Aliases for ZNF749 Gene

Aliases for ZNF749 Gene

  • Zinc Finger Protein 749 2 3 4 5
  • FLJ16360 2
  • ZNF749 5

External Ids for ZNF749 Gene

Previous GeneCards Identifiers for ZNF749 Gene

  • GC19P062646
  • GC19P057946
  • GC19P054263

Summaries for ZNF749 Gene

GeneCards Summary for ZNF749 Gene

ZNF749 (Zinc Finger Protein 749) is a Protein Coding gene. Diseases associated with ZNF749 include Benign Secondary Hypertension and Benign Renovascular Hypertension. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF180.

UniProtKB/Swiss-Prot Summary for ZNF749 Gene

Additional gene information for ZNF749 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF749 Gene

Genomics for ZNF749 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF749 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF749 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF749

Top Transcription factor binding sites by QIAGEN in the ZNF749 gene promoter:
  • HTF
  • XBP-1

Genomic Locations for ZNF749 Gene

Genomic Locations for ZNF749 Gene
chr19:57,428,565-57,447,101
(GRCh38/hg38)
Size:
18,537 bases
Orientation:
Plus strand
chr19:57,946,693-57,957,191
(GRCh37/hg19)
Size:
10,499 bases
Orientation:
Plus strand

Genomic View for ZNF749 Gene

Genes around ZNF749 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF749 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF749 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF749 Gene

Proteins for ZNF749 Gene

  • Protein details for ZNF749 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43361-ZN749_HUMAN
    Recommended name:
    Zinc finger protein 749
    Protein Accession:
    O43361

    Protein attributes for ZNF749 Gene

    Size:
    778 amino acids
    Molecular mass:
    90364 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAB97932.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for ZNF749 Gene

Post-translational modifications for ZNF749 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF749 Gene

No data available for DME Specific Peptides for ZNF749 Gene

Domains & Families for ZNF749 Gene

Gene Families for ZNF749 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF749 Gene

InterPro:
Blocks:
  • C2H2-type zinc finger signature
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF749 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 749 (ZN749_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O43361

UniProtKB/Swiss-Prot:

ZN749_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF749: view

Function for ZNF749 Gene

Molecular function for ZNF749 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF749 Gene

Gene Ontology (GO) - Molecular Function for ZNF749 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity IBA 21873635
GO:0043565 sequence-specific DNA binding IBA 21873635
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF749: view
genes like me logo Genes that share phenotypes with ZNF749: view

Animal Model Products

CRISPR Products

miRNA for ZNF749 Gene

miRTarBase miRNAs that target ZNF749

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF749

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF749 Gene

Localization for ZNF749 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF749 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF749 gene
Compartment Confidence
nucleus 4
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear membrane (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF749 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF749: view

Pathways & Interactions for ZNF749 Gene

genes like me logo Genes that share pathways with ZNF749: view

Pathways by source for ZNF749 Gene

2 Reactome pathways for ZNF749 Gene
1 KEGG pathway for ZNF749 Gene

Interacting Proteins for ZNF749 Gene

Gene Ontology (GO) - Biological Process for ZNF749 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF749: view

No data available for SIGNOR curated interactions for ZNF749 Gene

Drugs & Compounds for ZNF749 Gene

No Compound Related Data Available

Transcripts for ZNF749 Gene

mRNA/cDNA for ZNF749 Gene

4 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF749

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF749 Gene

No ASD Table

Relevant External Links for ZNF749 Gene

GeneLoc Exon Structure for
ZNF749

Expression for ZNF749 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF749 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF749

SOURCE GeneReport for Unigene cluster for ZNF749 Gene:

Hs.467358
genes like me logo Genes that share expression patterns with ZNF749: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF749 Gene

Orthologs for ZNF749 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF749 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZNF749 30
  • 98 (n)
Cow
(Bos Taurus)
Mammalia -- 31
  • 45 (a)
ManyToMany
Species where no ortholog for ZNF749 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ZNF749 Gene

ENSEMBL:
Gene Tree for ZNF749 (if available)
TreeFam:
Gene Tree for ZNF749 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF749: view image

Paralogs for ZNF749 Gene

(375) SIMAP similar genes for ZNF749 Gene using alignment to 2 proteins:

  • ZN749_HUMAN
  • C9J756_HUMAN
genes like me logo Genes that share paralogs with ZNF749: view

Variants for ZNF749 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF749 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs12986235 - p.Gln243Arg
rs2240038 - p.Ala405Thr
rs7246856 - p.Ile771Arg

Additional dbSNP identifiers (rs#s) for ZNF749 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF749 Gene

Variant ID Type Subtype PubMed ID
esv3583608 CNV loss 25503493

Variation tolerance for ZNF749 Gene

Residual Variation Intolerance Score: 67.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.06; 75.25% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF749 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF749

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF749 Gene

Disorders for ZNF749 Gene

MalaCards: The human disease database

(2) MalaCards diseases for ZNF749 Gene - From: DISEASES

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ZNF749

genes like me logo Genes that share disorders with ZNF749: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF749 Gene

Publications for ZNF749 Gene

  1. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  3. Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis. (PMID: 30575818) Tiemann K … Kani K (Oncogene 2019) 3
  4. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for ZNF749 Gene

Sources for ZNF749 Gene