Aliases for ZNF746 Gene

Aliases for ZNF746 Gene

  • Zinc Finger Protein 746 2 3 4 5
  • PARIS 2 3 4
  • Parkin-Interacting Substrate 3 4
  • Parkin Interacting Substrate 2
  • Parkin-Interacting Sustrate 3
  • FLJ31413 2
  • ZNF746 5

External Ids for ZNF746 Gene

Previous GeneCards Identifiers for ZNF746 Gene

  • GC07M148800
  • GC07M149169
  • GC07M143246

Summaries for ZNF746 Gene

GeneCards Summary for ZNF746 Gene

ZNF746 (Zinc Finger Protein 746) is a Protein Coding gene. Diseases associated with ZNF746 include Mitochondrial Complex Iv Deficiency. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and RNA polymerase II proximal promoter sequence-specific DNA binding. An important paralog of this gene is ZNF777.

UniProtKB/Swiss-Prot Summary for ZNF746 Gene

  • Transcription repressor that specifically binds to the 5'-TATTTT[T/G]-3' consensus sequence on promoters and repress transcription of PGC-1-alpha (PPARGC1A), thereby playing a role in regulation of neuron death.

Additional gene information for ZNF746 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF746 Gene

Genomics for ZNF746 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF746 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF746 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF746

Top Transcription factor binding sites by QIAGEN in the ZNF746 gene promoter:
  • ATF-2
  • CRE-BP1
  • E47
  • GCNF
  • GCNF-1
  • Nkx2-5
  • Pax-3
  • POU2F1
  • POU2F1a
  • RFX1

Genomic Locations for ZNF746 Gene

Genomic Locations for ZNF746 Gene
chr7:149,472,696-149,497,832
(GRCh38/hg38)
Size:
25,137 bases
Orientation:
Minus strand
chr7:149,169,884-149,194,908
(GRCh37/hg19)
Size:
25,025 bases
Orientation:
Minus strand

Genomic View for ZNF746 Gene

Genes around ZNF746 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF746 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF746 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF746 Gene

Proteins for ZNF746 Gene

  • Protein details for ZNF746 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6NUN9-ZN746_HUMAN
    Recommended name:
    Zinc finger protein 746
    Protein Accession:
    Q6NUN9
    Secondary Accessions:
    • A8K6Z9
    • Q6ZRF9

    Protein attributes for ZNF746 Gene

    Size:
    644 amino acids
    Molecular mass:
    69136 Da
    Quaternary structure:
    • Interacts (via C2H2-type zinc fingers) with PRKN.
    Miscellaneous:
    • May act as a downstream effector of PRKN and contribute to neurodegeneration in Parkinson disease cases caused by defects in PRKN: its accumulation due to the absence of PRKN, followed by up-regulation of PPARGC1A, could lead to the selective loss of dopamine neurons in the substantia nigra.

    Alternative splice isoforms for ZNF746 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF746 Gene

Post-translational modifications for ZNF746 Gene

  • Ubiquitinated by PRKN. 'Lys-48'-linked polyubiquitination by PRKN leads to degradation by the proteasome and may play a key role in regulation of neuron death.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF746 Gene

Domains & Families for ZNF746 Gene

Gene Families for ZNF746 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF746 Gene

InterPro:
Blocks:
  • KRAB box
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF746 Gene

GenScript: Design optimal peptide antigens:
  • Parkin-interacting sustrate (ZN746_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q6NUN9

UniProtKB/Swiss-Prot:

ZN746_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF746: view

Function for ZNF746 Gene

Molecular function for ZNF746 Gene

UniProtKB/Swiss-Prot Function:
Transcription repressor that specifically binds to the 5'-TATTTT[T/G]-3' consensus sequence on promoters and repress transcription of PGC-1-alpha (PPARGC1A), thereby playing a role in regulation of neuron death.

Phenotypes From GWAS Catalog for ZNF746 Gene

Gene Ontology (GO) - Molecular Function for ZNF746 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000976 transcription regulatory region sequence-specific DNA binding IDA 21376232
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA 21376232
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific IDA 21376232
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with ZNF746: view
genes like me logo Genes that share phenotypes with ZNF746: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF746

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF746 Gene

Localization for ZNF746 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF746 Gene

Cytoplasm. Nucleus. Note=Mainly localizes to the cytoplasm. probably translocates to the nucleus to repress selected genes.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF746 gene
Compartment Confidence
nucleus 4
mitochondrion 2
cytosol 2
plasma membrane 1
extracellular 1
cytoskeleton 1
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1

