Aliases for ZNF761 Gene

Aliases for ZNF761 Gene

  • Zinc Finger Protein 761 2 3 4 5
  • KIAA2033 2 4
  • Zinc Finger Protein 468 3
  • FLJ16231 2
  • FLJ35333 2
  • ZNF468 3
  • ZNF761 5

External Ids for ZNF761 Gene

Previous GeneCards Identifiers for ZNF761 Gene

  • GC19P058645
  • GC19P053936
  • GC19P050255

Summaries for ZNF761 Gene

GeneCards Summary for ZNF761 Gene

ZNF761 (Zinc Finger Protein 761) is a Protein Coding gene. Diseases associated with ZNF761 include Cloacal Exstrophy. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ENSG00000286261.

UniProtKB/Swiss-Prot Summary for ZNF761 Gene

Additional gene information for ZNF761 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF761 Gene

Genomics for ZNF761 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF761 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF761 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF761

Top Transcription factor binding sites by QIAGEN in the ZNF761 gene promoter:
  • Ik-3
  • IRF-1
  • MRF-2

Genomic Locations for ZNF761 Gene

Genomic Locations for ZNF761 Gene
chr19:53,431,984-53,458,261
(GRCh38/hg38)
Size:
26,278 bases
Orientation:
Plus strand
chr19:53,935,227-53,961,515
(GRCh37/hg19)
Size:
26,289 bases
Orientation:
Plus strand

Genomic View for ZNF761 Gene

Genes around ZNF761 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF761 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF761 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF761 Gene

Proteins for ZNF761 Gene

  • Protein details for ZNF761 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86XN6-ZN761_HUMAN
    Recommended name:
    Zinc finger protein 761
    Protein Accession:
    Q86XN6
    Secondary Accessions:
    • A0A087WXT7
    • Q6ZNB9

    Protein attributes for ZNF761 Gene

    Size:
    746 amino acids
    Molecular mass:
    87716 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC67660.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=BAD18456.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=BAD18456.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing in the N-terminal part.; Evidence={ECO:0000305};

neXtProt entry for ZNF761 Gene

Post-translational modifications for ZNF761 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF761 Gene

No data available for DME Specific Peptides for ZNF761 Gene

Domains & Families for ZNF761 Gene

Gene Families for ZNF761 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ZNF761 Gene

InterPro:
Blocks:
  • KRAB box
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF761 Gene

GenScript: Design optimal peptide antigens:
  • ZNF761 protein (Q6IQ01_HUMAN)
  • Zinc finger protein 761 (ZN761_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q86XN6

UniProtKB/Swiss-Prot:

ZN761_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF761: view

Function for ZNF761 Gene

Molecular function for ZNF761 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF761 Gene

Gene Ontology (GO) - Molecular Function for ZNF761 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF761: view

Phenotypes for ZNF761 Gene

GenomeRNAi human phenotypes for ZNF761:
genes like me logo Genes that share phenotypes with ZNF761: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF761

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF761 Gene

Localization for ZNF761 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF761 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF761 gene
Compartment Confidence
nucleus 3
mitochondrion 1

Gene Ontology (GO) - Cellular Components for ZNF761 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF761: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZNF761 Gene

Pathways & Interactions for ZNF761 Gene

genes like me logo Genes that share pathways with ZNF761: view

Pathways by source for ZNF761 Gene

2 Reactome pathways for ZNF761 Gene
1 KEGG pathway for ZNF761 Gene

Interacting Proteins for ZNF761 Gene

Gene Ontology (GO) - Biological Process for ZNF761 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF761: view

No data available for SIGNOR curated interactions for ZNF761 Gene

Drugs & Compounds for ZNF761 Gene

No Compound Related Data Available

Transcripts for ZNF761 Gene

mRNA/cDNA for ZNF761 Gene

4 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF761

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF761 Gene

No ASD Table

Relevant External Links for ZNF761 Gene

GeneLoc Exon Structure for
ZNF761

Expression for ZNF761 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF761 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZNF761 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF761

SOURCE GeneReport for Unigene cluster for ZNF761 Gene:

Hs.433293

Evidence on tissue expression from TISSUES for ZNF761 Gene

  • Nervous system(4)
genes like me logo Genes that share expression patterns with ZNF761: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF761 Gene

Orthologs for ZNF761 Gene

This gene was present in the common ancestor of human and mouse.

