Aliases for ZNF85 Gene

Aliases for ZNF85 Gene

  • Zinc Finger Protein 85 2 3 4 5
  • Zinc Finger Protein 85 (HPF4, HTF1) 2 3
  • HPF4 2 3
  • HTF1 2 3
  • Zinc Finger Protein HPF4 4
  • Zinc Finger Protein HTF1 4
  • ZNF85 5

External Ids for ZNF85 Gene

Previous GeneCards Identifiers for ZNF85 Gene

  • GC19P021544
  • GC19P021425
  • GC19P020882
  • GC19P020767
  • GC19P020897
  • GC19P021106
  • GC19P020597

Summaries for ZNF85 Gene

GeneCards Summary for ZNF85 Gene

ZNF85 (Zinc Finger Protein 85) is a Protein Coding gene. Diseases associated with ZNF85 include Thrombocytopenia. Among its related pathways are Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and transcription corepressor activity. An important paralog of this gene is ZNF93.

UniProtKB/Swiss-Prot Summary for ZNF85 Gene

Additional gene information for ZNF85 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF85 Gene

Genomics for ZNF85 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF85 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J020922 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE CraniofacialAtlas 605.8 +0.5 506 2.5 SP1 PRDM10 FOS LARP7 GABPA PKNOX1 POLR2A REST SMAD5 IKZF2 ZNF85 ZNF100 ZNF66 ZNF90 RPL7AP10 ZNF431 ZNF43 ZNF486 BNIP3P17 ENSG00000268416
GH19J020775 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 9.4 -146.4 -146404 2.4 SP1 CREB1 REST POLR2A FOS LARP7 DDX20 ZIC2 PKNOX1 IRF2 ZNF66 ENSG00000267481 ZNF90 ZNF506 ZNF100 ZNF486 ENSG00000268416 ZNF85 ENSG00000269779 BNIP3P24
GH19J021599 Promoter/Enhancer 1.8 Ensembl ENCODE CraniofacialAtlas dbSUPER 4.9 +679.3 679342 6.7 TEAD4 LEF1 IKZF1 JUND DDX20 MTA2 PKNOX1 ZNF24 MTA1 REST ENSG00000268555 ZNF429 ZNF708 ENSG00000268119 ZNF100 ZNF85 piR-56759-271 LOC101929007 LOC105372323 lnc-ZNF429-2
GH19J020927 Enhancer 0.3 Ensembl ENCODE 5.3 +5.1 5104 1.8 ENSG00000279404 ZNF66 ZNF85 ENSG00000268416 BNIP3P17 ZNF430
GH19J020970 Enhancer 0.2 FANTOM5 5.4 +47.2 47200 0.2 LOC112268247 lnc-ZNF626-5 piR-57133-313 ZNF85 ENSG00000268326 ZNF430
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF85 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF85

Top Transcription factor binding sites by QIAGEN in the ZNF85 gene promoter:
  • CBF(2)
  • CBF-A
  • CBF-B
  • CP1A
  • NF-Y
  • NF-YA
  • NF-YB

Genomic Locations for ZNF85 Gene

Genomic Locations for ZNF85 Gene
27,476 bases
Plus strand
27,476 bases
Plus strand

Genomic View for ZNF85 Gene

Genes around ZNF85 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF85 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF85 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF85 Gene

Proteins for ZNF85 Gene

  • Protein details for ZNF85 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 85
    Protein Accession:
    Secondary Accessions:
    • B9ZVP4
    • Q6NVI0

    Protein attributes for ZNF85 Gene

    595 amino acids
    Molecular mass:
    68736 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF85 Gene


neXtProt entry for ZNF85 Gene

Post-translational modifications for ZNF85 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF85 Gene

Domains & Families for ZNF85 Gene

Gene Families for ZNF85 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF85 Gene

  • C2H2-type zinc finger signature
  • KRAB box

Suggested Antigen Peptide Sequences for ZNF85 Gene

GenScript: Design optimal peptide antigens:
  • ZNF85 protein (Q49A12_HUMAN)
  • ZNF85 protein (Q6NVI0_HUMAN)
  • ZNF85 protein (Q96HE0_HUMAN)
  • Zinc finger protein HTF1 (ZNF85_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF85: view

Function for ZNF85 Gene

Molecular function for ZNF85 Gene

UniProtKB/Swiss-Prot Function:
May be a transcriptional repressor.
GENATLAS Biochemistry:
zinc finger protein (HPF4,HTF1) KRAB subfamily,member of ZNF91 family,expressed in normal adult testis and in seminomas

Gene Ontology (GO) - Molecular Function for ZNF85 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IBA 21873635
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding TAS 9839802
GO:0003700 DNA-binding transcription factor activity TAS 9839802
GO:0003714 transcription corepressor activity TAS 9839802
genes like me logo Genes that share ontologies with ZNF85: view
genes like me logo Genes that share phenotypes with ZNF85: view

Animal Model Products

CRISPR Products

miRNA for ZNF85 Gene

miRTarBase miRNAs that target ZNF85

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF85

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF85 Gene

Localization for ZNF85 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF85 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF85 gene
Compartment Confidence
nucleus 5
cytosol 2
plasma membrane 1
extracellular 1
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF85 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS,IBA 21873635
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with ZNF85: view

Pathways & Interactions for ZNF85 Gene

PathCards logo

SuperPathways for ZNF85 Gene

genes like me logo Genes that share pathways with ZNF85: view

Pathways by source for ZNF85 Gene

1 KEGG pathway for ZNF85 Gene

Gene Ontology (GO) - Biological Process for ZNF85 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA,IBA 21873635
GO:1903507 negative regulation of nucleic acid-templated transcription IEA --
genes like me logo Genes that share ontologies with ZNF85: view

