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Aliases for ZNF860 Gene

Aliases for ZNF860 Gene

  • Zinc Finger Protein 860 2 3 5

External Ids for ZNF860 Gene

Previous GeneCards Identifiers for ZNF860 Gene

  • GC03P032007

Summaries for ZNF860 Gene

GeneCards Summary for ZNF860 Gene

ZNF860 (Zinc Finger Protein 860) is a Protein Coding gene. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF808.

UniProtKB/Swiss-Prot for ZNF860 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF860 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF860 Gene

Genomics for ZNF860 Gene

GeneHancer (GH) Regulatory Elements for ZNF860 Gene

Promoters and enhancers for ZNF860 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I031978 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 550.8 -1.3 -1261 5 PKNOX1 CLOCK FOXA2 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B IRF4 OSBPL10 ZNF860 CNOT10 PIR35964 GC03P031804 GC03P031803 GC03P031801
GH03I031530 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10 -448.9 -448903 5.1 CLOCK MLX DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 ZNF263 SP3 GC03M031530 STT3B ZNF860 CMTM6 GC03P031521 GC03M031604
GH03I031944 Enhancer 1.3 Ensembl ENCODE dbSUPER 11.8 -34.8 -34785 5 FOXA2 MLX ARID4B DMAP1 SLC30A9 SP5 MIER2 PPARG KAT8 NFIL3 OSBPL10 ZNF860 OSBPL10-AS1 GC03P031801 GC03P031803 GC03P031804 PIR35964
GH03I031889 Enhancer 0.8 ENCODE dbSUPER 10.5 -89.7 -89710 4.7 ZNF687 CLOCK USF1 ZFP64 NEUROD1 DPF2 ZNF592 CTBP1 GATA3 CREB1 ZNF860 OSBPL10 PIR35964 GC03P031804 GC03P031803 GC03P031801
GH03I031941 Enhancer 0.7 dbSUPER 11.8 -40.1 -40066 0.8 SOX13 FOXA2 TEAD3 NR2F6 CREM SOX5 ZNF3 NFIA SP5 FOXA3 OSBPL10 ZNF860 GC03P031801 GC03P031803 GC03P031804 PIR35964
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF860 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF860 gene promoter:

Genomic Locations for ZNF860 Gene

Genomic Locations for ZNF860 Gene
chr3:31,981,771-31,991,736
(GRCh38/hg38)
Size:
9,966 bases
Orientation:
Plus strand
chr3:32,023,263-32,033,228
(GRCh37/hg19)

Genomic View for ZNF860 Gene

Genes around ZNF860 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF860 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF860 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF860 Gene

Proteins for ZNF860 Gene

  • Protein details for ZNF860 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NHJ4-ZN860_HUMAN
    Recommended name:
    Zinc finger protein 860
    Protein Accession:
    A6NHJ4
    Secondary Accessions:
    • B4DFA4

    Protein attributes for ZNF860 Gene

    Size:
    632 amino acids
    Molecular mass:
    73757 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF860 Gene

Post-translational modifications for ZNF860 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF860 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF860 Gene

Domains & Families for ZNF860 Gene

Gene Families for ZNF860 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF860 Gene

Suggested Antigen Peptide Sequences for ZNF860 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6NHJ4

UniProtKB/Swiss-Prot:

ZN860_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF860: view

Function for ZNF860 Gene

Molecular function for ZNF860 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF860 Gene

Gene Ontology (GO) - Molecular Function for ZNF860 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF860: view
genes like me logo Genes that share phenotypes with ZNF860: view

miRNA for ZNF860 Gene

miRTarBase miRNAs that target ZNF860

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF860 Gene

Localization for ZNF860 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF860 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF860 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF860 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF860: view

Pathways & Interactions for ZNF860 Gene

SuperPathways for ZNF860 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF860: view

