Aliases for ZNF835 Gene

Aliases for ZNF835 Gene

  • Zinc Finger Protein 835 2 3 4 5
  • BC37295_3 3

External Ids for ZNF835 Gene

Previous GeneCards Identifiers for ZNF835 Gene

  • GC19M061868
  • GC19M057174
  • GC19M053484

Summaries for ZNF835 Gene

GeneCards Summary for ZNF835 Gene

ZNF835 (Zinc Finger Protein 835) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity. An important paralog of this gene is ZFP28.

UniProtKB/Swiss-Prot Summary for ZNF835 Gene

Additional gene information for ZNF835 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF835 Gene

Genomics for ZNF835 Gene

GeneHancer (GH) Regulatory Elements for ZNF835 Gene

Promoters and enhancers for ZNF835 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J056671 Promoter/Enhancer 1.2 Ensembl ENCODE CraniofacialAtlas 522.8 +0.2 183 1.6 ZKSCAN1 HCFC1 POLR2A ETS1 CTCF NRF1 AFF1 MAX ZFX CHD2 ZNF835 ENSG00000286125 LOC105372473 SMIM17 ZIM2-AS1
GH19J056594 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 58.7 +76.3 76282 2.6 ZNF300 POLR2G PHF8 POLR2A ZBTB10 ZBTB26 ZBTB7A MXI1 ZNF341 ZNF148 ZIM2-AS1 ZNF71 ZNF548 ZNF549 U2AF2 ENSG00000269696 ZNF17 ZNF543 ZFP28 ZNF470
GH19J056673 Enhancer 0.2 Ensembl 513.5 -1.8 -1818 0.4 ZNF835 LOC105372473 lnc-ZNF835-1 ENSG00000286125 ZIM2-AS1
GH19J057388 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas 23.7 -718.4 -718372 2.5 FOXK2 ZBTB40 ZNF217 EP300 CTCF SIN3A NRF1 POLR2G SP1 NCOR1 ZNF548 ENSG00000269533 ZSCAN18 ENSG00000269696 ENSG00000176593 ZNF835 ZNF470 ZNF582-AS1 ZNF583 ZNF304
GH19J056403 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 23.9 +267.6 267582 2.8 ZNF217 EP300 SIN3A NRF1 ZNF300 POLR2G BCLAF1 NONO PHF8 SIX5 ZNF582 lnc-ZNF582-1 ZNF582-AS1 ZFP28 ZNF470 ZNF471 FIZ1 ZNF460-AS1 ENSG00000269696 ZNF542P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF835 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF835

Top Transcription factor binding sites by QIAGEN in the ZNF835 gene promoter:
  • C/EBPalpha
  • FOXO4
  • GATA-2
  • Hlf
  • Nkx3-1
  • Nkx3-1 v1
  • Nkx3-1 v2
  • Nkx3-1 v3
  • Nkx5-1
  • Sox5

Genomic Locations for ZNF835 Gene

Genomic Locations for ZNF835 Gene
9,804 bases
Minus strand
9,132 bases
Minus strand

Genomic View for ZNF835 Gene

Genes around ZNF835 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF835 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF835 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF835 Gene

Proteins for ZNF835 Gene

  • Protein details for ZNF835 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 835
    Protein Accession:
    Secondary Accessions:
    • B7Z5Y0
    • G3V1S0

    Protein attributes for ZNF835 Gene

    537 amino acids
    Molecular mass:
    59631 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAD23609.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for ZNF835 Gene

Post-translational modifications for ZNF835 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF835 Gene

No data available for DME Specific Peptides for ZNF835 Gene

Domains & Families for ZNF835 Gene

Gene Families for ZNF835 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF835 Gene

  • C2H2-type zinc finger signature

Suggested Antigen Peptide Sequences for ZNF835 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 835 (ZN835_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF835: view

Function for ZNF835 Gene

Molecular function for ZNF835 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF835 Gene

