Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ZNF76 Gene

Aliases for ZNF76 Gene

  • Zinc Finger Protein 76 2 3 5
  • Zinc Finger Protein 76 (Expressed In Testis) 2 3
  • Zinc Finger Protein 523 3 4
  • D6S229E 3 4
  • ZNF523 3 4
  • Zfp523 3

External Ids for ZNF76 Gene

Previous HGNC Symbols for ZNF76 Gene

  • D6S229E

Previous GeneCards Identifiers for ZNF76 Gene

  • GC06P035229
  • GC06P035274
  • GC06P035335
  • GC06P034948
  • GC06P035227
  • GC06P035323
  • GC06P035779
  • GC06P036306
  • GC06P037292
  • GC06P035481
  • GC06P035534
  • GC06P037762
  • GC06P038386
  • GC06P038976
  • GC06P039564
  • GC06P040125

Summaries for ZNF76 Gene

GeneCards Summary for ZNF76 Gene

ZNF76 (Zinc Finger Protein 76) is a Protein Coding gene. Diseases associated with ZNF76 include Cataract 1, Multiple Types. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF143.

UniProtKB/Swiss-Prot for ZNF76 Gene

  • May be involved in transcriptional regulation.

Gene Wiki entry for ZNF76 Gene

Additional gene information for ZNF76 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF76 Gene

Genomics for ZNF76 Gene

GeneHancer (GH) Regulatory Elements for ZNF76 Gene

Promoters and enhancers for ZNF76 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06I035258 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE 582 +1.3 1290 4.1 MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC ZNF76 GC06M038602 LOC101929285 TAF11 ENSG00000272374 DEF6 RPL10A RPS10 ENSG00000219023 TCP11
GH06I035264 Promoter 0.7 EPDnew 550.4 +5.8 5779 0.1 SCRT1 SCRT2 ZNF395 ZNF76 GC06M038602 ENSG00000217004
GH06I035467 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 40.7 +211.2 211231 5.4 CLOCK MLX ZFP64 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 RPL10A MIR7111 TAF11 BRPF3 ZNF76 ENSG00000272374 FANCE PPARD ARMC12 ANKS1A
GH06I035723 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 33.3 +470.2 470188 10.8 FEZF1 DMAP1 YY1 SLC30A9 ZNF213 ZNF143 ZNF548 MCM3 SP3 NFYC FKBP5 TAF11 SRSF3 ZNF76 ENSG00000272374 RPL10A STK38 ENSG00000219023 FANCE PPARD
GH06I035686 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 19.7 +428.9 428908 3.6 HDGF PKNOX1 CLOCK FOXA2 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 FKBP5 TAF11 SRSF3 ENSG00000272374 MAPK14 ZNF76 RPL10A ARMC12 ENSG00000232909 STK38
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF76 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF76 gene promoter:

Genomic Locations for ZNF76 Gene

Genomic Locations for ZNF76 Gene
chr6:35,258,909-35,295,987
(GRCh38/hg38)
Size:
37,079 bases
Orientation:
Plus strand
chr6:35,226,686-35,263,762
(GRCh37/hg19)

Genomic View for ZNF76 Gene

Genes around ZNF76 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF76 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF76 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF76 Gene

Proteins for ZNF76 Gene

  • Protein details for ZNF76 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P36508-ZNF76_HUMAN
    Recommended name:
    Zinc finger protein 76
    Protein Accession:
    P36508
    Secondary Accessions:
    • Q9BQB2

    Protein attributes for ZNF76 Gene

    Size:
    570 amino acids
    Molecular mass:
    61831 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF76 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF76 Gene

Post-translational modifications for ZNF76 Gene

No Post-translational modifications

No data available for DME Specific Peptides for ZNF76 Gene

Domains & Families for ZNF76 Gene

Gene Families for ZNF76 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF76 Gene

Suggested Antigen Peptide Sequences for ZNF76 Gene

Graphical View of Domain Structure for InterPro Entry

P36508

UniProtKB/Swiss-Prot:

ZNF76_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF76: view

Function for ZNF76 Gene

Molecular function for ZNF76 Gene

GENATLAS Biochemistry:
zinc finger protein 76 (C2H2 type,Kruppel-like),transactivator protein,DNA protein related to Xenopus laevis STAF and ZNF143
UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF76 Gene

Gene Ontology (GO) - Molecular Function for ZNF76 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA 10893243
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0043565 sequence-specific DNA binding IDA 10893243
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF76: view
genes like me logo Genes that share phenotypes with ZNF76: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF76 Gene

Localization for ZNF76 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF76 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF76 gene
Compartment Confidence
nucleus 5
cytoskeleton 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF76 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF76: view

