Aliases for ZNF771 Gene

Aliases for ZNF771 Gene

  • Zinc Finger Protein 771 2 3 4 5
  • Mesenchymal Stem Cell Protein DSC43 3 4
  • DSC43 3

External Ids for ZNF771 Gene

Previous GeneCards Identifiers for ZNF771 Gene

  • GC16P030327
  • GC16P027980

Summaries for ZNF771 Gene

GeneCards Summary for ZNF771 Gene

ZNF771 (Zinc Finger Protein 771) is a Protein Coding gene. Diseases associated with ZNF771 include Wolf-Hirschhorn Syndrome. Among its related pathways are Gene Expression. An important paralog of this gene is ZNF160.

UniProtKB/Swiss-Prot Summary for ZNF771 Gene

Additional gene information for ZNF771 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF771 Gene

Genomics for ZNF771 Gene

GeneHancer (GH) Regulatory Elements for ZNF771 Gene

Promoters and enhancers for ZNF771 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF771 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF771

Top Transcription factor binding sites by QIAGEN in the ZNF771 gene promoter:
  • AML1a
  • AREB6
  • Olf-1
  • Pax-5
  • STAT3
  • USF-1
  • USF-1:USF-2
  • USF1
  • USF2

Genomic Locations for ZNF771 Gene

Genomic Locations for ZNF771 Gene
chr16:30,407,414-30,431,108
(GRCh38/hg38)
Size:
23,695 bases
Orientation:
Plus strand
chr16:30,418,618-30,440,920
(GRCh37/hg19)
Size:
22,303 bases
Orientation:
Plus strand

Genomic View for ZNF771 Gene

Genes around ZNF771 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF771 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF771 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF771 Gene

Proteins for ZNF771 Gene

  • Protein details for ZNF771 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7L3S4-ZN771_HUMAN
    Recommended name:
    Zinc finger protein 771
    Protein Accession:
    Q7L3S4
    Secondary Accessions:
    • Q8TAQ7
    • Q9NYI6

    Protein attributes for ZNF771 Gene

    Size:
    317 amino acids
    Molecular mass:
    35702 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAF65445.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ZNF771 Gene

Post-translational modifications for ZNF771 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF771 Gene

No data available for DME Specific Peptides for ZNF771 Gene

Domains & Families for ZNF771 Gene

Gene Families for ZNF771 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF771 Gene

Blocks:
  • C2H2-type zinc finger signature
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF771 Gene

GenScript: Design optimal peptide antigens:
  • Mesenchymal stem cell protein DSC43 (ZN771_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q7L3S4

UniProtKB/Swiss-Prot:

ZN771_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF771: view

Function for ZNF771 Gene

Molecular function for ZNF771 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF771 Gene

Gene Ontology (GO) - Molecular Function for ZNF771 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF771: view
genes like me logo Genes that share phenotypes with ZNF771: view

Animal Model Products

CRISPR Products

miRNA for ZNF771 Gene

miRTarBase miRNAs that target ZNF771

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF771

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF771 Gene

Localization for ZNF771 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF771 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF771 gene
Compartment Confidence
nucleus 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (4)
  • Nucleoplasm (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF771 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
GO:0005654 nucleoplasm IDA --
GO:0005730 nucleolus IDA --
genes like me logo Genes that share ontologies with ZNF771: view

Pathways & Interactions for ZNF771 Gene

PathCards logo

SuperPathways for ZNF771 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF771: view

Pathways by source for ZNF771 Gene

2 Reactome pathways for ZNF771 Gene

Gene Ontology (GO) - Biological Process for ZNF771 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006974 cellular response to DNA damage stimulus IBA 21873635
genes like me logo Genes that share ontologies with ZNF771: view

No data available for SIGNOR curated interactions for ZNF771 Gene

Drugs & Compounds for ZNF771 Gene

No Compound Related Data Available

Transcripts for ZNF771 Gene

mRNA/cDNA for ZNF771 Gene

2 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF771

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF771 Gene

No ASD Table

Relevant External Links for ZNF771 Gene

GeneLoc Exon Structure for
ZNF771

Expression for ZNF771 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF771 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZNF771 Gene

This gene is overexpressed in Adipocyte (31.5), Lung (27.0), and Ovary (10.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZNF771 Gene



Protein tissue co-expression partners for ZNF771 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF771

SOURCE GeneReport for Unigene cluster for ZNF771 Gene:

Hs.148584

Evidence on tissue expression from TISSUES for ZNF771 Gene

  • Nervous system(4.4)
  • Muscle(4.3)
  • Liver(2.4)
genes like me logo Genes that share expression patterns with ZNF771: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF771 Gene

Orthologs for ZNF771 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF771 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF771 31 30
  • 99.47 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF771 31 30
  • 93.69 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF771 31 30
  • 91.83 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp771 17 31 30
  • 90.54 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ZNF771 31
  • 88 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii zgc:173575 31
  • 42 (a)
ManyToMany
si:dkey-191j3.3 31
  • 38 (a)
ManyToMany
si:dkey-20i20.10 31
  • 34 (a)
ManyToMany
si:ch73-92e7.6 31
  • 31 (a)
ManyToMany
si:dkey-20i20.3 31
  • 31 (a)
ManyToMany
si:dkey-20i20.8 31
  • 27 (a)
ManyToMany
si:dkey-20i20.7 31
  • 26 (a)
ManyToMany
si:dkey-20i20.9 31
  • 25 (a)
ManyToMany
Species where no ortholog for ZNF771 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF771 Gene

ENSEMBL:
Gene Tree for ZNF771 (if available)
TreeFam:
Gene Tree for ZNF771 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF771: view image

Paralogs for ZNF771 Gene

(482) SIMAP similar genes for ZNF771 Gene using alignment to 3 proteins:

  • ZN771_HUMAN
  • H3BRY2_HUMAN
  • I3L3L5_HUMAN
genes like me logo Genes that share paralogs with ZNF771: view

Variants for ZNF771 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF771 Gene

SNP ID Clinical significance and condition Chr 16 pos Variation AA Info Type
rs17852362 - p.Asp207Asn

Additional dbSNP identifiers (rs#s) for ZNF771 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF771 Gene

Variant ID Type Subtype PubMed ID
nsv827612 CNV gain 20364138

Variation tolerance for ZNF771 Gene

Gene Damage Index Score: 0.89; 18.50% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF771 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF771

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF771 Gene

Disorders for ZNF771 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZNF771 Gene - From: DISEASES

Disorder Aliases PubMed IDs
wolf-hirschhorn syndrome
  • whs
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ZNF771

genes like me logo Genes that share disorders with ZNF771: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF771 Gene

Publications for ZNF771 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 54
  3. The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery. (PMID: 29180619) Kumar R … Vertegaal ACO (Nature communications 2017) 3 54
  4. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 54
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 54

Products for ZNF771 Gene

Sources for ZNF771 Gene