Aliases for ZNF846 Gene

Aliases for ZNF846 Gene

  • Zinc Finger Protein 846 2 3 4 5

External Ids for ZNF846 Gene

Previous GeneCards Identifiers for ZNF846 Gene

  • GC19M009868
  • GC19M009449

Summaries for ZNF846 Gene

GeneCards Summary for ZNF846 Gene

ZNF846 (Zinc Finger Protein 846) is a Protein Coding gene. Among its related pathways are Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF778.

UniProtKB/Swiss-Prot Summary for ZNF846 Gene

Additional gene information for ZNF846 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF846 Gene

Genomics for ZNF846 Gene

GeneHancer (GH) Regulatory Elements for ZNF846 Gene

Promoters and enhancers for ZNF846 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF846 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF846

Top Transcription factor binding sites by QIAGEN in the ZNF846 gene promoter:
  • C/EBPalpha
  • CREB
  • deltaCREB
  • HNF-1
  • HNF-1A
  • HTF
  • p53
  • Pax-6
  • POU2F1c
  • XBP-1

Genomic Locations for ZNF846 Gene

Genomic Locations for ZNF846 Gene
chr19:9,751,993-9,793,180
(GRCh38/hg38)
Size:
41,188 bases
Orientation:
Minus strand
chr19:9,862,669-9,903,856
(GRCh37/hg19)
Size:
41,188 bases
Orientation:
Minus strand

Genomic View for ZNF846 Gene

Genes around ZNF846 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF846 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF846 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF846 Gene

Proteins for ZNF846 Gene

  • Protein details for ZNF846 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q147U1-ZN846_HUMAN
    Recommended name:
    Zinc finger protein 846
    Protein Accession:
    Q147U1
    Secondary Accessions:
    • A8K0H1
    • B3KUP1

    Protein attributes for ZNF846 Gene

    Size:
    533 amino acids
    Molecular mass:
    60552 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF846 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF846 Gene

Post-translational modifications for ZNF846 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF846 Gene

Domains & Families for ZNF846 Gene

Gene Families for ZNF846 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF846 Gene

Suggested Antigen Peptide Sequences for ZNF846 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 846 (ZN846_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q147U1

UniProtKB/Swiss-Prot:

ZN846_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF846: view

Function for ZNF846 Gene

Molecular function for ZNF846 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF846 Gene

Gene Ontology (GO) - Molecular Function for ZNF846 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity IBA 21873635
GO:0005515 protein binding IPI 25416956
GO:0043565 sequence-specific DNA binding IBA 21873635
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF846: view
genes like me logo Genes that share phenotypes with ZNF846: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF846 Gene

Localization for ZNF846 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF846 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF846 gene
Compartment Confidence
nucleus 4
cytoskeleton 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Actin filaments (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF846 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IBA 21873635
genes like me logo Genes that share ontologies with ZNF846: view

Pathways & Interactions for ZNF846 Gene

PathCards logo

SuperPathways for ZNF846 Gene

genes like me logo Genes that share pathways with ZNF846: view

Pathways by source for ZNF846 Gene

1 KEGG pathway for ZNF846 Gene

Interacting Proteins for ZNF846 Gene

;

Gene Ontology (GO) - Biological Process for ZNF846 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF846: view

No data available for SIGNOR curated interactions for ZNF846 Gene

Drugs & Compounds for ZNF846 Gene

No Compound Related Data Available

Transcripts for ZNF846 Gene

mRNA/cDNA for ZNF846 Gene

4 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
12 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF846 Gene

No ASD Table

Relevant External Links for ZNF846 Gene

GeneLoc Exon Structure for
ZNF846

Expression for ZNF846 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF846 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF846 Gene



Protein tissue co-expression partners for ZNF846 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF846

SOURCE GeneReport for Unigene cluster for ZNF846 Gene:

Hs.665717

Evidence on tissue expression from TISSUES for ZNF846 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with ZNF846: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF846 Gene

Orthologs for ZNF846 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF846 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF846 31 30
  • 99.44 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF846 30
  • 78.18 (n)
mouse
(Mus musculus)
Mammalia Zfp846 17 30
  • 64.77 (n)
rat
(Rattus norvegicus)
Mammalia Zfp846 30
  • 64.77 (n)
Species where no ortholog for ZNF846 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF846 Gene

ENSEMBL:
Gene Tree for ZNF846 (if available)
TreeFam:
Gene Tree for ZNF846 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF846: view image

Paralogs for ZNF846 Gene

(506) SIMAP similar genes for ZNF846 Gene using alignment to 5 proteins:

  • ZN846_HUMAN
  • K7ELQ5_HUMAN
  • K7ELV4_HUMAN
  • K7EML1_HUMAN
  • K7EMP9_HUMAN
genes like me logo Genes that share paralogs with ZNF846: view

Variants for ZNF846 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF846 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs10414485 - p.Cys450Tyr
rs10420364 - p.Tyr492Cys

Additional dbSNP identifiers (rs#s) for ZNF846 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF846 Gene

Variant ID Type Subtype PubMed ID
esv22853 CNV loss 19812545
esv2675791 CNV deletion 23128226
esv3643641 CNV loss 21293372
nsv2413 CNV deletion 18451855
nsv478334 CNV novel sequence insertion 20440878
nsv498892 CNV loss 21111241
nsv514908 CNV loss 21397061
nsv518826 CNV loss 19592680

Variation tolerance for ZNF846 Gene

Residual Variation Intolerance Score: 85.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.76; 78.93% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF846 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF846

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF846 Gene

Disorders for ZNF846 Gene

Additional Disease Information for ZNF846

No disorders were found for ZNF846 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF846 Gene

Publications for ZNF846 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 54
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3 54
  4. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PMID: 21145461) Bennett EJ … Harper JW (Cell 2010) 3 54
  5. A quantitative atlas of mitotic phosphorylation. (PMID: 18669648) Dephoure N … Gygi SP (Proceedings of the National Academy of Sciences of the United States of America 2008) 4 54

Products for ZNF846 Gene

Sources for ZNF846 Gene