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Aliases for ZNF777 Gene

Aliases for ZNF777 Gene

  • Zinc Finger Protein 777 2 3 5
  • KIAA1285 4

External Ids for ZNF777 Gene

Previous GeneCards Identifiers for ZNF777 Gene

  • GC07M148759
  • GC07M149128
  • GC07M143204

Summaries for ZNF777 Gene

GeneCards Summary for ZNF777 Gene

ZNF777 (Zinc Finger Protein 777) is a Protein Coding gene. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF282.

UniProtKB/Swiss-Prot for ZNF777 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF777 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF777 Gene

Genomics for ZNF777 Gene

GeneHancer (GH) Regulatory Elements for ZNF777 Gene

Promoters and enhancers for ZNF777 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07I149459 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 +0.6 630 2.4 ATF1 ARID4B SIN3A DMAP1 ZNF48 YY1 POLR2B ZNF766 GLIS2 ZNF207 ZNF777 ZNF746 ENSG00000261842
GH07I149461 Enhancer 0.2 ENCODE 550.8 -0.9 -942 0.2 ZNF777 ZNF746
GH07I150364 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 32.3 -907.4 -907350 7 MLX ZFP64 DMAP1 YY1 ZNF213 E2F8 ZNF143 NFYC ZC3H11A MEF2D REPIN1 ENSG00000284041 ZNF767P ENSG00000244151 NUB1 ZNF777 ATP6V0E2-AS1 ZNF862 ENSG00000273419 ASIC3
GH07I148986 Promoter/Enhancer 1.6 Ensembl ENCODE 45.1 +474.0 473983 2.6 PKNOX1 SMAD1 ARNT ARID4B SIN3A ZNF2 ZNF766 ZNF213 E2F8 ZNF143 GC07M148988 RNY1 GHET1 LOC155060 ZNF783 ZNF777 ZNF767P ZNF398 PDIA4 ENSG00000271664
GH07I148940 Enhancer 1.3 Ensembl ENCODE 53.7 +519.7 519722 2.8 PKNOX1 SMAD1 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B GC07P148942 RNY5 ZNF783 ZNF398 ZNF777 ZNF767P LOC155060 ENSG00000271664 ZNF212 ZNF282
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF777 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF777 gene promoter:

Genomic Locations for ZNF777 Gene

Genomic Locations for ZNF777 Gene
29,761 bases
Minus strand

Genomic View for ZNF777 Gene

Genes around ZNF777 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF777 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF777 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF777 Gene

Proteins for ZNF777 Gene

  • Protein details for ZNF777 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 777
    Protein Accession:
    Secondary Accessions:
    • Q8N2R2
    • Q8N659

    Protein attributes for ZNF777 Gene

    760 amino acids
    Molecular mass:
    85176 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH23985.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA86599.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC11033.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF777 Gene


neXtProt entry for ZNF777 Gene

Post-translational modifications for ZNF777 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF777 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF777 Gene

Domains & Families for ZNF777 Gene

Gene Families for ZNF777 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF777 Gene

Suggested Antigen Peptide Sequences for ZNF777 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF777: view

Function for ZNF777 Gene

Molecular function for ZNF777 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF777 Gene

Gene Ontology (GO) - Molecular Function for ZNF777 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF777: view
genes like me logo Genes that share phenotypes with ZNF777: view

Animal Model Products

CRISPR Products

miRNA for ZNF777 Gene

miRTarBase miRNAs that target ZNF777

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF777 Gene

Localization for ZNF777 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF777 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF777 gene
Compartment Confidence
nucleus 5

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF777 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF777: view

Pathways & Interactions for ZNF777 Gene

SuperPathways for ZNF777 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF777: view

Pathways by source for ZNF777 Gene

2 Reactome pathways for ZNF777 Gene

Gene Ontology (GO) - Biological Process for ZNF777 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with ZNF777: view

No data available for SIGNOR curated interactions for ZNF777 Gene

Drugs & Compounds for ZNF777 Gene

No Compound Related Data Available

Transcripts for ZNF777 Gene

mRNA/cDNA for ZNF777 Gene

Unigene Clusters for ZNF777 Gene

Zinc finger protein 777:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF777 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b
SP1: -

Relevant External Links for ZNF777 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF777 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF777 Gene

Protein differential expression in normal tissues from HIPED for ZNF777 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF777 Gene

Protein tissue co-expression partners for ZNF777 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF777 Gene:


SOURCE GeneReport for Unigene cluster for ZNF777 Gene:


Evidence on tissue expression from TISSUES for ZNF777 Gene

  • Nervous system(4.3)
  • Lung(4.2)
  • Liver(4.1)
genes like me logo Genes that share expression patterns with ZNF777: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF777 Gene

Orthologs for ZNF777 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF777 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF777 33 34
  • 99.68 (n)
(Canis familiaris)
Mammalia ZNF777 33 34
  • 90.18 (n)
(Bos Taurus)
Mammalia ZNF777 33 34
  • 89.29 (n)
(Rattus norvegicus)
Mammalia Zfp777 33
  • 86.57 (n)
(Mus musculus)
Mammalia Zfp777 33 16 34
  • 86.53 (n)
(Monodelphis domestica)
Mammalia ZNF777 34
  • 78 (a)
(Ornithorhynchus anatinus)
Mammalia ZNF777 34
  • 54 (a)
(Gallus gallus)
Aves LOC101750773 33
  • 80.48 (n)
ZNF777 34
  • 56 (a)
(Anolis carolinensis)
Reptilia ZNF777 34
  • 60 (a)
Species where no ortholog for ZNF777 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF777 Gene

Gene Tree for ZNF777 (if available)
Gene Tree for ZNF777 (if available)

Paralogs for ZNF777 Gene

Paralogs for ZNF777 Gene Pseudogenes for ZNF777 Gene

genes like me logo Genes that share paralogs with ZNF777: view

Variants for ZNF777 Gene

Sequence variations from dbSNP and Humsavar for ZNF777 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000102341 -- 149,457,301(-) C/T intron_variant
rs1000121165 -- 149,433,490(-) G/C intron_variant
rs1000280897 -- 149,439,871(-) C/A intron_variant
rs1000355940 -- 149,435,858(-) G/A intron_variant
rs1000382418 -- 149,446,379(-) A/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF777 Gene

Variant ID Type Subtype PubMed ID
dgv11713n54 CNV loss 21841781
esv28225 CNV loss 19812545
nsv1076965 CNV deletion 25765185
nsv1126816 CNV deletion 24896259
nsv608976 CNV loss 21841781

Variation tolerance for ZNF777 Gene

Residual Variation Intolerance Score: 14.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.14; 61.42% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF777 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF777 Gene

Disorders for ZNF777 Gene

Additional Disease Information for ZNF777

No disorders were found for ZNF777 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF777 Gene

Publications for ZNF777 Gene

  1. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10574462) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1999) 3 4 58
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  3. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 58
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  5. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y … Zou H (Journal of proteomics 2014) 4 58

Products for ZNF777 Gene

Sources for ZNF777 Gene

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