Aliases for ZNF786 Gene

Aliases for ZNF786 Gene

  • Zinc Finger Protein 786 2 3 4 5
  • DKFZp762I137 2
  • ZNF786 5

External Ids for ZNF786 Gene

Previous GeneCards Identifiers for ZNF786 Gene

  • GC07M148397
  • GC07M148088
  • GC07M148766
  • GC07M142845

Summaries for ZNF786 Gene

GeneCards Summary for ZNF786 Gene

ZNF786 (Zinc Finger Protein 786) is a Protein Coding gene. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF445.

UniProtKB/Swiss-Prot Summary for ZNF786 Gene

Additional gene information for ZNF786 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF786 Gene

Genomics for ZNF786 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF786 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF786 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF786

Top Transcription factor binding sites by QIAGEN in the ZNF786 gene promoter:
  • C/EBPalpha
  • Nkx2-5
  • oct-B3
  • POU2F1
  • POU2F1a
  • POU2F2
  • POU2F2 (Oct-2.1)
  • POU2F2B
  • POU2F2C
  • SRY

Genomic Locations for ZNF786 Gene

Genomic Locations for ZNF786 Gene
chr7:149,069,641-149,090,782
(GRCh38/hg38)
Size:
21,142 bases
Orientation:
Minus strand
chr7:148,766,733-148,787,874
(GRCh37/hg19)
Size:
21,142 bases
Orientation:
Minus strand

Genomic View for ZNF786 Gene

Genes around ZNF786 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF786 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF786 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF786 Gene

Proteins for ZNF786 Gene

  • Protein details for ZNF786 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N393-ZN786_HUMAN
    Recommended name:
    Zinc finger protein 786
    Protein Accession:
    Q8N393
    Secondary Accessions:
    • A1A568
    • B4DMI1

    Protein attributes for ZNF786 Gene

    Size:
    782 amino acids
    Molecular mass:
    89815 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF786 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF786 Gene

Post-translational modifications for ZNF786 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF786 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF786 Gene

Domains & Families for ZNF786 Gene

Gene Families for ZNF786 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF786 Gene

InterPro:
Blocks:
  • KRAB box
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF786 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ61318, weakly similar to Zinc finger protein Kr18 (B4DMI1_HUMAN)
  • ZNF786 protein (Q2VP97_HUMAN)
  • Zinc finger protein 786 (ZN786_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8N393

UniProtKB/Swiss-Prot:

ZN786_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF786: view

Function for ZNF786 Gene

Molecular function for ZNF786 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF786 Gene

Gene Ontology (GO) - Molecular Function for ZNF786 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IBA --
GO:0003700 DNA-binding transcription factor activity IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF786: view
genes like me logo Genes that share phenotypes with ZNF786: view

Animal Model Products

CRISPR Products

miRNA for ZNF786 Gene

miRTarBase miRNAs that target ZNF786

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF786

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF786 Gene

Localization for ZNF786 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF786 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF786 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF786 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
genes like me logo Genes that share ontologies with ZNF786: view

Pathways & Interactions for ZNF786 Gene

genes like me logo Genes that share pathways with ZNF786: view

Pathways by source for ZNF786 Gene

2 Reactome pathways for ZNF786 Gene
1 KEGG pathway for ZNF786 Gene

Gene Ontology (GO) - Biological Process for ZNF786 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF786: view

No data available for SIGNOR curated interactions for ZNF786 Gene

Drugs & Compounds for ZNF786 Gene

No Compound Related Data Available

Transcripts for ZNF786 Gene

mRNA/cDNA for ZNF786 Gene

1 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF786

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF786 Gene

No ASD Table

Relevant External Links for ZNF786 Gene

GeneLoc Exon Structure for
ZNF786

Expression for ZNF786 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF786 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF786 Gene



Protein tissue co-expression partners for ZNF786 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF786

SOURCE GeneReport for Unigene cluster for ZNF786 Gene:

Hs.729572

Evidence on tissue expression from TISSUES for ZNF786 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with ZNF786: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF786 Gene

Orthologs for ZNF786 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF786 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZNF786 30 31
  • 98.98 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ZNF425 30
  • 79.68 (n)
ZNF786 31
  • 70 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Zfp786 30
  • 74.47 (n)
Mouse
(Mus musculus)
Mammalia Zfp786 30 17 31
  • 74.42 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ZNF786 31
  • 61 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 40 (a)
ManyToMany
Species where no ortholog for ZNF786 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ZNF786 Gene

ENSEMBL:
Gene Tree for ZNF786 (if available)
TreeFam:
Gene Tree for ZNF786 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF786: view image

Paralogs for ZNF786 Gene

Paralogs for ZNF786 Gene

(481) SIMAP similar genes for ZNF786 Gene using alignment to 4 proteins:

  • ZN786_HUMAN
  • B4DMI1_HUMAN
  • H7BXP3_HUMAN
  • Q2VP97_HUMAN
genes like me logo Genes that share paralogs with ZNF786: view

Variants for ZNF786 Gene

Additional dbSNP identifiers (rs#s) for ZNF786 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF786 Gene

Variant ID Type Subtype PubMed ID
esv2666491 CNV deletion 23128226
esv2668984 CNV deletion 23128226
nsv1018754 CNV gain 25217958
nsv1140856 CNV deletion 24896259

Variation tolerance for ZNF786 Gene

Residual Variation Intolerance Score: 5.72% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.57; 30.36% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF786 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF786

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF786 Gene

Disorders for ZNF786 Gene

Additional Disease Information for ZNF786

No disorders were found for ZNF786 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF786 Gene

Publications for ZNF786 Gene

  1. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  2. An interactome perturbation framework prioritizes damaging missense mutations for developmental disorders. (PMID: 29892012) Chen S … Yu H (Nature genetics 2018) 3
  3. VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. (PMID: 29507755) Yue Y … Liu J (Cell discovery 2018) 3
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3

Products for ZNF786 Gene

Sources for ZNF786 Gene