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Aliases for ZNF77 Gene

Aliases for ZNF77 Gene

  • Zinc Finger Protein 77 2 3 4 5
  • ZNFpT1 3 4
  • Zinc Finger Protein 77 (PT1) 2
  • PT1 3

External Ids for ZNF77 Gene

Previous GeneCards Identifiers for ZNF77 Gene

  • GC19U990110
  • GC19M002873
  • GC19M002884
  • GC19M002847
  • GC19M002701
  • GC19M002897
  • GC19M002917

Summaries for ZNF77 Gene

GeneCards Summary for ZNF77 Gene

ZNF77 (Zinc Finger Protein 77) is a Protein Coding gene. Diseases associated with ZNF77 include Tuberculous Epididymitis and Papillary Transitional Carcinoma. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF555.

UniProtKB/Swiss-Prot for ZNF77 Gene

Additional gene information for ZNF77 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF77 Gene

Genomics for ZNF77 Gene

GeneHancer (GH) Regulatory Elements for ZNF77 Gene

Promoters and enhancers for ZNF77 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J002944 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 619.4 +0.6 560 3 ZFX SP1 CC2D1A MNT GTF2F1 ZSCAN21 FOS AHR MCM2 TFE3 ZNF77 SF3A2 CACTIN-AS1 APBA3 DOT1L CACTIN LMNB2 ENSG00000267139 ZNF555 ENSG00000267283
GH19J003604 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 113.4 -662.0 -661976 5.3 ZNF473 HDGF ZFX CBFA2T2 ZNF148 NKRF MLLT1 GTF2F1 NCOA3 CDC5L CACTIN-AS1 TBXA2R ZNF77 CACTIN ENSG00000267030 ZNF555 ENSG00000267769 YJU2 APBA3 GNA11
GH19J003150 Promoter/Enhancer 2.3 FANTOM5 Ensembl ENCODE dbSUPER 82.1 -208.1 -208109 6 ZNF473 SP1 CC2D1A ZFX CBFA2T2 ZNF148 GTF2F1 ZNF687 CDC5L BACH1 LOC100996351 GC19P003153 GC19P003154 PIR47090 ZNF77 CACTIN GNA11 DOT1L ZNF555 LMNB2
GH19J002038 Promoter/Enhancer 2.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 62.7 +894.3 894254 24.2 HDGF SP1 ZFX CC2D1A ELF3 CTCF ZKSCAN8 MNT ZNF148 NKRF MKNK2 ZNF77 SF3A2 DAZAP1 CIRBP TCF3 ZNF555 LMNB2 LOC100288123 PWWP3A
GH19J002268 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 54.6 +673.1 673133 7.5 HDGF ZFX SP1 CTCF ELF3 MNT SIX5 ZNF148 NKRF POLR2A GC19M002271 GC19P002271 OAZ1 SF3A2 ZNF77 DAZAP1 TCF3 LSM7 LINGO3 ZNF555
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF77 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF77 gene promoter:
  • AP-1
  • ATF-2
  • c-Jun
  • FOXD3
  • HTF
  • p53

Genomic Locations for ZNF77 Gene

Genomic Locations for ZNF77 Gene
chr19:2,933,218-2,945,279
(GRCh38/hg38)
Size:
12,062 bases
Orientation:
Minus strand
chr19:2,933,216-2,944,969
(GRCh37/hg19)
Size:
11,754 bases
Orientation:
Minus strand

Genomic View for ZNF77 Gene

Genes around ZNF77 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF77 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF77 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF77 Gene

Proteins for ZNF77 Gene

  • Protein details for ZNF77 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15935-ZNF77_HUMAN
    Recommended name:
    Zinc finger protein 77
    Protein Accession:
    Q15935
    Secondary Accessions:
    • Q86XJ3
    • Q9NPP0

    Protein attributes for ZNF77 Gene

    Size:
    545 amino acids
    Molecular mass:
    61964 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAA46337.1; Type=Frameshift; Positions=98, 317; Evidence={ECO:0000305};

neXtProt entry for ZNF77 Gene

Post-translational modifications for ZNF77 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF77 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF77 Gene

Domains & Families for ZNF77 Gene

Gene Families for ZNF77 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF77 Gene

Suggested Antigen Peptide Sequences for ZNF77 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ76041, highly similar to Homo sapiens zinc finger protein 77 (pT1) (ZNF77), mRNA (A8K4L4_HUMAN)
  • ZNFpT1 (ZNF77_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q15935

UniProtKB/Swiss-Prot:

ZNF77_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF77: view

Function for ZNF77 Gene

Molecular function for ZNF77 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
GENATLAS Biochemistry:
zinc finger protein 77

Phenotypes From GWAS Catalog for ZNF77 Gene

Gene Ontology (GO) - Molecular Function for ZNF77 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISA --
GO:0003674 molecular_function ND --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF77: view
genes like me logo Genes that share phenotypes with ZNF77: view

