ZNF841 Gene (Protein Coding)

Zinc Finger Protein 841

GC19M052056
GIFtS:
28
See more...

Aliases for ZNF841 Gene

Aliases for ZNF841 Gene

  • Zinc Finger Protein 841 2 3 4 5
  • LOC284371 2
  • ZNF841 5

External Ids for ZNF841 Gene

Previous GeneCards Identifiers for ZNF841 Gene

  • GC19M057262
  • GC19M052567
  • GC19M048898
  • GC19M052065
  • GC19M052052

Summaries for ZNF841 Gene

GeneCards Summary for ZNF841 Gene

ZNF841 (Zinc Finger Protein 841) is a Protein Coding gene. Among its related pathways are Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA-binding transcription factor activity. An important paralog of this gene is ZNF836.

UniProtKB/Swiss-Prot Summary for ZNF841 Gene

Additional gene information for ZNF841 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF841 Gene

Genomics for ZNF841 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for ZNF841 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF841 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF841

Top Transcription factor binding sites by QIAGEN in the ZNF841 gene promoter:
  • AREB6
  • C/EBPalpha

Genomic Locations for ZNF841 Gene

Latest Assembly
chr19:52,050,028-52,095,780
(GRCh38/hg38)
Size:
45,753 bases
Orientation:
Minus strand

Previous Assembly
chr19:52,561,348-52,599,018
(GRCh37/hg19 by Entrez Gene)
Size:
37,671 bases
Orientation:
Minus strand

chr19:52,567,719-52,599,018
(GRCh37/hg19 by Ensembl)
Size:
31,300 bases
Orientation:
Minus strand

Genomic View for ZNF841 Gene

Genes around ZNF841 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF841 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF841 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for ZNF841 Gene

Proteins for ZNF841 Gene

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  • Protein details for ZNF841 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZN19-ZN841_HUMAN
    Recommended name:
    Zinc finger protein 841
    Protein Accession:
    Q6ZN19
    Secondary Accessions:
    • B9EG58
    • Q6ZN82
    • Q6ZP71
    • Q8N9U7

    Protein attributes for ZNF841 Gene

    Size:
    808 amino acids
    Molecular mass:
    93148 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC04190.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=BAD18493.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF841 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF841 Gene

Protein Expression for ZNF841 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for ZNF841 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF841 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF841 Gene

Domains & Families for ZNF841 Gene

Gene Families for ZNF841 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF841 Gene

InterPro:
Blocks:
  • C2H2-type zinc finger signature
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF841 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 841 (ZN841_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q6ZN19

UniProtKB/Swiss-Prot:

ZN841_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF841: view

Function for ZNF841 Gene

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  4. Inhibitory RNAs for research
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  6. Cell Lines for research

Molecular function for ZNF841 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF841 Gene

Gene Ontology (GO) - Molecular Function for ZNF841 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IBA 21873635
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific IBA 21873635
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF841: view

Phenotypes for ZNF841 Gene

GenomeRNAi human phenotypes for ZNF841:
genes like me logo Genes that share phenotypes with ZNF841: view

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF841

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF841 Gene

Localization for ZNF841 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF841 Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF841 gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF841 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
genes like me logo Genes that share ontologies with ZNF841: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZNF841 Gene

Pathways & Interactions for ZNF841 Gene

PathCards logo

SuperPathways for ZNF841 Gene

genes like me logo Genes that share pathways with ZNF841: view

Pathways by source for ZNF841 Gene

1 KEGG pathway for ZNF841 Gene

Interacting Proteins for ZNF841 Gene

STRING Interaction Network Preview (showing top 5 STRING interactants - click image to see top 25)
STRING Interaction Network
Selected Interacting proteins: ENSP00000470746 for ZNF841 Gene via STRING

GPS-Prot Interaction Network for ZNF841

Gene Ontology (GO) - Biological Process for ZNF841 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IBA 21873635
GO:0045944 positive regulation of transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with ZNF841: view

