Aliases for ZNF839 Gene

Aliases for ZNF839 Gene

  • Zinc Finger Protein 839 2 3 4 5
  • Renal Carcinoma Antigen NY-REN-50 3 4
  • C14orf131 3 4
  • Chromosome 14 Open Reading Frame 131 2
  • ZNF839 5

External Ids for ZNF839 Gene

Previous HGNC Symbols for ZNF839 Gene

  • C14orf131

Previous GeneCards Identifiers for ZNF839 Gene

  • GC14P101855
  • GC14P102786
  • GC14P082969
  • GC14P102318
  • GC14P103526
  • GC14P103756
  • GC14P103948
  • GC14P104310
  • GC14P102381
  • GC14P102452
  • GC14P102462
  • GC14P102634
  • GC14P102802
  • GC14P102980
  • GC14P103172
  • GC14P103364

Summaries for ZNF839 Gene

GeneCards Summary for ZNF839 Gene

ZNF839 (Zinc Finger Protein 839) is a Protein Coding gene. Diseases associated with ZNF839 include Intraneural Perineurioma. Among its related pathways are Gene Expression.

Additional gene information for ZNF839 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF839 Gene

Genomics for ZNF839 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF839 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF839 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF839

Top Transcription factor binding sites by QIAGEN in the ZNF839 gene promoter:
  • AP-1
  • ATF-2
  • c-Jun
  • CREB
  • deltaCREB
  • Ik-3
  • p53
  • Sp1

Genomic Locations for ZNF839 Gene

Genomic Locations for ZNF839 Gene
chr14:102,317,377-102,343,174
(GRCh38/hg38)
Size:
25,798 bases
Orientation:
Plus strand
chr14:102,783,714-102,809,044
(GRCh37/hg19)
Size:
25,331 bases
Orientation:
Plus strand

Genomic View for ZNF839 Gene

Genes around ZNF839 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF839 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF839 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF839 Gene

Proteins for ZNF839 Gene

  • Protein details for ZNF839 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A8K0R7-ZN839_HUMAN
    Recommended name:
    Zinc finger protein 839
    Protein Accession:
    A8K0R7
    Secondary Accessions:
    • B3KSD2
    • Q53FH5
    • Q6GPI5
    • Q86TU1
    • Q9BQ86
    • Q9NUU3

    Protein attributes for ZNF839 Gene

    Size:
    811 amino acids
    Molecular mass:
    87484 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA92026.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=CAD62594.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF839 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF839 Gene

Post-translational modifications for ZNF839 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF839 Gene

Domains & Families for ZNF839 Gene

Gene Families for ZNF839 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ZNF839 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF839 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ43690 fis, clone TBAES2004055, highly similar to Homo sapiens NY-REN-25 antigen (B3KWS2_HUMAN)
  • NY-REN-50 antigen (Q9Y595_HUMAN)
  • Renal carcinoma antigen NY-REN-50 (ZN839_HUMAN)
genes like me logo Genes that share domains with ZNF839: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ZNF839 Gene

Function for ZNF839 Gene

Phenotypes From GWAS Catalog for ZNF839 Gene

Gene Ontology (GO) - Molecular Function for ZNF839 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF839: view
genes like me logo Genes that share phenotypes with ZNF839: view

Animal Model Products

CRISPR Products

miRNA for ZNF839 Gene

miRTarBase miRNAs that target ZNF839

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF839

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF839 Gene

Localization for ZNF839 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF839 gene
Compartment Confidence
nucleus 3
cytosol 2
plasma membrane 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
  • Plasma membrane (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ZNF839 Gene

Pathways & Interactions for ZNF839 Gene

PathCards logo

SuperPathways for ZNF839 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF839: view

Pathways by source for ZNF839 Gene

2 Reactome pathways for ZNF839 Gene

Interacting Proteins for ZNF839 Gene

STRING Interaction Network Preview (showing top 2 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: ENSP00000399863 A8K0R7-ZN839_HUMAN for ZNF839 Gene via STRING IID

