Aliases for ZNF777 Gene

Aliases for ZNF777 Gene

  • Zinc Finger Protein 777 2 3 4 5
  • KIAA1285 4

External Ids for ZNF777 Gene

Previous GeneCards Identifiers for ZNF777 Gene

  • GC07M148759
  • GC07M149128
  • GC07M143204

Summaries for ZNF777 Gene

GeneCards Summary for ZNF777 Gene

ZNF777 (Zinc Finger Protein 777) is a Protein Coding gene. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF398.

UniProtKB/Swiss-Prot Summary for ZNF777 Gene

Additional gene information for ZNF777 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF777 Gene

Genomics for ZNF777 Gene

GeneHancer (GH) Regulatory Elements for ZNF777 Gene

Promoters and enhancers for ZNF777 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF777 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF777

Top Transcription factor binding sites by QIAGEN in the ZNF777 gene promoter:
  • ATF
  • GR
  • GR-alpha
  • GR-beta
  • HFH-1
  • USF-1
  • USF-1:USF-2
  • USF1
  • USF2
  • ZIC2

Genomic Locations for ZNF777 Gene

Genomic Locations for ZNF777 Gene
chr7:149,431,363-149,461,062
(GRCh38/hg38)
Size:
29,700 bases
Orientation:
Minus strand
chr7:149,128,454-149,158,214
(GRCh37/hg19)
Size:
29,761 bases
Orientation:
Minus strand

Genomic View for ZNF777 Gene

Genes around ZNF777 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF777 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF777 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF777 Gene

Proteins for ZNF777 Gene

  • Protein details for ZNF777 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9ULD5-ZN777_HUMAN
    Recommended name:
    Zinc finger protein 777
    Protein Accession:
    Q9ULD5
    Secondary Accessions:
    • Q8N2R2
    • Q8N659

    Protein attributes for ZNF777 Gene

    Size:
    831 amino acids
    Molecular mass:
    93762 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH23985.2; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=BAA86599.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=BAA86599.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Vector contamination at the C-terminus.; Evidence={ECO:0000305}; Sequence=BAC11033.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

neXtProt entry for ZNF777 Gene

Post-translational modifications for ZNF777 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF777 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF777 Gene

Domains & Families for ZNF777 Gene

Gene Families for ZNF777 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF777 Gene

Blocks:
  • KRAB box
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF777 Gene

GenScript: Design optimal peptide antigens:
  • ZNF777 protein (Q3KR11_HUMAN)
  • Zinc finger protein 777 (ZN777_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9ULD5

UniProtKB/Swiss-Prot:

ZN777_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF777: view

Function for ZNF777 Gene

Molecular function for ZNF777 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF777 Gene

Gene Ontology (GO) - Molecular Function for ZNF777 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF777: view
genes like me logo Genes that share phenotypes with ZNF777: view

Animal Model Products

CRISPR Products

miRNA for ZNF777 Gene

miRTarBase miRNAs that target ZNF777

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF777

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF777 Gene

Localization for ZNF777 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF777 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF777 gene
Compartment Confidence
nucleus 4

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF777 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF777: view

Pathways & Interactions for ZNF777 Gene

genes like me logo Genes that share pathways with ZNF777: view

Pathways by source for ZNF777 Gene

2 Reactome pathways for ZNF777 Gene
1 KEGG pathway for ZNF777 Gene

Gene Ontology (GO) - Biological Process for ZNF777 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with ZNF777: view

No data available for SIGNOR curated interactions for ZNF777 Gene

Drugs & Compounds for ZNF777 Gene

No Compound Related Data Available

Transcripts for ZNF777 Gene

mRNA/cDNA for ZNF777 Gene

1 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF777

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF777 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b
SP1: -
SP2:
SP3:

Relevant External Links for ZNF777 Gene

GeneLoc Exon Structure for
ZNF777

Expression for ZNF777 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF777 Gene

Protein differential expression in normal tissues from HIPED for ZNF777 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF777 Gene



Protein tissue co-expression partners for ZNF777 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF777

SOURCE GeneReport for Unigene cluster for ZNF777 Gene:

Hs.38512

Evidence on tissue expression from TISSUES for ZNF777 Gene

  • Nervous system(4.3)
  • Lung(4.2)
  • Liver(4.1)
genes like me logo Genes that share expression patterns with ZNF777: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF777 Gene

Orthologs for ZNF777 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF777 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF777 31 30
  • 99.68 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF777 31 30
  • 90.18 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF777 31 30
  • 89.29 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zfp777 30
  • 86.57 (n)
mouse
(Mus musculus)
Mammalia Zfp777 17 31 30
  • 86.53 (n)
oppossum
(Monodelphis domestica)
Mammalia ZNF777 31
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZNF777 31
  • 54 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC101750773 30
  • 80.48 (n)
ZNF777 31
  • 56 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZNF777 31
  • 60 (a)
OneToOne
Species where no ortholog for ZNF777 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF777 Gene

ENSEMBL:
Gene Tree for ZNF777 (if available)
TreeFam:
Gene Tree for ZNF777 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF777: view image

Paralogs for ZNF777 Gene

Pseudogenes.org Pseudogenes for ZNF777 Gene

genes like me logo Genes that share paralogs with ZNF777: view

Variants for ZNF777 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF777 Gene

SNP ID Clinical significance and condition Chr 07 pos Variation AA Info Type
691473 Uncertain Significance: Pyloric stenosis; Esophageal atresia 149,431,955(-) T/C MISSENSE_VARIANT
rs17852167 - p.Ala512Thr
rs3735318 - p.Arg70Trp
rs3735319 - p.Val115Ala

Additional dbSNP identifiers (rs#s) for ZNF777 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF777 Gene

Variant ID Type Subtype PubMed ID
dgv11713n54 CNV loss 21841781
esv28225 CNV loss 19812545
nsv1076965 CNV deletion 25765185
nsv1126816 CNV deletion 24896259
nsv608976 CNV loss 21841781

Variation tolerance for ZNF777 Gene

Residual Variation Intolerance Score: 14.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.14; 61.42% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF777 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF777

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF777 Gene

Disorders for ZNF777 Gene

Additional Disease Information for ZNF777

No disorders were found for ZNF777 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF777 Gene

Publications for ZNF777 Gene

  1. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10574462) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1999) 3 4 54
  2. VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. (PMID: 29507755) Yue Y … Liu J (Cell discovery 2018) 3 54
  3. Quantitative mapping of RNA-mediated nuclear estrogen receptor β interactome in human breast cancer cells. (PMID: 29509190) Giurato G … Tarallo R (Scientific data 2018) 3 54
  4. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 54
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 54

Products for ZNF777 Gene

Sources for ZNF777 Gene