Aliases for ZNF765 Gene

Aliases for ZNF765 Gene

  • Zinc Finger Protein 765 2 3 4 5
  • ZNF765 5

External Ids for ZNF765 Gene

Previous GeneCards Identifiers for ZNF765 Gene

  • GC19P058591
  • GC19P053898
  • GC19P050219

Summaries for ZNF765 Gene

GeneCards Summary for ZNF765 Gene

ZNF765 (Zinc Finger Protein 765) is a Protein Coding gene. Among its related pathways are Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF813.

UniProtKB/Swiss-Prot Summary for ZNF765 Gene

Additional gene information for ZNF765 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF765 Gene

Genomics for ZNF765 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF765 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF765 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF765

Top Transcription factor binding sites by QIAGEN in the ZNF765 gene promoter:
  • AREB6
  • Ik-1
  • IRF-1

Genomic Locations for ZNF765 Gene

Genomic Locations for ZNF765 Gene
chr19:53,389,793-53,430,413
(GRCh38/hg38)
Size:
40,621 bases
Orientation:
Plus strand
chr19:53,893,046-53,930,574
(GRCh37/hg19)
Size:
37,529 bases
Orientation:
Plus strand

Genomic View for ZNF765 Gene

Genes around ZNF765 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF765 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF765 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF765 Gene

Proteins for ZNF765 Gene

  • Protein details for ZNF765 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7L2R6-ZN765_HUMAN
    Recommended name:
    Zinc finger protein 765
    Protein Accession:
    Q7L2R6
    Secondary Accessions:
    • A8MYG0
    • B4DF18
    • B7ZAI5
    • B9EIL1
    • Q9BV49

    Protein attributes for ZNF765 Gene

    Size:
    523 amino acids
    Molecular mass:
    61633 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

    Alternative splice isoforms for ZNF765 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF765 Gene

Post-translational modifications for ZNF765 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF765 Gene

No data available for DME Specific Peptides for ZNF765 Gene

Domains & Families for ZNF765 Gene

Gene Families for ZNF765 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF765 Gene

InterPro:
Blocks:
  • KRAB box
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF765 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 765 (ZN765_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q7L2R6

UniProtKB/Swiss-Prot:

ZN765_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF765: view

Function for ZNF765 Gene

Molecular function for ZNF765 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF765 Gene

Gene Ontology (GO) - Molecular Function for ZNF765 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0016503 pheromone receptor activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF765: view

Phenotypes for ZNF765 Gene

genes like me logo Genes that share phenotypes with ZNF765: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF765

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZNF765 Gene

Localization for ZNF765 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF765 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF765 gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF765 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ZNF765: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZNF765 Gene

Pathways & Interactions for ZNF765 Gene

PathCards logo

SuperPathways for ZNF765 Gene

genes like me logo Genes that share pathways with ZNF765: view

Pathways by source for ZNF765 Gene

1 KEGG pathway for ZNF765 Gene

Gene Ontology (GO) - Biological Process for ZNF765 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with ZNF765: view

No data available for SIGNOR curated interactions for ZNF765 Gene

Drugs & Compounds for ZNF765 Gene

No Compound Related Data Available

Transcripts for ZNF765 Gene

mRNA/cDNA for ZNF765 Gene

2 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF765

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF765 Gene

No ASD Table

Relevant External Links for ZNF765 Gene

GeneLoc Exon Structure for
ZNF765

Expression for ZNF765 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF765 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF765

SOURCE GeneReport for Unigene cluster for ZNF765 Gene:

Hs.685640

Evidence on tissue expression from TISSUES for ZNF765 Gene

  • Lung(4.6)
  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with ZNF765: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF765 Gene

Orthologs for ZNF765 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF765 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia -- 31
  • 96 (a)
ManyToMany
Dog
(Canis familiaris)
Mammalia -- 31
  • 50 (a)
ManyToMany
Cow
(Bos Taurus)
Mammalia -- 31
  • 37 (a)
ManyToMany
Species where no ortholog for ZNF765 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ZNF765 Gene

ENSEMBL:
Gene Tree for ZNF765 (if available)
TreeFam:
Gene Tree for ZNF765 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF765: view image

Paralogs for ZNF765 Gene

(491) SIMAP similar genes for ZNF765 Gene using alignment to 3 proteins:

  • ZN765_HUMAN
  • D6RF03_HUMAN
  • E9PDE6_HUMAN

Pseudogenes.org Pseudogenes for ZNF765 Gene

genes like me logo Genes that share paralogs with ZNF765: view

Variants for ZNF765 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF765 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs10425136 - p.Ser389Gly

Additional dbSNP identifiers (rs#s) for ZNF765 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF765 Gene

Variant ID Type Subtype PubMed ID
dgv3646n100 CNV loss 25217958
dgv3647n100 CNV loss 25217958
dgv530e201 CNV deletion 23290073
dgv6535n54 CNV gain 21841781
dgv6536n54 CNV gain 21841781
esv2718812 CNV deletion 23290073
esv2758770 CNV loss 17122850
esv3556588 CNV deletion 23714750
esv3574764 CNV gain 25503493
esv3583515 CNV loss 25503493
esv3644752 CNV gain 21293372
esv3644754 CNV loss 21293372
esv3644755 CNV loss 21293372
esv3893242 CNV loss 25118596
esv3893243 CNV gain 25118596
esv8848 CNV loss 19470904
nsv1055773 CNV gain 25217958
nsv1064557 CNV gain 25217958
nsv1160662 CNV deletion 26073780
nsv458767 CNV loss 19166990
nsv458768 CNV loss 19166990
nsv470154 CNV loss 18288195
nsv515728 CNV gain+loss 19592680
nsv521988 CNV loss 19592680
nsv580082 CNV loss 21841781
nsv580086 CNV loss 21841781
nsv817866 CNV gain 17921354
nsv9749 CNV loss 18304495
nsv978846 CNV duplication 23825009

Variation tolerance for ZNF765 Gene

Residual Variation Intolerance Score: 59.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.91; 59.32% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF765 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF765

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF765 Gene

Disorders for ZNF765 Gene

Additional Disease Information for ZNF765

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform

No disorders were found for ZNF765 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF765 Gene

Publications for ZNF765 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3
  4. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  5. VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. (PMID: 29507755) Yue Y … Liu J (Cell discovery 2018) 3

Products for ZNF765 Gene

Sources for ZNF765 Gene