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ZNF768 Gene(Protein Coding)

Zinc Finger Protein 768

GCID:
GC16M030524
GIFtS:
38
Genes Participants
UDN Logo

Aliases for ZNF768 Gene

Aliases for ZNF768 Gene

  • Zinc Finger Protein 768 2 3 5

External Ids for ZNF768 Gene

Previous GeneCards Identifiers for ZNF768 Gene

  • GC16M030443
  • GC16M030444
  • GC16M030535
  • GC16M028098

Summaries for ZNF768 Gene

GeneCards Summary for ZNF768 Gene

ZNF768 (Zinc Finger Protein 768) is a Protein Coding gene. An important paralog of this gene is ZNF358.

UniProtKB/Swiss-Prot for ZNF768 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF768 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF768 Gene

Genomics for ZNF768 Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for ZNF768 Gene

Promoters and enhancers for ZNF768 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH16I030525 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 550.8 -0.5 -529 3.8 HDGF PKNOX1 CLOCK SMAD1 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B IRF4 ENSG00000278922 ZNF768 ENSG00000260267 BCL7C SRCAP SETD1A FUS INO80E SMG1P2 SMG1P5
GH16I031125 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.8 -604.3 -604317 10.7 HDGF CLOCK ARNT NEUROD1 SIN3A ZNF766 ZNF207 ZNF548 MCM3 SP3 ENSG00000261385 PRSS8 SRCAP SETD1A ENSG00000260267 SMG1P5 ZNF764 ENSG00000260304 KAT8 BCL7C
GH16I030555 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 11 -31.3 -31250 4.2 ZFP64 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 ZNF548 SP3 NFYC ZNF764 ENSG00000260869 FUS SETD1A ZNF785 SRCAP ENSG00000260114 TAOK2 INO80E SMG1P2
GH16I030566 Promoter/Enhancer 2.3 FANTOM5 Ensembl ENCODE dbSUPER 10.2 -43.1 -43053 6 ZFP64 FEZF1 DMAP1 YY1 ZNF213 E2F8 ZNF416 ZNF143 ZNF548 SP3 SETD1A SRCAP ENSG00000260267 FUS INO80E ZNF747 NPIPB13 ZNF764 SMG1P5 SMG1P2
GH16I030649 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10 -124.4 -124429 3.6 HDGF PKNOX1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 POLR2B PRR14 SETD1A ENSG00000260267 SRCAP SMG1P5 ENSG00000260304 BCL7C ZNF747 FUS INO80E
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF768 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF768 gene promoter:

Genomic Locations for ZNF768 Gene

Genomic Locations for ZNF768 Gene
chr16:30,524,001-30,526,821
(GRCh38/hg38)
Size:
2,821 bases
Orientation:
Minus strand
chr16:30,535,322-30,538,142
(GRCh37/hg19)

Genomic View for ZNF768 Gene

Genes around ZNF768 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF768 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF768 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for ZNF768 Gene

Proteins for ZNF768 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for ZNF768 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H5H4-ZN768_HUMAN
    Recommended name:
    Zinc finger protein 768
    Protein Accession:
    Q9H5H4
    Secondary Accessions:
    • Q569L7
    • Q96CX4

    Protein attributes for ZNF768 Gene

    Size:
    540 amino acids
    Molecular mass:
    60229 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH13760.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH92403.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB15652.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ZNF768 Gene

Protein Expression for ZNF768 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for ZNF768 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF768 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF768 Gene

Domains & Families for ZNF768 Gene

Gene Families for ZNF768 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF768 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF768 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H5H4

UniProtKB/Swiss-Prot:

ZN768_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF768: view

Function for ZNF768 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for ZNF768 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF768 Gene

Gene Ontology (GO) - Molecular Function for ZNF768 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003723 RNA binding IDA,HDA 22681889
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF768: view

Phenotypes for ZNF768 Gene

GenomeRNAi human phenotypes for ZNF768:
genes like me logo Genes that share phenotypes with ZNF768: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZNF768 Gene

Localization for ZNF768 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF768 Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF768 gene
Compartment Confidence
nucleus 5
cytoskeleton 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleus (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF768 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005665 DNA-directed RNA polymerase II, core complex IEA --
genes like me logo Genes that share ontologies with ZNF768: view

