Aliases for ZNF768 Gene

Aliases for ZNF768 Gene

  • Zinc Finger Protein 768 2 3 4 5
  • FLJ23436 2
  • ZNF768 5

External Ids for ZNF768 Gene

Previous GeneCards Identifiers for ZNF768 Gene

  • GC16M030443
  • GC16M030444
  • GC16M030535
  • GC16M028098

Summaries for ZNF768 Gene

GeneCards Summary for ZNF768 Gene

ZNF768 (Zinc Finger Protein 768) is a Protein Coding gene. Among its related pathways are Herpes simplex virus 1 infection. An important paralog of this gene is ZNF287.

UniProtKB/Swiss-Prot Summary for ZNF768 Gene

Additional gene information for ZNF768 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF768 Gene

Genomics for ZNF768 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF768 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J030525 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 600.4 +5.1 5148 4 ZNF221 SP1 HNRNPL ZNF629 PRDM10 REST RFX1 SIX5 IKZF1 ZNF692 ENSG00000278922 lnc-ITGAL-1 ZNF768 SRCAP SETD1A ZNF764 ENSG00000260267 INO80E RNF40 ZNF747
GH16J030531 Promoter/Enhancer 1.1 EPDnew Ensembl dbSUPER 600.7 +1.1 1067 1 RBFOX2 ZNF18 CEBPB POLR2A GATA4 ZNF747 ZNF768 piR-58374 piR-45123-001 ENSG00000261459 ITGAL
GH16J030529 Promoter/Enhancer 0.8 Ensembl dbSUPER 600.7 +1.9 1866 0.2 PKNOX1 GATA3 POLR2A TCF7L2 GATA4 ZNF768 piR-58374 ENSG00000278922 ENSG00000261459 ZNF747 lnc-ITGAL-1 ITGAL
GH16J030532 Promoter/Enhancer 0.7 Ensembl dbSUPER 600.7 -0.3 -334 0.6 RBFOX2 TARDBP ZNF768 piR-58374 piR-45123-001 ENSG00000261459 ZNF747
GH16J031125 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 10.8 -598.8 -598771 10.7 ARHGAP35 CREB1 GATAD2A ZBTB33 ATF7 PRDM10 LEF1 IKZF1 ZNF692 NFRKB ENSG00000261385 PRSS8 piR-49673 SRCAP SETD1A SMG1P5 ENSG00000260267 ENSG00000260304 KAT8 BCL7C
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF768 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF768

Top Transcription factor binding sites by QIAGEN in the ZNF768 gene promoter:
  • AML1a
  • c-Ets-1
  • CREB
  • deltaCREB
  • NF-1
  • Nkx2-5
  • Olf-1
  • p53

Genomic Locations for ZNF768 Gene

Genomic Locations for ZNF768 Gene
chr16:30,524,004-30,532,367
(GRCh38/hg38)
Size:
8,364 bases
Orientation:
Minus strand
chr16:30,535,322-30,538,142
(GRCh37/hg19)
Size:
2,821 bases
Orientation:
Minus strand

Genomic View for ZNF768 Gene

Genes around ZNF768 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF768 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF768 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF768 Gene

Proteins for ZNF768 Gene

  • Protein details for ZNF768 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H5H4-ZN768_HUMAN
    Recommended name:
    Zinc finger protein 768
    Protein Accession:
    Q9H5H4
    Secondary Accessions:
    • Q569L7
    • Q96CX4

    Protein attributes for ZNF768 Gene

    Size:
    540 amino acids
    Molecular mass:
    60229 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH13760.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH92403.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB15652.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ZNF768 Gene

Post-translational modifications for ZNF768 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF768 Gene

No data available for DME Specific Peptides for ZNF768 Gene

Domains & Families for ZNF768 Gene

Gene Families for ZNF768 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF768 Gene

Suggested Antigen Peptide Sequences for ZNF768 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ59521, moderately similar to Zinc finger and SCAN domain-containing protein 2 (B7Z2Y7_HUMAN)
  • Zinc finger protein 768 (ZN768_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9H5H4

UniProtKB/Swiss-Prot:

ZN768_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF768: view

Function for ZNF768 Gene

Molecular function for ZNF768 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF768 Gene

Gene Ontology (GO) - Molecular Function for ZNF768 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity IBA 21873635
GO:0003723 RNA binding HDA 22681889
GO:0043565 sequence-specific DNA binding IBA 21873635
genes like me logo Genes that share ontologies with ZNF768: view

