Aliases for ZNF84 Gene

Aliases for ZNF84 Gene

  • Zinc Finger Protein 84 2 3 4 5
  • Zinc Finger Protein HPF2 3 4
  • HPF2 2 3
  • Zinc Finger Protein 84 (HPF2) 2
  • ZNF84 5

External Ids for ZNF84 Gene

Previous GeneCards Identifiers for ZNF84 Gene

  • GC12P131135
  • GC12P133187
  • GC12P131801
  • GC12P131390
  • GC12P132224
  • GC12P132124
  • GC12P133613

Summaries for ZNF84 Gene

GeneCards Summary for ZNF84 Gene

ZNF84 (Zinc Finger Protein 84) is a Protein Coding gene. Among its related pathways are Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF184.

UniProtKB/Swiss-Prot Summary for ZNF84 Gene

Additional gene information for ZNF84 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF84 Gene

Genomics for ZNF84 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF84 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF84 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF84

Top Transcription factor binding sites by QIAGEN in the ZNF84 gene promoter:
  • FOXD3
  • FOXJ2
  • Pax-2
  • Pax-2a
  • Pax-2b

Genomic Locations for ZNF84 Gene

Genomic Locations for ZNF84 Gene
chr12:133,037,286-133,063,304
(GRCh38/hg38)
Size:
26,019 bases
Orientation:
Plus strand
chr12:133,613,878-133,639,885
(GRCh37/hg19)
Size:
26,008 bases
Orientation:
Plus strand

Genomic View for ZNF84 Gene

Genes around ZNF84 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF84 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF84 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF84 Gene

Proteins for ZNF84 Gene

  • Protein details for ZNF84 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P51523-ZNF84_HUMAN
    Recommended name:
    Zinc finger protein 84
    Protein Accession:
    P51523
    Secondary Accessions:
    • B2RAK5
    • D3DXJ1
    • Q3ZCV9
    • Q5D057
    • Q86XU8
    • Q9NNX7
    • Q9UC17
    • Q9UC18

    Protein attributes for ZNF84 Gene

    Size:
    738 amino acids
    Molecular mass:
    85457 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF84 Gene

Post-translational modifications for ZNF84 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF84 Gene

Domains & Families for ZNF84 Gene

Gene Families for ZNF84 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF84 Gene

InterPro:
Blocks:
  • C2H2-type zinc finger signature
  • KRAB box
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF84 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein HPF2 (ZNF84_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P51523

UniProtKB/Swiss-Prot:

ZNF84_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF84: view

Function for ZNF84 Gene

Molecular function for ZNF84 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF84 Gene

Gene Ontology (GO) - Molecular Function for ZNF84 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding NAS 2505992
GO:0008270 zinc ion binding NAS 2505992
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF84: view
genes like me logo Genes that share phenotypes with ZNF84: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF84

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF84 Gene

Localization for ZNF84 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF84 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF84 gene
Compartment Confidence
nucleus 3
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF84 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF84: view

Pathways & Interactions for ZNF84 Gene

PathCards logo

SuperPathways for ZNF84 Gene

genes like me logo Genes that share pathways with ZNF84: view

Pathways by source for ZNF84 Gene

1 KEGG pathway for ZNF84 Gene

Gene Ontology (GO) - Biological Process for ZNF84 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF84: view

No data available for SIGNOR curated interactions for ZNF84 Gene

Drugs & Compounds for ZNF84 Gene

No Compound Related Data Available

Transcripts for ZNF84 Gene

mRNA/cDNA for ZNF84 Gene

4 REFSEQ mRNAs :
18 NCBI additional mRNA sequence :
16 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF84

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF84 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b · 5c · 5d · 5e ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c · 8d · 8e ^ 9
SP1: - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - - - -
SP4: - - - - - - - - - -
SP5: - - - - - - - - - - - - -
SP6: - - - - - - -
SP7: - - - - -
SP8: - - - - - -
SP9: - - - - -
SP10: - - - - -
SP11: - -
SP12: - -
SP13:

