Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ZNF778 Gene

Aliases for ZNF778 Gene

  • Zinc Finger Protein 778 2 3 3 5

External Ids for ZNF778 Gene

Previous GeneCards Identifiers for ZNF778 Gene

  • GC16P087812
  • GC16P089284
  • GC16P074983

Summaries for ZNF778 Gene

Entrez Gene Summary for ZNF778 Gene

  • The protein encoded by this gene is a member of the krueppel C2H2-type zinc-finger protein family, and it contains one KRAB domain and eighteen C2H2-type zinc fingers. This gene is a candidate gene for autism and variable cognitive impairment in the 16q24.3 microdeletion syndrome. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2011]

GeneCards Summary for ZNF778 Gene

ZNF778 (Zinc Finger Protein 778) is a Protein Coding gene. Diseases associated with ZNF778 include 16Q24.3 Microdeletion Syndrome and Kbg Syndrome. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF560.

UniProtKB/Swiss-Prot for ZNF778 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF778 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF778 Gene

Genomics for ZNF778 Gene

GeneHancer (GH) Regulatory Elements for ZNF778 Gene

Promoters and enhancers for ZNF778 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J089216 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 650.4 +15.3 15277 2.6 PKNOX1 CLOCK MLX ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 IRF4 ENSG00000259877 PIR52460 ZNF778 AFG3L1P TCF25 CDK10 TRAPPC2L PIEZO1 CTU2 ZNF276
GH16J089201 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE dbSUPER 650.7 -0.1 -132 0.6 MXI1 USF1 RB1 SAP130 ARID4B SIN3A ZIC2 POLR2A VEZF1 ZSCAN29 SLC22A31 ZNF778 CDH15 LINC02138 CBFA2T3 ENSG00000259877
GH16J089200 Enhancer 1 ENCODE dbSUPER 650.7 -1.6 -1620 0.2 ELF3 ARID4B DMAP1 THRB RARA PRPF4 CREM THAP11 NFKBIZ KLF11 ZNF778 SLC22A31 CDH15 LINC02138 CBFA2T3
GH16J089480 Promoter/Enhancer 2.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 26.2 +284.7 284716 12 CLOCK MLX FEZF1 DMAP1 IRF4 YY1 SLC30A9 E2F8 ZNF143 ZNF548 ANKRD11 ZC3H18 AFG3L1P SPG7 ZNF778 TCF25 MC1R ENSG00000259877 RPL13 RNU6-430P
GH16J089993 Enhancer 1.5 Ensembl ENCODE dbSUPER 37.6 +793.2 793209 3.5 HDGF PKNOX1 CLOCK FOXA2 ARNT ZFP64 ARID4B SIN3A ZNF2 ZBTB7B PIR44838 AFG3L1P ENSG00000259877 ANKRD11 MC1R ACSF3 TCF25 LOC101927863 ENSG00000268218 SNORD68
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF778 on UCSC Golden Path with GeneCards custom track

Genomic Locations for ZNF778 Gene

Genomic Locations for ZNF778 Gene
35,034 bases
Plus strand
11,855 bases
Plus strand

Genomic View for ZNF778 Gene

Genes around ZNF778 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF778 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF778 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF778 Gene

Proteins for ZNF778 Gene

  • Protein details for ZNF778 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 778
    Protein Accession:
    Secondary Accessions:
    • Q08AG0

    Protein attributes for ZNF778 Gene

    729 amino acids
    Molecular mass:
    81964 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB71183.1; Type=Frameshift; Positions=393; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF778 Gene


neXtProt entry for ZNF778 Gene

Post-translational modifications for ZNF778 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF778 Gene

Domains & Families for ZNF778 Gene

Gene Families for ZNF778 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF778 Gene

Suggested Antigen Peptide Sequences for ZNF778 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF778: view

Function for ZNF778 Gene

Molecular function for ZNF778 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF778 Gene

Gene Ontology (GO) - Molecular Function for ZNF778 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding ISA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity IBA --
GO:0005515 protein binding IPI 25416956
GO:0043565 sequence-specific DNA binding IBA --
genes like me logo Genes that share ontologies with ZNF778: view
genes like me logo Genes that share phenotypes with ZNF778: view

Animal Model Products

miRNA for ZNF778 Gene

miRTarBase miRNAs that target ZNF778

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF778 Gene

Localization for ZNF778 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF778 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF778 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (3)
  • Nucleus (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF778 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF778: view

