Aliases for ZNF804B Gene

Aliases for ZNF804B Gene

  • Zinc Finger Protein 804B 2 3 4 5
  • Zinc Finger 804B 2 3
  • FLJ32110 2
  • ZNF804B 5

External Ids for ZNF804B Gene

Previous GeneCards Identifiers for ZNF804B Gene

  • GC07P088227
  • GC07P088388
  • GC07P082997

Summaries for ZNF804B Gene

GeneCards Summary for ZNF804B Gene

ZNF804B (Zinc Finger Protein 804B) is a Protein Coding gene. Diseases associated with ZNF804B include Body Dysmorphic Disorder. Among its related pathways are Gene Expression. An important paralog of this gene is GPATCH8.

Additional gene information for ZNF804B Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF804B Gene

Genomics for ZNF804B Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF804B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J088758 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE CraniofacialAtlas 610.9 -0.4 -399 1.8 PRDM10 KDM1A EZH2 SOX6 SCRT2 MGA RAD21 CTCF UBTF ZNF766 ZNF804B ENSG00000227979 lnc-ZNF804B-3 STEAP4
GH07J088289 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 10 -468.7 -468728 4.3 CREB1 ZBTB33 TARDBP FOXA1 ATF7 BRCA1 BMI1 CTBP1 CEBPB ZNF444 EIF4A1P13 ENSG00000207094 ZNF804B TEX47 SRI STEAP4 lnc-STEAP4-1 ENSG00000228113
GH07J088682 Enhancer 1 Ensembl ENCODE 9.5 -76.4 -76399 1.8 ZNF512 LEF1 JUND REST ZNF740 BRD9 DPF2 HDAC1 SOX6 FOXJ2 ZNF804B LOC107986816 lnc-ZNF804B-3 ENSG00000227979 ENSG00000233420 STEAP4
GH07J088395 Enhancer 0.9 Ensembl ENCODE 10 -363.3 -363299 4.4 RELA TCF12 IKZF2 TRIM22 PKNOX1 CEBPB ARID3A DPF2 RUNX3 BCL11A ZNF804B STEAP4 L13713-216 piR-34924
GH07J088723 Enhancer 0.5 UCNEbase Ensembl 10.8 -36.4 -36376 0.2 ZNF804B TEX47 ENSG00000227979 lnc-ZNF804B-3 LOC107986816 ENSG00000233420 STEAP4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF804B on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF804B

Top Transcription factor binding sites by QIAGEN in the ZNF804B gene promoter:
  • ATF
  • Egr-1
  • Egr-4
  • FOXJ2
  • FOXJ2 (long isoform)
  • MyoD
  • Nkx2-5
  • STAT1
  • STAT1alpha
  • STAT1beta

Genomic Locations for ZNF804B Gene

Genomic Locations for ZNF804B Gene
chr7:88,759,700-89,338,528
(GRCh38/hg38)
Size:
578,829 bases
Orientation:
Plus strand
chr7:88,388,682-88,966,346
(GRCh37/hg19)
Size:
577,665 bases
Orientation:
Plus strand

Genomic View for ZNF804B Gene

Genes around ZNF804B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF804B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF804B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF804B Gene

Proteins for ZNF804B Gene

  • Protein details for ZNF804B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A4D1E1-Z804B_HUMAN
    Recommended name:
    Zinc finger protein 804B
    Protein Accession:
    A4D1E1
    Secondary Accessions:
    • B2RTV2
    • Q7Z714
    • Q96MN7

    Protein attributes for ZNF804B Gene

    Size:
    1349 amino acids
    Molecular mass:
    152573 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF804B Gene

Post-translational modifications for ZNF804B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF804B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF804B Gene

Domains & Families for ZNF804B Gene

Gene Families for ZNF804B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ZNF804B Gene

Suggested Antigen Peptide Sequences for ZNF804B Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 804B (Z804B_HUMAN)
genes like me logo Genes that share domains with ZNF804B: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ZNF804B Gene

