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Aliases for ZNF738 Gene

Aliases for ZNF738 Gene

  • Zinc Finger Protein 738 2 3 5
  • Protein ZNF738 3

External Ids for ZNF738 Gene

Previous GeneCards Identifiers for ZNF738 Gene

  • GC19P021541
  • GC19P021032

Summaries for ZNF738 Gene

GeneCards Summary for ZNF738 Gene

ZNF738 (Zinc Finger Protein 738) is a Protein Coding gene. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and ubiquitin-protein transferase activity. An important paralog of this gene is ZNF720.

UniProtKB/Swiss-Prot for ZNF738 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF738 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF738 Gene

Genomics for ZNF738 Gene

GeneHancer (GH) Regulatory Elements for ZNF738 Gene

Promoters and enhancers for ZNF738 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J021358 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 670.7 +0.4 440 2.1 PKNOX1 SIN3A ZBTB40 ZNF335 ZNF350 ZNF143 FOS NFYA SMAD5 CBFB ZNF738 LOC105372321 ZNF708 ZNF100 LOC641367 ZNF43 ZNF66 ENSG00000213976 LOC100422298
GH19J021141 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 5.6 -216.0 -215977 3.7 HDGF PKNOX1 ATF1 SMAD1 ARID4B SIN3A DMAP1 ZNF48 YY1 TCF12 ZNF431 ZNF100 ZNF708 ZNF714 LOC641367 ENSG00000268555 LOC105372321 ZNF738 ZNF429 RPL7AP10
GH19J021019 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE 4.4 -336.7 -336654 4.6 HDGF PKNOX1 ATF1 SMAD1 ARID4B SIN3A DMAP1 YY1 POLR2B ZNF207 ZNF714 ZNF430 ZNF100 LOC641367 ZNF90 BNIP3P26 RPL7AP10 ZNF66 ZNF431 ZNF486
GH19J021438 Enhancer 0.5 ENCODE 16 +80.7 80749 2 SMARCE1 ZNF217 CTBP1 GATA3 CEBPA ZNF738 LOC105372321 GC19P021412 ENSG00000269237
GH19J021256 Enhancer 0.6 ENCODE 12.9 -102.0 -102016 0.2 CTCF TEAD1 TEAD4 TEAD2 NCOA1 REST RAD21 TEAD3 ARID2 ZNF738 ENSG00000269839 ENSG00000268747
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF738 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF738 gene promoter:
  • GATA-1

Genomic Locations for ZNF738 Gene

Genomic Locations for ZNF738 Gene
chr19:21,358,930-21,388,582
(GRCh38/hg38)
Size:
29,653 bases
Orientation:
Plus strand
chr19:21,541,732-21,571,384
(GRCh37/hg19)
Size:
29,653 bases
Orientation:
Plus strand

Genomic View for ZNF738 Gene

Genes around ZNF738 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF738 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF738 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF738 Gene

Proteins for ZNF738 Gene

  • Protein details for ZNF738 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NE65-ZN738_HUMAN
    Recommended name:
    Protein ZNF738
    Protein Accession:
    Q8NE65
    Secondary Accessions:
    • A8K4N7

    Protein attributes for ZNF738 Gene

    Size:
    137 amino acids
    Molecular mass:
    15884 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF738 Gene

Post-translational modifications for ZNF738 Gene

  • Ubiquitination at isoforms=32 and posLast=1212
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ZNF738 Gene

Domains & Families for ZNF738 Gene

Gene Families for ZNF738 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ZNF738 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF738 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ZNF738: view

No data available for UniProtKB/Swiss-Prot for ZNF738 Gene

Function for ZNF738 Gene

Molecular function for ZNF738 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF738 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0004842 ubiquitin-protein transferase activity ISS --
GO:0019787 ubiquitin-like protein transferase activity IBA --
genes like me logo Genes that share ontologies with ZNF738: view
genes like me logo Genes that share phenotypes with ZNF738: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF738 Gene

Localization for ZNF738 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF738 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF738 gene
Compartment Confidence
nucleus 4
cytosol 2
extracellular 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for ZNF738 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF738: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZNF738 Gene

