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Aliases for ZNF75D Gene

Aliases for ZNF75D Gene

  • Zinc Finger Protein 75D 2 3 5
  • Zinc Finger Protein 82 3 4
  • Zinc Finger Protein 75 3 4
  • ZNF75 3 4
  • ZNF82 3 4
  • Zinc Finger Protein 75 (D8C6) 2
  • ZKSCAN24 3
  • ZSCAN28 3
  • D8C6 3

External Ids for ZNF75D Gene

Previous HGNC Symbols for ZNF75D Gene

  • ZNF82
  • ZNF75

Previous GeneCards Identifiers for ZNF75D Gene

  • GC0XM134248
  • GC0XM134384
  • GC0XM123779

Summaries for ZNF75D Gene

Entrez Gene Summary for ZNF75D Gene

  • This gene encodes a protein that likely functions as a transcription factor. The protein, which belongs to the ZNF75 family, includes an N-terminal SCAN domain, a KRAB box, and five C2H2-type zinc finger motifs. Another functional gene belonging to this family is located on chromosome 16, while pseudogenes have been identified on chromosomes 11 and 12. Alternative splicing results in multiple transcripts variants. [provided by RefSeq, Jun 2010]

GeneCards Summary for ZNF75D Gene

ZNF75D (Zinc Finger Protein 75D) is a Protein Coding gene. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA binding transcription factor activity. An important paralog of this gene is ZNF75A.

UniProtKB/Swiss-Prot for ZNF75D Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF75D Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF75D Gene

Genomics for ZNF75D Gene

GeneHancer (GH) Regulatory Elements for ZNF75D Gene

Promoters and enhancers for ZNF75D Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XI135340 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 +1.1 1149 5.3 HDGF PKNOX1 ARNT ARID4B SIN3A FEZF1 ZNF2 YY1 POLR2B ZNF766 ZNF449 ZNF75D PIR55917 RTL8B LOC105373342
GH0XI135295 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE 550.2 +48.6 48612 1.2 CTCF IKZF1 NBN LOC100421043 ZNF75D ETDA
GH0XI135519 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 27.8 -177.4 -177388 5 PKNOX1 SMAD1 ARNT SIN3A YY1 POLR2B ZNF766 ZNF143 KLF13 SP3 INTS6L INTS6L-AS1 ZNF75D PIR34853
GH0XI134989 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE 24.7 +353.5 353457 2.4 SMAD1 ATF1 GLI4 ZNF2 ZNF121 ZNF766 GLIS2 E2F8 KLF7 ATF7 SMIM10 ZNF75D RTL8B
GH0XI134913 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE 23.3 +429.7 429748 2.1 PKNOX1 ARID4B SIN3A GLI4 ZNF2 ZNF121 POLR2B ZNF766 ZNF143 ATF7 MOSPD1 ZNF75D INTS6L FAM122B PHF6 RTL8B GC0XP134864
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF75D on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF75D gene promoter:

Genomic Locations for ZNF75D Gene

Genomic Locations for ZNF75D Gene
96,030 bases
Minus strand

Genomic View for ZNF75D Gene

Genes around ZNF75D on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF75D Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF75D Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF75D Gene

Proteins for ZNF75D Gene

  • Protein details for ZNF75D Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 75D
    Protein Accession:
    Secondary Accessions:
    • A6NK62
    • B3KRI7
    • Q5JPG0
    • Q6LDE0

    Protein attributes for ZNF75D Gene

    510 amino acids
    Molecular mass:
    59298 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF75D Gene


neXtProt entry for ZNF75D Gene

Post-translational modifications for ZNF75D Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF75D Gene

Domains & Families for ZNF75D Gene

Gene Families for ZNF75D Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Suggested Antigen Peptide Sequences for ZNF75D Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF75D: view

Function for ZNF75D Gene

Molecular function for ZNF75D Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF75D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity IEA --
GO:0008270 zinc ion binding NAS 8288223
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF75D: view

Phenotypes for ZNF75D Gene

genes like me logo Genes that share phenotypes with ZNF75D: view

Animal Model Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF75D Gene

Localization for ZNF75D Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF75D Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF75D gene
Compartment Confidence
nucleus 5
golgi apparatus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF75D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF75D: view