Gene Ontology (GO) - Biological Process for ZNF839 Gene

None

No data available for SIGNOR curated interactions for ZNF839 Gene

Drugs & Compounds for ZNF839 Gene

No Compound Related Data Available

Transcripts for ZNF839 Gene

mRNA/cDNA for ZNF839 Gene

3 REFSEQ mRNAs :
16 NCBI additional mRNA sequence :
12 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF839

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF839 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c · 5d ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11
SP1: - - - -
SP2: - -
SP3: - - - -
SP4: -
SP5: -
SP6: - -
SP7: -
SP8:

Relevant External Links for ZNF839 Gene

GeneLoc Exon Structure for
ZNF839

Expression for ZNF839 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF839 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF839 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF839

SOURCE GeneReport for Unigene cluster for ZNF839 Gene:

Hs.743359

Evidence on tissue expression from TISSUES for ZNF839 Gene

  • Nervous system(4.2)
  • Lung(4.1)
genes like me logo Genes that share expression patterns with ZNF839: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF839 Gene

Orthologs for ZNF839 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF839 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZNF839 30 31
  • 98.4 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ZNF839 30 31
  • 76.18 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Zfp839 30
  • 67.8 (n)
Mouse
(Mus musculus)
Mammalia Zfp839 30 17 31
  • 67.29 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ZNF839 31
  • 61 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia ZNF839 31
  • 37 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia ZNF839 31
  • 37 (a)
OneToOne
Chicken
(Gallus gallus)
Aves ZNF839 31
  • 36 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia ZNF839 31
  • 42 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii znf839 31
  • 21 (a)
OneToOne
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.453 31
  • 15 (a)
OneToOne
Species where no ortholog for ZNF839 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for ZNF839 Gene

ENSEMBL:
Gene Tree for ZNF839 (if available)
TreeFam:
Gene Tree for ZNF839 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF839: view image

Paralogs for ZNF839 Gene

(2) SIMAP similar genes for ZNF839 Gene using alignment to 8 proteins:

  • ZN839_HUMAN
  • H0YKI3_HUMAN
  • H0YKY1_HUMAN
  • H0YLB6_HUMAN
  • H0YM06_HUMAN
  • H0YM94_HUMAN
  • H0YMU1_HUMAN
  • H0YNU6_HUMAN

Pseudogenes.org Pseudogenes for ZNF839 Gene

genes like me logo Genes that share paralogs with ZNF839: view

No data available for Paralogs for ZNF839 Gene

Variants for ZNF839 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF839 Gene

SNP ID Clinical significance and condition Chr 14 pos Variation AA Info Type
730604 Benign: not provided 102,339,200(+) G/A MISSENSE_VARIANT
rs1053019 - p.Phe731Leu
rs1543540 - p.Ala314Thr
rs28646161 - p.Val693Met
rs9464 - p.Pro531Ser

Additional dbSNP identifiers (rs#s) for ZNF839 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF839 Gene

Variant ID Type Subtype PubMed ID
esv29657 CNV gain 19812545
esv3635547 CNV gain 21293372
nsv1131164 CNV deletion 24896259
nsv827062 CNV gain 20364138
nsv827063 CNV gain 20364138

Variation tolerance for ZNF839 Gene

Residual Variation Intolerance Score: 97.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.22; 81.05% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF839 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF839

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF839 Gene

Disorders for ZNF839 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZNF839 Gene - From: DISEASES

Disorder Aliases PubMed IDs
intraneural perineurioma
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with ZNF839: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF839 Gene

Publications for ZNF839 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  2. Regulation of ETAA1-mediated ATR activation couples DNA replication fidelity and genome stability. (PMID: 31615875) Achuthankutty D … Mailand N (The Journal of cell biology 2019) 3
  3. Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing. (PMID: 28611215) Fei T … Brown M (Proceedings of the National Academy of Sciences of the United States of America 2017) 3
  4. Polymorphisms in MicroRNA Binding Sites Predict Colorectal Cancer Survival. (PMID: 28138309) Yang YP … Bao BY (International journal of medical sciences 2017) 3
  5. Systematic interactome mapping of acute lymphoblastic leukemia cancer gene products reveals EXT-1 tumor suppressor as a Notch1 and FBWX7 common interactor. (PMID: 27229929) Daakour S … Twizere JC (BMC cancer 2016) 3

Products for ZNF839 Gene

Sources for ZNF839 Gene