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Aliases for ZNF81 Gene

Aliases for ZNF81 Gene

  • Zinc Finger Protein 81 2 3 4 5
  • HFZ20 3 4
  • Mental Retardation, X-Linked 45 2
  • Zinc Finger Protein 81 (HFZ20) 2
  • DJ54B20.6 3
  • MRX45 3

External Ids for ZNF81 Gene

Previous HGNC Symbols for ZNF81 Gene

  • MRX45

Previous GeneCards Identifiers for ZNF81 Gene

  • GC0XU990240
  • GC0XM046035
  • GC0XM046352
  • GC0XP046779
  • GC0XP047452
  • GC0XP047581
  • GC0XP047696
  • GC0XP045408

Summaries for ZNF81 Gene

Entrez Gene Summary for ZNF81 Gene

  • This gene encodes a protein that likely functions as a transcription factor. The protein contains an N-terminal KRAB domain and several C2H2-type zinc finger motifs. Mutations in this gene cause an X-linked form of intellectual disability (MRX45). Microduplication of a region of chromosome X including this gene has also been associated with other forms of intellectual disability. [provided by RefSeq, Jul 2017]

GeneCards Summary for ZNF81 Gene

ZNF81 (Zinc Finger Protein 81) is a Protein Coding gene. Diseases associated with ZNF81 include X-Linked Non-Specific Intellectual Disability and Non-Syndromic X-Linked Intellectual Disability. Among its related pathways are Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA-binding transcription factor activity. An important paralog of this gene is ZNF41.

UniProtKB/Swiss-Prot for ZNF81 Gene

Additional gene information for ZNF81 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF81 Gene

Genomics for ZNF81 Gene

GeneHancer (GH) Regulatory Elements for ZNF81 Gene

Promoters and enhancers for ZNF81 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ047835 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 619.1 +0.0 30 2.6 SIX5 MYC YY1 ELF1 SP1 MLLT1 KAT8 IKZF1 GLIS2 POLR2A ZNF81 WAS PIR57381
GH0XJ047216 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 37.9 -618.3 -618267 5.2 HDGF SP1 ZFX SIX5 NKRF POLR2A MLLT1 GTF2F1 ZNF687 ZSCAN21 CDK16 LOC105373194 ENSG00000224072 ZNF81 ZNF182 INE1 LINC01560 ZNF674-AS1 UBA1 RBM10
GH0XJ048573 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 40.8 +738.3 738265 3.7 SP1 ZFX MNT NKRF MLLT1 CSDE1 ZSCAN21 NFRKB BACH1 MYC ENSG00000204620 RBM3 ZNF182 ZNF81 ENSG00000228343 ENSG00000270012 FTSJ1 PRICKLE3 PQBP1 HDAC6
GH0XJ048785 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 26.7 +951.0 951030 5 MLLT1 CDC5L MCM2 PRDM1 ZNF639 SMARCA4 MTA1 DPF2 IKZF1 ZNF512 GATA1 ENSG00000204620 ENSG00000270012 ZNF81 FTSJ1 PQBP1 CCDC22 ZNF182 RBM3 SLC38A5
GH0XJ047657 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 29.4 -178.0 -178029 3.1 SP1 CC2D1A ELF3 ZFX MNT NKRF MLLT1 ZNF121 POLR2A GTF2F1 UXT UXT-AS1 INE1 ENSG00000204620 ZNF81 FTSJ1 UBA1 RBM3 ZNF182 RBM10
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF81 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF81 gene promoter:
  • E4BP4
  • FOXO4
  • GATA-1
  • GATA-2
  • GATA-3
  • Pbx1a
  • SRF
  • SRF (504 AA)
  • STAT3

Genomic Locations for ZNF81 Gene

Genomic Locations for ZNF81 Gene
chrX:47,836,871-48,002,561
(GRCh38/hg38)
Size:
165,691 bases
Orientation:
Plus strand
chrX:47,696,301-47,861,960
(GRCh37/hg19)
Size:
165,660 bases
Orientation:
Plus strand

