Aliases for ZNF736 Gene

Aliases for ZNF736 Gene

  • Zinc Finger Protein 736 2 3 4 5
  • KRAB-Containing Zinc-Finger Repressor Protein 3
  • ZNF736 5

External Ids for ZNF736 Gene

Previous GeneCards Identifiers for ZNF736 Gene

  • GC00U922630
  • GC07P063767
  • GC07P060153

Summaries for ZNF736 Gene

GeneCards Summary for ZNF736 Gene

ZNF736 (Zinc Finger Protein 736) is a Protein Coding gene. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF727.

UniProtKB/Swiss-Prot Summary for ZNF736 Gene

Additional gene information for ZNF736 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF736 Gene

Genomics for ZNF736 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF736 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF736 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF736

Genomic Locations for ZNF736 Gene

Genomic Locations for ZNF736 Gene
chr7:64,307,459-64,356,634
(GRCh38/hg38)
Size:
49,176 bases
Orientation:
Plus strand
chr7:63,767,837-63,815,238
(GRCh37/hg19)
Size:
47,402 bases
Orientation:
Plus strand

Genomic View for ZNF736 Gene

Genes around ZNF736 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF736 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF736 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF736 Gene

Proteins for ZNF736 Gene

  • Protein details for ZNF736 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    B4DX44-ZN736_HUMAN
    Recommended name:
    Zinc finger protein 736
    Protein Accession:
    B4DX44

    Protein attributes for ZNF736 Gene

    Size:
    427 amino acids
    Molecular mass:
    49868 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF736 Gene

Post-translational modifications for ZNF736 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF736 Gene

No data available for DME Specific Peptides for ZNF736 Gene

Domains & Families for ZNF736 Gene

Gene Families for ZNF736 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF736 Gene

Suggested Antigen Peptide Sequences for ZNF736 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 736 (ZN736_HUMAN)

Graphical View of Domain Structure for InterPro Entry

B4DX44

UniProtKB/Swiss-Prot:

ZN736_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF736: view

Function for ZNF736 Gene

Molecular function for ZNF736 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF736 Gene

Gene Ontology (GO) - Molecular Function for ZNF736 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IBA 21873635
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF736: view

Phenotypes for ZNF736 Gene

genes like me logo Genes that share phenotypes with ZNF736: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF736

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF736 Gene

Localization for ZNF736 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF736 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF736 gene
Compartment Confidence
nucleus 4
cytosol 2
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF736 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IBA 21873635
genes like me logo Genes that share ontologies with ZNF736: view

Pathways & Interactions for ZNF736 Gene

genes like me logo Genes that share pathways with ZNF736: view

Pathways by source for ZNF736 Gene

2 Reactome pathways for ZNF736 Gene
1 KEGG pathway for ZNF736 Gene

Interacting Proteins for ZNF736 Gene

Gene Ontology (GO) - Biological Process for ZNF736 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA,IBA 21873635
genes like me logo Genes that share ontologies with ZNF736: view

No data available for SIGNOR curated interactions for ZNF736 Gene

Drugs & Compounds for ZNF736 Gene

No Compound Related Data Available

Transcripts for ZNF736 Gene

mRNA/cDNA for ZNF736 Gene

2 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF736

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF736 Gene

No ASD Table

Relevant External Links for ZNF736 Gene

GeneLoc Exon Structure for
ZNF736

Expression for ZNF736 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF736 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF736

SOURCE GeneReport for Unigene cluster for ZNF736 Gene:

Hs.734771
genes like me logo Genes that share expression patterns with ZNF736: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF736 Gene

Orthologs for ZNF736 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF736 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZNF736 30 31
  • 99.06 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Zfp85-rs1 31
  • 43 (a)
ManyToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 43 (a)
ManyToMany
-- 31
  • 28 (a)
ManyToMany
Cow
(Bos Taurus)
Mammalia -- 31
  • 39 (a)
OneToMany
Dog
(Canis familiaris)
Mammalia -- 31
  • 29 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 40 (a)
ManyToMany
-- 31
  • 30 (a)
ManyToMany
-- 31
  • 28 (a)
ManyToMany
-- 31
  • 26 (a)
ManyToMany
-- 31
  • 24 (a)
ManyToMany
-- 31
  • 23 (a)
ManyToMany
-- 31
  • 23 (a)
ManyToMany
-- 31
  • 23 (a)
ManyToMany
Species where no ortholog for ZNF736 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ZNF736 Gene

ENSEMBL:
Gene Tree for ZNF736 (if available)
TreeFam:
Gene Tree for ZNF736 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF736: view image

Paralogs for ZNF736 Gene

Paralogs for ZNF736 Gene

(487) SIMAP similar genes for ZNF736 Gene using alignment to 1 proteins:

  • ZN736_HUMAN
genes like me logo Genes that share paralogs with ZNF736: view

Variants for ZNF736 Gene

Additional dbSNP identifiers (rs#s) for ZNF736 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF736 Gene

Variant ID Type Subtype PubMed ID
dgv1099e201 CNV deletion 23290073
dgv1108n67 CNV loss 20364138
dgv11415n54 CNV loss 21841781
dgv1212e199 CNV deletion 23128226
dgv240n111 CNV duplication 26073780
dgv6434n100 CNV loss 25217958
esv2422405 CNV duplication 17116639
esv2764000 CNV gain+loss 21179565
esv3410592 CNV insertion 20981092
esv3613414 CNV loss 21293372
esv3891131 CNV gain+loss 25118596
esv3891132 CNV gain 25118596
nsv1016645 CNV gain+loss 25217958
nsv1018445 CNV gain 25217958
nsv1018858 CNV loss 25217958
nsv1019909 CNV gain 25217958
nsv1137241 CNV deletion 24896259
nsv464515 CNV loss 19166990
nsv518721 CNV loss 19592680
nsv522412 CNV loss 19592680
nsv607304 CNV gain 21841781
nsv607309 CNV loss 21841781
nsv607310 CNV loss 21841781
nsv958455 CNV deletion 24416366
nsv966818 CNV duplication 23825009

Variation tolerance for ZNF736 Gene

Gene Damage Index Score: 11.33; 92.64% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF736 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF736

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF736 Gene

Disorders for ZNF736 Gene

No disorders were found for ZNF736 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF736 Gene

Publications for ZNF736 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3
  4. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier LW … Wilson RK (Nature 2003) 4
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3

Products for ZNF736 Gene

Sources for ZNF736 Gene