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Aliases for ZNF780A Gene

Aliases for ZNF780A Gene

  • Zinc Finger Protein 780A 2 3 5
  • ZNF780 3

External Ids for ZNF780A Gene

Previous GeneCards Identifiers for ZNF780A Gene

  • GC19M045268
  • GC19M040575
  • GC19M037011

Summaries for ZNF780A Gene

GeneCards Summary for ZNF780A Gene

ZNF780A (Zinc Finger Protein 780A) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA binding transcription factor activity. An important paralog of this gene is ZNF30.

UniProtKB/Swiss-Prot for ZNF780A Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF780A Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF780A Gene

Genomics for ZNF780A Gene

GeneHancer (GH) Regulatory Elements for ZNF780A Gene

Promoters and enhancers for ZNF780A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I040089 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 596.7 +1.2 1208 2.4 MLX ZFP64 FEZF1 DMAP1 YY1 ZNF213 E2F8 ZNF416 ZNF143 ZNF548 ZNF780A ENSG00000269296 ENSG00000269749 ENSG00000269843 SNRPA FBL PLEKHG2 ITPKC SUPT5H CYP2G1P
GH19I039397 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 91.9 +684.7 684661 20 CLOCK MLX ZFP64 FEZF1 DMAP1 YBX1 IRF4 YY1 SLC30A9 ZNF213 ZFP36 PLEKHG2 HNRNPL ZNF780B FBL ZNF780A SUPT5H AKT2 RN7SL566P RPS16
GH19I040747 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 67.2 -661.0 -661025 9.8 CLOCK MLX ZFP64 FEZF1 DMAP1 YBX1 YY1 ZNF213 E2F8 ZNF416 SNRPA C19orf54 HNRNPUL1 ENSG00000269843 CCDC97 COQ8B ZNF780A FBL AKT2 ZNF780B
GH19I040596 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 45.9 -510.0 -509960 10 CLOCK MLX FEZF1 DMAP1 YY1 ZNF213 E2F8 ZNF416 ZNF143 ZNF548 LTBP4 HNRNPUL1 ZNF780B SNRPA ENSG00000269843 CCDC97 AKT2 FBL ZNF780A CYP2G1P
GH19I040347 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 55.7 -256.8 -256848 2.2 CLOCK MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 PLD3 C19orf47 ZNF780B SNRPA HNRNPUL1 CYP2G1P ENSG00000269843 ZNF780A SUPT5H CCDC97
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF780A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF780A gene promoter:

Genomic Locations for ZNF780A Gene

Genomic Locations for ZNF780A Gene
chr19:40,069,152-40,091,736
(GRCh38/hg38)
Size:
22,585 bases
Orientation:
Minus strand
chr19:40,575,059-40,596,845
(GRCh37/hg19)

Genomic View for ZNF780A Gene

Genes around ZNF780A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF780A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF780A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF780A Gene

Proteins for ZNF780A Gene

  • Protein details for ZNF780A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75290-Z780A_HUMAN
    Recommended name:
    Zinc finger protein 780A
    Protein Accession:
    O75290
    Secondary Accessions:
    • E9PB48
    • Q6ZN87

    Protein attributes for ZNF780A Gene

    Size:
    641 amino acids
    Molecular mass:
    74531 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAC34327.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF780A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF780A Gene

Post-translational modifications for ZNF780A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF780A Gene

Domains & Families for ZNF780A Gene

Gene Families for ZNF780A Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF780A Gene

Suggested Antigen Peptide Sequences for ZNF780A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O75290

UniProtKB/Swiss-Prot:

Z780A_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF780A: view

Function for ZNF780A Gene

Molecular function for ZNF780A Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF780A Gene

Gene Ontology (GO) - Molecular Function for ZNF780A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF780A: view

Phenotypes for ZNF780A Gene

GenomeRNAi human phenotypes for ZNF780A:
genes like me logo Genes that share phenotypes with ZNF780A: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF780A Gene

Localization for ZNF780A Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF780A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF780A gene
Compartment Confidence
nucleus 5
cytosol 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Centrosome (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF780A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF780A: view

Pathways & Interactions for ZNF780A Gene

SuperPathways for ZNF780A Gene

No Data Available

Interacting Proteins for ZNF780A Gene

Gene Ontology (GO) - Biological Process for ZNF780A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA --
genes like me logo Genes that share ontologies with ZNF780A: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF780A Gene

Drugs & Compounds for ZNF780A Gene

No Compound Related Data Available

Transcripts for ZNF780A Gene

Unigene Clusters for ZNF780A Gene

Zinc finger protein 780A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF780A Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b
SP1: -
SP2: -
SP3: -
SP4: - - -

Relevant External Links for ZNF780A Gene

GeneLoc Exon Structure for
ZNF780A
ECgene alternative splicing isoforms for
ZNF780A

Expression for ZNF780A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF780A Gene

Protein differential expression in normal tissues from HIPED for ZNF780A Gene

This gene is overexpressed in Lung (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF780A Gene



Protein tissue co-expression partners for ZNF780A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF780A Gene:

ZNF780A

SOURCE GeneReport for Unigene cluster for ZNF780A Gene:

Hs.115140
genes like me logo Genes that share expression patterns with ZNF780A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF780A Gene

Orthologs for ZNF780A Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF780A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF780A 34
  • 70 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp607 33 34
  • 69.43 (n)
C030039L03Rik 34
  • 55 (a)
OneToMany
Zfp59 34
  • 51 (a)
OneToMany
Zfp60 34
  • 49 (a)
OneToMany
Zfp850 34
  • 49 (a)
OneToMany
Zfp607b 16
cow
(Bos Taurus)
Mammalia ZNF383 34
  • 49 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 47 (a)
OneToMany
Species where no ortholog for ZNF780A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF780A Gene

ENSEMBL:
Gene Tree for ZNF780A (if available)
TreeFam:
Gene Tree for ZNF780A (if available)

Paralogs for ZNF780A Gene

(525) SIMAP similar genes for ZNF780A Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ZNF780A: view

Variants for ZNF780A Gene

Sequence variations from dbSNP and Humsavar for ZNF780A Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000292012 -- 40,091,716(-) A/G upstream_transcript_variant
rs1000360503 -- 40,085,610(-) G/A intron_variant
rs1000384518 -- 40,069,700(-) G/A 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1000549972 -- 40,088,752(-) G/A intron_variant
rs1000603683 -- 40,093,403(-) A/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF780A Gene

Variant ID Type Subtype PubMed ID
esv3644341 CNV loss 21293372
nsv2488 CNV deletion 18451855
nsv963048 CNV duplication 23825009

Variation tolerance for ZNF780A Gene

Residual Variation Intolerance Score: 67.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.23; 52.46% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF780A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF780A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF780A Gene

Disorders for ZNF780A Gene

Additional Disease Information for ZNF780A

No disorders were found for ZNF780A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF780A Gene

Publications for ZNF780A Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A … Hentze MW (Cell 2012) 3 58
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 58

Products for ZNF780A Gene

Sources for ZNF780A Gene