Aliases for ZNF774 Gene

Aliases for ZNF774 Gene

  • Zinc Finger Protein 774 2 3 4 5
  • MGC75360 2
  • ZNF774 5

External Ids for ZNF774 Gene

Previous GeneCards Identifiers for ZNF774 Gene

  • GC15P088697
  • GC15P090895
  • GC15P067007
  • GC15P090297

Summaries for ZNF774 Gene

GeneCards Summary for ZNF774 Gene

ZNF774 (Zinc Finger Protein 774) is a Protein Coding gene. Among its related pathways are Gene Expression. An important paralog of this gene is ZNF572.

UniProtKB/Swiss-Prot Summary for ZNF774 Gene

Additional gene information for ZNF774 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF774 Gene

Genomics for ZNF774 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF774 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15J090351 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 616.7 +1.0 1043 1.8 SP1 CREB1 PRDM10 ZNF629 RFX1 SIX5 IKZF1 ZNF692 RCOR2 BACH1 IQGAP1 ZNF774 ENSG00000259314 TTLL13P NDUFA3P4
GH15J090295 Promoter 0.6 EPDnew 610.8 -56.4 -56358 0.1 REST CTCF CTBP1 RAD21 RB1 ZNF774 RF00017-1895 RN7SL736P piR-30417-010 lnc-NGRN-1 piR-51904-006 piR-30145-018 piR-59470-003 NGRN GDPGP1
GH15J090350 Promoter 0.3 EPDnew 600.7 -1.3 -1318 0.1 GABARAPL3 ZNF774 lnc-CIB1-134 ENSG00000275674
GH15J090405 Promoter/Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 24.1 +55.8 55751 4.1 PRDM1 IKZF2 RELB ZNF10 CEBPB RUNX3 ZBTB17 ZNF707 ELF1 PRDM6 IQGAP1 ZNF774 CRTC3 ENSG00000259212 GABARAPL3 VPS33B ZNF710 CIB1 FES FJ601684-136
GH15J090387 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 14.9 +37.4 37362 3.2 HNRNPL CREB1 POLR2A BACH1 ZHX2 LARP7 GABPA PHF21A RBFOX2 PATZ1 IQGAP1 lnc-CIB1-5 ZNF774 ENSG00000259177 CRTC3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF774 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF774

Top Transcription factor binding sites by QIAGEN in the ZNF774 gene promoter:
  • AP-4
  • CUTL1
  • FOXD1
  • FOXO1
  • FOXO1a
  • FOXO4
  • GCNF
  • GCNF-1
  • GCNF-2
  • Tal-1beta

Genomic Locations for ZNF774 Gene

Genomic Locations for ZNF774 Gene
chr15:90,351,439-90,369,146
(GRCh38/hg38)
Size:
17,708 bases
Orientation:
Plus strand
chr15:90,895,477-90,909,324
(GRCh37/hg19)
Size:
13,848 bases
Orientation:
Plus strand

Genomic View for ZNF774 Gene

Genes around ZNF774 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF774 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF774 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF774 Gene

Proteins for ZNF774 Gene

  • Protein details for ZNF774 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6NX45-ZN774_HUMAN
    Recommended name:
    Zinc finger protein 774
    Protein Accession:
    Q6NX45
    Secondary Accessions:
    • A8K020

    Protein attributes for ZNF774 Gene

    Size:
    483 amino acids
    Molecular mass:
    55068 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF774 Gene

Post-translational modifications for ZNF774 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF774 Gene

No data available for DME Specific Peptides for ZNF774 Gene

Domains & Families for ZNF774 Gene

Gene Families for ZNF774 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF774 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF774 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 774 (ZN774_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q6NX45

UniProtKB/Swiss-Prot:

ZN774_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF774: view

Function for ZNF774 Gene

Molecular function for ZNF774 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF774 Gene

Gene Ontology (GO) - Molecular Function for ZNF774 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF774: view
genes like me logo Genes that share phenotypes with ZNF774: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF774

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF774 Gene

Localization for ZNF774 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF774 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF774 gene
Compartment Confidence
nucleus 4

Subcellular locations from the

Human Protein Atlas (HPA)
  • Intermediate filaments (3)
  • Cytosol (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF774 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF774: view

