Aliases for ZNF80 Gene

Aliases for ZNF80 Gene

  • Zinc Finger Protein 80 2 3 4 5
  • PT17 2 3
  • Zinc Finger Protein 80 (PT17) 2
  • ZNFPT17 3
  • ZNFpT17 4
  • ZNF80 5

External Ids for ZNF80 Gene

Previous GeneCards Identifiers for ZNF80 Gene

  • GC03M110734
  • GC03M113524
  • GC03M115234
  • GC03M115274
  • GC03M115263
  • GC03M115431
  • GC03M113953
  • GC03M111327

Summaries for ZNF80 Gene

GeneCards Summary for ZNF80 Gene

ZNF80 (Zinc Finger Protein 80) is a Protein Coding gene. Diseases associated with ZNF80 include Apperceptive Agnosia and Localized Chondrosarcoma. An important paralog of this gene is ZNF805.

UniProtKB/Swiss-Prot Summary for ZNF80 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF80 Gene

Genomics for ZNF80 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF80 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J114237 Promoter 0.8 EPDnew Ensembl 600.7 +0.1 71 0.2 PKNOX1 MEIS2 ZNF80 piR-36531-021 piR-33422-286 piR-58297-325 piR-58297-326 piR-47162-088 DRD3
GH03J114212 Promoter/Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 2.2 +22.2 22219 6.5 CTCF POLR2A BACH1 STAT3 PRDM1 ZIC2 IKZF2 TRIM22 YY1 PKNOX1 ENSG00000241490 HSALNG0028156 LOC107986115 TIGIT DRD3 ZNF80 lnc-ZNF80-1
GH03J114220 Promoter/Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 1.9 +13.3 13295 6.7 JUND NR2C2 GABPA FOSL1 CEBPG ZNF584 ATF4 ATF3 JUN TRIM28 DRD3 TIGIT ZNF80 ENSG00000241490 LOC107986115 lnc-ZNF80-1
GH03J114230 Enhancer 0.8 Ensembl ENCODE dbSUPER 0.7 +4.5 4478 7 ZNF316 MAFF MAFK MAFG EMSY FAM214BP1 lnc-ZNF80-1 ZNF80 ENSG00000241490 LOC107986115 DRD3
GH03J114274 Enhancer 0.5 Ensembl 0.3 -37.6 -37622 0.4 ZFX NFE2 ZNF316 MAFF MAFK MAFG NFE2L2 BACH1 EMSY TIGIT piR-50852-098 ZNF80
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF80 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF80

Top Transcription factor binding sites by QIAGEN in the ZNF80 gene promoter:
  • C/EBPalpha
  • GCNF
  • GCNF-1
  • GCNF-2
  • HSF2
  • NF-1
  • NF-kappaB
  • NF-kappaB1
  • RFX1
  • Zic3

Genomic Locations for ZNF80 Gene

Genomic Locations for ZNF80 Gene
chr3:114,234,631-114,237,578
(GRCh38/hg38)
Size:
2,948 bases
Orientation:
Minus strand
chr3:113,953,478-113,956,425
(GRCh37/hg19)
Size:
2,948 bases
Orientation:
Minus strand

Genomic View for ZNF80 Gene

Genes around ZNF80 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF80 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF80 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF80 Gene

Proteins for ZNF80 Gene

  • Protein details for ZNF80 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P51504-ZNF80_HUMAN
    Recommended name:
    Zinc finger protein 80
    Protein Accession:
    P51504
    Secondary Accessions:
    • Q6NSW4
    • Q6NT14

    Protein attributes for ZNF80 Gene

    Size:
    273 amino acids
    Molecular mass:
    31224 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF80 Gene

Post-translational modifications for ZNF80 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF80 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF80 Gene

Domains & Families for ZNF80 Gene

Gene Families for ZNF80 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF80 Gene

InterPro:
Blocks:
  • C2H2-type zinc finger signature
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF80 Gene

GenScript: Design optimal peptide antigens:
  • ZNFpT17 (ZNF80_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P51504

UniProtKB/Swiss-Prot:

ZNF80_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF80: view

Function for ZNF80 Gene

Molecular function for ZNF80 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
GENATLAS Biochemistry:
zinc finger protein 80,driven by solitary LTR of ERV9 family

Phenotypes From GWAS Catalog for ZNF80 Gene

Gene Ontology (GO) - Molecular Function for ZNF80 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity IBA 21873635
GO:0043565 sequence-specific DNA binding IBA 21873635
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF80: view
genes like me logo Genes that share phenotypes with ZNF80: view