Genomic View for ZNF81 Gene

Genes around ZNF81 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF81 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF81 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF81 Gene

Proteins for ZNF81 Gene

  • Protein details for ZNF81 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P51508-ZNF81_HUMAN
    Recommended name:
    Zinc finger protein 81
    Protein Accession:
    P51508
    Secondary Accessions:
    • Q6RX22
    • Q96QH6

    Protein attributes for ZNF81 Gene

    Size:
    661 amino acids
    Molecular mass:
    75960 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF81 Gene

Post-translational modifications for ZNF81 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF81 Gene

Domains & Families for ZNF81 Gene

Gene Families for ZNF81 Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF81 Gene

Suggested Antigen Peptide Sequences for ZNF81 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 81 (B1AJV1_HUMAN)
  • Zinc finger protein 81 (B1AJV2_HUMAN)
  • cDNA FLJ45002 fis, clone BRAWH3011577, moderately similar to Zinc finger protein 175 (Q6ZT36_HUMAN)
  • HFZ20 (ZNF81_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P51508

UniProtKB/Swiss-Prot:

ZNF81_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF81: view

Function for ZNF81 Gene

Molecular function for ZNF81 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
GENATLAS Biochemistry:
zinc finger protein 81 (H2F10) (C2H2 type,Kruppel-like)

Gene Ontology (GO) - Molecular Function for ZNF81 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISA --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF81: view
genes like me logo Genes that share phenotypes with ZNF81: view

Human Phenotype Ontology for ZNF81 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for ZNF81 - Now 50% OFF >
  • * ZNF81 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * ZNF81 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF81 Gene

Localization for ZNF81 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF81 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF81 gene
Compartment Confidence
nucleus 4
cytosol 3
cytoskeleton 2

Gene Ontology (GO) - Cellular Components for ZNF81 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF81: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZNF81 Gene

Pathways & Interactions for ZNF81 Gene

PathCards logo

SuperPathways for ZNF81 Gene

genes like me logo Genes that share pathways with ZNF81: view

Pathways by source for ZNF81 Gene

1 KEGG pathway for ZNF81 Gene

Interacting Proteins for ZNF81 Gene

Gene Ontology (GO) - Biological Process for ZNF81 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with ZNF81: view

No data available for SIGNOR curated interactions for ZNF81 Gene

Drugs & Compounds for ZNF81 Gene

No Compound Related Data Available

Transcripts for ZNF81 Gene

mRNA/cDNA for ZNF81 Gene

Unigene Clusters for ZNF81 Gene

Zinc finger protein 81:
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for ZNF81 - Now 50% OFF >
  • * ZNF81 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * ZNF81 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF81 Gene

No ASD Table

Relevant External Links for ZNF81 Gene

GeneLoc Exon Structure for
ZNF81
ECgene alternative splicing isoforms for
ZNF81

Expression for ZNF81 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF81 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF81 Gene:

ZNF81

SOURCE GeneReport for Unigene cluster for ZNF81 Gene:

Hs.114246

Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF81 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • digestive
  • integumentary
  • nervous
  • reproductive
  • respiratory
  • skeletal muscle
  • skeleton
  • urinary
Regions:
Head and neck:
  • brain
  • cerebellum
  • cheek
  • chin
  • cranial nerve
  • ear
  • eye
  • eyelid
  • face
  • forehead
  • head
  • jaw
  • lip
  • mandible
  • maxilla
  • mouth
  • nose
  • outer ear
  • salivary gland
  • skull
  • tooth
Thorax:
  • lung
  • rib
  • rib cage
Pelvis:
  • pelvis
  • testicle
  • urinary bladder
Limb:
  • ankle
  • digit
  • elbow
  • finger
  • foot
  • hand
  • hip
  • knee
  • lower limb
  • shoulder
  • toe
  • upper limb
  • wrist
General:
  • hair
  • peripheral nerve
  • peripheral nervous system
  • skin
  • spinal column
  • vertebrae
genes like me logo Genes that share expression patterns with ZNF81: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Evidence on tissue expression from TISSUES for ZNF81 Gene

