Aliases for ZNF83 Gene

Aliases for ZNF83 Gene

  • Zinc Finger Protein 83 2 3 4 5
  • Zinc Finger Protein 816B 2 3 4
  • Zinc Finger Protein HPF1 3 4
  • ZNF816B 3 4
  • HPF1 2 3
  • Zinc Finger Protein 83 (HPF1) 2
  • FLJ11015 2
  • ZNF83 5

External Ids for ZNF83 Gene

Previous HGNC Symbols for ZNF83 Gene

  • ZNF816B

Previous GeneCards Identifiers for ZNF83 Gene

  • GC19M053746
  • GC19M053476
  • GC19M057773
  • GC19M057807
  • GC19M057189
  • GC19M053115
  • GC19M049446

Summaries for ZNF83 Gene

GeneCards Summary for ZNF83 Gene

ZNF83 (Zinc Finger Protein 83) is a Protein Coding gene. Among its related pathways are Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA-binding transcription factor activity. An important paralog of this gene is ZNF880.

UniProtKB/Swiss-Prot Summary for ZNF83 Gene

Gene Wiki entry for ZNF83 Gene

Additional gene information for ZNF83 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF83 Gene

Genomics for ZNF83 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF83 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF83 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF83

Top Transcription factor binding sites by QIAGEN in the ZNF83 gene promoter:
  • AREB6
  • Ik-1
  • Nkx3-1
  • Nkx3-1 v1
  • Nkx3-1 v2
  • Nkx3-1 v3
  • Nkx3-1 v4

Genomic Locations for ZNF83 Gene

Genomic Locations for ZNF83 Gene
chr19:52,594,060-52,690,581
(GRCh38/hg38)
Size:
96,522 bases
Orientation:
Minus strand
chr19:53,097,313-53,193,886
(GRCh37/hg19)
Size:
96,574 bases
Orientation:
Minus strand

Genomic View for ZNF83 Gene

Genes around ZNF83 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF83 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF83 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF83 Gene

Proteins for ZNF83 Gene

  • Protein details for ZNF83 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P51522-ZNF83_HUMAN
    Recommended name:
    Zinc finger protein 83
    Protein Accession:
    P51522
    Secondary Accessions:
    • A8MT75
    • Q3ZCX0
    • Q6PI08

    Protein attributes for ZNF83 Gene

    Size:
    516 amino acids
    Molecular mass:
    59710 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF83 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF83 Gene

Post-translational modifications for ZNF83 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF83 Gene

Domains & Families for ZNF83 Gene

Gene Families for ZNF83 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF83 Gene

InterPro:
Blocks:
  • C2H2-type zinc finger signature
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF83 Gene

GenScript: Design optimal peptide antigens:
  • ZNF83 protein (Q6P579_HUMAN)
  • Zinc finger protein HPF1 (ZNF83_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P51522

UniProtKB/Swiss-Prot:

ZNF83_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF83: view

Function for ZNF83 Gene

Molecular function for ZNF83 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
GENATLAS Biochemistry:
zinc finger protein 83 (C2H2 type)

Phenotypes From GWAS Catalog for ZNF83 Gene

Gene Ontology (GO) - Molecular Function for ZNF83 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 16237761
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF83: view
genes like me logo Genes that share phenotypes with ZNF83: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF83

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF83 Gene

Localization for ZNF83 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF83 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF83 gene
Compartment Confidence
nucleus 5
plasma membrane 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF83 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF83: view

Pathways & Interactions for ZNF83 Gene

PathCards logo

SuperPathways for ZNF83 Gene

genes like me logo Genes that share pathways with ZNF83: view

Pathways by source for ZNF83 Gene

1 KEGG pathway for ZNF83 Gene

Gene Ontology (GO) - Biological Process for ZNF83 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF83: view

No data available for SIGNOR curated interactions for ZNF83 Gene

Drugs & Compounds for ZNF83 Gene

No Compound Related Data Available

Transcripts for ZNF83 Gene

mRNA/cDNA for ZNF83 Gene

21 REFSEQ mRNAs :
40 NCBI additional mRNA sequence :
19 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF83

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF83 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d
SP1: - -
SP2:
SP3: - - - -
SP4: - - -

Relevant External Links for ZNF83 Gene

GeneLoc Exon Structure for
ZNF83

Expression for ZNF83 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF83 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF83

SOURCE GeneReport for Unigene cluster for ZNF83 Gene:

Hs.467210

Evidence on tissue expression from TISSUES for ZNF83 Gene

  • Nervous system(4.8)
genes like me logo Genes that share expression patterns with ZNF83: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF83 Gene