Pathways & Interactions for ZNF738 Gene

SuperPathways for ZNF738 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF738: view

Pathways by source for ZNF738 Gene

2 Reactome pathways for ZNF738 Gene

Interacting Proteins for ZNF738 Gene

Gene Ontology (GO) - Biological Process for ZNF738 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000209 protein polyubiquitination ISS --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0070647 protein modification by small protein conjugation or removal IBA --
genes like me logo Genes that share ontologies with ZNF738: view

No data available for SIGNOR curated interactions for ZNF738 Gene

Drugs & Compounds for ZNF738 Gene

No Compound Related Data Available

Transcripts for ZNF738 Gene

mRNA/cDNA for ZNF738 Gene

(4) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF738 Gene

Zinc finger protein 738:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF738 Gene

No ASD Table

Relevant External Links for ZNF738 Gene

GeneLoc Exon Structure for
ZNF738
ECgene alternative splicing isoforms for
ZNF738

Expression for ZNF738 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF738 Gene

Protein differential expression in normal tissues from HIPED for ZNF738 Gene

This gene is overexpressed in Serum (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF738 Gene



Protein tissue co-expression partners for ZNF738 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF738 Gene:

ZNF738

SOURCE GeneReport for Unigene cluster for ZNF738 Gene:

Hs.124384
genes like me logo Genes that share expression patterns with ZNF738: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF738 Gene

Orthologs for ZNF738 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF738 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF738 34
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 34
  • 53 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Gm26965 34
  • 47 (a)
ManyToMany
RP24-242F4.8 34
  • 40 (a)
ManyToMany
Gm10037 34
  • 39 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia -- 34
  • 39 (a)
ManyToMany
-- 34
  • 34 (a)
ManyToMany
-- 34
  • 32 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 23 (a)
OneToMany
Species where no ortholog for ZNF738 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF738 Gene

ENSEMBL:
Gene Tree for ZNF738 (if available)
TreeFam:
Gene Tree for ZNF738 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF738: view image

Paralogs for ZNF738 Gene

Paralogs for ZNF738 Gene

(406) SIMAP similar genes for ZNF738 Gene using alignment to 5 proteins:

  • ZN738_HUMAN
  • E9PE46_HUMAN
  • M0R024_HUMAN
  • M0R0N2_HUMAN
  • M0R3I0_HUMAN

Pseudogenes.org Pseudogenes for ZNF738 Gene

genes like me logo Genes that share paralogs with ZNF738: view

Variants for ZNF738 Gene

Sequence variations from dbSNP and Humsavar for ZNF738 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000077288 -- 21,356,954(+) AGAAGA/AGA upstream_transcript_variant
rs1000096284 -- 21,388,998(+) C/T downstream_transcript_variant
rs1000127592 -- 21,379,368(+) C/T non_coding_transcript_variant
rs1000310246 -- 21,373,045(+) C/A intron_variant
rs1000450139 -- 21,380,919(+) C/G non_coding_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF738 Gene

Variant ID Type Subtype PubMed ID
esv2663001 CNV deletion 23128226
esv2665276 CNV deletion 23128226
esv2718325 CNV deletion 23290073
esv2718330 CNV deletion 23290073
esv2718331 CNV deletion 23290073
esv2718332 CNV deletion 23290073
esv2718333 CNV deletion 23290073
esv2751783 CNV loss 17911159
esv4924 OTHER complex 18987735
nsv1061327 CNV gain 25217958
nsv1138683 CNV deletion 24896259
nsv1138684 CNV deletion 24896259
nsv1140249 OTHER inversion 24896259
nsv1151573 OTHER inversion 26484159
nsv458377 CNV gain 19166990
nsv578809 CNV gain 21841781
nsv578952 CNV gain 21841781
nsv963023 CNV duplication 23825009

Variation tolerance for ZNF738 Gene

Gene Damage Index Score: 1.16; 23.52% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF738 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF738

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF738 Gene

Disorders for ZNF738 Gene

Additional Disease Information for ZNF738

No disorders were found for ZNF738 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF738 Gene

Publications for ZNF738 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 4 58
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for ZNF738 Gene

Sources for ZNF738 Gene

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