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Aliases for ZNF766 Gene

Aliases for ZNF766 Gene

  • Zinc Finger Protein 766 2 3 3 5

External Ids for ZNF766 Gene

Previous GeneCards Identifiers for ZNF766 Gene

  • GC19P057467
  • GC19P052772
  • GC19P049103

Summaries for ZNF766 Gene

GeneCards Summary for ZNF766 Gene

ZNF766 (Zinc Finger Protein 766) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF480.

UniProtKB/Swiss-Prot for ZNF766 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF766 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF766 Gene

Genomics for ZNF766 Gene

GeneHancer (GH) Regulatory Elements for ZNF766 Gene

Promoters and enhancers for ZNF766 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J052268 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 661.6 +0.7 660 2.6 HDGF PKNOX1 SMAD1 MLX ARID4B SIN3A DMAP1 YY1 POLR2B E2F8 ZNF766 ZNF701 ZNF600 ZNF808 ENSG00000268970 ENSG00000269001 ZNF137P SPACA6P-AS ZNF160 ZNF816
GH19J051687 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 94 -579.1 -579080 6.9 HDGF PKNOX1 ARNT SIN3A FEZF1 ZNF2 ZBTB7B E2F8 ZNF207 ZNF143 SPACA6 ZNF137P ZNF841 ZNF808 ZNF616 ZNF766 ZNF836 ZNF577 ENSG00000268970 ENSG00000269825
GH19J051393 Promoter/Enhancer 1.9 FANTOM5 Ensembl ENCODE 106.7 -874.5 -874524 2.8 HDGF PKNOX1 SMAD1 ARNT ZFP64 ARID4B SIN3A IRF4 YY1 POLR2B ENSG00000268889 LOC105372446 ZNF766 ZNF841 ZNF616 ZNF577 ZNF836 ZNF175 ZNF432 ZNF613
GH19J051360 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 42.2 -904.6 -904628 8.5 MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC PPARGC1A MEF2D ETFB CLDND2 ENSG00000268520 ZNF836 POLD1 ZNF616 ZNF766 ZNF175 ZNF841 ZNF577
GH19J052137 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 36.4 -129.9 -129939 3.3 PKNOX1 FOXA2 SMAD1 ARNT ARID4B SIN3A DMAP1 YY1 POLR2B E2F8 ZNF616 ZNF137P ZNF160 ZNF808 ENSG00000268970 ZNF600 ZNF350 ZNF816 ZNF836 ZNF577
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF766 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF766 gene promoter:
  • ATF-2
  • c-Jun
  • AREB6
  • AP-1
  • c-Fos

Genomic Locations for ZNF766 Gene

Genomic Locations for ZNF766 Gene
chr19:52,269,571-52,296,046
(GRCh38/hg38)
Size:
26,476 bases
Orientation:
Plus strand
chr19:52,772,824-52,795,977
(GRCh37/hg19)
Size:
23,154 bases
Orientation:
Plus strand

Genomic View for ZNF766 Gene

Genes around ZNF766 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF766 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF766 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF766 Gene

Proteins for ZNF766 Gene

  • Protein details for ZNF766 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5HY98-ZN766_HUMAN
    Recommended name:
    Zinc finger protein 766
    Protein Accession:
    Q5HY98
    Secondary Accessions:
    • B2RNE0
    • Q7Z326

    Protein attributes for ZNF766 Gene

    Size:
    468 amino acids
    Molecular mass:
    54507 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAD98055.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ZNF766 Gene

Post-translational modifications for ZNF766 Gene

  • Ubiquitination at posLast=157157
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ZNF766 Gene

Domains & Families for ZNF766 Gene

Gene Families for ZNF766 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF766 Gene

Suggested Antigen Peptide Sequences for ZNF766 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5HY98

UniProtKB/Swiss-Prot:

ZN766_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF766: view

Function for ZNF766 Gene

Molecular function for ZNF766 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF766 Gene