Pathways & Interactions for ZNF778 Gene

SuperPathways for ZNF778 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF778: view

Pathways by source for ZNF778 Gene

2 Reactome pathways for ZNF778 Gene

Gene Ontology (GO) - Biological Process for ZNF778 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with ZNF778: view

No data available for SIGNOR curated interactions for ZNF778 Gene

Drugs & Compounds for ZNF778 Gene

No Compound Related Data Available

Transcripts for ZNF778 Gene

mRNA/cDNA for ZNF778 Gene

(11) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(15) Selected AceView cDNA sequences:
(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF778 Gene

Zinc finger protein 778:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF778 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7
SP1: -
SP3: -

Relevant External Links for ZNF778 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF778 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF778 Gene

Protein differential expression in normal tissues from HIPED for ZNF778 Gene

This gene is overexpressed in Pancreas (48.7) and Platelet (18.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF778 Gene

Protein tissue co-expression partners for ZNF778 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF778 Gene:


SOURCE GeneReport for Unigene cluster for ZNF778 Gene:

genes like me logo Genes that share expression patterns with ZNF778: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF778 Gene

Orthologs for ZNF778 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF778 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF778 34 33
  • 98.54 (n)
(Mus musculus)
Mammalia Zfp26 16 33
  • 65.03 (n)
Zfp560 34
  • 40 (a)
(Rattus norvegicus)
Mammalia Zfp26 33
  • 64.79 (n)
(Bos Taurus)
Mammalia -- 34
  • 36 (a)
Species where no ortholog for ZNF778 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF778 Gene

Gene Tree for ZNF778 (if available)
Gene Tree for ZNF778 (if available)
Evolutionary constrained regions (ECRs) for ZNF778: view image

Paralogs for ZNF778 Gene

Paralogs for ZNF778 Gene

(545) SIMAP similar genes for ZNF778 Gene using alignment to 4 proteins:

  • ZN778_HUMAN
  • A0PJ55_HUMAN
genes like me logo Genes that share paralogs with ZNF778: view

Variants for ZNF778 Gene

Sequence variations from dbSNP and Humsavar for ZNF778 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs150830617 benign, not specified 89,224,749(+) A/C/G 5_prime_UTR_variant, coding_sequence_variant, intron_variant, missense_variant, non_coding_transcript_variant
rs1000037757 -- 89,211,977(+) G/A genic_upstream_transcript_variant, intron_variant
rs1000041781 -- 89,201,760(+) G/C upstream_transcript_variant
rs1000054584 -- 89,208,727(+) A/G genic_upstream_transcript_variant, intron_variant
rs1000162116 -- 89,223,595(+) A/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF778 Gene

Variant ID Type Subtype PubMed ID
dgv3066n100 CNV gain 25217958
esv1006131 CNV deletion 20482838
esv2665882 CNV deletion 23128226
esv2763149 CNV gain 21179565
esv3304105 CNV mobile element insertion 20981092
esv3441548 CNV insertion 20981092
esv3639571 CNV loss 21293372
esv3892939 CNV loss 25118596
nsv1063024 CNV gain 25217958
nsv428331 CNV gain+loss 18775914
nsv457622 CNV loss 19166990
nsv469681 CNV loss 16826518
nsv482951 CNV loss 15286789
nsv509638 CNV insertion 20534489
nsv573674 CNV gain 21841781
nsv573734 CNV loss 21841781
nsv827843 CNV gain 20364138
nsv827844 CNV gain 20364138

Variation tolerance for ZNF778 Gene

Residual Variation Intolerance Score: 97.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.37; 63.44% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF778 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF778 Gene

Disorders for ZNF778 Gene

MalaCards: The human disease database

(3) MalaCards diseases for ZNF778 Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
16q24.3 microdeletion syndrome
  • chromosome 16q24.3 microdeletion syndrome
kbg syndrome
  • kbgs
  • autistic disorder
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ZNF778

genes like me logo Genes that share disorders with ZNF778: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF778 Gene

Publications for ZNF778 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 58
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58
  5. Identification of ANKRD11 and ZNF778 as candidate genes for autism and variable cognitive impairment in the novel 16q24.3 microdeletion syndrome. (PMID: 19920853) Willemsen MH … Kleefstra T (European journal of human genetics : EJHG 2010) 3 58

Products for ZNF778 Gene

Sources for ZNF778 Gene

Loading form....