Aliases for ZNF845 Gene

Aliases for ZNF845 Gene

  • Zinc Finger Protein 845 2 3 4 5

External Ids for ZNF845 Gene

Previous GeneCards Identifiers for ZNF845 Gene

  • GC19P058546
  • GC19P053837
  • GC19P050157

Summaries for ZNF845 Gene

GeneCards Summary for ZNF845 Gene

ZNF845 (Zinc Finger Protein 845) is a Protein Coding gene. Diseases associated with ZNF845 include Hypoplastic Right Heart Syndrome and Hypoplastic Left Heart Syndrome. Among its related pathways are Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF347.

UniProtKB/Swiss-Prot Summary for ZNF845 Gene

Additional gene information for ZNF845 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF845 Gene

Genomics for ZNF845 Gene

GeneHancer (GH) Regulatory Elements for ZNF845 Gene

Promoters and enhancers for ZNF845 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF845 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF845

Top Transcription factor binding sites by QIAGEN in the ZNF845 gene promoter:
  • AREB6
  • C/EBPalpha

Genomic Locations for ZNF845 Gene

Genomic Locations for ZNF845 Gene
chr19:53,333,714-53,356,906
(GRCh38/hg38)
Size:
23,193 bases
Orientation:
Plus strand
chr19:53,837,002-53,858,122
(GRCh37/hg19)
Size:
21,121 bases
Orientation:
Plus strand

Genomic View for ZNF845 Gene

Genes around ZNF845 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF845 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF845 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF845 Gene

Proteins for ZNF845 Gene

  • Protein details for ZNF845 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96IR2-ZN845_HUMAN
    Recommended name:
    Zinc finger protein 845
    Protein Accession:
    Q96IR2

    Protein attributes for ZNF845 Gene

    Size:
    970 amino acids
    Molecular mass:
    113133 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF845 Gene

Post-translational modifications for ZNF845 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF845 Gene

No data available for DME Specific Peptides for ZNF845 Gene

Domains & Families for ZNF845 Gene

Gene Families for ZNF845 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF845 Gene

Suggested Antigen Peptide Sequences for ZNF845 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 845 (ZN845_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96IR2

UniProtKB/Swiss-Prot:

ZN845_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF845: view

Function for ZNF845 Gene

Molecular function for ZNF845 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF845 Gene

Gene Ontology (GO) - Molecular Function for ZNF845 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IBA 21873635
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF845: view
genes like me logo Genes that share phenotypes with ZNF845: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF845 Gene

Localization for ZNF845 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF845 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF845 gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF845 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IBA 21873635
genes like me logo Genes that share ontologies with ZNF845: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZNF845 Gene

Pathways & Interactions for ZNF845 Gene

PathCards logo

SuperPathways for ZNF845 Gene

genes like me logo Genes that share pathways with ZNF845: view

Pathways by source for ZNF845 Gene

1 KEGG pathway for ZNF845 Gene

Gene Ontology (GO) - Biological Process for ZNF845 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF845: view

No data available for SIGNOR curated interactions for ZNF845 Gene

Drugs & Compounds for ZNF845 Gene

No Compound Related Data Available

Transcripts for ZNF845 Gene

mRNA/cDNA for ZNF845 Gene

4 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF845 Gene

No ASD Table

Relevant External Links for ZNF845 Gene

GeneLoc Exon Structure for
ZNF845

Expression for ZNF845 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF845 Gene

Protein differential expression in normal tissues from HIPED for ZNF845 Gene

This gene is overexpressed in Placenta (58.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZNF845 Gene



Protein tissue co-expression partners for ZNF845 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF845

SOURCE GeneReport for Unigene cluster for ZNF845 Gene:

Hs.720672

Evidence on tissue expression from TISSUES for ZNF845 Gene

  • Nervous system(4.2)
  • Eye(4.1)
genes like me logo Genes that share expression patterns with ZNF845: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF845 Gene

Orthologs for ZNF845 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF845 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF845 31 30
  • 99.07 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC102548633 30
  • 61.99 (n)
mouse
(Mus musculus)
Mammalia LOC101055890 30
  • 61.39 (n)
Gm4944 31
  • 50 (a)
ManyToMany
Gm31526 17
cow
(Bos Taurus)
Mammalia -- 31
  • 44 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 48 (a)
ManyToMany
-- 31
  • 46 (a)
ManyToMany
-- 31
  • 41 (a)
ManyToMany
-- 31
  • 41 (a)
ManyToMany
-- 31
  • 36 (a)
ManyToMany
CSA.1668 31
  • 36 (a)
ManyToMany
Species where no ortholog for ZNF845 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF845 Gene

ENSEMBL:
Gene Tree for ZNF845 (if available)
TreeFam:
Gene Tree for ZNF845 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF845: view image

Paralogs for ZNF845 Gene

(531) SIMAP similar genes for ZNF845 Gene using alignment to 2 proteins:

  • ZN845_HUMAN
  • M0R2N3_HUMAN

Pseudogenes.org Pseudogenes for ZNF845 Gene

genes like me logo Genes that share paralogs with ZNF845: view

Variants for ZNF845 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF845 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
769986 Likely Benign: not provided 53,345,526(+) T/C SYNONYMOUS_VARIANT
769987 Likely Benign: not provided 53,345,559(+) G/A SYNONYMOUS_VARIANT
769988 Likely Benign: not provided 53,345,584(+) C/T SYNONYMOUS_VARIANT
777508 Benign: not provided 53,351,112(+) C/T MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for ZNF845 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF845 Gene

Variant ID Type Subtype PubMed ID
dgv670e214 CNV loss 21293372
esv2670793 CNV deletion 23128226
esv2718787 CNV deletion 23290073
esv2718812 CNV deletion 23290073
esv2718816 CNV deletion 23290073
esv3644750 CNV gain 21293372
nsv1055773 CNV gain 25217958
nsv1078889 OTHER inversion 25765185
nsv1141887 OTHER inversion 24896259
nsv580080 CNV loss 21841781
nsv978846 CNV duplication 23825009

Variation tolerance for ZNF845 Gene

Residual Variation Intolerance Score: 93% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.24; 76.21% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF845 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF845

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF845 Gene

Disorders for ZNF845 Gene

MalaCards: The human disease database

(2) MalaCards diseases for ZNF845 Gene - From: DISEASES

Disorder Aliases PubMed IDs
hypoplastic right heart syndrome
  • right hypoplastic heart syndrome
hypoplastic left heart syndrome
  • hlhs
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ZNF845

genes like me logo Genes that share disorders with ZNF845: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF845 Gene

Publications for ZNF845 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  2. VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. (PMID: 29507755) Yue Y … Liu J (Cell discovery 2018) 3 54
  3. Quantitative mapping of RNA-mediated nuclear estrogen receptor β interactome in human breast cancer cells. (PMID: 29509190) Giurato G … Tarallo R (Scientific data 2018) 3 54
  4. The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery. (PMID: 29180619) Kumar R … Vertegaal ACO (Nature communications 2017) 3 54
  5. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 54

Products for ZNF845 Gene