Aliases for ZNF837 Gene

Aliases for ZNF837 Gene

  • Zinc Finger Protein 837 2 3 4 5
  • ZNF837 5

External Ids for ZNF837 Gene

Previous GeneCards Identifiers for ZNF837 Gene

  • GC19M063571
  • GC19M058878
  • GC19M055188

Summaries for ZNF837 Gene

GeneCards Summary for ZNF837 Gene

ZNF837 (Zinc Finger Protein 837) is a Protein Coding gene. Diseases associated with ZNF837 include Gracile Syndrome. An important paralog of this gene is ZNF304.

UniProtKB/Swiss-Prot Summary for ZNF837 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF837 Gene

Genomics for ZNF837 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF837 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF837 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF837

Top Transcription factor binding sites by QIAGEN in the ZNF837 gene promoter:
  • AhR
  • AREB6
  • Arnt
  • CUTL1
  • E47
  • LyF-1
  • SEF-1 (1)
  • Spz1
  • ZID

Genomic Locations for ZNF837 Gene

Latest Assembly
13,413 bases
Minus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
13,408 bases
Minus strand

(GRCh37/hg19 by Ensembl)
13,443 bases
Minus strand

Genomic View for ZNF837 Gene

Genes around ZNF837 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF837 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF837 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF837 Gene

Proteins for ZNF837 Gene

  • Protein details for ZNF837 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 837
    Protein Accession:

    Protein attributes for ZNF837 Gene

    531 amino acids
    Molecular mass:
    58078 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF837 Gene

Post-translational modifications for ZNF837 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF837 Gene

No data available for DME Specific Peptides for ZNF837 Gene

Domains & Families for ZNF837 Gene

Gene Families for ZNF837 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF837 Gene

  • C2H2-type zinc finger signature

Suggested Antigen Peptide Sequences for ZNF837 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 837 (ZN837_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF837: view

Function for ZNF837 Gene

Molecular function for ZNF837 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF837 Gene

Gene Ontology (GO) - Molecular Function for ZNF837 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IBA 21873635
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific IBA 21873635
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 32296183
GO:0042802 identical protein binding IPI 32296183
genes like me logo Genes that share ontologies with ZNF837: view

Phenotypes for ZNF837 Gene

genes like me logo Genes that share phenotypes with ZNF837: view

miRNA for ZNF837 Gene

miRTarBase miRNAs that target ZNF837

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF837

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF837 Gene

Localization for ZNF837 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF837 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF837 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF837 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
genes like me logo Genes that share ontologies with ZNF837: view

Pathways & Interactions for ZNF837 Gene

PathCards logo

SuperPathways for ZNF837 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF837 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006357 regulation of transcription by RNA polymerase II IBA 21873635
genes like me logo Genes that share ontologies with ZNF837: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF837 Gene

Drugs & Compounds for ZNF837 Gene

No Compound Related Data Available

Transcripts for ZNF837 Gene

mRNA/cDNA for ZNF837 Gene

4 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF837

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF837 Gene

ExUns: 1a · 1b ^ 2a · 2b
SP2: -

Relevant External Links for ZNF837 Gene

GeneLoc Exon Structure for

Expression for ZNF837 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF837 Gene

Protein differential expression in normal tissues from HIPED for ZNF837 Gene

This gene is overexpressed in Lung (41.0) and Pancreatic juice (28.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF837 Gene

Protein tissue co-expression partners for ZNF837 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF837

SOURCE GeneReport for Unigene cluster for ZNF837 Gene:

genes like me logo Genes that share expression patterns with ZNF837: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF837 Gene

Orthologs for ZNF837 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF837 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF837 30
  • 98.93 (n)
(Canis familiaris)
Mammalia ZNF837 30 31
  • 76.97 (n)
Species where no ortholog for ZNF837 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ZNF837 Gene

Gene Tree for ZNF837 (if available)
Gene Tree for ZNF837 (if available)
Evolutionary constrained regions (ECRs) for ZNF837: view image

Paralogs for ZNF837 Gene

(353) SIMAP similar genes for ZNF837 Gene using alignment to 1 proteins:

  • ZN837_HUMAN
genes like me logo Genes that share paralogs with ZNF837: view

Variants for ZNF837 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF837 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs7255596 - p.Ala242Thr
rs7256940 - p.Gln153Arg

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for ZNF837 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for ZNF837 Gene

Variant ID Type Subtype PubMed ID
nsv515731 CNV gain+loss 19592680
nsv817878 CNV loss 17921354
nsv833887 CNV loss 17160897
nsv833888 CNV loss 17160897

Variation tolerance for ZNF837 Gene

Gene Damage Index Score: 4.23; 62.26% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF837 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF837 Gene

Disorders for ZNF837 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZNF837 Gene - From: COP

Disorder Aliases PubMed IDs
gracile syndrome
  • growth retardation, amino aciduria, cholestasis, iron overload, lactic acidosis, and early death
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ZNF837

genes like me logo Genes that share disorders with ZNF837: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF837 Gene

Publications for ZNF837 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3
  2. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4

Products for ZNF837 Gene

Sources for ZNF837 Gene