Aliases for ZNF773 Gene

Aliases for ZNF773 Gene

  • Zinc Finger Protein 773 2 3 4 5
  • Zinc Finger Protein 419B 2 3 4
  • ZNF419B 3 4

External Ids for ZNF773 Gene

Previous HGNC Symbols for ZNF773 Gene

  • ZNF419B

Previous GeneCards Identifiers for ZNF773 Gene

  • GC19P062706
  • GC19P058011
  • GC19P054323

Summaries for ZNF773 Gene

GeneCards Summary for ZNF773 Gene

ZNF773 (Zinc Finger Protein 773) is a Protein Coding gene. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF419.

UniProtKB/Swiss-Prot Summary for ZNF773 Gene

Additional gene information for ZNF773 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF773 Gene

Genomics for ZNF773 Gene

GeneHancer (GH) Regulatory Elements for ZNF773 Gene

Promoters and enhancers for ZNF773 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF773 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF773

Top Transcription factor binding sites by QIAGEN in the ZNF773 gene promoter:
  • AP-1
  • AP-4
  • c-Fos
  • c-Jun
  • HTF
  • Nkx6-1
  • SREBP-1a
  • SREBP-1b
  • SREBP-1c
  • XBP-1

Genomic Locations for ZNF773 Gene

Genomic Locations for ZNF773 Gene
chr19:57,499,854-57,518,437
(GRCh38/hg38)
Size:
18,584 bases
Orientation:
Plus strand
chr19:58,011,283-58,029,772
(GRCh37/hg19)
Size:
18,490 bases
Orientation:
Plus strand

Genomic View for ZNF773 Gene

Genes around ZNF773 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF773 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF773 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF773 Gene

Proteins for ZNF773 Gene

  • Protein details for ZNF773 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6PK81-ZN773_HUMAN
    Recommended name:
    Zinc finger protein 773
    Protein Accession:
    Q6PK81
    Secondary Accessions:
    • Q96DL8

    Protein attributes for ZNF773 Gene

    Size:
    442 amino acids
    Molecular mass:
    50502 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF773 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF773 Gene

Post-translational modifications for ZNF773 Gene

  • Ubiquitination at Lys343
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ZNF773 Gene

Domains & Families for ZNF773 Gene

Gene Families for ZNF773 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF773 Gene

Blocks:
  • KRAB box
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF773 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 419B (ZN773_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q6PK81

UniProtKB/Swiss-Prot:

ZN773_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF773: view

Function for ZNF773 Gene

Molecular function for ZNF773 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF773 Gene

Gene Ontology (GO) - Molecular Function for ZNF773 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF773: view
genes like me logo Genes that share phenotypes with ZNF773: view

Animal Model Products

CRISPR Products

miRNA for ZNF773 Gene

miRTarBase miRNAs that target ZNF773

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF773

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF773 Gene

Localization for ZNF773 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF773 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF773 gene
Compartment Confidence
nucleus 4
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli fibrillar center (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF773 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF773: view

Pathways & Interactions for ZNF773 Gene

genes like me logo Genes that share pathways with ZNF773: view

Pathways by source for ZNF773 Gene

2 Reactome pathways for ZNF773 Gene
1 KEGG pathway for ZNF773 Gene

Interacting Proteins for ZNF773 Gene

;

Gene Ontology (GO) - Biological Process for ZNF773 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF773: view

No data available for SIGNOR curated interactions for ZNF773 Gene

Drugs & Compounds for ZNF773 Gene

No Compound Related Data Available

Transcripts for ZNF773 Gene

mRNA/cDNA for ZNF773 Gene

5 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF773

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF773 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5
SP1:
SP2:
SP3: - -

Relevant External Links for ZNF773 Gene

GeneLoc Exon Structure for
ZNF773

Expression for ZNF773 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF773 Gene

Protein differential expression in normal tissues from HIPED for ZNF773 Gene

This gene is overexpressed in Fetal heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZNF773 Gene



Protein tissue co-expression partners for ZNF773 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF773

SOURCE GeneReport for Unigene cluster for ZNF773 Gene:

Hs.579576

Evidence on tissue expression from TISSUES for ZNF773 Gene

  • Lung(4.1)
genes like me logo Genes that share expression patterns with ZNF773: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF773 Gene

Orthologs for ZNF773 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF773 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF773 31 30
  • 98.79 (n)
OneToOne
cow
(Bos Taurus)
Mammalia -- 31
  • 71 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Zfp978 30
  • 66.54 (n)
mouse
(Mus musculus)
Mammalia Zfp772 17 30
  • 65.07 (n)
Zfp534 31
  • 30 (a)
ManyToMany
Species where no ortholog for ZNF773 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF773 Gene

ENSEMBL:
Gene Tree for ZNF773 (if available)
TreeFam:
Gene Tree for ZNF773 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF773: view image

Paralogs for ZNF773 Gene

(501) SIMAP similar genes for ZNF773 Gene using alignment to 3 proteins:

  • ZN773_HUMAN
  • M0QX16_HUMAN
  • M0QYZ8_HUMAN

Pseudogenes.org Pseudogenes for ZNF773 Gene

genes like me logo Genes that share paralogs with ZNF773: view

Variants for ZNF773 Gene

Additional dbSNP identifiers (rs#s) for ZNF773 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF773 Gene

Variant ID Type Subtype PubMed ID
esv2719071 CNV deletion 23290073
esv2719072 CNV deletion 23290073
esv2719074 CNV deletion 23290073
nsv1056203 CNV gain 25217958
nsv1067145 CNV gain 25217958
nsv522762 CNV loss 19592680
nsv525323 CNV loss 19592680
nsv963083 CNV duplication 23825009

Variation tolerance for ZNF773 Gene

Residual Variation Intolerance Score: 89.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.78; 66.74% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF773 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF773

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF773 Gene

Disorders for ZNF773 Gene

Additional Disease Information for ZNF773

No disorders were found for ZNF773 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF773 Gene

Publications for ZNF773 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 54
  3. VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. (PMID: 29507755) Yue Y … Liu J (Cell discovery 2018) 3 54
  4. The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery. (PMID: 29180619) Kumar R … Vertegaal ACO (Nature communications 2017) 3 54
  5. Human POGZ modulates dissociation of HP1alpha from mitotic chromosome arms through Aurora B activation. (PMID: 20562864) Nozawa RS … Obuse C (Nature cell biology 2010) 3 54

Products for ZNF773 Gene

Sources for ZNF773 Gene