Aliases for ZNF789 Gene

Aliases for ZNF789 Gene

  • Zinc Finger Protein 789 2 3 4 5

External Ids for ZNF789 Gene

Previous GeneCards Identifiers for ZNF789 Gene

  • GC07P098908
  • GC07P099072
  • GC07P093707
  • GC07P099074
  • GC07P099078

Summaries for ZNF789 Gene

GeneCards Summary for ZNF789 Gene

ZNF789 (Zinc Finger Protein 789) is a Protein Coding gene. Diseases associated with ZNF789 include Adult Pineoblastoma and Adult Pineal Parenchymal Tumor. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA-binding transcription factor activity. An important paralog of this gene is ZNF7.

UniProtKB/Swiss-Prot Summary for ZNF789 Gene

Additional gene information for ZNF789 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF789 Gene

Genomics for ZNF789 Gene

GeneHancer (GH) Regulatory Elements for ZNF789 Gene

Promoters and enhancers for ZNF789 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF789 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF789

Top Transcription factor binding sites by QIAGEN in the ZNF789 gene promoter:
  • C/EBPalpha
  • CP2
  • FAC1
  • FOXO1
  • FOXO1a
  • GATA-1
  • HNF-3beta
  • N-Myc
  • Pax-6
  • RORalpha1

Genomic Locations for ZNF789 Gene

Genomic Locations for ZNF789 Gene
chr7:99,472,829-99,503,650
(GRCh38/hg38)
Size:
30,822 bases
Orientation:
Plus strand
chr7:99,070,464-99,101,273
(GRCh37/hg19)
Size:
30,810 bases
Orientation:
Plus strand

Genomic View for ZNF789 Gene

Genes around ZNF789 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF789 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF789 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF789 Gene

Proteins for ZNF789 Gene

  • Protein details for ZNF789 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5FWF6-ZN789_HUMAN
    Recommended name:
    Zinc finger protein 789
    Protein Accession:
    Q5FWF6
    Secondary Accessions:
    • A4D282
    • A6NH61
    • Q6ZMZ9

    Protein attributes for ZNF789 Gene

    Size:
    425 amino acids
    Molecular mass:
    49984 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=EAL23876.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF789 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF789 Gene

Post-translational modifications for ZNF789 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF789 Gene

Domains & Families for ZNF789 Gene

Gene Families for ZNF789 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF789 Gene

Blocks:
  • KRAB box
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF789 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 789 (ZN789_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q5FWF6

UniProtKB/Swiss-Prot:

ZN789_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF789: view

Function for ZNF789 Gene

Molecular function for ZNF789 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF789 Gene

Gene Ontology (GO) - Molecular Function for ZNF789 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF789: view
genes like me logo Genes that share phenotypes with ZNF789: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZNF789 Gene

Localization for ZNF789 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF789 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF789 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF789 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with ZNF789: view

Pathways & Interactions for ZNF789 Gene

PathCards logo

SuperPathways for ZNF789 Gene

No Data Available

Interacting Proteins for ZNF789 Gene

;

Gene Ontology (GO) - Biological Process for ZNF789 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF789: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF789 Gene

Drugs & Compounds for ZNF789 Gene

No Compound Related Data Available

Transcripts for ZNF789 Gene

mRNA/cDNA for ZNF789 Gene

7 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
12 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF789 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6a · 6b
SP1: - - - -
SP2: -
SP3: - - - - -
SP4:
SP5:

Relevant External Links for ZNF789 Gene

GeneLoc Exon Structure for
ZNF789

Expression for ZNF789 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF789 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF789

SOURCE GeneReport for Unigene cluster for ZNF789 Gene:

Hs.440384

Evidence on tissue expression from TISSUES for ZNF789 Gene

  • Spleen(4.2)
genes like me logo Genes that share expression patterns with ZNF789: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF789 Gene

Orthologs for ZNF789 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF789 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF789 31 30
  • 99.53 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF789 31 30
  • 81.75 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF789 31 30
  • 80 (n)
OneToOne
Species where no ortholog for ZNF789 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF789 Gene

ENSEMBL:
Gene Tree for ZNF789 (if available)
TreeFam:
Gene Tree for ZNF789 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF789: view image

Paralogs for ZNF789 Gene

Paralogs for ZNF789 Gene

(429) SIMAP similar genes for ZNF789 Gene using alignment to 5 proteins:

  • ZN789_HUMAN
  • C9J3R7_HUMAN
  • C9J487_HUMAN
  • C9JUE3_HUMAN
  • F8WEN0_HUMAN
genes like me logo Genes that share paralogs with ZNF789: view

Variants for ZNF789 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF789 Gene

SNP ID Clinical significance and condition Chr 07 pos Variation AA Info Type
rs6962772 - p.Thr77Ala

Additional dbSNP identifiers (rs#s) for ZNF789 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF789 Gene

Variant ID Type Subtype PubMed ID
esv3576408 CNV gain 25503493
esv3614278 CNV loss 21293372
nsv831069 CNV loss 17160897

Variation tolerance for ZNF789 Gene

Residual Variation Intolerance Score: 55.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.38; 90.85% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF789 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF789

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF789 Gene

Disorders for ZNF789 Gene

MalaCards: The human disease database

(3) MalaCards diseases for ZNF789 Gene - From: DISEASES

Disorder Aliases PubMed IDs
adult pineoblastoma
adult pineal parenchymal tumor
  • adult pineal parenchymal neoplasm
pineal parenchymal tumor of intermediate differentiation
  • pineal parenchymal tumour of intermediate differentiation
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ZNF789

genes like me logo Genes that share disorders with ZNF789: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF789 Gene

Publications for ZNF789 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  2. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer SW … Tsui LC (Science (New York, N.Y.) 2003) 3 4 54
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 54
  4. Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. (PMID: 16712791) Wang AG … Kim NS (Biochemical and biophysical research communications 2006) 3 54
  5. Transcriptome analysis of human gastric cancer. (PMID: 16341674) Oh JH … Kim NS (Mammalian genome : official journal of the International Mammalian Genome Society 2005) 3 54

Products for ZNF789 Gene