Aliases for ZNF816 Gene

Aliases for ZNF816 Gene

  • Zinc Finger Protein 816 2 3 4 5
  • Zinc Finger Protein 816A 2 3
  • ZNF816A 3 4
  • ZNF816 5

External Ids for ZNF816 Gene

Previous HGNC Symbols for ZNF816 Gene

  • ZNF816A

Previous GeneCards Identifiers for ZNF816 Gene

  • GC19M053453
  • GC19M049780

Summaries for ZNF816 Gene

GeneCards Summary for ZNF816 Gene

ZNF816 (Zinc Finger Protein 816) is a Protein Coding gene. Among its related pathways are Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA-binding transcription factor activity. An important paralog of this gene is ZNF813.

UniProtKB/Swiss-Prot Summary for ZNF816 Gene

Additional gene information for ZNF816 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF816 Gene

Genomics for ZNF816 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF816 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF816 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF816

Genomic Locations for ZNF816 Gene

Genomic Locations for ZNF816 Gene
chr19:52,949,379-52,962,911
(GRCh38/hg38)
Size:
13,533 bases
Orientation:
Minus strand
chr19:53,430,388-53,466,164
(GRCh37/hg19)
Size:
35,777 bases
Orientation:
Minus strand

Genomic View for ZNF816 Gene

Genes around ZNF816 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF816 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF816 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF816 Gene

Proteins for ZNF816 Gene

  • Protein details for ZNF816 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q0VGE8-ZN816_HUMAN
    Recommended name:
    Zinc finger protein 816
    Protein Accession:
    Q0VGE8
    Secondary Accessions:
    • A8K7H5
    • Q3KR39
    • Q659B3

    Protein attributes for ZNF816 Gene

    Size:
    651 amino acids
    Molecular mass:
    75725 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF816 Gene

Post-translational modifications for ZNF816 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF816 Gene

Domains & Families for ZNF816 Gene

Gene Families for ZNF816 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Transcription factors

Protein Domains for ZNF816 Gene

InterPro:
Blocks:
  • KRAB box
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF816 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 816 (ZN816_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q0VGE8

UniProtKB/Swiss-Prot:

ZN816_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF816: view

Function for ZNF816 Gene

Molecular function for ZNF816 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF816 Gene

Gene Ontology (GO) - Molecular Function for ZNF816 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF816: view
genes like me logo Genes that share phenotypes with ZNF816: view

Animal Model Products

CRISPR Products

miRNA for ZNF816 Gene

miRTarBase miRNAs that target ZNF816

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF816

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF816 Gene

Localization for ZNF816 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF816 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF816 gene
Compartment Confidence
nucleus 4
cytosol 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF816 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ZNF816: view

Pathways & Interactions for ZNF816 Gene

PathCards logo

SuperPathways for ZNF816 Gene

genes like me logo Genes that share pathways with ZNF816: view

Pathways by source for ZNF816 Gene

1 KEGG pathway for ZNF816 Gene

Gene Ontology (GO) - Biological Process for ZNF816 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF816: view

No data available for SIGNOR curated interactions for ZNF816 Gene

Drugs & Compounds for ZNF816 Gene

(1) Drugs for ZNF816 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Tumor necrosis factor alpha (TNF-alpha) inhibitors Pharma 0
genes like me logo Genes that share compounds with ZNF816: view

Transcripts for ZNF816 Gene

mRNA/cDNA for ZNF816 Gene

3 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF816

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF816 Gene

No ASD Table

Relevant External Links for ZNF816 Gene

GeneLoc Exon Structure for
ZNF816

Expression for ZNF816 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF816 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF816

SOURCE GeneReport for Unigene cluster for ZNF816 Gene:

Hs.655592

Evidence on tissue expression from TISSUES for ZNF816 Gene

  • Intestine(4.5)
  • Skin(3.7)
  • Nervous system(3.6)
  • Lung(3.6)
  • Bone(2.2)
genes like me logo Genes that share expression patterns with ZNF816: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF816 Gene

Orthologs for ZNF816 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF816 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LOC748668 30
  • 98.72 (n)
ZNF816 31
  • 49 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Zfp141 30
  • 65.66 (n)
Dog
(Canis familiaris)
Mammalia -- 31
  • 52 (a)
ManyToMany
Cow
(Bos Taurus)
Mammalia -- 31
  • 44 (a)
ManyToMany
Species where no ortholog for ZNF816 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ZNF816 Gene

ENSEMBL:
Gene Tree for ZNF816 (if available)
TreeFam:
Gene Tree for ZNF816 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF816: view image

Paralogs for ZNF816 Gene

(516) SIMAP similar genes for ZNF816 Gene using alignment to 6 proteins:

  • ZN816_HUMAN
  • F5GXJ3_HUMAN
  • I3L0H5_HUMAN
  • M0QY99_HUMAN
  • M0QZX7_HUMAN
  • M0R0G1_HUMAN
genes like me logo Genes that share paralogs with ZNF816: view

Variants for ZNF816 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF816 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
732130 Likely Benign: not provided 52,951,117(-) G/A NONSENSE,INTRON_VARIANT
773361 Likely Benign: not provided 52,950,277(-) G/C MISSENSE_VARIANT,INTRON_VARIANT
773362 Likely Benign: not provided 52,950,834(-) T/C MISSENSE_VARIANT,INTRON_VARIANT
rs11084210 - p.Ser162Leu
rs12459008 - p.Ile80Asn

Additional dbSNP identifiers (rs#s) for ZNF816 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF816 Gene

Variant ID Type Subtype PubMed ID
esv2718786 CNV deletion 23290073
esv2718787 CNV deletion 23290073
esv2718796 CNV deletion 23290073
esv2718799 CNV deletion 23290073
esv2718808 CNV deletion 23290073
esv2758769 CNV loss 17122850
nsv1057118 CNV gain 25217958
nsv1064234 CNV gain 25217958
nsv1066762 CNV gain 25217958
nsv1078889 OTHER inversion 25765185
nsv1127696 CNV deletion 24896259
nsv1140479 CNV deletion 24896259
nsv428370 CNV loss 18775914
nsv580030 CNV gain 21841781
nsv963071 CNV duplication 23825009

Variation tolerance for ZNF816 Gene

Residual Variation Intolerance Score: 98.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.29; 94.10% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF816 Gene

Human Gene Mutation Database (HGMD)
ZNF816
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF816

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF816 Gene

Disorders for ZNF816 Gene

Additional Disease Information for ZNF816

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform

No disorders were found for ZNF816 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF816 Gene

Publications for ZNF816 Gene

  1. Association analyses identify six new psoriasis susceptibility loci in the Chinese population. (PMID: 20953187) Sun LD … Zhang XJ (Nature genetics 2010) 3 41
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  4. The full-ORF clone resource of the German cDNA Consortium. (PMID: 17974005) Bechtel S … Schupp I (BMC genomics 2007) 4
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3

Products for ZNF816 Gene

Sources for ZNF816 Gene