Phenotypes for ZNF768 Gene

genes like me logo Genes that share phenotypes with ZNF768: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF768

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZNF768 Gene

Localization for ZNF768 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF768 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF768 gene
Compartment Confidence
nucleus 4
cytosol 2
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF768 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
GO:0005665 RNA polymerase II, core complex IEA --
genes like me logo Genes that share ontologies with ZNF768: view

Pathways & Interactions for ZNF768 Gene

PathCards logo

SuperPathways for ZNF768 Gene

genes like me logo Genes that share pathways with ZNF768: view

Pathways by source for ZNF768 Gene

1 KEGG pathway for ZNF768 Gene

Gene Ontology (GO) - Biological Process for ZNF768 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with ZNF768: view

No data available for SIGNOR curated interactions for ZNF768 Gene

Drugs & Compounds for ZNF768 Gene

No Compound Related Data Available

Transcripts for ZNF768 Gene

mRNA/cDNA for ZNF768 Gene

1 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF768

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF768 Gene

No ASD Table

Relevant External Links for ZNF768 Gene

GeneLoc Exon Structure for
ZNF768

Expression for ZNF768 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF768 Gene

Protein differential expression in normal tissues from HIPED for ZNF768 Gene

This gene is overexpressed in Lung (38.6) and Liver (28.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZNF768 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF768

SOURCE GeneReport for Unigene cluster for ZNF768 Gene:

Hs.85658

Evidence on tissue expression from TISSUES for ZNF768 Gene

  • Nervous system(4.2)
  • Muscle(2.3)
genes like me logo Genes that share expression patterns with ZNF768: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF768 Gene

Orthologs for ZNF768 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ZNF768 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZNF768 31
  • 100 (a)
OneToOne
LOC100615883 30
  • 98.89 (n)
Cow
(Bos Taurus)
Mammalia -- 31
  • 94 (a)
OneToMany
-- 31
  • 93 (a)
OneToMany
ZNF768 30
  • 91.05 (n)
Dog
(Canis familiaris)
Mammalia ZNF768 30 31
  • 91.73 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia LOC102553763 30
  • 88.56 (n)
Mouse
(Mus musculus)
Mammalia Zfp768 30 17 31
  • 87.96 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia ZNF768 31
  • 80 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii ZNF768 31
  • 14 (a)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta CG2116 31
  • 15 (a)
OneToOne
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MET32 33
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.10667 31
  • 10 (a)
OneToOne
Species where no ortholog for ZNF768 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for ZNF768 Gene

ENSEMBL:
Gene Tree for ZNF768 (if available)
TreeFam:
Gene Tree for ZNF768 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF768: view image

Paralogs for ZNF768 Gene

(508) SIMAP similar genes for ZNF768 Gene using alignment to 2 proteins:

  • ZN768_HUMAN
  • H3BS42_HUMAN
genes like me logo Genes that share paralogs with ZNF768: view

Variants for ZNF768 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF768 Gene

SNP ID Clinical significance and condition Chr 16 pos Variation AA Info Type
rs10871453 - p.Glu181Asp
rs3751848 - p.Ala488Ser

Additional dbSNP identifiers (rs#s) for ZNF768 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF768 Gene

Variant ID Type Subtype PubMed ID
nsv1136213 CNV deletion 24896259
nsv1784 CNV insertion 18451855

Variation tolerance for ZNF768 Gene

Residual Variation Intolerance Score: 16.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.09; 84.49% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF768 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF768

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF768 Gene

Disorders for ZNF768 Gene

No disorders were found for ZNF768 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF768 Gene

Publications for ZNF768 Gene

  1. Diagnostic potential of zinc finger protein-specific autoantibodies and associated linear B-cell epitopes in colorectal cancer. (PMID: 25875936) O'Reilly JA … Kijanka GS (PloS one 2015) 2 3
  2. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  3. H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids. (PMID: 30804502) Nakamura K … Groth A (Nature cell biology 2019) 3
  4. PLEKHA4/kramer Attenuates Dishevelled Ubiquitination to Modulate Wnt and Planar Cell Polarity Signaling. (PMID: 31091453) Shami Shah A … Baskin JM (Cell reports 2019) 3
  5. Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation. (PMID: 30948266) Lee SH … Mayr C (Molecular cell 2019) 3

Products for ZNF768 Gene

Sources for ZNF768 Gene