Pathways & Interactions for ZNF76 Gene

SuperPathways for ZNF76 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF76 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II TAS 9705341
GO:0006359 regulation of transcription by RNA polymerase III TAS 9705341
GO:0006366 transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with ZNF76: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF76 Gene

Drugs & Compounds for ZNF76 Gene

No Compound Related Data Available

Transcripts for ZNF76 Gene

Unigene Clusters for ZNF76 Gene

Zinc finger protein 76:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF76 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b · 13c · 13d ^ 14 ^ 15 ^
SP1: - - -
SP2: - - - -
SP3: - - -
SP4: - - - - - -
SP5: - - -
SP6: -
SP7: - - -
SP8: -
SP9: - -
SP10:

ExUns: 16 ^ 17
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for ZNF76 Gene

GeneLoc Exon Structure for
ZNF76
ECgene alternative splicing isoforms for
ZNF76

Expression for ZNF76 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF76 Gene

Protein differential expression in normal tissues from HIPED for ZNF76 Gene

This gene is overexpressed in Plasma (61.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZNF76 Gene



Protein tissue co-expression partners for ZNF76 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF76 Gene:

ZNF76

SOURCE GeneReport for Unigene cluster for ZNF76 Gene:

Hs.388024

mRNA Expression by UniProt/SwissProt for ZNF76 Gene:

P36508-ZNF76_HUMAN
Tissue specificity: Testis.
genes like me logo Genes that share expression patterns with ZNF76: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF76 Gene

Orthologs for ZNF76 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF76 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF76 33 34
  • 99.24 (n)
oppossum
(Monodelphis domestica)
Mammalia ZNF76 34
  • 92 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF76 33 34
  • 90.92 (n)
dog
(Canis familiaris)
Mammalia ZNF76 33 34
  • 90.76 (n)
rat
(Rattus norvegicus)
Mammalia Zfp523 33
  • 89.08 (n)
mouse
(Mus musculus)
Mammalia Zfp523 33 16 34
  • 88.91 (n)
chicken
(Gallus gallus)
Aves ZNF76 33 34
  • 68.25 (n)
zebrafish
(Danio rerio)
Actinopterygii zgc:153635 33
  • 66.14 (n)
ZNF76 34
  • 63 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 52 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8333 33
Species where no ortholog for ZNF76 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF76 Gene

ENSEMBL:
Gene Tree for ZNF76 (if available)
TreeFam:
Gene Tree for ZNF76 (if available)

Paralogs for ZNF76 Gene

Paralogs for ZNF76 Gene

(191) SIMAP similar genes for ZNF76 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ZNF76: view

Variants for ZNF76 Gene

Sequence variations from dbSNP and Humsavar for ZNF76 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000057218 -- 35,259,759(+) G/C 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant, non_coding_transcript_variant
rs1000138451 -- 35,268,851(+) G/A genic_upstream_transcript_variant, intron_variant
rs1000177145 -- 35,288,352(+) A/G intron_variant
rs1000359561 -- 35,295,892(+) G/T 3_prime_UTR_variant, genic_downstream_transcript_variant, non_coding_transcript_variant
rs1000409778 -- 35,281,842(+) A/AA genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF76 Gene

Variant ID Type Subtype PubMed ID
esv2750621 CNV gain 17666407
esv2759419 CNV loss 17122850

Variation tolerance for ZNF76 Gene

Residual Variation Intolerance Score: 79.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.57; 77.97% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF76 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF76

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF76 Gene

Disorders for ZNF76 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZNF76 Gene - From: DISEASES

Disorder Aliases PubMed IDs
cataract 1, multiple types
  • ctrct1
- elite association - COSMIC cancer census association via MalaCards
Search ZNF76 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ZNF76

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with ZNF76: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF76 Gene

Publications for ZNF76 Gene

  1. A testis-expressed Zn finger gene (ZNF76) in human 6p21.3 centromeric to the MHC is closely linked to the human homolog of the t-complex gene tcp-11. (PMID: 1427894) Ragoussis J … Trowsdale J (Genomics 1992) 2 3 4 58
  2. The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature. (PMID: 20546612) Zhao J … Grant SF (BMC medical genetics 2010) 3 44 58
  3. Risk of meningioma and common variation in genes related to innate immunity. (PMID: 20406964) Rajaraman P … Inskip PD (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2010) 3 44 58
  4. Polymorphisms in innate immunity genes and risk of childhood leukemia. (PMID: 20438785) Han S … Kang D (Human immunology 2010) 3 44 58
  5. Many sequence variants affecting diversity of adult human height. (PMID: 18391951) Gudbjartsson DF … Stefansson K (Nature genetics 2008) 3 44 58

Products for ZNF76 Gene

Sources for ZNF76 Gene

Content
Loading form....