Aliases for ZNF766 Gene

Aliases for ZNF766 Gene

  • Zinc Finger Protein 766 2 3 4 5
  • ZNF766 5

External Ids for ZNF766 Gene

Previous GeneCards Identifiers for ZNF766 Gene

  • GC19P057467
  • GC19P052772
  • GC19P049103

Summaries for ZNF766 Gene

GeneCards Summary for ZNF766 Gene

ZNF766 (Zinc Finger Protein 766) is a Protein Coding gene. Diseases associated with ZNF766 include Fanconi Anemia, Complementation Group B. Among its related pathways are Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF888.

UniProtKB/Swiss-Prot Summary for ZNF766 Gene

Additional gene information for ZNF766 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF766 Gene

Genomics for ZNF766 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF766 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF766 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF766

Top Transcription factor binding sites by QIAGEN in the ZNF766 gene promoter:
  • AP-1
  • AREB6
  • ATF-2
  • c-Fos
  • c-Jun

Genomic Locations for ZNF766 Gene

Genomic Locations for ZNF766 Gene
chr19:52,269,251-52,296,046
(GRCh38/hg38)
Size:
26,796 bases
Orientation:
Plus strand
chr19:52,772,824-52,795,977
(GRCh37/hg19)
Size:
23,154 bases
Orientation:
Plus strand

Genomic View for ZNF766 Gene

Genes around ZNF766 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF766 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF766 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF766 Gene

Proteins for ZNF766 Gene

  • Protein details for ZNF766 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5HY98-ZN766_HUMAN
    Recommended name:
    Zinc finger protein 766
    Protein Accession:
    Q5HY98
    Secondary Accessions:
    • B2RNE0
    • Q7Z326

    Protein attributes for ZNF766 Gene

    Size:
    468 amino acids
    Molecular mass:
    54507 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAD98055.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ZNF766 Gene

Post-translational modifications for ZNF766 Gene

  • Ubiquitination at Lys157
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ZNF766 Gene

Domains & Families for ZNF766 Gene

Gene Families for ZNF766 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF766 Gene

InterPro:
Blocks:
  • KRAB box
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF766 Gene

GenScript: Design optimal peptide antigens:
  • ZNF766 protein (Q08EK0_HUMAN)
  • Zinc finger protein 766 (ZN766_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q5HY98

UniProtKB/Swiss-Prot:

ZN766_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF766: view

Function for ZNF766 Gene

Molecular function for ZNF766 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF766 Gene

Gene Ontology (GO) - Molecular Function for ZNF766 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF766: view
genes like me logo Genes that share phenotypes with ZNF766: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF766

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF766 Gene

Localization for ZNF766 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF766 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF766 gene
Compartment Confidence
nucleus 5
cytoskeleton 2
mitochondrion 1
peroxisome 0
cytosol 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF766 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,HDA 21630459
genes like me logo Genes that share ontologies with ZNF766: view

Pathways & Interactions for ZNF766 Gene

PathCards logo

SuperPathways for ZNF766 Gene

genes like me logo Genes that share pathways with ZNF766: view

Pathways by source for ZNF766 Gene

1 KEGG pathway for ZNF766 Gene

Gene Ontology (GO) - Biological Process for ZNF766 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF766: view

No data available for SIGNOR curated interactions for ZNF766 Gene

Drugs & Compounds for ZNF766 Gene

No Compound Related Data Available

Transcripts for ZNF766 Gene

mRNA/cDNA for ZNF766 Gene

1 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF766

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF766 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d · 8e · 8f
SP1: - - - - -
SP2: - - - - - -
SP3: - - - - -
SP4: - - -
SP5: - - - -
SP6: -
SP7: - - - - - - -
SP8:

Relevant External Links for ZNF766 Gene

GeneLoc Exon Structure for
ZNF766

Expression for ZNF766 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF766 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF766

SOURCE GeneReport for Unigene cluster for ZNF766 Gene:

Hs.439662

Evidence on tissue expression from TISSUES for ZNF766 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with ZNF766: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF766 Gene

Orthologs for ZNF766 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF766 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZNF766 30 31
  • 99.15 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia -- 31
  • 43 (a)
ManyToMany
Cow
(Bos Taurus)
Mammalia -- 31
  • 34 (a)
ManyToMany
Species where no ortholog for ZNF766 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ZNF766 Gene

ENSEMBL:
Gene Tree for ZNF766 (if available)
TreeFam:
Gene Tree for ZNF766 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF766: view image

Paralogs for ZNF766 Gene

(511) SIMAP similar genes for ZNF766 Gene using alignment to 8 proteins:

  • ZN766_HUMAN
  • G3XAE0_HUMAN
  • M0QXI4_HUMAN
  • M0R139_HUMAN
  • M0R1P9_HUMAN
  • M0R2P3_HUMAN
  • M0R2R1_HUMAN
  • Q08EK0_HUMAN

Pseudogenes.org Pseudogenes for ZNF766 Gene

genes like me logo Genes that share paralogs with ZNF766: view

Variants for ZNF766 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF766 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs12462608 - p.Cys95Tyr

Additional dbSNP identifiers (rs#s) for ZNF766 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF766 Gene

Variant ID Type Subtype PubMed ID
nsv1140251 OTHER inversion 24896259
nsv833873 CNV gain 17160897
nsv960862 CNV duplication 23825009

Variation tolerance for ZNF766 Gene

Residual Variation Intolerance Score: 65.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.57; 30.33% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF766 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF766

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF766 Gene

Disorders for ZNF766 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZNF766 Gene - From: DISEASES

Disorder Aliases PubMed IDs
fanconi anemia, complementation group b
  • fancb
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with ZNF766: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF766 Gene

Publications for ZNF766 Gene

  1. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3
  3. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3
  5. Proteomic characterization of the human sperm nucleus. (PMID: 21630459) de Mateo S … Oliva R (Proteomics 2011) 3

Products for ZNF766 Gene

Sources for ZNF766 Gene