Relevant External Links for ZNF84 Gene

GeneLoc Exon Structure for
ZNF84

Expression for ZNF84 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF84 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF84

SOURCE GeneReport for Unigene cluster for ZNF84 Gene:

Hs.445019

Evidence on tissue expression from TISSUES for ZNF84 Gene

  • Nervous system(4.8)
  • Lung(4.2)
genes like me logo Genes that share expression patterns with ZNF84: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF84 Gene

Orthologs for ZNF84 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF84 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZNF84 30 31
  • 99.64 (n)
OneToMany
Cow
(Bos Taurus)
Mammalia ZNF84 30
  • 89.57 (n)
-- 31
  • 83 (a)
OneToMany
Dog
(Canis familiaris)
Mammalia ZNF26 30
  • 88.89 (n)
-- 31
  • 83 (a)
OneToMany
Fruit Fly
(Drosophila melanogaster)
Insecta CG14711 32
  • 50 (a)
Kr 32
  • 49 (a)
CG3485 32
  • 44 (a)
crol 32
  • 43 (a)
CG15436 32
  • 42 (a)
CG5245 32
  • 41 (a)
CG12299 32
  • 40 (a)
CG18555 32
  • 40 (a)
CG11762 32
  • 39 (a)
BG:DS02740.8 32
  • 37 (a)
CG8319 32
  • 37 (a)
CG11247 32
  • 37 (a)
Neu2 32
  • 36 (a)
CG10543 32
  • 33 (a)
CG8301 32
  • 31 (a)
CG7987 32
  • 31 (a)
CG18476 32
  • 30 (a)
CG18011 32
  • 25 (a)
Worm
(Caenorhabditis elegans)
Secernentea M03D4.4 32
  • 32 (a)
Species where no ortholog for ZNF84 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Zebrafish (Danio rerio)

Evolution for ZNF84 Gene

ENSEMBL:
Gene Tree for ZNF84 (if available)
TreeFam:
Gene Tree for ZNF84 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF84: view image

Paralogs for ZNF84 Gene

(562) SIMAP similar genes for ZNF84 Gene using alignment to 9 proteins:

  • ZNF84_HUMAN
  • F5H0T0_HUMAN
  • F5H1B1_HUMAN
  • F5H1R3_HUMAN
  • F5H3F5_HUMAN
  • F5H630_HUMAN
  • F5H6X5_HUMAN
  • J3KQ53_HUMAN
  • L8E909_HUMAN

Pseudogenes.org Pseudogenes for ZNF84 Gene

genes like me logo Genes that share paralogs with ZNF84: view

Variants for ZNF84 Gene

Additional dbSNP identifiers (rs#s) for ZNF84 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF84 Gene

Variant ID Type Subtype PubMed ID
dgv1590n100 CNV gain 25217958
dgv1592n100 CNV gain 25217958
dgv1593n100 CNV gain 25217958
dgv330e199 CNV deletion 23128226
dgv917n106 CNV deletion 24896259
esv27162 CNV gain+loss 19812545
esv2759923 CNV loss 17122850
esv3631326 CNV loss 21293372
esv3631327 CNV gain 21293372
nsv1048027 CNV gain 25217958
nsv1054933 CNV gain 25217958
nsv1071081 CNV deletion 25765185
nsv525745 CNV gain 19592680
nsv9048 CNV gain 18304495
nsv9049 CNV gain 18304495

Additional Variant Information for ZNF84 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF84

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for ZNF84 Gene

Disorders for ZNF84 Gene

No disorders were found for ZNF84 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF84 Gene

Publications for ZNF84 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  3. Members of the zinc finger protein gene family sharing a conserved N-terminal module. (PMID: 1945843) Rosati M … Grimaldi G (Nucleic acids research 1991) 3 4
  4. The human genome contains hundreds of genes coding for finger proteins of the Krüppel type. (PMID: 2505992) Bellefroid EJ … Martial JA (DNA (Mary Ann Liebert, Inc.) 1989) 3 4
  5. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3

Products for ZNF84 Gene

Sources for ZNF84 Gene