Orthologs for ZNF83 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF83 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZNF83 31
  • 57 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia -- 31
  • 43 (a)
ManyToMany
Cow
(Bos Taurus)
Mammalia -- 31
  • 41 (a)
ManyToMany
Species where no ortholog for ZNF83 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ZNF83 Gene

ENSEMBL:
Gene Tree for ZNF83 (if available)
TreeFam:
Gene Tree for ZNF83 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF83: view image

Paralogs for ZNF83 Gene

Paralogs for ZNF83 Gene

(648) SIMAP similar genes for ZNF83 Gene using alignment to 11 proteins:

  • ZNF83_HUMAN
  • H9XFB5_HUMAN
  • L0R8M2_HUMAN
  • M0QXM0_HUMAN
  • M0R099_HUMAN
  • M0R0P3_HUMAN
  • M0R183_HUMAN
  • M0R1T0_HUMAN
  • M0R287_HUMAN
  • M0R3A5_HUMAN
  • Q6P579_HUMAN

Pseudogenes.org Pseudogenes for ZNF83 Gene

genes like me logo Genes that share paralogs with ZNF83: view

Variants for ZNF83 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF83 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
769463 Benign: not provided 52,613,680(-) GCCACACTCATTACAT INFRAME_DELETION
rs575275768 Not Provided: not provided 52,613,741(-) T/G MISSENSE_VARIANT
rs1056185 - p.Ser96Asn
rs11545619 - p.His392Arg
rs329940 - p.Thr119Met

Additional dbSNP identifiers (rs#s) for ZNF83 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF83 Gene

Variant ID Type Subtype PubMed ID
esv2094808 CNV deletion 18987734
esv2677925 CNV deletion 23128226
esv2718786 CNV deletion 23290073
esv2718787 CNV deletion 23290073
esv2718792 CNV deletion 23290073
esv2718793 CNV deletion 23290073
esv2718794 CNV deletion 23290073
esv2718796 CNV deletion 23290073
esv3583509 CNV loss 25503493
esv3644699 CNV loss 21293372
esv3644704 CNV loss 21293372
esv3644705 CNV gain 21293372
esv3644706 CNV loss 21293372
esv3644707 CNV gain 21293372
esv3644708 CNV loss 21293372
esv3644709 CNV gain 21293372
esv3644710 CNV loss 21293372
esv3644712 CNV gain 21293372
esv3893231 CNV loss 25118596
esv3893233 CNV loss 25118596
esv3893234 CNV gain 25118596
nsv1065584 CNV loss 25217958
nsv1066762 CNV gain 25217958
nsv1066876 CNV gain 25217958
nsv1072896 CNV deletion 25765185
nsv1078889 OTHER inversion 25765185
nsv1109211 CNV deletion 24896259
nsv1140479 CNV deletion 24896259
nsv1143408 CNV deletion 24896259
nsv1146332 OTHER inversion 26484159
nsv1153811 CNV deletion 26484159
nsv458744 CNV gain 19166990
nsv509752 CNV insertion 20534489
nsv519070 CNV loss 19592680
nsv522273 CNV loss 19592680
nsv527815 CNV loss 19592680
nsv580028 CNV gain 21841781
nsv580029 CNV loss 21841781
nsv817857 CNV gain 17921354
nsv828616 CNV gain 20364138
nsv833874 CNV loss 17160897
nsv961237 CNV duplication 23825009
nsv961238 CNV duplication 23825009

Variation tolerance for ZNF83 Gene

Residual Variation Intolerance Score: 64.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.51; 91.11% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF83 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF83

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF83 Gene

Disorders for ZNF83 Gene

Additional Disease Information for ZNF83

No disorders were found for ZNF83 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF83 Gene

Publications for ZNF83 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  2. Assignment of the human ZNF83 (HPF1) zinc finger gene to chromosome 19q13.3-q13.4. (PMID: 8088807) Marine JC … Szpirer C (Genomics 1994) 2 3
  3. The human genome contains hundreds of genes coding for finger proteins of the Krüppel type. (PMID: 2505992) Bellefroid EJ … Martial JA (DNA (Mary Ann Liebert, Inc.) 1989) 3 4
  4. A human MAP kinase interactome. (PMID: 20936779) Bandyopadhyay S … Ideker T (Nature methods 2010) 3
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3

Products for ZNF83 Gene

  • Signalway Proteins for ZNF83

Sources for ZNF83 Gene