This gene encodes a protein with two C2H2 zinc finger motifs and a score-and-three (23)-amino acid peptide repeat (STPR) domain. The STPR domain of the encoded protein binds to double stranded DNA and may also contain a nuclear localization signal, suggesting that this protein interacts with chromosomal DNA. Alternatively spliced transcript variants encoding multiple isoforms h... See more...

Aliases for ZNF821 Gene

Aliases for ZNF821 Gene

  • Zinc Finger Protein 821 2 3 4 5
  • ZNF821 5

External Ids for ZNF821 Gene

Previous GeneCards Identifiers for ZNF821 Gene

  • GC16M070452
  • GC16M071893
  • GC16M057661

Summaries for ZNF821 Gene

Entrez Gene Summary for ZNF821 Gene

  • This gene encodes a protein with two C2H2 zinc finger motifs and a score-and-three (23)-amino acid peptide repeat (STPR) domain. The STPR domain of the encoded protein binds to double stranded DNA and may also contain a nuclear localization signal, suggesting that this protein interacts with chromosomal DNA. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]

GeneCards Summary for ZNF821 Gene

ZNF821 (Zinc Finger Protein 821) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is IKZF4.

UniProtKB/Swiss-Prot Summary for ZNF821 Gene

Additional gene information for ZNF821 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF821 Gene

Genomics for ZNF821 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF821 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF821 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF821

Top Transcription factor binding sites by QIAGEN in the ZNF821 gene promoter:
  • AML1a
  • AREB6
  • C/EBPalpha
  • CHOP-10
  • HSF2
  • IRF-7A
  • p53
  • POU3F2
  • RREB-1
  • RSRFC4

Genomic Locations for ZNF821 Gene

Genomic Locations for ZNF821 Gene
chr16:71,859,680-71,895,336
(GRCh38/hg38)
Size:
35,657 bases
Orientation:
Minus strand
chr16:71,893,583-71,929,239
(GRCh37/hg19)
Size:
35,657 bases
Orientation:
Minus strand

Genomic View for ZNF821 Gene

Genes around ZNF821 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF821 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF821 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF821 Gene

Proteins for ZNF821 Gene

  • Protein details for ZNF821 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75541-ZN821_HUMAN
    Recommended name:
    Zinc finger protein 821
    Protein Accession:
    O75541
    Secondary Accessions:
    • A6NK48
    • B4DKK4
    • D3DWS3

    Protein attributes for ZNF821 Gene

    Size:
    412 amino acids
    Molecular mass:
    46794 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF821 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF821 Gene

Post-translational modifications for ZNF821 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Abcam antibodies for ZNF821
  • Boster Bio Antibodies for ZNF821

No data available for DME Specific Peptides for ZNF821 Gene

Domains & Families for ZNF821 Gene

Gene Families for ZNF821 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ZNF821 Gene

InterPro:
Blocks:
  • C2H2-type zinc finger signature
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF821 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ57016 (B4DKK4_HUMAN)
  • Zinc finger protein 821 (ZN821_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O75541

UniProtKB/Swiss-Prot:

ZN821_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF821: view

Function for ZNF821 Gene

Molecular function for ZNF821 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF821 Gene

Gene Ontology (GO) - Molecular Function for ZNF821 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000976 transcription regulatory region sequence-specific DNA binding IBA 21873635
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity IBA 21873635
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with ZNF821: view
genes like me logo Genes that share phenotypes with ZNF821: view

Animal Model Products

CRISPR Products

miRNA for ZNF821 Gene

miRTarBase miRNAs that target ZNF821

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF821

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF821 Gene

Localization for ZNF821 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF821 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF821 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (3)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF821 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IBA 21873635
genes like me logo Genes that share ontologies with ZNF821: view

Pathways & Interactions for ZNF821 Gene

PathCards logo

SuperPathways for ZNF821 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF821 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045944 positive regulation of transcription by RNA polymerase II IBA 21873635
genes like me logo Genes that share ontologies with ZNF821: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF821 Gene

