene information for ZNF878 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF878 Gene

Genomics for ZNF878 Gene

GeneHancer (GH) Regulatory Elements for ZNF878 Gene

Promoters and enhancers for ZNF878 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J012050 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 600.7 +1.1 1059 3.4 SP1 ELF3 NKRF POLR2A AHR SP7 HNF1A PPARG SP5 MLLT1 ENSG00000257355 ZNF878 ZNF433 ZNF433-AS1 ZNF491 ZNF441 ZNF625 RNA5SP464 ZNF625-ZNF20 RPS6P25
GH19J012781 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 59.1 -736.3 -736331 16 MTA3 ZNF652 SP1 ZFX CC2D1A ELF3 CTCF MNT SIX5 CBFA2T2 IER2 CCDC130 ZNF136 ZNF44 ZNF791 ZNF564 TRMT1 WDR83OS ZNF442 MRI1
GH19J011923 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 42.1 +127.4 127366 4.4 HDGF ZNF652 ZFX SP1 CTCF ZNF148 NKRF POLR2A ZNF121 CEBPG ZNF700 ENSG00000267179 ZNF627 ZNF136 ZNF44 ZNF763 ZNF20 ZNF564 ZNF442 ZNF791
GH19J012918 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 31.9 -866.9 -866903 2.2 ZFX SP1 NKRF MLLT1 ZNF121 POLR2A ZNF384 ZNF687 ZSCAN21 ZBTB7A MIR5695 SYCE2 CCDC130 ZNF136 TRMT1 ZNF44 ZNF20 ZNF763 ZNF564 ZNF700
GH19J012774 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 21.8 -724.4 -724439 6.2 SP1 ZFX ELF3 CTCF ZKSCAN8 MNT SIX5 CBFA2T2 ZNF148 NKRF GC19P012779 HOOK2 CCDC130 WDR83OS ZNF44 ZNF564 ZNF700 ZNF136 ZNF799 TRIR
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF878 on UCSC Golden Path with GeneCards custom track

Genomic Locations for ZNF878 Gene

Genomic Locations for ZNF878 Gene
chr19:12,043,648-12,052,967
(GRCh38/hg38)
Size:
9,320 bases
Orientation:
Minus strand
chr19:12,154,620-12,167,127
(GRCh37/hg19)
Size:
12,508 bases
Orientation:
Minus strand

Genomic View for ZNF878 Gene

Genes around ZNF878 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF878 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF878 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF878 Gene

Proteins for ZNF878 Gene

  • Protein details for ZNF878 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    C9JN71-ZN878_HUMAN
    Recommended name:
    Zinc finger protein 878
    Protein Accession:
    C9JN71

    Protein attributes for ZNF878 Gene

    Size:
    531 amino acids
    Molecular mass:
    61540 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF878 Gene

Post-translational modifications for ZNF878 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF878 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF878 Gene

Domains & Families for ZNF878 Gene

Gene Families for ZNF878 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF878 Gene

Suggested Antigen Peptide Sequences for ZNF878 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 878 (ZN878_HUMAN)

Graphical View of Domain Structure for InterPro Entry

C9JN71

UniProtKB/Swiss-Prot:

ZN878_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF878: view

Function for ZNF878 Gene

Molecular function for ZNF878 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF878 Gene

Gene Ontology (GO) - Molecular Function for ZNF878 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISA --
GO:0003676 nucleic acid binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF878: view
genes like me logo Genes that share phenotypes with ZNF878: view

Animal Model Products

CRISPR Products

miRNA for ZNF878 Gene

miRTarBase miRNAs that target ZNF878

Clone Products

  • Applied Biological Materials (abm): Clones for ZNF878 - Now 50% OFF >
  • * ZNF878 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * ZNF878 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF878 Gene

Localization for ZNF878 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF878 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF878 gene
Compartment Confidence
nucleus 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF878 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF878: view

Pathways & Interactions for ZNF878 Gene

PathCards logo

SuperPathways for ZNF878 Gene

genes like me logo Genes that share pathways with ZNF878: view

Pathways by source for ZNF878 Gene

1 KEGG pathway for ZNF878 Gene

Interacting Proteins for ZNF878 Gene

Gene Ontology (GO) - Biological Process for ZNF878 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with ZNF878: view

No data available for SIGNOR curated interactions for ZNF878 Gene

Drugs & Compounds for ZNF878 Gene

No Compound Related Data Available

Transcripts for ZNF878 Gene

mRNA/cDNA for ZNF878 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Unigene Clusters for ZNF878 Gene

Zinc finger protein 878:
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for ZNF878 - Now 50% OFF >
  • * ZNF878 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * ZNF878 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF878 Gene

No ASD Table

Relevant External Links for ZNF878 Gene

GeneLoc Exon Structure for
ZNF878
ECgene alternative splicing isoforms for
ZNF878

Expression for ZNF878 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF878 Gene

Protein differential expression in normal tissues from HIPED for ZNF878 Gene

This gene is overexpressed in Bone marrow stromal cell (61.6) and Bone marrow mesenchymal stem cell (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZNF878 Gene



Protein tissue co-expression partners for ZNF878 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF878 Gene:

ZNF878

SOURCE GeneReport for Unigene cluster for ZNF878 Gene:

Hs.704229
genes like me logo Genes that share expression patterns with ZNF878: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF878 Gene

Orthologs for ZNF878 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF878 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF878 35 34
  • 99.4 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp617 17 34
  • 68.25 (n)
Gm14408 35
  • 50 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia LOC102548917 34
  • 66.98 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 53 (a)
ManyToMany
-- 35
  • 46 (a)
ManyToMany
-- 35
  • 46 (a)
ManyToMany
-- 35
  • 45 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 45 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 40 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii CT573234.2 35
  • 41 (a)
ManyToMany
CR388132.2 35
  • 40 (a)
ManyToMany
Species where no ortholog for ZNF878 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF878 Gene

ENSEMBL:
Gene Tree for ZNF878 (if available)
TreeFam:
Gene Tree for ZNF878 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF878: view image

Paralogs for ZNF878 Gene

(530) SIMAP similar genes for ZNF878 Gene using alignment to 2 proteins:

  • ZN878_HUMAN
  • M0R1P6_HUMAN
genes like me logo Genes that share paralogs with ZNF878: view

Variants for ZNF878 Gene

Sequence variations from dbSNP and Humsavar for ZNF878 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000060186 -- 12,047,996(-) A/G genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000189957 -- 12,047,779(-) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000196831 -- 12,051,498(-) G/A genic_upstream_transcript_variant, intron_variant
rs1000270526 -- 12,051,832(-) G/A genic_upstream_transcript_variant, intron_variant
rs1000529517 -- 12,050,142(-) T/C genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF878 Gene

Variant ID Type Subtype PubMed ID
esv3643691 CNV loss 21293372
nsv525966 CNV gain 19592680
nsv578619 CNV loss 21841781
nsv963005 CNV duplication 23825009

Variation tolerance for ZNF878 Gene

Residual Variation Intolerance Score: 92% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.97; 68.16% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF878 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF878

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF878 Gene

Disorders for ZNF878 Gene

Additional Disease Information for ZNF878

No disorders were found for ZNF878 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF878 Gene

Publications for ZNF878 Gene

  1. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 58
  2. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 4 58

Products for ZNF878 Gene

Sources for ZNF878 Gene

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