Gene Ontology (GO) - Molecular Function for ZNF835 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity IBA 21873635
GO:0044212 transcription regulatory region DNA binding IBA 21873635
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF835: view
genes like me logo Genes that share phenotypes with ZNF835: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF835 Gene

Localization for ZNF835 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF835 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF835 gene
Compartment Confidence
nucleus 4

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF835 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IBA 21873635
genes like me logo Genes that share ontologies with ZNF835: view

Pathways & Interactions for ZNF835 Gene

PathCards logo

SuperPathways for ZNF835 Gene

No Data Available

Interacting Proteins for ZNF835 Gene


Gene Ontology (GO) - Biological Process for ZNF835 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IBA 21873635
GO:0045944 positive regulation of transcription by RNA polymerase II IBA 21873635
genes like me logo Genes that share ontologies with ZNF835: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF835 Gene

Drugs & Compounds for ZNF835 Gene

No Compound Related Data Available

Transcripts for ZNF835 Gene

mRNA/cDNA for ZNF835 Gene

4 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF835 Gene

No ASD Table

Relevant External Links for ZNF835 Gene

GeneLoc Exon Structure for

Expression for ZNF835 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF835 Gene

Protein differential expression in normal tissues from HIPED for ZNF835 Gene

This gene is overexpressed in Rectum (24.7), Urinary Bladder (20.2), and Adrenal (12.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF835 Gene

Protein tissue co-expression partners for ZNF835 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF835

SOURCE GeneReport for Unigene cluster for ZNF835 Gene:


Evidence on tissue expression from TISSUES for ZNF835 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with ZNF835: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF835 Gene

Orthologs for ZNF835 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF835 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF835 31 30
  • 99.57 (n)
(Canis familiaris)
Mammalia ZNF835 31 30
  • 81.47 (n)
(Monodelphis domestica)
Mammalia -- 31
  • 39 (a)
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 35 (a)
(Bos Taurus)
Mammalia -- 31
  • 35 (a)
-- 31
  • 34 (a)
(Gallus gallus)
Aves -- 31
  • 36 (a)
(Anolis carolinensis)
Reptilia -- 31
  • 26 (a)
Species where no ortholog for ZNF835 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF835 Gene

Gene Tree for ZNF835 (if available)
Gene Tree for ZNF835 (if available)
Evolutionary constrained regions (ECRs) for ZNF835: view image

Paralogs for ZNF835 Gene

Paralogs for ZNF835 Gene

(500) SIMAP similar genes for ZNF835 Gene using alignment to 2 proteins:

  • ZN835_HUMAN
genes like me logo Genes that share paralogs with ZNF835: view

Variants for ZNF835 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF835 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs12460400 - p.Glu88Ala
rs12462469 - p.Glu29Lys

Additional dbSNP identifiers (rs#s) for ZNF835 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF835 Gene

Variant ID Type Subtype PubMed ID
dgv546e201 CNV deletion 23290073
esv22638 CNV loss 19812545
esv2719042 CNV deletion 23290073
esv2719043 CNV deletion 23290073
esv2719045 CNV deletion 23290073
esv2741485 CNV deletion 23290073
esv3644873 CNV gain 21293372
nsv1055357 CNV gain 25217958
nsv1110730 CNV insertion 24896259
nsv1120365 CNV tandem duplication 24896259
nsv580388 CNV loss 21841781
nsv952152 CNV deletion 24416366

Variation tolerance for ZNF835 Gene

Residual Variation Intolerance Score: 49.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.15; 92.33% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF835 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF835 Gene

Disorders for ZNF835 Gene

Additional Disease Information for ZNF835

No disorders were found for ZNF835 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF835 Gene

Publications for ZNF835 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  2. Heterozygous deletion of chromosome 17p renders prostate cancer vulnerable to inhibition of RNA polymerase II. (PMID: 30349055) Li Y … Lu X (Nature communications 2018) 3 54
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3 54
  4. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 4 54

Products for ZNF835 Gene

Sources for ZNF835 Gene