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Aliases for ZNF749 Gene

Aliases for ZNF749 Gene

  • Zinc Finger Protein 749 2 3 5

External Ids for ZNF749 Gene

Previous GeneCards Identifiers for ZNF749 Gene

  • GC19P062646
  • GC19P057946
  • GC19P054263

Summaries for ZNF749 Gene

GeneCards Summary for ZNF749 Gene

ZNF749 (Zinc Finger Protein 749) is a Protein Coding gene. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF17.

UniProtKB/Swiss-Prot for ZNF749 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF749 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF749 Gene

Genomics for ZNF749 Gene

GeneHancer (GH) Regulatory Elements for ZNF749 Gene

Promoters and enhancers for ZNF749 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I057434 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 564.6 +7.0 6968 2.4 PKNOX1 MLX ARID4B SIN3A ZNF2 YY1 POLR2B ZNF766 ZNF143 FOS ZNF749 ZNF324B ZNF264 ZNF543 ZNF134 ZNF416 ZNF256 ZNF805 ZNF17 ZNF304
GH19I057681 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 20.3 +253.6 253578 1.6 PKNOX1 ARID4B SIN3A DMAP1 YY1 POLR2B E2F8 ZNF416 ZNF207 ZNF143 ZNF551 ENSG00000269026 GC19P057683 ZNF17 ZNF549 ZNF304 ZNF134 ZNF773 ZNF446 ZNF211
GH19I056594 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 19.6 -833.1 -833128 1.4 HDGF PKNOX1 ZNF133 ARID4B SIN3A FEZF1 YBX1 GLI4 ZNF48 YY1 ZNF71 U2AF2 ZNF17 ZNF543 ZNF549 ZNF264 ZNF773 ENSG00000269696 ZNF550 ZFP28
GH19I058361 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 11.2 +933.8 933837 2.1 HDGF PKNOX1 CLOCK SMAD1 ARNT ARID4B NEUROD1 SIN3A DMAP1 ZBTB7B LOC105372483 ENSG00000268230 RNA5SP473 ZNF497 ZNF548 ZNF417 ZNF134 TRIM28 ZSCAN22 ZNF274
GH19I057818 Promoter/Enhancer 1.7 Ensembl ENCODE dbSUPER 13.7 +391.2 391217 3.3 PKNOX1 SMAD1 FOXA2 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 POLR2B ENSG00000268750 ZNF587B ENSG00000269867 TRIM28 ZNF264 ZNF805 ZNF543 ZNF587 ZNF749 ZNF549
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF749 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF749 gene promoter:

Genomic Locations for ZNF749 Gene

Genomic Locations for ZNF749 Gene
chr19:57,428,568-57,447,485
(GRCh38/hg38)
Size:
18,918 bases
Orientation:
Plus strand
chr19:57,946,693-57,957,191
(GRCh37/hg19)

Genomic View for ZNF749 Gene

Genes around ZNF749 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF749 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF749 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF749 Gene

Proteins for ZNF749 Gene

  • Protein details for ZNF749 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43361-ZN749_HUMAN
    Recommended name:
    Zinc finger protein 749
    Protein Accession:
    O43361

    Protein attributes for ZNF749 Gene

    Size:
    778 amino acids
    Molecular mass:
    90364 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAB97932.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for ZNF749 Gene

Post-translational modifications for ZNF749 Gene

No Post-translational modifications

Other Protein References for ZNF749 Gene

No data available for DME Specific Peptides for ZNF749 Gene

Domains & Families for ZNF749 Gene

Gene Families for ZNF749 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Suggested Antigen Peptide Sequences for ZNF749 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O43361

UniProtKB/Swiss-Prot:

ZN749_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF749: view

Function for ZNF749 Gene

Molecular function for ZNF749 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF749 Gene

Gene Ontology (GO) - Molecular Function for ZNF749 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF749: view
genes like me logo Genes that share phenotypes with ZNF749: view

miRNA for ZNF749 Gene

miRTarBase miRNAs that target ZNF749

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF749 Gene

Localization for ZNF749 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF749 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF749 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear membrane (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF749 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF749: view

Pathways & Interactions for ZNF749 Gene

SuperPathways for ZNF749 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF749: view

Pathways by source for ZNF749 Gene

2 Reactome pathways for ZNF749 Gene

Gene Ontology (GO) - Biological Process for ZNF749 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF749: view

No data available for SIGNOR curated interactions for ZNF749 Gene

Drugs & Compounds for ZNF749 Gene

No Compound Related Data Available

Transcripts for ZNF749 Gene

Unigene Clusters for ZNF749 Gene

Zinc finger protein 749:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF749 Gene

No ASD Table

Relevant External Links for ZNF749 Gene

GeneLoc Exon Structure for
ZNF749
ECgene alternative splicing isoforms for
ZNF749

Expression for ZNF749 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF749 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF749 Gene:

ZNF749

SOURCE GeneReport for Unigene cluster for ZNF749 Gene:

Hs.467358
genes like me logo Genes that share expression patterns with ZNF749: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF749 Gene

Orthologs for ZNF749 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF749 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF749 33
  • 98 (n)
cow
(Bos Taurus)
Mammalia -- 34
  • 45 (a)
ManyToMany
Species where no ortholog for ZNF749 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF749 Gene

ENSEMBL:
Gene Tree for ZNF749 (if available)
TreeFam:
Gene Tree for ZNF749 (if available)

Paralogs for ZNF749 Gene

(375) SIMAP similar genes for ZNF749 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZNF749: view

Variants for ZNF749 Gene

Sequence variations from dbSNP and Humsavar for ZNF749 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000059844 -- 57,445,263(+) T/C/G coding_sequence_variant, missense_variant, synonymous_variant
rs1000085993 -- 57,439,065(+) G/A intron_variant
rs1000263083 -- 57,443,068(+) G/T intron_variant
rs1000665016 -- 57,438,953(+) C/T intron_variant
rs1000672323 -- 57,430,771(+) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF749 Gene

Variant ID Type Subtype PubMed ID
esv3583608 CNV loss 25503493

Variation tolerance for ZNF749 Gene

Residual Variation Intolerance Score: 67.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.06; 75.25% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF749 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF749

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF749 Gene

Disorders for ZNF749 Gene

Additional Disease Information for ZNF749

No disorders were found for ZNF749 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF749 Gene

Publications for ZNF749 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 3 4 58
  3. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 58
  4. Lysine acetylation targets protein complexes and co-regulates major cellular functions. (PMID: 19608861) Choudhary C … Mann M (Science (New York, N.Y.) 2009) 4 58
  5. Distinct class of putative "non-conserved" promoters in humans: comparative studies of alternative promoters of human and mouse genes. (PMID: 17567985) Tsuritani K … Suzuki Y (Genome research 2007) 3 58

Products for ZNF749 Gene

Sources for ZNF749 Gene

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