Aliases for ZNF875 Gene

Aliases for ZNF875 Gene

  • Zinc Finger Protein 875 2 3 4 5
  • HKR1, GLI-Kruppel Zinc Finger Family Member 2 3
  • Krueppel-Related Zinc Finger Protein 1 3 4
  • Oncogene HKR1 2 3
  • HKR1 3 4
  • GLI-Kruppel Family Member HKR1 2
  • Protein HKR1 4
  • ZNF875 5

External Ids for ZNF875 Gene

Previous HGNC Symbols for ZNF875 Gene

  • HKR1

Previous GeneCards Identifiers for ZNF875 Gene

  • GC19P037313
  • GC19P037314
  • GC19P037362
  • GC19P037756

Summaries for ZNF875 Gene

GeneCards Summary for ZNF875 Gene

ZNF875 (Zinc Finger Protein 875) is a Protein Coding gene. Diseases associated with ZNF875 include Partial Fetal Alcohol Syndrome. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. An important paralog of this gene is ZNF133.

UniProtKB/Swiss-Prot Summary for ZNF875 Gene

Gene Wiki entry for ZNF875 Gene

Additional gene information for ZNF875 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF875 Gene

Genomics for ZNF875 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF875 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J037333 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 600.4 +22.1 22148 2 SP1 CREB1 PRDM10 ZNF629 ZNF692 POLR2A GABPA ZNF143 ZSCAN4 SMAD5 ZNF875 ZNF383 ZNF793 ZNF850 ZNF345 ZNF527 ZNF567 ZNF540 ZNF571 ZNF382
GH19J037312 Promoter/Enhancer 1.3 Ensembl ENCODE CraniofacialAtlas 619.4 +0.0 13 1.5 RFX1 ZNF600 RBAK RFX3 SP2 BMI1 PKNOX1 KLF8 SAP130 ELF1 ZNF875 lnc-ZNF527-6 ZNF527 ZNF567 ZNF383 ZNF345 ENSG00000267682 ZNF850 ZNF793 ZNF571
GH19J037466 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas 166.5 +155.4 155364 4.8 ZNF221 SP1 HNRNPL CREB1 GATAD2A PRDM10 ZNF629 SIX5 NFKBIZ KDM1A ZNF570 ZNF569 lnc-ZNF569-1 ZNF567 ZNF345 ZNF383 ZNF527 ZNF585B ZNF850 ZNF571
GH19J037593 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 164.6 +281.9 281864 3 ZNF221 CEBPG HNRNPL CREB1 PRDM10 ZNF629 RFX1 SIX5 IKZF1 ZNF692 ZNF571 ZNF540 HSALNG0125851 ZNF567 ZNF527 ZFP30 ZNF345 ZNF383 ZNF875 ZNF607
GH19J037346 Promoter 0.6 EPDnew 604.6 +33.5 33469 0.1 ZIC2 ZNF561 ZNF610 ZNF875 ZNF527 ENSG00000267682 RF00017-2955 LINC01535
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF875 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF875

Genomic Locations for ZNF875 Gene

Genomic Locations for ZNF875 Gene
56,529 bases
Plus strand
56,529 bases
Plus strand

Genomic View for ZNF875 Gene

Genes around ZNF875 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF875 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF875 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF875 Gene

Proteins for ZNF875 Gene

  • Protein details for ZNF875 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 875
    Protein Accession:
    Secondary Accessions:
    • A8MRS7
    • Q6PJD0
    • Q9BSW9
    • Q9UM09

    Protein attributes for ZNF875 Gene

    659 amino acids
    Molecular mass:
    75128 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA86058.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF875 Gene


neXtProt entry for ZNF875 Gene

Post-translational modifications for ZNF875 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF875 Gene

Domains & Families for ZNF875 Gene

Gene Families for ZNF875 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF875 Gene

  • KRAB box

Suggested Antigen Peptide Sequences for ZNF875 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 875 (HKR1_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF875: view

Function for ZNF875 Gene

Molecular function for ZNF875 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF875 Gene