Animal Model Products

CRISPR Products

miRNA for ZNF77 Gene

miRTarBase miRNAs that target ZNF77

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF77

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF77 Gene

Localization for ZNF77 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF77 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF77 gene
Compartment Confidence
nucleus 5
cytosol 3
plasma membrane 1
extracellular 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF77 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IBA 21873635
genes like me logo Genes that share ontologies with ZNF77: view

Pathways & Interactions for ZNF77 Gene

genes like me logo Genes that share pathways with ZNF77: view

Pathways by source for ZNF77 Gene

2 Reactome pathways for ZNF77 Gene
1 KEGG pathway for ZNF77 Gene

Interacting Proteins for ZNF77 Gene

Gene Ontology (GO) - Biological Process for ZNF77 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with ZNF77: view

No data available for SIGNOR curated interactions for ZNF77 Gene

Drugs & Compounds for ZNF77 Gene

No Compound Related Data Available

Transcripts for ZNF77 Gene

mRNA/cDNA for ZNF77 Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(30) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Unigene Clusters for ZNF77 Gene

Zinc finger protein 77:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF77

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF77 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4
SP1: -
SP2:

Relevant External Links for ZNF77 Gene

GeneLoc Exon Structure for
ZNF77
ECgene alternative splicing isoforms for
ZNF77

Expression for ZNF77 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF77 Gene

Protein differential expression in normal tissues from HIPED for ZNF77 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZNF77 Gene



Protein tissue co-expression partners for ZNF77 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF77 Gene:

ZNF77

SOURCE GeneReport for Unigene cluster for ZNF77 Gene:

Hs.38004
genes like me logo Genes that share expression patterns with ZNF77: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF77 Gene

Orthologs for ZNF77 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF77 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF77 35 34
  • 98.65 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF77 35 34
  • 73.52 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF77 35
  • 45 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gm4723 35
  • 45 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 45 (a)
ManyToMany
-- 35
  • 42 (a)
ManyToMany
-- 35
  • 41 (a)
ManyToMany
-- 35
  • 39 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 42 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 38 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii CR388132.2 35
  • 36 (a)
ManyToMany
CT573234.2 35
  • 36 (a)
ManyToMany
Species where no ortholog for ZNF77 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF77 Gene

ENSEMBL:
Gene Tree for ZNF77 (if available)
TreeFam:
Gene Tree for ZNF77 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF77: view image

Paralogs for ZNF77 Gene

(459) SIMAP similar genes for ZNF77 Gene using alignment to 2 proteins:

  • ZNF77_HUMAN
  • A8K4L4_HUMAN
genes like me logo Genes that share paralogs with ZNF77: view

Variants for ZNF77 Gene

Sequence variations from dbSNP and Humsavar for ZNF77 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000016839 -- 2,945,494(-) C/T upstream_transcript_variant
rs1000208748 -- 2,935,597(-) C/T intron_variant
rs1000237649 -- 2,945,321(-) G/A/C upstream_transcript_variant
rs1000534960 -- 2,944,800(-) C/G intron_variant
rs1000580363 -- 2,935,794(-) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF77 Gene

Variant ID Type Subtype PubMed ID
dgv1690n106 CNV deletion 24896259
esv2717920 CNV deletion 23290073
esv2717921 CNV deletion 23290073
esv3426491 CNV duplication 20981092
esv3893157 CNV loss 25118596
nsv1065985 CNV loss 25217958

Variation tolerance for ZNF77 Gene

Residual Variation Intolerance Score: 90.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.81; 58.38% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF77 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF77
Human Gene Mutation Database (HGMD)
ZNF77

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF77 Gene

Disorders for ZNF77 Gene

MalaCards: The human disease database

(8) MalaCards diseases for ZNF77 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
tuberculous epididymitis
  • tuberculosis of epididymis
papillary transitional carcinoma
  • papillary transitional cell carcinoma
bone squamous cell carcinoma
bladder diverticulum
  • diverticulum - bladder
acute interstitial pneumonia
  • aip
- elite association - COSMIC cancer census association via MalaCards
Search ZNF77 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ZNF77

genes like me logo Genes that share disorders with ZNF77: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF77 Gene

Publications for ZNF77 Gene

  1. Chromosomal localization of four human zinc finger cDNAs. (PMID: 8478004) Huebner K … Pelicci PG (Human genetics 1993) 2 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Lung colonization by Aspergillus fumigatus is controlled by ZNF77. (PMID: 30237437) Gago S … Bowyer P (Nature communications 2018) 3 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. TNIP2 is a Hub Protein in the NF-κB Network with Both Protein and RNA Mediated Interactions. (PMID: 27609421) Banks CA … Washburn MP (Molecular & cellular proteomics : MCP 2016) 3 58

Products for ZNF77 Gene

Sources for ZNF77 Gene

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