Pathways & Interactions for ZNF75D Gene

SuperPathways for ZNF75D Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF75D: view

Pathways by source for ZNF75D Gene

2 Reactome pathways for ZNF75D Gene

Interacting Proteins for ZNF75D Gene

Gene Ontology (GO) - Biological Process for ZNF75D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF75D: view

No data available for SIGNOR curated interactions for ZNF75D Gene

Drugs & Compounds for ZNF75D Gene

(1) Drugs for ZNF75D Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Zinc Approved, Investigational Pharma 2430
genes like me logo Genes that share compounds with ZNF75D: view

Transcripts for ZNF75D Gene

Unigene Clusters for ZNF75D Gene

Zinc finger protein 75D:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF75D Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b
SP1: - - -
SP2: - - - -
SP3: - -

Relevant External Links for ZNF75D Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF75D Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF75D Gene

Protein differential expression in normal tissues from HIPED for ZNF75D Gene

This gene is overexpressed in Adipocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF75D Gene

Protein tissue co-expression partners for ZNF75D Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF75D Gene:


SOURCE GeneReport for Unigene cluster for ZNF75D Gene:


Evidence on tissue expression from TISSUES for ZNF75D Gene

  • Nervous system(4.3)
  • Lung(4.2)
  • Lymph node(4.2)
genes like me logo Genes that share expression patterns with ZNF75D: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF75D Gene

Orthologs for ZNF75D Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF75D Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF75D 33 34
  • 99.74 (n)
(Canis familiaris)
Mammalia ZNF75D 33 34
  • 87.1 (n)
(Bos Taurus)
Mammalia ZNF75D 33 34
  • 83.47 (n)
-- 34
  • 62 (a)
ZNF75 34
  • 61 (a)
-- 34
  • 57 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 38 (a)
Species where no ortholog for ZNF75D was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF75D Gene

Gene Tree for ZNF75D (if available)
Gene Tree for ZNF75D (if available)

Paralogs for ZNF75D Gene

Paralogs for ZNF75D Gene Pseudogenes for ZNF75D Gene

genes like me logo Genes that share paralogs with ZNF75D: view

Variants for ZNF75D Gene

Sequence variations from dbSNP and Humsavar for ZNF75D Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs782539023 benign, Abnormality of neuronal migration 135,287,570(-) C/G/T coding_sequence_variant, intron_variant, missense_variant
rs1000015206 -- 135,285,173(-) G/A genic_downstream_transcript_variant, intron_variant
rs1000123787 -- 135,275,937(-) C/A genic_downstream_transcript_variant, intron_variant
rs1000125013 -- 135,345,515(-) G/A upstream_transcript_variant
rs1000236163 -- 135,284,526(-) T/G genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF75D Gene

Variant ID Type Subtype PubMed ID
esv2758894 CNV gain 17122850
nsv469825 CNV loss 16826518
nsv469871 CNV loss 16826518
nsv7104 CNV deletion 18451855
nsv7458 OTHER inversion 18451855

Variation tolerance for ZNF75D Gene

Residual Variation Intolerance Score: 49.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.46; 9.99% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF75D Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF75D Gene

Disorders for ZNF75D Gene

Additional Disease Information for ZNF75D

No disorders were found for ZNF75D Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF75D Gene

Publications for ZNF75D Gene

  1. Isolation of a zinc finger motif (ZNF75) mapping on chromosome Xq26. (PMID: 1505955) Villa A … Redolfi E (Genomics 1992) 2 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. ZNF75: isolation of a cDNA clone of the KRAB zinc finger gene subfamily mapped in YACs 1 Mb telomeric of HPRT. (PMID: 8288223) Villa A … Repetto M (Genomics 1993) 3 4 58
  4. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L … Andersson-Svahn H (Molecular & cellular proteomics : MCP 2008) 3 58
  5. The full-ORF clone resource of the German cDNA Consortium. (PMID: 17974005) Bechtel S … Schupp I (BMC genomics 2007) 4 58

Products for ZNF75D Gene

Sources for ZNF75D Gene

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