Aliases for ZNF74 Gene

Aliases for ZNF74 Gene

  • Zinc Finger Protein 74 2 3 4 5
  • Zinc Finger Protein 520 3 4
  • ZNF520 3 4
  • HZNF7 3 4
  • Zinc Finger Protein 74 (Cos52) 2
  • ZFP520 3
  • COS52 3

External Ids for ZNF74 Gene

Previous GeneCards Identifiers for ZNF74 Gene

  • GC22P017450
  • GC22P019073
  • GC22P020748
  • GC22P004012

Summaries for ZNF74 Gene

GeneCards Summary for ZNF74 Gene

ZNF74 (Zinc Finger Protein 74) is a Protein Coding gene. Diseases associated with ZNF74 include Digeorge Syndrome and Chromosome 22Q11.2 Duplication Syndrome. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is ZNF879.

UniProtKB/Swiss-Prot Summary for ZNF74 Gene

Gene Wiki entry for ZNF74 Gene

Additional gene information for ZNF74 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF74 Gene

Genomics for ZNF74 Gene

GeneHancer (GH) Regulatory Elements for ZNF74 Gene

Promoters and enhancers for ZNF74 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF74 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF74

Top Transcription factor binding sites by QIAGEN in the ZNF74 gene promoter:
  • Arnt
  • Cdc5
  • FOXD1
  • HTF
  • RP58
  • SEF-1 (1)
  • YY1

Genomic Locations for ZNF74 Gene

Genomic Locations for ZNF74 Gene
chr22:20,394,115-20,408,463
(GRCh38/hg38)
Size:
14,349 bases
Orientation:
Plus strand
chr22:20,748,405-20,762,752
(GRCh37/hg19)
Size:
14,348 bases
Orientation:
Plus strand

Genomic View for ZNF74 Gene

Genes around ZNF74 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF74 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF74 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF74 Gene

Proteins for ZNF74 Gene

  • Protein details for ZNF74 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16587-ZNF74_HUMAN
    Recommended name:
    Zinc finger protein 74
    Protein Accession:
    Q16587
    Secondary Accessions:
    • B5MCE3
    • B7Z5Y2
    • Q6IBV2
    • Q6PJP1
    • Q9UC04
    • Q9UF05
    • Q9UF06
    • Q9UF07

    Protein attributes for ZNF74 Gene

    Size:
    644 amino acids
    Molecular mass:
    72207 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAF21777.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=AAF21778.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=AAF21779.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=AAF21780.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=CAA50632.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=CAA63379.1; Type=Frameshift; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF74 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF74 Gene

Post-translational modifications for ZNF74 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF74 Gene

Domains & Families for ZNF74 Gene

Gene Families for ZNF74 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF74 Gene

Blocks:
  • C2H2-type zinc finger signature
  • KRAB box
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF74 Gene

GenScript: Design optimal peptide antigens:
  • ZNF74 protein (Q05BG0_HUMAN)
  • hZNF7 (ZNF74_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q16587

UniProtKB/Swiss-Prot:

ZNF74_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF74: view

Function for ZNF74 Gene

Molecular function for ZNF74 Gene

UniProtKB/Swiss-Prot Function:
May play a role in RNA metabolism.
GENATLAS Biochemistry:
zinc finger protein 74,64kDa (C2H2 type,Kruppel associated box),commonly deleted in DiGeorge syndrome,including ZNF74-1 and ZNF74-2,expressed only in neural crest-derived tissues and neuroepithelium of spinal cord as well as to foregut endoderm epithelia (esophagus,respiratory tract,putatively involved in the DiGeorge

Phenotypes From GWAS Catalog for ZNF74 Gene

Gene Ontology (GO) - Molecular Function for ZNF74 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003723 RNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF74: view
genes like me logo Genes that share phenotypes with ZNF74: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF74 Gene

Localization for ZNF74 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF74 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF74 gene
Compartment Confidence
nucleus 5
cytoskeleton 4
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Actin filaments (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF74 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0015629 actin cytoskeleton IDA --
genes like me logo Genes that share ontologies with ZNF74: view

Pathways & Interactions for ZNF74 Gene

genes like me logo Genes that share pathways with ZNF74: view

Pathways by source for ZNF74 Gene

2 Reactome pathways for ZNF74 Gene
1 KEGG pathway for ZNF74 Gene

Gene Ontology (GO) - Biological Process for ZNF74 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA,TAS --
GO:0007275 multicellular organism development TAS 1639391
genes like me logo Genes that share ontologies with ZNF74: view