No data available for SIGNOR curated interactions for ZNF85 Gene

Drugs & Compounds for ZNF85 Gene

(1) Drugs for ZNF85 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with ZNF85: view

Transcripts for ZNF85 Gene

mRNA/cDNA for ZNF85 Gene

16 NCBI additional mRNA sequence :
14 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF85

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF85 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d
SP1: - -
SP2: - - - - - -
SP3: -
SP4: - -
SP5: - - - - - - -
SP6: - - - -

Relevant External Links for ZNF85 Gene

GeneLoc Exon Structure for

Expression for ZNF85 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF85 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Testis (Reproductive System)

mRNA differential expression in normal tissues according to GTEx for ZNF85 Gene

This gene is overexpressed in Testis (x6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF85 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF85

SOURCE GeneReport for Unigene cluster for ZNF85 Gene:


mRNA Expression by UniProt/SwissProt for ZNF85 Gene:

Tissue specificity: Widely expressed, including in testis.

Evidence on tissue expression from TISSUES for ZNF85 Gene

  • Lung(4.2)
genes like me logo Genes that share expression patterns with ZNF85: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF85 Gene

Orthologs for ZNF85 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF85 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF85 30 31
  • 99.09 (n)
(Bos Taurus)
Mammalia -- 31
  • 58 (a)
(Mus musculus)
Mammalia Zfp493 31
  • 58 (a)
(Monodelphis domestica)
Mammalia -- 31
  • 52 (a)
-- 31
  • 43 (a)
(Canis familiaris)
Mammalia -- 31
  • 42 (a)
(Anolis carolinensis)
Reptilia -- 31
  • 54 (a)
-- 31
  • 46 (a)
-- 31
  • 41 (a)
-- 31
  • 39 (a)
-- 31
  • 36 (a)
-- 31
  • 36 (a)
-- 31
  • 35 (a)
-- 31
  • 30 (a)
(Danio rerio)
Actinopterygii wufc22b08 30
Fruit Fly
(Drosophila melanogaster)
Insecta bowl 32
  • 46 (a)
sob 32
  • 46 (a)
CG18764 32
  • 43 (a)
CG10147 32
  • 36 (a)
EG:95B7.7 32
  • 32 (a)
CG7386 32
  • 30 (a)
Species where no ortholog for ZNF85 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for ZNF85 Gene

Gene Tree for ZNF85 (if available)
Gene Tree for ZNF85 (if available)
Evolutionary constrained regions (ECRs) for ZNF85: view image

Paralogs for ZNF85 Gene

Paralogs for ZNF85 Gene

(596) SIMAP similar genes for ZNF85 Gene using alignment to 12 proteins:

  • M0QY93_HUMAN
  • M0QZ75_HUMAN
  • M0R0J7_HUMAN
  • M0R0V3_HUMAN
  • M0R120_HUMAN
  • M0R1W3_HUMAN
  • M0R385_HUMAN
  • Q49A12_HUMAN
  • Q96HE0_HUMAN
genes like me logo Genes that share paralogs with ZNF85: view

Variants for ZNF85 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF85 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs1063156 - p.Thr266Ala
rs11665978 - p.Gly184Arg
rs11670246 - p.Phe270Ser
rs56231962 - p.Arg115Ile
rs56321708 - p.Gln84Arg

Additional dbSNP identifiers (rs#s) for ZNF85 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF85 Gene

Variant ID Type Subtype PubMed ID
dgv201n21 CNV loss 19592680
dgv3470n100 CNV gain 25217958
esv2763043 CNV gain 21179565
esv3583298 CNV loss 25503493
esv3583299 CNV loss 25503493
nsv1055738 CNV gain 25217958
nsv1058430 CNV loss 25217958
nsv1063954 CNV gain 25217958
nsv1066170 CNV loss 25217958
nsv1067455 CNV gain 25217958
nsv1138680 CNV deletion 24896259
nsv2438 CNV insertion 18451855
nsv458377 CNV gain 19166990
nsv509727 CNV insertion 20534489
nsv578809 CNV gain 21841781
nsv578946 CNV loss 21841781
nsv578947 CNV loss 21841781
nsv960809 CNV duplication 23825009

Variation tolerance for ZNF85 Gene

Residual Variation Intolerance Score: 97.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.95; 59.76% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF85 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF85 Gene

Disorders for ZNF85 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZNF85 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
- elite association - COSMIC cancer census association via MalaCards
Search ZNF85 in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with ZNF85: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF85 Gene

Publications for ZNF85 Gene

  1. Functional analysis of ZNF85 KRAB zinc finger protein, a member of the highly homologous ZNF91 family. (PMID: 9839802) Poncelet DA … Martial JA (DNA and cell biology 1998) 3 4 23
  2. The evolutionarily conserved Krüppel-associated box domain defines a subfamily of eukaryotic multifingered proteins. (PMID: 2023909) Bellefroid EJ … Martial JA (Proceedings of the National Academy of Sciences of the United States of America 1991) 3 4
  3. The human genome contains hundreds of genes coding for finger proteins of the Krüppel type. (PMID: 2505992) Bellefroid EJ … Martial JA (DNA (Mary Ann Liebert, Inc.) 1989) 2 3
  4. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3

Products for ZNF85 Gene

Sources for ZNF85 Gene