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Aliases for ZNF80 Gene

Aliases for ZNF80 Gene

  • Zinc Finger Protein 80 2 3 5
  • ZNFPT17 3 4
  • Zinc Finger Protein 80 (PT17) 2
  • PT17 3

External Ids for ZNF80 Gene

Previous GeneCards Identifiers for ZNF80 Gene

  • GC03M110734
  • GC03M113524
  • GC03M115234
  • GC03M115274
  • GC03M115263
  • GC03M115431
  • GC03M113953
  • GC03M111327

Summaries for ZNF80 Gene

GeneCards Summary for ZNF80 Gene

ZNF80 (Zinc Finger Protein 80) is a Protein Coding gene. An important paralog of this gene is ZNF543.

UniProtKB/Swiss-Prot for ZNF80 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF80 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF80 Gene

Genomics for ZNF80 Gene

GeneHancer (GH) Regulatory Elements for ZNF80 Gene

Promoters and enhancers for ZNF80 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I114212 Promoter/Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 2.2 +22.2 22219 6.5 PKNOX1 BMI1 FEZF1 BATF IRF4 ZNF121 SCRT2 ATF7 ETV6 FOS ENSG00000241490 TIGIT DRD3 ZNF80 GC03P114229
GH03I114220 Enhancer 1.1 FANTOM5 ENCODE dbSUPER 1.8 +13.3 13295 6.7 MEIS2 JUN CEBPG GABPA FOSL1 ATF4 IKZF1 NR2C1 ETV6 NR2C2 DRD3 TIGIT ZNF80 GC03P114229 ENSG00000241490
GH03I114234 Enhancer 0.3 dbSUPER 0.8 +2.3 2298 1.9 MAFG LOC645180 ZNF80 GC03P114229 ENSG00000241490
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF80 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF80 gene promoter:

Genomic Locations for ZNF80 Gene

Genomic Locations for ZNF80 Gene
chr3:114,234,631-114,237,578
(GRCh38/hg38)
Size:
2,948 bases
Orientation:
Minus strand
chr3:113,953,478-113,956,425
(GRCh37/hg19)

Genomic View for ZNF80 Gene

Genes around ZNF80 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF80 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF80 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF80 Gene

Proteins for ZNF80 Gene

  • Protein details for ZNF80 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P51504-ZNF80_HUMAN
    Recommended name:
    Zinc finger protein 80
    Protein Accession:
    P51504
    Secondary Accessions:
    • Q6NSW4
    • Q6NT14

    Protein attributes for ZNF80 Gene

    Size:
    273 amino acids
    Molecular mass:
    31224 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF80 Gene

Post-translational modifications for ZNF80 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF80 Gene

No data available for DME Specific Peptides for ZNF80 Gene

Domains & Families for ZNF80 Gene

Gene Families for ZNF80 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF80 Gene

Suggested Antigen Peptide Sequences for ZNF80 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P51504

UniProtKB/Swiss-Prot:

ZNF80_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF80: view

Function for ZNF80 Gene

Molecular function for ZNF80 Gene

GENATLAS Biochemistry:
zinc finger protein 80,driven by solitary LTR of ERV9 family
UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF80 Gene

Gene Ontology (GO) - Molecular Function for ZNF80 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF80: view
genes like me logo Genes that share phenotypes with ZNF80: view

miRNA for ZNF80 Gene

miRTarBase miRNAs that target ZNF80

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF80 Gene

Localization for ZNF80 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF80 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF80 gene
Compartment Confidence
nucleus 5
cytosol 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for ZNF80 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF80: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZNF80 Gene

Pathways & Interactions for ZNF80 Gene

SuperPathways for ZNF80 Gene

No Data Available

Interacting Proteins for ZNF80 Gene

Gene Ontology (GO) - Biological Process for ZNF80 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF80: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF80 Gene

Drugs & Compounds for ZNF80 Gene

No Compound Related Data Available

Transcripts for ZNF80 Gene

mRNA/cDNA for ZNF80 Gene

(6) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(11) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF80 Gene

Zinc finger protein 80:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF80 Gene

No ASD Table

Relevant External Links for ZNF80 Gene

GeneLoc Exon Structure for
ZNF80
ECgene alternative splicing isoforms for
ZNF80

Expression for ZNF80 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF80 Gene

mRNA differential expression in normal tissues according to GTEx for ZNF80 Gene

This gene is overexpressed in Whole Blood (x8.3), Spleen (x7.9), and Small Intestine - Terminal Ileum (x7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF80 Gene



NURSA nuclear receptor signaling pathways regulating expression of ZNF80 Gene:

ZNF80

SOURCE GeneReport for Unigene cluster for ZNF80 Gene:

Hs.271079
genes like me logo Genes that share expression patterns with ZNF80: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF80 Gene

Orthologs for ZNF80 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF80 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF80 33 34
  • 98.29 (n)
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 25 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii si:dkey-7j22.3 34
  • 31 (a)
ManyToMany
CU138542.3 34
  • 25 (a)
ManyToMany
Species where no ortholog for ZNF80 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF80 Gene

ENSEMBL:
Gene Tree for ZNF80 (if available)
TreeFam:
Gene Tree for ZNF80 (if available)

Paralogs for ZNF80 Gene

Paralogs for ZNF80 Gene

(538) SIMAP similar genes for ZNF80 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ZNF80: view

Variants for ZNF80 Gene

Sequence variations from dbSNP and Humsavar for ZNF80 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000019547 -- 114,212,030(-) G/A 3_prime_UTR_variant, genic_downstream_transcript_variant, intron_variant
rs1000184751 -- 114,231,707(-) T/G genic_downstream_transcript_variant, intron_variant
rs1000267551 -- 114,237,721(-) T/C/G upstream_transcript_variant
rs1000406333 -- 114,216,426(-) T/G genic_downstream_transcript_variant, intron_variant
rs1000460093 -- 114,216,762(-) G/C genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF80 Gene

Variant ID Type Subtype PubMed ID
esv3439997 CNV duplication 20981092
nsv1009866 CNV loss 25217958
nsv519379 CNV loss 19592680

Variation tolerance for ZNF80 Gene

Residual Variation Intolerance Score: 86.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.04; 50.37% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF80 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF80

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF80 Gene

Disorders for ZNF80 Gene

Additional Disease Information for ZNF80

No disorders were found for ZNF80 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF80 Gene

Publications for ZNF80 Gene

  1. Chromosomal localization of four human zinc finger cDNAs. (PMID: 8478004) Huebner K … Pelicci PG (Human genetics 1993) 2 3 4 58
  2. Characterization and genomic mapping of the ZNF80 locus: expression of this zinc-finger gene is driven by a solitary LTR of ERV9 endogenous retroviral family. (PMID: 7659503) Di Cristofano A … La Mantia G (Nucleic acids research 1995) 3 4 58
  3. A cohesin-RAD21 interactome. (PMID: 22145905) Panigrahi AK … Pati D (The Biochemical journal 2012) 3 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for ZNF80 Gene

Sources for ZNF80 Gene

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