Drugs & Compounds for ZNF821 Gene

No Compound Related Data Available

Transcripts for ZNF821 Gene

mRNA/cDNA for ZNF821 Gene

11 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
21 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF821

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF821 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c · 12d · 12e · 12f
SP1: - - - - - -
SP2: - - - - - - -
SP3: - - - - - - -
SP4: -
SP5: - - - - -
SP6: - - - - -
SP7: - - - -
SP8: - - - -
SP9: - - - -
SP10: - -
SP11: - - - - - - - -
SP12: - - - -
SP13: - - - -

Relevant External Links for ZNF821 Gene

GeneLoc Exon Structure for
ZNF821

Expression for ZNF821 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF821 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Testis (Reproductive System)

mRNA differential expression in normal tissues according to GTEx for ZNF821 Gene

This gene is overexpressed in Testis (x4.2) and Brain - Cerebellar Hemisphere (x4.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF821 Gene



Protein tissue co-expression partners for ZNF821 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF821

SOURCE GeneReport for Unigene cluster for ZNF821 Gene:

Hs.744055

Evidence on tissue expression from TISSUES for ZNF821 Gene

  • Nervous system(4.6)
  • Intestine(4.1)
genes like me logo Genes that share expression patterns with ZNF821: view

No data available for Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF821 Gene

Orthologs for ZNF821 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF821 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZNF821 30 31
  • 99.27 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ZNF821 30 31
  • 94.26 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ZNF821 30 31
  • 93.77 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia ZNF821 31
  • 93 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia ZNF821 31
  • 92 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Zfp821 30 17 31
  • 89.72 (n)
OneToOne
Chicken
(Gallus gallus)
Aves ZNF821 30 31
  • 77.67 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia ZNF821 31
  • 67 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia znf821 30
  • 67.43 (n)
Str.882 30
Zebrafish
(Danio rerio)
Actinopterygii LOC571740 30
  • 57.85 (n)
CABZ01083862.1 31
  • 50 (a)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta peb 31
  • 4 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 12 (a)
OneToOne
Species where no ortholog for ZNF821 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for ZNF821 Gene

ENSEMBL:
Gene Tree for ZNF821 (if available)
TreeFam:
Gene Tree for ZNF821 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF821: view image

Paralogs for ZNF821 Gene

(3) SIMAP similar genes for ZNF821 Gene using alignment to 9 proteins:

  • ZN821_HUMAN
  • H3BPS7_HUMAN
  • H3BQE4_HUMAN
  • H3BR59_HUMAN
  • H3BR75_HUMAN
  • H3BRD6_HUMAN
  • H3BS68_HUMAN
  • H3BTZ4_HUMAN
  • H3BVG7_HUMAN
genes like me logo Genes that share paralogs with ZNF821: view

Variants for ZNF821 Gene

Additional dbSNP identifiers (rs#s) for ZNF821 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF821 Gene

Variant ID Type Subtype PubMed ID
esv1001782 CNV insertion 20482838
esv3303504 CNV mobile element insertion 20981092
esv3431278 CNV insertion 20981092
nsv7285 OTHER inversion 18451855

Variation tolerance for ZNF821 Gene

Residual Variation Intolerance Score: 44.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.54; 11.74% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF821 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF821

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF821 Gene

Disorders for ZNF821 Gene

Additional Disease Information for ZNF821

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform

No disorders were found for ZNF821 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF821 Gene

Publications for ZNF821 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
  2. Large-scale concatenation cDNA sequencing. (PMID: 9110174) Yu W … Gibbs RA (Genome research 1997) 2 3
  3. A "double adaptor" method for improved shotgun library construction. (PMID: 8619474) Andersson B … Gibbs RA (Analytical biochemistry 1996) 2 3
  4. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  5. Systematic identification of molecular links between core and candidate genes in breast cancer. (PMID: 25640309) Arroyo R … Aloy P (Journal of molecular biology 2015) 3

Products for ZNF821 Gene

Sources for ZNF821 Gene