Aliases for ZNF785 Gene

Aliases for ZNF785 Gene

  • Zinc Finger Protein 785 2 3 4 5
  • Zinc Finger Protein 688 3
  • ZNF688 3

External Ids for ZNF785 Gene

Previous GeneCards Identifiers for ZNF785 Gene

  • GC16M030498
  • GC16M030008
  • GC16M030590
  • GC16M028154

Summaries for ZNF785 Gene

GeneCards Summary for ZNF785 Gene

ZNF785 (Zinc Finger Protein 785) is a Protein Coding gene. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF689.

UniProtKB/Swiss-Prot Summary for ZNF785 Gene

Additional gene information for ZNF785 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF785 Gene

Genomics for ZNF785 Gene

GeneHancer (GH) Regulatory Elements for ZNF785 Gene

Promoters and enhancers for ZNF785 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF785 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF785 gene promoter:
  • ATF6
  • CREB
  • deltaCREB
  • NF-kappaB
  • NF-kappaB1
  • STAT1
  • STAT1alpha
  • STAT1beta
  • STAT3
  • ZIC2

Genomic Locations for ZNF785 Gene

Genomic Locations for ZNF785 Gene
chr16:30,573,219-30,586,421
(GRCh38/hg38)
Size:
13,203 bases
Orientation:
Minus strand
chr16:30,585,061-30,597,092
(GRCh37/hg19)
Size:
12,032 bases
Orientation:
Minus strand

Genomic View for ZNF785 Gene

Genes around ZNF785 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF785 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF785 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF785 Gene

Proteins for ZNF785 Gene

  • Protein details for ZNF785 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A8K8V0-ZN785_HUMAN
    Recommended name:
    Zinc finger protein 785
    Protein Accession:
    A8K8V0
    Secondary Accessions:
    • O75701
    • Q8IW91
    • Q8WV14
    • Q96MN0

    Protein attributes for ZNF785 Gene

    Size:
    405 amino acids
    Molecular mass:
    46168 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF785 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF785 Gene

Post-translational modifications for ZNF785 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF785 Gene

Domains & Families for ZNF785 Gene

Gene Families for ZNF785 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF785 Gene

Suggested Antigen Peptide Sequences for ZNF785 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ51514, highly similar to Zinc finger protein 688 (B4DQL1_HUMAN)
  • Zinc finger protein 785 (ZN785_HUMAN)

Graphical View of Domain Structure for InterPro Entry

A8K8V0

UniProtKB/Swiss-Prot:

ZN785_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF785: view

Function for ZNF785 Gene

Molecular function for ZNF785 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF785 Gene

Gene Ontology (GO) - Molecular Function for ZNF785 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISA --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF785: view
genes like me logo Genes that share phenotypes with ZNF785: view

Animal Model Products

CRISPR Products

miRNA for ZNF785 Gene

miRTarBase miRNAs that target ZNF785

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF785 Gene

Localization for ZNF785 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF785 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF785 gene
Compartment Confidence
nucleus 4
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF785 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF785: view

Pathways & Interactions for ZNF785 Gene

genes like me logo Genes that share pathways with ZNF785: view

Pathways by source for ZNF785 Gene

2 Reactome pathways for ZNF785 Gene
1 KEGG pathway for ZNF785 Gene

Gene Ontology (GO) - Biological Process for ZNF785 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with ZNF785: view

No data available for SIGNOR curated interactions for ZNF785 Gene

Drugs & Compounds for ZNF785 Gene

No Compound Related Data Available

Transcripts for ZNF785 Gene

mRNA/cDNA for ZNF785 Gene

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF785 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c
SP1: - - -
SP2: - - - - -
SP3: -
SP4: - -
SP5: - -

Relevant External Links for ZNF785 Gene

GeneLoc Exon Structure for
ZNF785
ECgene alternative splicing isoforms for
ZNF785

Expression for ZNF785 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF785 Gene

Protein differential expression in normal tissues from HIPED for ZNF785 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF785 Gene



Protein tissue co-expression partners for ZNF785 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF785 Gene:

ZNF785

SOURCE GeneReport for Unigene cluster for ZNF785 Gene:

Hs.513509

Evidence on tissue expression from TISSUES for ZNF785 Gene

  • Nervous system(4.1)
  • Blood(4)
genes like me logo Genes that share expression patterns with ZNF785: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF785 Gene

Orthologs for ZNF785 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF785 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF785 33 32
  • 99.67 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF785 33 32
  • 82.29 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 33
  • 35 (a)
OneToMany
Species where no ortholog for ZNF785 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF785 Gene

ENSEMBL:
Gene Tree for ZNF785 (if available)
TreeFam:
Gene Tree for ZNF785 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF785: view image

Paralogs for ZNF785 Gene

(278) SIMAP similar genes for ZNF785 Gene using alignment to 3 proteins:

  • ZN785_HUMAN
  • H3BR67_HUMAN
  • I3L119_HUMAN
genes like me logo Genes that share paralogs with ZNF785: view

Variants for ZNF785 Gene

Sequence variations from dbSNP and Humsavar for ZNF785 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000122027 -- 30,575,603(-) G/A genic_downstream_transcript_variant, intron_variant
rs1000431698 -- 30,575,303(-) A/G genic_downstream_transcript_variant, intron_variant
rs1000474494 -- 30,586,463(-) C/T upstream_transcript_variant
rs1000775156 -- 30,587,520(-) C/T upstream_transcript_variant
rs1000780617 -- 30,581,816(-) G/A 3_prime_UTR_variant, downstream_transcript_variant, genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF785 Gene

Variant ID Type Subtype PubMed ID
nsv471847 CNV novel sequence insertion 20440878

Variation tolerance for ZNF785 Gene

Residual Variation Intolerance Score: 75.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.15; 39.03% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF785 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF785

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF785 Gene

Disorders for ZNF785 Gene

Additional Disease Information for ZNF785

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ZNF785 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF785 Gene

Publications for ZNF785 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 56
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 56
  3. Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. (PMID: 10493829) Loftus BJ … Adams MD (Genomics 1999) 2 3 56
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 56
  5. Heterozygous HTRA1 mutations are associated with autosomal dominant cerebral small vessel disease. (PMID: 26063658) Verdura E … Tournier-Lasserve E (Brain : a journal of neurology 2015) 4 56

Products for ZNF785 Gene

Sources for ZNF785 Gene