Orthologs for ZNF761 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZNF761 30
  • 98.66 (n)
Mouse
(Mus musculus)
Mammalia Zfp51 30 17
  • 63.98 (n)
Rat
(Rattus norvegicus)
Mammalia Znf761 30
  • 63.75 (n)
Species where no ortholog for ZNF761 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ZNF761 Gene

ENSEMBL:
Gene Tree for ZNF761 (if available)
TreeFam:
Gene Tree for ZNF761 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF761: view image

Paralogs for ZNF761 Gene

(515) SIMAP similar genes for ZNF761 Gene using alignment to 2 proteins:

  • ZN761_HUMAN
  • Q6IQ01_HUMAN
genes like me logo Genes that share paralogs with ZNF761: view

Variants for ZNF761 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF761 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs139713552 - p.Ile678Val
rs1984432 - p.Val168Ile
rs2617726 - p.Glu603Gln
rs2708742 - p.Gly528Ser
rs2708743 - p.Ile122Ser

Additional dbSNP identifiers (rs#s) for ZNF761 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF761 Gene

Variant ID Type Subtype PubMed ID
dgv1071e212 CNV gain 25503493
dgv3646n100 CNV loss 25217958
dgv3647n100 CNV loss 25217958
dgv3648n100 CNV gain 25217958
dgv3649n100 CNV loss 25217958
dgv3650n100 CNV gain+loss 25217958
dgv3651n100 CNV gain 25217958
dgv3652n100 CNV gain 25217958
dgv431n27 CNV gain 19166990
dgv530e201 CNV deletion 23290073
dgv6535n54 CNV gain 21841781
dgv6536n54 CNV gain 21841781
dgv6537n54 CNV gain 21841781
dgv6538n54 CNV loss 21841781
dgv6539n54 CNV loss 21841781
dgv661e199 CNV deletion 23128226
dgv88e19 CNV loss 19470904
esv2491793 CNV deletion 19546169
esv2718812 CNV deletion 23290073
esv2718823 CNV deletion 23290073
esv2758770 CNV loss 17122850
esv2762954 CNV gain+loss 21179565
esv3310473 CNV novel sequence insertion 20981092
esv3403561 CNV insertion 20981092
esv3556588 CNV deletion 23714750
esv3583517 CNV loss 25503493
esv3644756 CNV gain 21293372
esv3644757 CNV loss 21293372
esv3644758 CNV gain 21293372
esv3644759 CNV loss 21293372
esv3893241 CNV gain+loss 25118596
esv3893242 CNV loss 25118596
esv3893243 CNV gain 25118596
esv3893244 CNV gain 25118596
esv8848 CNV loss 19470904
nsv1055497 CNV gain 25217958
nsv1055773 CNV gain 25217958
nsv1059834 CNV gain 25217958
nsv1160662 CNV deletion 26073780
nsv458767 CNV loss 19166990
nsv458768 CNV loss 19166990
nsv470154 CNV loss 18288195
nsv470156 CNV gain 18288195
nsv515728 CNV gain+loss 19592680
nsv521988 CNV loss 19592680
nsv580082 CNV loss 21841781
nsv580086 CNV loss 21841781
nsv580097 CNV gain+loss 21841781
nsv580101 CNV gain 21841781
nsv580104 CNV gain 21841781
nsv956579 CNV deletion 24416366
nsv963077 CNV duplication 23825009

Additional Variant Information for ZNF761 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF761

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for ZNF761 Gene

Disorders for ZNF761 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZNF761 Gene - From: DISEASES

Disorder Aliases PubMed IDs
cloacal exstrophy
  • oeis complex
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with ZNF761: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF761 Gene

Publications for ZNF761 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3
  3. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4
  4. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A … Hentze MW (Cell 2012) 3
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for ZNF761 Gene

Sources for ZNF761 Gene