Animal Model Products

CRISPR Products

miRNA for ZNF80 Gene

miRTarBase miRNAs that target ZNF80

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF80

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF80 Gene

Localization for ZNF80 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF80 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF80 gene
Compartment Confidence
nucleus 4
endoplasmic reticulum 2
cytosol 2
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for ZNF80 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
genes like me logo Genes that share ontologies with ZNF80: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZNF80 Gene

Pathways & Interactions for ZNF80 Gene

PathCards logo

SuperPathways for ZNF80 Gene

No Data Available

Interacting Proteins for ZNF80 Gene

Gene Ontology (GO) - Biological Process for ZNF80 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF80: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF80 Gene

Drugs & Compounds for ZNF80 Gene

No Compound Related Data Available

Transcripts for ZNF80 Gene

mRNA/cDNA for ZNF80 Gene

1 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF80

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF80 Gene

No ASD Table

Relevant External Links for ZNF80 Gene

GeneLoc Exon Structure for
ZNF80

Expression for ZNF80 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF80 Gene

mRNA differential expression in normal tissues according to GTEx for ZNF80 Gene

This gene is overexpressed in Whole Blood (x8.3), Spleen (x7.9), and Small Intestine - Terminal Ileum (x7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF80 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF80

SOURCE GeneReport for Unigene cluster for ZNF80 Gene:

Hs.271079

Evidence on tissue expression from TISSUES for ZNF80 Gene

  • Muscle(2.2)
  • Heart(2)
genes like me logo Genes that share expression patterns with ZNF80: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF80 Gene

Orthologs for ZNF80 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF80 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZNF80 30 31
  • 98.29 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 25 (a)
OneToMany
Zebrafish
(Danio rerio)
Actinopterygii si:dkey-7j22.3 31
  • 31 (a)
ManyToMany
CU138542.3 31
  • 25 (a)
ManyToMany
Species where no ortholog for ZNF80 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for ZNF80 Gene

ENSEMBL:
Gene Tree for ZNF80 (if available)
TreeFam:
Gene Tree for ZNF80 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF80: view image

Paralogs for ZNF80 Gene

(538) SIMAP similar genes for ZNF80 Gene using alignment to 1 proteins:

  • ZNF80_HUMAN
genes like me logo Genes that share paralogs with ZNF80: view

Variants for ZNF80 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF80 Gene

SNP ID Clinical significance and condition Chr 03 pos Variation AA Info Type
716849 Benign: not provided 114,236,301(-) A/G SYNONYMOUS_VARIANT
716850 Benign: not provided 114,236,519(-) C/T MISSENSE_VARIANT
773867 Likely Benign: not provided 114,236,313(-) A/G SYNONYMOUS_VARIANT
775898 Benign: not provided 114,236,765(-) G/A MISSENSE_VARIANT
778091 Benign: not provided 114,236,380(-) AG/A FRAMESHIFT_VARIANT

Additional dbSNP identifiers (rs#s) for ZNF80 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF80 Gene

Variant ID Type Subtype PubMed ID
esv3439997 CNV duplication 20981092
nsv1009866 CNV loss 25217958
nsv519379 CNV loss 19592680

Variation tolerance for ZNF80 Gene

Residual Variation Intolerance Score: 86.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.04; 50.37% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF80 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF80

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF80 Gene

Disorders for ZNF80 Gene

MalaCards: The human disease database

(3) MalaCards diseases for ZNF80 Gene - From: DISEASES

Disorder Aliases PubMed IDs
apperceptive agnosia
localized chondrosarcoma
aspiration pneumonitis
  • aspiration pneumonia
- elite association - COSMIC cancer census association via MalaCards
Search ZNF80 in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with ZNF80: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF80 Gene

Publications for ZNF80 Gene

  1. Chromosomal localization of four human zinc finger cDNAs. (PMID: 8478004) Huebner K … Pelicci PG (Human genetics 1993) 2 3 4
  2. Characterization and genomic mapping of the ZNF80 locus: expression of this zinc-finger gene is driven by a solitary LTR of ERV9 endogenous retroviral family. (PMID: 7659503) Di Cristofano A … La Mantia G (Nucleic acids research 1995) 3 4
  3. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  4. A cohesin-RAD21 interactome. (PMID: 22145905) Panigrahi AK … Pati D (The Biochemical journal 2012) 3
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for ZNF80 Gene

Sources for ZNF80 Gene