Pathways by source for ZNF860 Gene

2 Reactome pathways for ZNF860 Gene

Interacting Proteins for ZNF860 Gene

Gene Ontology (GO) - Biological Process for ZNF860 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA --
genes like me logo Genes that share ontologies with ZNF860: view

No data available for SIGNOR curated interactions for ZNF860 Gene

Drugs & Compounds for ZNF860 Gene

No Compound Related Data Available

Transcripts for ZNF860 Gene

mRNA/cDNA for ZNF860 Gene

(2) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(11) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF860 Gene

Zinc finger protein 860:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF860 Gene

No ASD Table

Relevant External Links for ZNF860 Gene

GeneLoc Exon Structure for
ZNF860
ECgene alternative splicing isoforms for
ZNF860

Expression for ZNF860 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF860 Gene

mRNA differential expression in normal tissues according to GTEx for ZNF860 Gene

This gene is overexpressed in Esophagus - Mucosa (x4.4).

Protein differential expression in normal tissues from HIPED for ZNF860 Gene

This gene is overexpressed in Fetal ovary (31.3), Fetal heart (19.1), and Fetal testis (18.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZNF860 Gene



Protein tissue co-expression partners for ZNF860 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF860 Gene:

ZNF860

SOURCE GeneReport for Unigene cluster for ZNF860 Gene:

Hs.585139

Evidence on tissue expression from TISSUES for ZNF860 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with ZNF860: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF860 Gene

Orthologs for ZNF860 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF860 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF860 33 34
  • 93.99 (n)
dog
(Canis familiaris)
Mammalia -- 34
  • 52 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia -- 34
  • 43 (a)
ManyToMany
Species where no ortholog for ZNF860 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF860 Gene

ENSEMBL:
Gene Tree for ZNF860 (if available)
TreeFam:
Gene Tree for ZNF860 (if available)

Paralogs for ZNF860 Gene

(487) SIMAP similar genes for ZNF860 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for ZNF860 Gene

genes like me logo Genes that share paralogs with ZNF860: view

Variants for ZNF860 Gene

Sequence variations from dbSNP and Humsavar for ZNF860 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000035986 -- 32,000,455(+) A/G genic_downstream_transcript_variant, intron_variant
rs1000156100 -- 31,994,646(+) T/G genic_downstream_transcript_variant, intron_variant
rs1000298873 -- 31,986,028(+) T/C 5_prime_UTR_variant, intron_variant, non_coding_transcript_variant
rs1000374836 -- 31,980,699(+) G/A upstream_transcript_variant
rs1000405524 -- 32,000,778(+) C/A/T genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF860 Gene

Variant ID Type Subtype PubMed ID
esv2661264 CNV deletion 23128226
esv2725102 CNV deletion 23290073
esv2725103 CNV deletion 23290073
esv3595765 CNV loss 21293372
esv3595766 CNV loss 21293372
nsv1003285 CNV gain 25217958
nsv1011573 CNV gain 25217958
nsv590033 CNV loss 21841781
nsv954459 CNV deletion 24416366
nsv967000 CNV duplication 23825009

Variation tolerance for ZNF860 Gene

Residual Variation Intolerance Score: 88.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.04; 87.54% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF860 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF860

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF860 Gene

Disorders for ZNF860 Gene

Additional Disease Information for ZNF860

No disorders were found for ZNF860 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF860 Gene

Publications for ZNF860 Gene

  1. The DNA sequence, annotation and analysis of human chromosome 3. (PMID: 16641997) Muzny DM … Gibbs RA (Nature 2006) 3 4 58
  2. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 58
  3. Genome-wide association study of periodontal health measured by probing depth in adults ages 18-49 years. (PMID: 24347629) Shaffer JR … Marazita ML (G3 (Bethesda, Md.) 2014) 3 58
  4. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A … Hentze MW (Cell 2012) 3 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 4 58

Products for ZNF860 Gene

Sources for ZNF860 Gene

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