Function for ZNF804B Gene

Phenotypes From GWAS Catalog for ZNF804B Gene

Gene Ontology (GO) - Molecular Function for ZNF804B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF804B: view
genes like me logo Genes that share phenotypes with ZNF804B: view

Animal Model Products

CRISPR Products

miRNA for ZNF804B Gene

miRTarBase miRNAs that target ZNF804B

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF804B

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF804B Gene

Localization for ZNF804B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF804B gene
Compartment Confidence
nucleus 3
cytoskeleton 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for ZNF804B Gene

Pathways & Interactions for ZNF804B Gene

PathCards logo

SuperPathways for ZNF804B Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF804B: view

Pathways by source for ZNF804B Gene

2 Reactome pathways for ZNF804B Gene

Interacting Proteins for ZNF804B Gene

STRING Interaction Network Preview (showing top 1 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: ENSP00000329638 A4D1E1-Z804B_HUMAN for ZNF804B Gene via STRING IID

Gene Ontology (GO) - Biological Process for ZNF804B Gene

None

No data available for SIGNOR curated interactions for ZNF804B Gene

Drugs & Compounds for ZNF804B Gene

No Compound Related Data Available

Transcripts for ZNF804B Gene

mRNA/cDNA for ZNF804B Gene

1 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF804B

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF804B Gene

No ASD Table

Relevant External Links for ZNF804B Gene

GeneLoc Exon Structure for
ZNF804B

Expression for ZNF804B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF804B Gene

mRNA differential expression in normal tissues according to GTEx for ZNF804B Gene

This gene is overexpressed in Thyroid (x33.1) and Pancreas (x4.6).

Protein differential expression in normal tissues from HIPED for ZNF804B Gene

This gene is overexpressed in Adipocyte (66.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZNF804B Gene



Protein tissue co-expression partners for ZNF804B Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF804B

SOURCE GeneReport for Unigene cluster for ZNF804B Gene:

Hs.684410

Evidence on tissue expression from TISSUES for ZNF804B Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with ZNF804B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF804B Gene

Orthologs for ZNF804B Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF804B Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZNF804B 30 31
  • 98.74 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ZNF804B 30 31
  • 84.78 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ZNF804B 30 31
  • 84.24 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Zfp804b 30 17 31
  • 77.84 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Zfp804b 30
  • 76.35 (n)
Oppossum
(Monodelphis domestica)
Mammalia ZNF804B 31
  • 49 (a)
OneToOne
Chicken
(Gallus gallus)
Aves ZNF804B 30 31
  • 60.35 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia ZNF804B 31
  • 37 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii znf804b 31
  • 22 (a)
OneToOne
Species where no ortholog for ZNF804B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for ZNF804B Gene

ENSEMBL:
Gene Tree for ZNF804B (if available)
TreeFam:
Gene Tree for ZNF804B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF804B: view image

Paralogs for ZNF804B Gene

Paralogs for ZNF804B Gene

genes like me logo Genes that share paralogs with ZNF804B: view

Variants for ZNF804B Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF804B Gene

SNP ID Clinical significance and condition Chr 07 pos Variation AA Info Type
709869 Benign: not provided 89,334,207(+) A/G MISSENSE_VARIANT
709870 Benign: not provided 89,334,611(+) G/A SYNONYMOUS_VARIANT
709871 Benign: not provided 89,335,224(+) C/T MISSENSE_VARIANT
709872 Benign: not provided 89,335,574(+) C/T SYNONYMOUS_VARIANT
716082 Benign: not provided 89,334,150(+) C/A MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for ZNF804B Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF804B Gene