No data available for SIGNOR curated interactions for ZNF841 Gene

Drugs & Compounds for ZNF841 Gene

Products:

  1. Drug products for research
No Compound Related Data Available

Transcripts for ZNF841 Gene

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mRNA/cDNA for ZNF841 Gene

10 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF841

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF841 Gene

No ASD Table

Relevant External Links for ZNF841 Gene

GeneLoc Exon Structure for
ZNF841

Expression for ZNF841 Gene

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mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF841 Gene

mRNA expression in normal human tissues for ZNF841 Gene
mRNA expression by GTEx for ZNF841 Gene

Protein differential expression in normal tissues from HIPED for ZNF841 Gene

This gene is overexpressed in Oral epithelium (68.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF841 Gene



Protein tissue co-expression partners for ZNF841 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF841

Evidence on tissue expression from TISSUES for ZNF841 Gene

  • Lung(4.3)
  • Kidney(4.2)
  • Heart(4.2)
genes like me logo Genes that share expression patterns with ZNF841: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF841 Gene

Orthologs for ZNF841 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF841 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia ZNF841 30 31
  • 99.42 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia -- 31
  • 51 (a)
 ManyToMany
-- 31
  • 51 (a)
 ManyToMany
-- 31
  • 50 (a)
 ManyToMany
-- 31
  • 50 (a)
 ManyToMany
-- 31
  • 46 (a)
 ManyToMany
Mouse
(Mus musculus)
 Mammalia Zfp51 31
  • 42 (a)
 ManyToMany
Sea Squirt
(Ciona savignyi)
 Ascidiacea -- 31
  • 46 (a)
 ManyToMany
-- 31
  • 43 (a)
 ManyToMany
-- 31
  • 41 (a)
 ManyToMany
-- 31
  • 39 (a)
 ManyToMany
-- 31
  • 35 (a)
 ManyToMany
CSA.1668 31
  • 35 (a)
 ManyToMany
Species where no ortholog for ZNF841 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ZNF841 Gene

ENSEMBL:
Gene Tree for ZNF841 (if available)
TreeFam:
Gene Tree for ZNF841 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF841: view image

Paralogs for ZNF841 Gene

Paralogs for ZNF841 Gene

(545) SIMAP similar genes for ZNF841 Gene using alignment to 3 proteins:

  • ZN841_HUMAN
  • M0QYV6_HUMAN
  • M0R0F3_HUMAN
genes like me logo Genes that share paralogs with ZNF841: view

Variants for ZNF841 Gene

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dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for ZNF841 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for ZNF841 Gene

Variant ID Type Subtype PubMed ID
dgv1067e212 CNV gain 25503493
dgv143e55 CNV gain 17911159
dgv3626n100 CNV gain 25217958
dgv425n27 CNV gain 19166990
dgv6523n54 CNV gain 21841781
esv2758767 CNV gain+loss 17122850
esv3583507 CNV loss 25503493
esv3644684 CNV gain 21293372
nsv1140251 OTHER inversion 24896259
nsv2535 CNV deletion 18451855
nsv833872 CNV loss 17160897
nsv963068 CNV duplication 23825009
nsv978838 CNV duplication 23825009

Variation tolerance for ZNF841 Gene

Residual Variation Intolerance Score: 23.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.28; 70.35% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF841 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF841

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF841 Gene

Disorders for ZNF841 Gene

Additional Disease Information for ZNF841

Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform

No disorders were found for ZNF841 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF841 Gene

Publications for ZNF841 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  2. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4
  3. Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism. (PMID: 28986522) Antoniali G … Tell G (Nature communications 2017) 3
  4. Inhaled corticosteroid treatment modulates ZNF432 gene variant's effect on bronchodilator response in asthmatics. (PMID: 24280104) Wu AC … Tantisira K (The Journal of allergy and clinical immunology 2014) 3
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

ExternalLinks

View latest publications for ZNF841 gene in Mastermind

Products for ZNF841 Gene

Sources for ZNF841 Gene