Gene Ontology (GO) - Cellular Components for ZNF746 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IC 21376232
GO:0005737 cytoplasm IEA,IDA 21376232
genes like me logo Genes that share ontologies with ZNF746: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZNF746 Gene

Pathways & Interactions for ZNF746 Gene

genes like me logo Genes that share pathways with ZNF746: view

Pathways by source for ZNF746 Gene

2 Reactome pathways for ZNF746 Gene
1 KEGG pathway for ZNF746 Gene

Gene Ontology (GO) - Biological Process for ZNF746 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IDA 21376232
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0045892 negative regulation of transcription, DNA-templated IDA 21376232
GO:0045944 positive regulation of transcription by RNA polymerase II IDA 21376232
GO:1901216 positive regulation of neuron death IBA,IDA 21376232
genes like me logo Genes that share ontologies with ZNF746: view

No data available for SIGNOR curated interactions for ZNF746 Gene

Drugs & Compounds for ZNF746 Gene

No Compound Related Data Available

Transcripts for ZNF746 Gene

mRNA/cDNA for ZNF746 Gene

3 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF746

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF746 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b
SP1: -
SP2:
SP3:

Relevant External Links for ZNF746 Gene

GeneLoc Exon Structure for
ZNF746

Expression for ZNF746 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF746 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ZNF746 Gene

This gene is overexpressed in Whole Blood (x6.9).

Protein differential expression in normal tissues from HIPED for ZNF746 Gene

This gene is overexpressed in Brain (54.6) and Urine (14.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZNF746 Gene



Protein tissue co-expression partners for ZNF746 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF746

SOURCE GeneReport for Unigene cluster for ZNF746 Gene:

Hs.24643

Evidence on tissue expression from TISSUES for ZNF746 Gene

  • Nervous system(2.7)
genes like me logo Genes that share expression patterns with ZNF746: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF746 Gene

Orthologs for ZNF746 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF746 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZNF746 30 31
  • 99.38 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ZNF746 31
  • 96 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia ZNF746 30 31
  • 89.17 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Zfp746 30 17 31
  • 87.14 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Zfp746 30
  • 86.63 (n)
Oppossum
(Monodelphis domestica)
Mammalia ZNF746 31
  • 71 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia ZNF746 31
  • 55 (a)
OneToOne
Chicken
(Gallus gallus)
Aves -- 31
  • 25 (a)
OneToMany
-- 31
  • 23 (a)
OneToMany
Species where no ortholog for ZNF746 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ZNF746 Gene

ENSEMBL:
Gene Tree for ZNF746 (if available)
TreeFam:
Gene Tree for ZNF746 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF746: view image

Paralogs for ZNF746 Gene

genes like me logo Genes that share paralogs with ZNF746: view

Variants for ZNF746 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF746 Gene

SNP ID Clinical significance and condition Chr 07 pos Variation AA Info Type
818168 Not Provided: not provided 149,474,393(-) CCCG/C INFRAME_DELETION
818169 Not Provided: not provided 149,492,897(-) C/T MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for ZNF746 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF746 Gene

Variant ID Type Subtype PubMed ID
dgv11713n54 CNV loss 21841781
dgv3693n106 CNV deletion 24896259
esv2735330 CNV deletion 23290073
nsv1033447 CNV loss 25217958
nsv1074558 CNV deletion 25765185
nsv608976 CNV loss 21841781
nsv970602 CNV duplication 23825009

Variation tolerance for ZNF746 Gene

Residual Variation Intolerance Score: 16% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.83; 34.31% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF746 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF746

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF746 Gene

Disorders for ZNF746 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZNF746 Gene - From: DISEASES

Disorder Aliases PubMed IDs
mitochondrial complex iv deficiency
  • cytochrome c oxidase deficiency
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ZNF746

genes like me logo Genes that share disorders with ZNF746: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF746 Gene

Publications for ZNF746 Gene

  1. PARIS (ZNF746) repression of PGC-1α contributes to neurodegeneration in Parkinson's disease. (PMID: 21376232) Shin JH … Dawson TM (Cell 2011) 2 3 4
  2. Reduced expression of the Kinesin-Associated Protein 3 (KIFAP3) gene increases survival in sporadic amyotrophic lateral sclerosis. (PMID: 19451621) Landers JE … Brown RH (Proceedings of the National Academy of Sciences of the United States of America 2009) 3 41
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. Parkin interacting substrate zinc finger protein 746 is a pathological mediator in Parkinson's disease. (PMID: 31237944) Brahmachari S … Dawson TM (Brain : a journal of neurology 2019) 3

Products for ZNF746 Gene

Sources for ZNF746 Gene