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Aliases for ZNF878 Gene

Aliases for ZNF878 Gene

  • Zinc Finger Protein 878 2 3 5

External Ids for ZNF878 Gene

Previous GeneCards Identifiers for ZNF878 Gene

  • GC19M012017
  • GC19M012154
  • GC19M011728

Summaries for ZNF878 Gene

GeneCards Summary for ZNF878 Gene

ZNF878 (Zinc Finger Protein 878) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF433.

UniProtKB/Swiss-Prot for ZNF878 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF878 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF878 Gene

Genomics for ZNF878 Gene

GeneHancer (GH) Regulatory Elements for ZNF878 Gene

Promoters and enhancers for ZNF878 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I012051 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 +0.4 359 2 HDGF PKNOX1 ARID4B DMAP1 ZNF48 ETS1 SLC30A9 POLR2B ZNF207 RUNX3 ZNF878 ENSG00000257355 ZNF433-AS1 RNA5SP464 ZNF625-ZNF20 PIR32603
GH19I012052 Enhancer 0.3 ENCODE 550.8 +1.7 1748 0.2 ZBTB33 ZNF878 ENSG00000257355 ZNF433-AS1 RNA5SP464 ZNF625-ZNF20 PIR32603
GH19I012781 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 50.7 -736.3 -736331 16 CLOCK MLX FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 JUNB CCDC130 ZNF136 ZNF44 ZNF791 ZNF564 WDR83OS TRMT1 ZNF700 TRIR
GH19I012983 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 40.2 -931.8 -931835 3.2 HDGF PKNOX1 CLOCK FOXA2 MLX ARID4B SIN3A DMAP1 ZNF2 ZNF766 ZNF136 ZNF625 ZNF442 ZNF844 CCDC130 ZNF564 ZNF799 WDR83OS ZNF788 ZNF709
GH19I012733 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 33.1 -682.9 -682871 5.7 CLOCK ZFP64 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 TRIR ASNA1 ZNF136 CCDC130 ZNF44 ZNF564 WDR83OS ZNF700 ZNF791 ZNF878
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF878 on UCSC Golden Path with GeneCards custom track

Genomic Locations for ZNF878 Gene

Genomic Locations for ZNF878 Gene
chr19:12,043,648-12,052,967
(GRCh38/hg38)
Size:
9,320 bases
Orientation:
Minus strand
chr19:12,154,620-12,167,127
(GRCh37/hg19)

Genomic View for ZNF878 Gene

Genes around ZNF878 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF878 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF878 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF878 Gene

Proteins for ZNF878 Gene

  • Protein details for ZNF878 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    C9JN71-ZN878_HUMAN
    Recommended name:
    Zinc finger protein 878
    Protein Accession:
    C9JN71

    Protein attributes for ZNF878 Gene

    Size:
    531 amino acids
    Molecular mass:
    61540 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF878 Gene

Post-translational modifications for ZNF878 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF878 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF878 Gene

Domains & Families for ZNF878 Gene

Gene Families for ZNF878 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF878 Gene

Suggested Antigen Peptide Sequences for ZNF878 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

C9JN71

UniProtKB/Swiss-Prot:

ZN878_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF878: view

Function for ZNF878 Gene

Molecular function for ZNF878 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF878 Gene

Gene Ontology (GO) - Molecular Function for ZNF878 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF878: view

Phenotypes for ZNF878 Gene

genes like me logo Genes that share phenotypes with ZNF878: view

miRNA for ZNF878 Gene

miRTarBase miRNAs that target ZNF878

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF878 Gene

Localization for ZNF878 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF878 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF878 gene
Compartment Confidence
nucleus 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF878 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF878: view

Pathways & Interactions for ZNF878 Gene

SuperPathways for ZNF878 Gene

No Data Available

Interacting Proteins for ZNF878 Gene

Gene Ontology (GO) - Biological Process for ZNF878 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF878: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF878 Gene

Drugs & Compounds for ZNF878 Gene

No Compound Related Data Available

Transcripts for ZNF878 Gene

mRNA/cDNA for ZNF878 Gene

(3) REFSEQ mRNAs :
(0) Additional mRNA sequences :
-
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF878 Gene

Zinc finger protein 878:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF878 Gene

No ASD Table

Relevant External Links for ZNF878 Gene

GeneLoc Exon Structure for
ZNF878
ECgene alternative splicing isoforms for
ZNF878

Expression for ZNF878 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF878 Gene

Protein differential expression in normal tissues from HIPED for ZNF878 Gene

This gene is overexpressed in Bone marrow stromal cell (61.6) and Bone marrow mesenchymal stem cell (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZNF878 Gene



Protein tissue co-expression partners for ZNF878 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF878 Gene:

ZNF878

SOURCE GeneReport for Unigene cluster for ZNF878 Gene:

Hs.704229
genes like me logo Genes that share expression patterns with ZNF878: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF878 Gene

Orthologs for ZNF878 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF878 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF878 33 34
  • 99.4 (n)
mouse
(Mus musculus)
Mammalia Zfp617 33 16
  • 68.25 (n)
Gm14408 34
  • 50 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia LOC102548917 33
  • 66.98 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 53 (a)
ManyToMany
-- 34
  • 46 (a)
ManyToMany
-- 34
  • 46 (a)
ManyToMany
-- 34
  • 45 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 45 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 40 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii CT573234.2 34
  • 41 (a)
ManyToMany
CR388132.2 34
  • 40 (a)
ManyToMany
Species where no ortholog for ZNF878 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF878 Gene

ENSEMBL:
Gene Tree for ZNF878 (if available)
TreeFam:
Gene Tree for ZNF878 (if available)

Paralogs for ZNF878 Gene

(530) SIMAP similar genes for ZNF878 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZNF878: view

Variants for ZNF878 Gene

Sequence variations from dbSNP and Humsavar for ZNF878 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000060186 -- 12,047,996(-) A/G genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000189957 -- 12,047,779(-) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000196831 -- 12,051,498(-) G/A genic_upstream_transcript_variant, intron_variant
rs1000270526 -- 12,051,832(-) G/A genic_upstream_transcript_variant, intron_variant
rs1000529517 -- 12,050,142(-) T/C genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF878 Gene

Variant ID Type Subtype PubMed ID
esv3643691 CNV loss 21293372
nsv525966 CNV gain 19592680
nsv578619 CNV loss 21841781
nsv963005 CNV duplication 23825009

Variation tolerance for ZNF878 Gene

Residual Variation Intolerance Score: 92% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.97; 68.16% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF878 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF878

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF878 Gene

Disorders for ZNF878 Gene

Additional Disease Information for ZNF878

No disorders were found for ZNF878 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF878 Gene

Publications for ZNF878 Gene

  1. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 58
  2. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 4 58

Products for ZNF878 Gene

Sources for ZNF878 Gene

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