Pathways & Interactions for ZNF774 Gene

PathCards logo

SuperPathways for ZNF774 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF774: view

Pathways by source for ZNF774 Gene

2 Reactome pathways for ZNF774 Gene

Gene Ontology (GO) - Biological Process for ZNF774 Gene

None

No data available for SIGNOR curated interactions for ZNF774 Gene

Drugs & Compounds for ZNF774 Gene

No Compound Related Data Available

Transcripts for ZNF774 Gene

mRNA/cDNA for ZNF774 Gene

1 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF774

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF774 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b
SP1:
SP2: -

Relevant External Links for ZNF774 Gene

GeneLoc Exon Structure for
ZNF774

Expression for ZNF774 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF774 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF774

SOURCE GeneReport for Unigene cluster for ZNF774 Gene:

Hs.55307

Evidence on tissue expression from TISSUES for ZNF774 Gene

  • Nervous system(4.1)
  • Adrenal gland(4.1)
genes like me logo Genes that share expression patterns with ZNF774: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF774 Gene

Orthologs for ZNF774 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF774 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZNF774 30 31
  • 99.24 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ZNF774 30
  • 89.42 (n)
Cow
(Bos Taurus)
Mammalia ZNF774 31
  • 87 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia ZNF774 31
  • 81 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 38 (a)
ManyToMany
Chicken
(Gallus gallus)
Aves -- 31
  • 46 (a)
ManyToMany
-- 31
  • 44 (a)
ManyToMany
-- 31
  • 43 (a)
ManyToMany
-- 31
  • 43 (a)
ManyToMany
-- 31
  • 43 (a)
ManyToMany
-- 31
  • 42 (a)
ManyToMany
-- 31
  • 41 (a)
ManyToMany
ZNF302 31
  • 40 (a)
ManyToMany
-- 31
  • 37 (a)
ManyToMany
-- 31
  • 34 (a)
ManyToMany
Lizard
(Anolis carolinensis)
Reptilia ZNF774 31
  • 41 (a)
OneToOne
Species where no ortholog for ZNF774 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ZNF774 Gene

ENSEMBL:
Gene Tree for ZNF774 (if available)
TreeFam:
Gene Tree for ZNF774 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF774: view image

Paralogs for ZNF774 Gene

(497) SIMAP similar genes for ZNF774 Gene using alignment to 4 proteins:

  • ZN774_HUMAN
  • E7EQ77_HUMAN
  • H0YLG8_HUMAN
  • H0YNW6_HUMAN
genes like me logo Genes that share paralogs with ZNF774: view

Variants for ZNF774 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF774 Gene

SNP ID Clinical significance and condition Chr 15 pos Variation AA Info Type
783719 Benign: not provided 90,360,176(+) A/G SYNONYMOUS_VARIANT
rs11854320 - p.Val147Ile
rs16944267 - p.Pro65Leu
rs2589957 - p.Asn83Ser

Additional dbSNP identifiers (rs#s) for ZNF774 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF774 Gene

Variant ID Type Subtype PubMed ID
dgv2658n100 CNV gain 25217958
dgv2659n100 CNV gain 25217958
dgv4705n54 CNV gain 21841781
esv2751541 CNV gain 17911159
esv2761843 CNV gain 21179565
esv3552836 CNV deletion 23714750
esv3637223 CNV loss 21293372
nsv1113731 CNV deletion 24896259
nsv457246 CNV gain 19166990
nsv570394 CNV gain 21841781
nsv570395 CNV loss 21841781
nsv833087 CNV loss 17160897

Variation tolerance for ZNF774 Gene

Residual Variation Intolerance Score: 83.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.48; 71.65% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF774 Gene

Human Gene Mutation Database (HGMD)
ZNF774
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF774

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF774 Gene

Disorders for ZNF774 Gene

Additional Disease Information for ZNF774

No disorders were found for ZNF774 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF774 Gene

Publications for ZNF774 Gene

  1. Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population. (PMID: 22446963) Okada Y … Yamamoto K (Nature genetics 2012) 3 41
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  3. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  4. Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations. (PMID: 31515488) Fragoza R … Yu H (Nature communications 2019) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3

Products for ZNF774 Gene

Sources for ZNF774 Gene