Orthologs for ZNF81 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF81 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF81 35 34
  • 99.85 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF81 35 34
  • 90.12 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF81 35 34
  • 88.5 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100363372 34
  • 81.74 (n)
Species where no ortholog for ZNF81 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF81 Gene

ENSEMBL:
Gene Tree for ZNF81 (if available)
TreeFam:
Gene Tree for ZNF81 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF81: view image

Paralogs for ZNF81 Gene

Paralogs for ZNF81 Gene

(528) SIMAP similar genes for ZNF81 Gene using alignment to 4 proteins:

  • ZNF81_HUMAN
  • B1AJV1_HUMAN
  • B1AJV2_HUMAN
  • L8E7Y0_HUMAN

Pseudogenes.org Pseudogenes for ZNF81 Gene

genes like me logo Genes that share paralogs with ZNF81: view

Variants for ZNF81 Gene

Sequence variations from dbSNP and Humsavar for ZNF81 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1017729265 uncertain-significance, Non-syndromic X-linked intellectual disability 47,921,943(+) G/A 3_prime_UTR_variant
rs1023977933 uncertain-significance, Non-syndromic X-linked intellectual disability 47,917,661(+) G/T 3_prime_UTR_variant
rs1026039563 uncertain-significance, Non-syndromic X-linked intellectual disability 47,922,054(+) A/G 3_prime_UTR_variant
rs1057515906 uncertain-significance, Non-syndromic X-linked intellectual disability 47,846,152(+) A/G 5_prime_UTR_variant
rs1057515907 uncertain-significance, Non-syndromic X-linked intellectual disability 47,916,635(+) G/A 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF81 Gene

Variant ID Type Subtype PubMed ID
esv2545209 CNV deletion 19546169
esv2758866 CNV gain+loss 17122850
esv3307234 CNV mobile element insertion 20981092
esv3360804 CNV insertion 20981092

Variation tolerance for ZNF81 Gene

Residual Variation Intolerance Score: 86.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.73; 57.60% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF81 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF81
Human Gene Mutation Database (HGMD)
ZNF81

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF81 Gene

Disorders for ZNF81 Gene

MalaCards: The human disease database

(4) MalaCards diseases for ZNF81 Gene - From: HGMD, Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
x-linked non-specific intellectual disability
  • x-linked non-syndromic intellectual disability
non-syndromic x-linked intellectual disability
  • non-specific x-linked mental retardation
syndromic x-linked intellectual disability
  • syndromic intellectual disability, x-linked
aland island eye disease
  • aied
- elite association - COSMIC cancer census association via MalaCards
Search ZNF81 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

ZNF81_HUMAN
  • Note=A chromosomal aberration involving ZNF81 is found in a severe mental retardation patient. Translocation t(X;9)(p11.23;q34.3). {ECO:0000269 PubMed:15121780}.

Additional Disease Information for ZNF81

genes like me logo Genes that share disorders with ZNF81: view

No data available for Genatlas for ZNF81 Gene

Publications for ZNF81 Gene

  1. Zinc finger 81 (ZNF81) mutations associated with X-linked mental retardation. (PMID: 15121780) Kleefstra T … van Bokhoven H (Journal of medical genetics 2004) 2 3 4 58
  2. A novel X-linked member of the human zinc finger protein gene family: isolation, mapping, and expression. (PMID: 8507979) Marino M … Grimaldi G (Mammalian genome : official journal of the International Mammalian Genome Society 1993) 2 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 58
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 58

Products for ZNF81 Gene

Sources for ZNF81 Gene

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