No data available for SIGNOR curated interactions for ZNF74 Gene

Drugs & Compounds for ZNF74 Gene

No Compound Related Data Available

Transcripts for ZNF74 Gene

mRNA/cDNA for ZNF74 Gene

4 REFSEQ mRNAs :
14 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF74 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c · 8d
SP1: - -
SP2: - - - - - -
SP3: - - -
SP4: - - - -
SP5: - - - - -
SP6: - -
SP7: - - - - - - -
SP8: - - - - - - - - -
SP9:

Relevant External Links for ZNF74 Gene

GeneLoc Exon Structure for
ZNF74

Expression for ZNF74 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF74 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZNF74 Gene

This gene is overexpressed in Pancreas (60.2) and Peripheral blood mononuclear cells (8.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF74 Gene



Protein tissue co-expression partners for ZNF74 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF74

SOURCE GeneReport for Unigene cluster for ZNF74 Gene:

Hs.517418

mRNA Expression by UniProt/SwissProt for ZNF74 Gene:

Q16587-ZNF74_HUMAN
Tissue specificity: Highly expressed in the fetal brain.

Evidence on tissue expression from TISSUES for ZNF74 Gene

  • Nervous system(4.7)
  • Muscle(4)
genes like me logo Genes that share expression patterns with ZNF74: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF74 Gene

Orthologs for ZNF74 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF74 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF74 31 30
  • 99.79 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF74 31 30
  • 81.54 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF74 31 30
  • 76.01 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 42 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 31 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG9797 32
  • 38 (a)
CG6654 31
  • 22 (a)
OneToMany
Species where no ortholog for ZNF74 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF74 Gene

ENSEMBL:
Gene Tree for ZNF74 (if available)
TreeFam:
Gene Tree for ZNF74 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF74: view image

Paralogs for ZNF74 Gene

Paralogs for ZNF74 Gene

(532) SIMAP similar genes for ZNF74 Gene using alignment to 6 proteins:

  • ZNF74_HUMAN
  • B5MDQ6_HUMAN
  • C9J3V1_HUMAN
  • F8WDT0_HUMAN
  • L8E7G9_HUMAN
  • Q05BG0_HUMAN
genes like me logo Genes that share paralogs with ZNF74: view

Variants for ZNF74 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF74 Gene

SNP ID Clinical significance and condition Chr 22 pos Variation AA Info Type
rs3747076 - p.Glu117Lys

Additional dbSNP identifiers (rs#s) for ZNF74 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF74 Gene

Variant ID Type Subtype PubMed ID
dgv4483n100 CNV gain 25217958
dgv7993n54 CNV gain 21841781
esv3568277 CNV loss 25503493
esv3647292 CNV gain 21293372
esv3647293 CNV gain 21293372
esv3893438 CNV gain 25118596
nsv1056614 CNV loss 25217958
nsv436864 CNV insertion 17901297
nsv509809 CNV insertion 20534489
nsv519901 CNV gain 19592680
nsv523162 CNV loss 19592680
nsv588293 CNV gain 21841781
nsv828954 CNV gain 20364138
nsv834135 CNV gain 17160897
nsv834136 CNV loss 17160897
nsv834138 CNV loss 17160897

Variation tolerance for ZNF74 Gene

Residual Variation Intolerance Score: 82.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.33; 63.07% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF74 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF74

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF74 Gene

Disorders for ZNF74 Gene

MalaCards: The human disease database

(8) MalaCards diseases for ZNF74 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
digeorge syndrome
  • cayler cardiofacial syndrome
chromosome 22q11.2 duplication syndrome
  • chromosome 22q11.2 microduplication syndrome
dysgraphia
  • agraphia
velocardiofacial syndrome
  • digeorge syndrome
writing disorder
- elite association - COSMIC cancer census association via MalaCards
Search ZNF74 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ZNF74

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with ZNF74: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF74 Gene

Publications for ZNF74 Gene

  1. Association of ZNF74 gene genotypes with age-at-onset of schizophrenia. (PMID: 11705709) Takase K … Arinami T (Schizophrenia research 2001) 3 4 41 54
  2. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I … O'Brien KP (Nature 1999) 2 3 4 54
  3. Cloning of six new genes with zinc finger motifs mapping to short and long arms of human acrocentric chromosome 22 (p and q11.2). (PMID: 1639391) Aubry M … Rouleau GA (Genomics 1992) 2 3 4 54
  4. A genome annotation-driven approach to cloning the human ORFeome. (PMID: 15461802) Collins JE … Dunham I (Genome biology 2004) 3 4 54
  5. The KRAB zinc finger gene ZNF74 encodes an RNA-binding protein tightly associated with the nuclear matrix. (PMID: 8663113) Grondin B … Aubry M (The Journal of biological chemistry 1996) 3 4 54

Products for ZNF74 Gene