Gene Ontology (GO) - Molecular Function for ZNF766 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding ISA --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF766: view
genes like me logo Genes that share phenotypes with ZNF766: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF766 Gene

Localization for ZNF766 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF766 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF766 gene
Compartment Confidence
nucleus 5
cytoskeleton 3
mitochondrion 1
peroxisome 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF766 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus HDA,IEA 21630459
genes like me logo Genes that share ontologies with ZNF766: view

Pathways & Interactions for ZNF766 Gene

SuperPathways for ZNF766 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF766 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with ZNF766: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF766 Gene

Drugs & Compounds for ZNF766 Gene

No Compound Related Data Available

Transcripts for ZNF766 Gene

mRNA/cDNA for ZNF766 Gene

(4) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(9) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF766 Gene

Zinc finger protein 766:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF766 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d · 8e · 8f
SP1: - - - - -
SP2: - - - - - -
SP3: - - - - -
SP4: - - -
SP5: - - - -
SP6: -
SP7: - - - - - - -
SP8:

Relevant External Links for ZNF766 Gene

GeneLoc Exon Structure for
ZNF766
ECgene alternative splicing isoforms for
ZNF766

Expression for ZNF766 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF766 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF766 Gene:

ZNF766

SOURCE GeneReport for Unigene cluster for ZNF766 Gene:

Hs.439662

Evidence on tissue expression from TISSUES for ZNF766 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with ZNF766: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF766 Gene

Orthologs for ZNF766 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF766 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF766 34 33
  • 99.15 (n)
OneToOne
dog
(Canis familiaris)
Mammalia -- 34
  • 43 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia -- 34
  • 34 (a)
ManyToMany
Species where no ortholog for ZNF766 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF766 Gene

ENSEMBL:
Gene Tree for ZNF766 (if available)
TreeFam:
Gene Tree for ZNF766 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF766: view image

Paralogs for ZNF766 Gene

Paralogs for ZNF766 Gene

(511) SIMAP similar genes for ZNF766 Gene using alignment to 8 proteins:

  • ZN766_HUMAN
  • G3XAE0_HUMAN
  • M0QXI4_HUMAN
  • M0R139_HUMAN
  • M0R1P9_HUMAN
  • M0R2P3_HUMAN
  • M0R2R1_HUMAN
  • Q08EK0_HUMAN

Pseudogenes.org Pseudogenes for ZNF766 Gene

genes like me logo Genes that share paralogs with ZNF766: view

Variants for ZNF766 Gene

Sequence variations from dbSNP and Humsavar for ZNF766 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000000713 -- 52,278,160(+) A/G intron_variant
rs1000102521 -- 52,289,399(+) A/G intron_variant
rs1000245302 -- 52,273,278(+) G/T genic_upstream_transcript_variant, intron_variant
rs1000456929 -- 52,268,079(+) A/G upstream_transcript_variant
rs1000653812 -- 52,274,976(+) C/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF766 Gene

Variant ID Type Subtype PubMed ID
nsv1140251 OTHER inversion 24896259
nsv833873 CNV gain 17160897
nsv960862 CNV duplication 23825009

Variation tolerance for ZNF766 Gene

Residual Variation Intolerance Score: 65.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.57; 30.33% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF766 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF766

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF766 Gene

Disorders for ZNF766 Gene

Additional Disease Information for ZNF766

No disorders were found for ZNF766 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF766 Gene

Publications for ZNF766 Gene

  1. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  2. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 58
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 58
  4. Proteomic characterization of the human sperm nucleus. (PMID: 21630459) de Mateo S … Oliva R (Proteomics 2011) 3 58
  5. The full-ORF clone resource of the German cDNA Consortium. (PMID: 17974005) Bechtel S … Schupp I (BMC genomics 2007) 4 58

Products for ZNF766 Gene

Sources for ZNF766 Gene

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