Variant ID Type Subtype PubMed ID
dgv11493n54 CNV gain 21841781
dgv1932e212 CNV loss 25503493
dgv6525n100 CNV gain 25217958
dgv6526n100 CNV gain 25217958
dgv6527n100 CNV gain 25217958
esv1007484 CNV insertion 20482838
esv1248186 CNV insertion 17803354
esv1580714 CNV insertion 17803354
esv1612109 CNV insertion 17803354
esv24052 CNV gain+loss 19812545
esv2579632 CNV deletion 19546169
esv2659894 CNV deletion 23128226
esv2667313 CNV deletion 23128226
esv2674153 CNV deletion 23128226
esv2678151 CNV deletion 23128226
esv2734786 CNV deletion 23290073
esv2752187 CNV gain 17911159
esv2752188 CNV gain 17911159
esv2759544 CNV loss 17122850
esv27626 CNV gain 19812545
esv2764019 CNV loss 21179565
esv28076 CNV loss 19812545
esv3302490 CNV tandem duplication 20981092
esv33064 CNV loss 17666407
esv3393154 CNV insertion 20981092
esv3442756 CNV duplication 20981092
esv3571966 CNV loss 25503493
esv3571967 CNV loss 25503493
esv3571968 CNV loss 25503493
esv3571971 CNV loss 25503493
esv3576400 CNV gain 25503493
esv3576401 CNV gain 25503493
esv3614055 CNV loss 21293372
esv3614061 CNV loss 21293372
esv3614062 CNV loss 21293372
esv3614063 CNV loss 21293372
esv3614065 CNV loss 21293372
esv3614066 CNV loss 21293372
esv3614070 CNV gain 21293372
esv3614071 CNV gain 21293372
esv3614073 CNV loss 21293372
esv3614074 CNV gain 21293372
esv7198 OTHER inversion 19470904
nsv1015471 CNV gain 25217958
nsv1016918 CNV loss 25217958
nsv1018241 CNV loss 25217958
nsv1019035 CNV gain 25217958
nsv1027869 CNV loss 25217958
nsv1028588 CNV loss 25217958
nsv1029018 CNV gain 25217958
nsv1078264 CNV insertion 25765185
nsv1134901 CNV tandem duplication 24896259
nsv1143188 CNV tandem duplication 24896259
nsv1150424 CNV duplication 26484159
nsv365593 CNV deletion 16902084
nsv366862 CNV insertion 16902084
nsv464626 CNV gain 19166990
nsv464627 CNV loss 19166990
nsv464629 CNV loss 19166990
nsv515995 CNV gain+loss 19592680
nsv5829 CNV insertion 18451855
nsv607745 CNV gain 21841781
nsv607746 CNV loss 21841781
nsv607747 CNV loss 21841781
nsv607748 CNV loss 21841781
nsv607749 CNV loss 21841781
nsv818535 CNV loss 17921354
nsv831054 CNV gain 17160897
nsv831055 CNV loss 17160897
nsv831056 CNV loss 17160897

Variation tolerance for ZNF804B Gene

Residual Variation Intolerance Score: 98.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.04; 87.51% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF804B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF804B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF804B Gene

Disorders for ZNF804B Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZNF804B Gene - From: DISEASES

Disorder Aliases PubMed IDs
body dysmorphic disorder
  • body dysmorphia
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ZNF804B

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with ZNF804B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF804B Gene

Publications for ZNF804B Gene

  1. Novel associations for hypothyroidism include known autoimmune risk loci. (PMID: 22493691) Eriksson N … Do CB (PloS one 2012) 3 41
  2. A genome-wide association study on common SNPs and rare CNVs in anorexia nervosa. (PMID: 21079607) Wang K … Price Foundation Collaborative Group (Molecular psychiatry 2011) 3 41
  3. Genome-wide association study of anthropometric traits and evidence of interactions with age and study year in Filipino women. (PMID: 20966902) Croteau-Chonka DC … Mohlke KL (Obesity (Silver Spring, Md.) 2011) 3 41
  4. A Japanese-specific allele in the GALNT11 gene. (PMID: 20547088) Yuasa I … Henke J (Legal medicine (Tokyo, Japan) 2010) 3 4
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41

Products for ZNF804B Gene

Sources for ZNF804B Gene