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Aliases for ZNF776 Gene

Aliases for ZNF776 Gene

  • Zinc Finger Protein 776 2 3 5

External Ids for ZNF776 Gene

Previous GeneCards Identifiers for ZNF776 Gene

  • GC19P062950
  • GC19P058258
  • GC19P054570

Summaries for ZNF776 Gene

GeneCards Summary for ZNF776 Gene

ZNF776 (Zinc Finger Protein 776) is a Protein Coding gene. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF417.

UniProtKB/Swiss-Prot for ZNF776 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF776 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF776 Gene

Genomics for ZNF776 Gene

GeneHancer (GH) Regulatory Elements for ZNF776 Gene

Promoters and enhancers for ZNF776 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I057746 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 +0.3 291 1.8 PKNOX1 ATF1 SMAD1 ZNF133 SIN3A GLI4 ZNF2 YY1 ETS1 POLR2B ZNF776 TRIM28 ZNF264 ZNF805 ZNF543 ZNF814 ZNF548 ZSCAN1 ZNF134 ZNF586
GH19I058181 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 45.5 +436.4 436440 2.5 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ZNF274 ZNF134 ZNF606 ZNF17 ZNF417 ZNF549 ZNF550 ZNF773 LOC105372483 ZNF264
GH19I058553 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 28.7 +810.3 810317 7.2 CLOCK FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 CHMP2A UBE2M TRIM28 ZNF417 ZNF134 ZNF606 ZNF274 MZF1 LOC100128398 ERVK3-1
GH19I058325 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 31.2 +580.1 580075 3.6 CLOCK ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF416 ZSCAN22 LOC105372480 PIR44424 ZNF134 ZNF606 ZNF417 ZNF549 ZNF135 ZNF17 ZNF446
GH19I058379 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 19.2 +634.3 634289 2.9 ZFP64 FEZF1 DMAP1 IRF4 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC ZNF837 LOC100128398 ZNF606 ZNF329 ZNF135 TRIM28 ZNF132 ZNF446 ZSCAN18 ZNF548
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF776 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF776 gene promoter:

Genomic Locations for ZNF776 Gene

Genomic Locations for ZNF776 Gene
chr19:57,746,796-57,758,159
(GRCh38/hg38)
Size:
11,364 bases
Orientation:
Plus strand
chr19:58,258,164-58,269,527
(GRCh37/hg19)

Genomic View for ZNF776 Gene

Genes around ZNF776 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF776 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF776 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF776 Gene

Proteins for ZNF776 Gene

  • Protein details for ZNF776 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q68DI1-ZN776_HUMAN
    Recommended name:
    Zinc finger protein 776
    Protein Accession:
    Q68DI1
    Secondary Accessions:
    • Q6ZS36
    • Q8N968

    Protein attributes for ZNF776 Gene

    Size:
    518 amino acids
    Molecular mass:
    59613 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC04588.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305}; Sequence=BAC87119.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for ZNF776 Gene

Post-translational modifications for ZNF776 Gene

No Post-translational modifications

Other Protein References for ZNF776 Gene

No data available for DME Specific Peptides for ZNF776 Gene

Domains & Families for ZNF776 Gene

Gene Families for ZNF776 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Suggested Antigen Peptide Sequences for ZNF776 Gene

Graphical View of Domain Structure for InterPro Entry

Q68DI1

UniProtKB/Swiss-Prot:

ZN776_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF776: view

Function for ZNF776 Gene

Molecular function for ZNF776 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF776 Gene

Gene Ontology (GO) - Molecular Function for ZNF776 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF776: view
genes like me logo Genes that share phenotypes with ZNF776: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF776 Gene

Localization for ZNF776 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF776 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF776 gene
Compartment Confidence
nucleus 5
cytosol 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF776 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF776: view

Pathways & Interactions for ZNF776 Gene

SuperPathways for ZNF776 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF776: view

Pathways by source for ZNF776 Gene

2 Reactome pathways for ZNF776 Gene

Interacting Proteins for ZNF776 Gene

Gene Ontology (GO) - Biological Process for ZNF776 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF776: view

No data available for SIGNOR curated interactions for ZNF776 Gene

Drugs & Compounds for ZNF776 Gene

No Compound Related Data Available

Transcripts for ZNF776 Gene

Unigene Clusters for ZNF776 Gene

Zinc finger protein 776:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF776 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c
SP1: - -
SP2:
SP3:
SP4: - - -
SP5: -
SP6:

Relevant External Links for ZNF776 Gene

GeneLoc Exon Structure for
ZNF776
ECgene alternative splicing isoforms for
ZNF776

Expression for ZNF776 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF776 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF776 Gene:

ZNF776

SOURCE GeneReport for Unigene cluster for ZNF776 Gene:

Hs.720254

Evidence on tissue expression from TISSUES for ZNF776 Gene

  • Nervous system(4.5)
genes like me logo Genes that share expression patterns with ZNF776: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF776 Gene

Orthologs for ZNF776 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF776 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF776 33
  • 99.42 (n)
dog
(Canis familiaris)
Mammalia -- 34
  • 49 (a)
OneToMany
Species where no ortholog for ZNF776 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF776 Gene

ENSEMBL:
Gene Tree for ZNF776 (if available)
TreeFam:
Gene Tree for ZNF776 (if available)

Paralogs for ZNF776 Gene

(519) SIMAP similar genes for ZNF776 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ZNF776: view

Variants for ZNF776 Gene

Sequence variations from dbSNP and Humsavar for ZNF776 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs193921007 uncertain-significance, Malignant tumor of prostate 57,753,704(+) A/C/G coding_sequence_variant, missense_variant
rs1000244364 -- 57,754,892(+) C/T 3_prime_UTR_variant
rs1000576868 -- 57,756,114(+) G/A 3_prime_UTR_variant
rs1000638877 -- 57,745,393(+) G/A upstream_transcript_variant
rs1000806278 -- 57,751,809(+) G/A/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF776 Gene

Variant ID Type Subtype PubMed ID
nsv1066059 CNV gain 25217958

Variation tolerance for ZNF776 Gene

Residual Variation Intolerance Score: 20.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.49; 10.67% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF776 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF776

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF776 Gene

Disorders for ZNF776 Gene

Additional Disease Information for ZNF776

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ZNF776 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF776 Gene

Publications for ZNF776 Gene

  1. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 58
  4. Integrated genome-wide association, coexpression network, and expression single nucleotide polymorphism analysis identifies novel pathway in allergic rhinitis. (PMID: 25085501) Bunyavanich S … Weiss ST (BMC medical genomics 2014) 3 58
  5. Uncovering global SUMOylation signaling networks in a site-specific manner. (PMID: 25218447) Hendriks IA … Vertegaal AC (Nature structural & molecular biology 2014) 4 58

Products for ZNF776 Gene

Sources for ZNF776 Gene

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