Gene Ontology (GO) - Molecular Function for ZNF875 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity IBA 21873635
GO:0043565 sequence-specific DNA binding IBA 21873635
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF875: view
genes like me logo Genes that share phenotypes with ZNF875: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF875

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF875 Gene

Localization for ZNF875 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF875 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF875 gene
Compartment Confidence
nucleus 5
mitochondrion 2
cytosol 2
golgi apparatus 2
plasma membrane 1
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF875 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF875: view

Pathways & Interactions for ZNF875 Gene

genes like me logo Genes that share pathways with ZNF875: view

Pathways by source for ZNF875 Gene

2 Reactome pathways for ZNF875 Gene
1 KEGG pathway for ZNF875 Gene

Interacting Proteins for ZNF875 Gene

Gene Ontology (GO) - Biological Process for ZNF875 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA,NAS 2850480
GO:0007275 multicellular organism development NAS 2850480
genes like me logo Genes that share ontologies with ZNF875: view

No data available for SIGNOR curated interactions for ZNF875 Gene

Drugs & Compounds for ZNF875 Gene

No Compound Related Data Available

Transcripts for ZNF875 Gene

mRNA/cDNA for ZNF875 Gene

13 NCBI additional mRNA sequence :
28 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF875

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF875 Gene

No ASD Table

Relevant External Links for ZNF875 Gene

GeneLoc Exon Structure for

Expression for ZNF875 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF875

SOURCE GeneReport for Unigene cluster for ZNF875 Gene:


Evidence on tissue expression from TISSUES for ZNF875 Gene

  • Nervous system(4)
  • Eye(2.4)
No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF875 Gene

Orthologs for ZNF875 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ZNF875 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia HKR1 30 31
  • 98.73 (n)
(Canis familiaris)
Mammalia HKR1 30 31
  • 86.87 (n)
(Bos Taurus)
Mammalia HKR1 30
  • 82.94 (n)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TDA9 33
Species where no ortholog for ZNF875 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ZNF875 Gene

Gene Tree for ZNF875 (if available)
Gene Tree for ZNF875 (if available)
Evolutionary constrained regions (ECRs) for ZNF875: view image

Paralogs for ZNF875 Gene

genes like me logo Genes that share paralogs with ZNF875: view

Variants for ZNF875 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF875 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
692312 Uncertain Significance: Fetal akinesia sequence; Arthrogryposis multiplex congenita 37,363,301(+) TG/T FRAMESHIFT_VARIANT,NON_CODING_TRANSCRIPT_VARIANT
rs2921563 - p.Arg448His
rs3745764 - p.Thr628Ile

Additional dbSNP identifiers (rs#s) for ZNF875 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF875 Gene

Variant ID Type Subtype PubMed ID
esv2758759 CNV loss 17122850
nsv9718 CNV loss 18304495

Variation tolerance for ZNF875 Gene

Residual Variation Intolerance Score: 91.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.38; 90.83% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF875 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF875 Gene

Disorders for ZNF875 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZNF875 Gene - From: DISEASES

Disorder Aliases PubMed IDs
partial fetal alcohol syndrome
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ZNF875

genes like me logo Genes that share disorders with ZNF875: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF875 Gene

Publications for ZNF875 Gene

  1. The Krüppel-type zinc finger family gene, HKR1, is induced in lung cancer by exposure to platinum drugs. (PMID: 9813242) Oguri T … Watanabe H (Gene 1998) 2 3 4
  2. The GLI-Kruppel family of human genes. (PMID: 2850480) Ruppert JM … Vogelstein B (Molecular and cellular biology 1988) 2 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. Methylation of the genes ROD1, NLRC5, and HKR1 is associated with aging in Hainan centenarians. (PMID: 29394898) Zeng Q … Luan F (BMC medical genomics 2018) 3
  5. Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing. (PMID: 28611215) Fei T … Brown M (Proceedings of the National Academy of Sciences of the United States of America 2017) 3

Products for ZNF875 Gene

Sources for ZNF875 Gene