Aliases for ZNF770 Gene

Aliases for ZNF770 Gene

  • Zinc Finger Protein 770 2 3 4 5
  • PRO1914 3

External Ids for ZNF770 Gene

Previous GeneCards Identifiers for ZNF770 Gene

  • GC15M033058
  • GC15M035270
  • GC15M012115

Summaries for ZNF770 Gene

GeneCards Summary for ZNF770 Gene

ZNF770 (Zinc Finger Protein 770) is a Protein Coding gene. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA-binding transcription factor activity, RNA polymerase II-specific. An important paralog of this gene is ZNF518A.

UniProtKB/Swiss-Prot Summary for ZNF770 Gene

Additional gene information for ZNF770 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF770 Gene

Genomics for ZNF770 Gene

GeneHancer (GH) Regulatory Elements for ZNF770 Gene

Promoters and enhancers for ZNF770 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15J034984 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 508.7 +1.2 1200 5 ZBTB40 ZNF217 EP300 ZSCAN5C SIN3A NRF1 TCF12 POLR2G SP1 GTF2E2 ZNF770 AQR ENSG00000279364
GH15J034967 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 7.7 +19.0 18995 2.6 FOXK2 ZBTB40 ZNF217 EP300 CTCF ZSCAN5C SIN3A NRF1 MYC TCF12 AQR ZNF770 ENSG00000259181 lnc-ZNF770-2
GH15J034993 Enhancer 1 Ensembl ENCODE 10.6 -6.4 -6404 3 SP1 ZBTB11 HINFP NFYB BCL11A RELA CBFB ZNF384 NANOG ARNT ENSG00000259181 ZNF770 ENSG00000280396 LOC105370764
GH15J034999 Enhancer 0.8 Ensembl ENCODE 10.8 -12.4 -12405 3 ZNF316 FOS FOSL2 MAFK CEBPB JUN NFE2 GTF2F1 JUND EP300 ENSG00000280396 lnc-ZNF770-1 AQR ZNF770 ENSG00000259181 ENSG00000259587 LOC105370764
GH15J034991 Enhancer 0.7 Ensembl ENCODE 11 -3.7 -3704 1.6 CTCF ZBTB17 ZNF335 PKNOX1 RAD21 MAFK ZNF362 IKZF1 PRDM1 ENSG00000259181 ZNF770 LOC105370764
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF770 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF770

Top Transcription factor binding sites by QIAGEN in the ZNF770 gene promoter:
  • AML1a
  • AREB6
  • ATF-2
  • FOXD1
  • HTF
  • NCX
  • TBP
  • TFIID

Genomic Locations for ZNF770 Gene

Genomic Locations for ZNF770 Gene
chr15:34,978,341-34,988,296
(GRCh38/hg38)
Size:
9,956 bases
Orientation:
Minus strand
chr15:35,270,542-35,280,497
(GRCh37/hg19)
Size:
9,956 bases
Orientation:
Minus strand

Genomic View for ZNF770 Gene

Genes around ZNF770 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF770 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF770 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF770 Gene

Proteins for ZNF770 Gene

  • Protein details for ZNF770 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6IQ21-ZN770_HUMAN
    Recommended name:
    Zinc finger protein 770
    Protein Accession:
    Q6IQ21
    Secondary Accessions:
    • Q6ZMZ6
    • Q9NWV2

    Protein attributes for ZNF770 Gene

    Size:
    691 amino acids
    Molecular mass:
    80007 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAD18579.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ZNF770 Gene

Post-translational modifications for ZNF770 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF770 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF770 Gene

Domains & Families for ZNF770 Gene

Gene Families for ZNF770 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF770 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF770 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 770 (ZN770_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q6IQ21

UniProtKB/Swiss-Prot:

ZN770_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF770: view

Function for ZNF770 Gene

Molecular function for ZNF770 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF770 Gene

Gene Ontology (GO) - Molecular Function for ZNF770 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IBA 21873635
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF770: view
genes like me logo Genes that share phenotypes with ZNF770: view

Animal Model Products

miRNA for ZNF770 Gene

miRTarBase miRNAs that target ZNF770

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF770 Gene

Localization for ZNF770 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF770 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF770 gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF770 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
genes like me logo Genes that share ontologies with ZNF770: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZNF770 Gene

Pathways & Interactions for ZNF770 Gene

PathCards logo

SuperPathways for ZNF770 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF770: view

Pathways by source for ZNF770 Gene

2 Reactome pathways for ZNF770 Gene

Gene Ontology (GO) - Biological Process for ZNF770 Gene

None

No data available for SIGNOR curated interactions for ZNF770 Gene

Drugs & Compounds for ZNF770 Gene

No Compound Related Data Available

Transcripts for ZNF770 Gene

mRNA/cDNA for ZNF770 Gene

1 REFSEQ mRNAs :
14 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF770 Gene

No ASD Table

Relevant External Links for ZNF770 Gene

GeneLoc Exon Structure for
ZNF770

Expression for ZNF770 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF770 Gene

Protein differential expression in normal tissues from HIPED for ZNF770 Gene

This gene is overexpressed in Amniocyte (50.8) and Lung (11.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZNF770 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF770

SOURCE GeneReport for Unigene cluster for ZNF770 Gene:

Hs.744990
genes like me logo Genes that share expression patterns with ZNF770: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF770 Gene

Orthologs for ZNF770 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF770 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF770 31 30
  • 99.66 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF770 31 30
  • 88.77 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF770 31 30
  • 87.68 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zfp770 30
  • 83.14 (n)
mouse
(Mus musculus)
Mammalia Zfp770 17 31 30
  • 82.58 (n)
oppossum
(Monodelphis domestica)
Mammalia ZNF770 31
  • 64 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZNF770 31 30
  • 65.81 (n)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia znf770 30
  • 54.03 (n)
Str.12795 30
zebrafish
(Danio rerio)
Actinopterygii BX004873.1 31
  • 29 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta crol 31
  • 14 (a)
OneToMany
Species where no ortholog for ZNF770 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF770 Gene

ENSEMBL:
Gene Tree for ZNF770 (if available)
TreeFam:
Gene Tree for ZNF770 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF770: view image

Paralogs for ZNF770 Gene

Pseudogenes.org Pseudogenes for ZNF770 Gene

genes like me logo Genes that share paralogs with ZNF770: view

Variants for ZNF770 Gene

Additional dbSNP identifiers (rs#s) for ZNF770 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF770 Gene

Variant ID Type Subtype PubMed ID
esv2761865 CNV gain 21179565
esv3569431 CNV gain 25503493
nsv522411 CNV gain 19592680
nsv827295 CNV gain 20364138

Variation tolerance for ZNF770 Gene

Residual Variation Intolerance Score: 9.69% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.45; 28.31% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF770 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF770

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF770 Gene

Disorders for ZNF770 Gene

Additional Disease Information for ZNF770

No disorders were found for ZNF770 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF770 Gene

Publications for ZNF770 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 54
  4. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 54
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 54

Products for ZNF770 Gene

Sources for ZNF770 Gene