Aliases for ZNF75A Gene

Aliases for ZNF75A Gene

  • Zinc Finger Protein 75a 2 3 5
  • Zinc Finger Protein 75A 3 4
  • FLJ31529 2
  • ZNF75A 5

External Ids for ZNF75A Gene

Previous GeneCards Identifiers for ZNF75A Gene

  • GC16U990066
  • GC16P003389
  • GC16P003355
  • GC16P003295
  • GC16P003325
  • GC16P003306
  • GC16P003777
  • GC16P003854
  • GC16P003904
  • GC16P004079
  • GC16P003318
  • GC16P003375
  • GC16P003410
  • GC16P003455
  • GC16P003488
  • GC16P003574
  • GC16P003621

Summaries for ZNF75A Gene

GeneCards Summary for ZNF75A Gene

ZNF75A (Zinc Finger Protein 75a) is a Protein Coding gene. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA-binding transcription factor activity. An important paralog of this gene is ZNF75D.

UniProtKB/Swiss-Prot Summary for ZNF75A Gene

Additional gene information for ZNF75A Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF75A Gene

Genomics for ZNF75A Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF75A Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF75A on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF75A

Top Transcription factor binding sites by QIAGEN in the ZNF75A gene promoter:
  • FOXL1
  • GATA-1
  • Ik-2
  • Meis-1
  • Meis-1a
  • Meis-1b
  • MZF-1

Genomic Locations for ZNF75A Gene

Genomic Locations for ZNF75A Gene
17,594 bases
Plus strand
13,447 bases
Plus strand

Genomic View for ZNF75A Gene

Genes around ZNF75A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF75A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF75A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF75A Gene

Proteins for ZNF75A Gene

  • Protein details for ZNF75A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 75A
    Protein Accession:
    Secondary Accessions:
    • Q0VDI8
    • Q92669

    Protein attributes for ZNF75A Gene

    296 amino acids
    Molecular mass:
    34694 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF75A Gene

Post-translational modifications for ZNF75A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF75A Gene

Domains & Families for ZNF75A Gene

Gene Families for ZNF75A Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF75A Gene

  • C2H2-type zinc finger signature
  • KRAB box

Suggested Antigen Peptide Sequences for ZNF75A Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 75A (ZN75A_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF75A: view

Function for ZNF75A Gene

Molecular function for ZNF75A Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
GENATLAS Biochemistry:
zinc finger protein 75,related sequence A

Phenotypes From GWAS Catalog for ZNF75A Gene

Gene Ontology (GO) - Molecular Function for ZNF75A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity IEA,IBA 21873635
GO:0043565 sequence-specific DNA binding IBA 21873635
genes like me logo Genes that share ontologies with ZNF75A: view
genes like me logo Genes that share phenotypes with ZNF75A: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF75A

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF75A Gene

Localization for ZNF75A Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF75A Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF75A gene
Compartment Confidence
nucleus 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli fibrillar center (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF75A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IBA 21873635
genes like me logo Genes that share ontologies with ZNF75A: view

Pathways & Interactions for ZNF75A Gene

PathCards logo

SuperPathways for ZNF75A Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF75A: view

Pathways by source for ZNF75A Gene

2 Reactome pathways for ZNF75A Gene

Gene Ontology (GO) - Biological Process for ZNF75A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with ZNF75A: view

No data available for SIGNOR curated interactions for ZNF75A Gene

Drugs & Compounds for ZNF75A Gene

No Compound Related Data Available

Transcripts for ZNF75A Gene

mRNA/cDNA for ZNF75A Gene

11 NCBI additional mRNA sequence :
11 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF75A

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF75A Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c
SP1: - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - -
SP4: - - -
SP5: - - -
SP9: -

Relevant External Links for ZNF75A Gene

GeneLoc Exon Structure for

Expression for ZNF75A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF75A Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF75A Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF75A

SOURCE GeneReport for Unigene cluster for ZNF75A Gene:


Evidence on tissue expression from TISSUES for ZNF75A Gene

  • Blood(4.2)
genes like me logo Genes that share expression patterns with ZNF75A: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF75A Gene

Orthologs for ZNF75A Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF75A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF75A 30 31
  • 99.21 (n)
(Canis familiaris)
Mammalia ZNF75A 30
  • 89.94 (n)
-- 31
  • 50 (a)
-- 31
  • 49 (a)
(Bos Taurus)
Mammalia ZNF75A 30 31
  • 88.36 (n)
-- 31
  • 53 (a)
(Monodelphis domestica)
Mammalia ZNF75A 31
  • 34 (a)
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 4 (a)
Species where no ortholog for ZNF75A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ZNF75A Gene

Gene Tree for ZNF75A (if available)
Gene Tree for ZNF75A (if available)
Evolutionary constrained regions (ECRs) for ZNF75A: view image

Paralogs for ZNF75A Gene

(445) SIMAP similar genes for ZNF75A Gene using alignment to 2 proteins:

  • I3L2I5_HUMAN
genes like me logo Genes that share paralogs with ZNF75A: view

Variants for ZNF75A Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF75A Gene

SNP ID Clinical significance and condition Chr 16 pos Variation AA Info Type
VAR_035570 A breast cancer sample p.Gln228Glu
rs17611866 - p.Val84Ala

Additional dbSNP identifiers (rs#s) for ZNF75A Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF75A Gene

Variant ID Type Subtype PubMed ID
nsv1036149 CNV gain 25217958
nsv1044147 CNV loss 25217958

Variation tolerance for ZNF75A Gene

Residual Variation Intolerance Score: 22.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.28; 6.31% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF75A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF75A Gene

Disorders for ZNF75A Gene

Additional Disease Information for ZNF75A

No disorders were found for ZNF75A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF75A Gene

Publications for ZNF75A Gene

  1. The ZNF75 zinc finger gene subfamily: isolation and mapping of the four members in humans and great apes. (PMID: 8661144) Villa A … Vezzoni P (Genomics 1996) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3

Products for ZNF75A Gene

  • Signalway Proteins for ZNF75A

Sources for ZNF75A Gene