Pathways & Interactions for ZNF768 Gene

SuperPathways for ZNF768 Gene

PathCards logo More details on SuperPathways for ZNF768
No Data Available

Gene Ontology (GO) - Biological Process for ZNF768 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with ZNF768: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF768 Gene

Drugs & Compounds for ZNF768 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for ZNF768 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for ZNF768 Gene

(3) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(108) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF768 Gene

Zinc finger protein 768:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF768 Gene

No ASD Table

Relevant External Links for ZNF768 Gene

GeneLoc Exon Structure for
ZNF768
ECgene alternative splicing isoforms for
ZNF768

Expression for ZNF768 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF768 Gene

mRNA expression in normal human tissues for ZNF768 Gene
mRNA expression by GTEx for ZNF768 GenemRNA expression by BioGPS for ZNF768 Gene

Protein differential expression in normal tissues from HIPED for ZNF768 Gene

This gene is overexpressed in Lung (38.6) and Liver (28.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZNF768 Gene



NURSA nuclear receptor signaling pathways regulating expression of ZNF768 Gene:

ZNF768

SOURCE GeneReport for Unigene cluster for ZNF768 Gene:

Hs.85658

Evidence on tissue expression from TISSUES for ZNF768 Gene

  • Nervous system(4.2)
  • Muscle(2.3)
genes like me logo Genes that share expression patterns with ZNF768: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF768 Gene

Orthologs for ZNF768 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ZNF768 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia ZNF768 34
  • 100 (a)
 OneToOne
LOC100615883 33
  • 98.89 (n)
cow
(Bos Taurus)
 Mammalia -- 34
  • 94 (a)
 OneToMany
-- 34
  • 93 (a)
 OneToMany
ZNF768 33
  • 91.05 (n)
dog
(Canis familiaris)
 Mammalia ZNF768 33 34
  • 91.73 (n)
rat
(Rattus norvegicus)
 Mammalia LOC102553763 33
  • 88.56 (n)
mouse
(Mus musculus)
 Mammalia Zfp768 33 16 34
  • 87.96 (n)
oppossum
(Monodelphis domestica)
 Mammalia ZNF768 34
  • 80 (a)
 OneToOne
zebrafish
(Danio rerio)
 Actinopterygii ZNF768 34
  • 14 (a)
 OneToOne
fruit fly
(Drosophila melanogaster)
 Insecta CG2116 34
  • 15 (a)
 OneToOne
baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes MET32 36
sea squirt
(Ciona savignyi)
 Ascidiacea CSA.10667 34
  • 10 (a)
 OneToOne
Species where no ortholog for ZNF768 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF768 Gene

ENSEMBL:
Gene Tree for ZNF768 (if available)
TreeFam:
Gene Tree for ZNF768 (if available)

Paralogs for ZNF768 Gene

Paralogs for ZNF768 Gene

(508) SIMAP similar genes for ZNF768 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZNF768: view

Variants for ZNF768 Gene

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  1. SNP Genotyping and Copy Number Assay

Sequence variations from dbSNP and Humsavar for ZNF768 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000200368 -- 30,525,419(-) C/T coding_sequence_variant, missense_variant
rs1000220204 -- 30,527,561(-) C/A 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000720862 -- 30,527,392(-) G/C 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000868120 -- 30,530,020(-) G/A genic_upstream_transcript_variant, intron_variant
rs1000978717 -- 30,530,482(-) G/A genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF768 Gene

Variant ID Type Subtype PubMed ID
nsv1136213 CNV deletion 24896259
nsv1784 CNV insertion 18451855

Variation tolerance for ZNF768 Gene

Residual Variation Intolerance Score: 16.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.09; 84.49% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF768 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF768

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF768 Gene

Disorders for ZNF768 Gene

Additional Disease Information for ZNF768

ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ZNF768 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF768 Gene

Publications for ZNF768 Gene

  1. Diagnostic potential of zinc finger protein-specific autoantibodies and associated linear B-cell epitopes in colorectal cancer. (PMID: 25875936) O'Reilly JA … Kijanka GS (PloS one 2015) 2 3 58
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  3. Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes. (PMID: 25281560) Lambert JP … Gingras AC (Journal of proteomics 2015) 3 58
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 58

Products for ZNF768 Gene

Sources for ZNF768 Gene

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