This gene encodes a kruppel-associated box-containing zinc finger protein (KRAB-ZFP). The encoded protein contains an N-terminal kruppel-associated box (KRAB) domain and nine C-terminal C2H2-type zinc finger domains. The KRAB-ZFPs represent the largest family of mammalian transcriptional repressors, which function through the recruitment of the nuclear co-factor KRAB-Associated... See more...

Aliases for ZNF735 Gene

Aliases for ZNF735 Gene

  • Zinc Finger Protein 735 2 3 5
  • Zinc Finger Protein 735 Pseudogene 3 4
  • Putative Zinc Finger Protein 735 3 4
  • ZNF735P 3 4
  • Zinc Finger Protein 735, Pseudogene 2
  • ZNF735 5

External Ids for ZNF735 Gene

Previous HGNC Symbols for ZNF735 Gene

  • ZNF735P

Previous GeneCards Identifiers for ZNF735 Gene

  • GC07U901816
  • GC07P063102
  • GC07P063305
  • GC07P063668
  • GC07P060048

Summaries for ZNF735 Gene

Entrez Gene Summary for ZNF735 Gene

  • This gene encodes a kruppel-associated box-containing zinc finger protein (KRAB-ZFP). The encoded protein contains an N-terminal kruppel-associated box (KRAB) domain and nine C-terminal C2H2-type zinc finger domains. The KRAB-ZFPs represent the largest family of mammalian transcriptional repressors, which function through the recruitment of the nuclear co-factor KRAB-Associated Protein 1 (KAP1), to engage histone modifiers and induce heterochromatin formation. [provided by RefSeq, Jul 2017]

GeneCards Summary for ZNF735 Gene

ZNF735 (Zinc Finger Protein 735) is a Protein Coding gene. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF716.

UniProtKB/Swiss-Prot Summary for ZNF735 Gene

Additional gene information for ZNF735 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF735 Gene

Genomics for ZNF735 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF735 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J064044 Promoter/Enhancer 0.7 Ensembl ENCODE 0.1 -161.4 -161378 1.8 SP2 GABPB1 SP1 ENSG00000285544 BNIP3P11 ZNF727 piR-40295 ZNF735
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF735 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF735

Genomic Locations for ZNF735 Gene

Genomic Locations for ZNF735 Gene
chr7:64,207,090-64,220,508
(GRCh38/hg38)
Size:
13,419 bases
Orientation:
Plus strand
chr7:63,667,581-63,680,668
(GRCh37/hg19)
Size:
13,088 bases
Orientation:
Plus strand

Genomic View for ZNF735 Gene

Genes around ZNF735 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF735 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF735 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF735 Gene

Proteins for ZNF735 Gene

  • Protein details for ZNF735 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0CB33-ZN735_HUMAN
    Recommended name:
    Putative zinc finger protein 735
    Protein Accession:
    P0CB33

    Protein attributes for ZNF735 Gene

    Size:
    412 amino acids
    Molecular mass:
    47565 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF735 Gene

Post-translational modifications for ZNF735 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF735 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF735 Gene

Domains & Families for ZNF735 Gene

Gene Families for ZNF735 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF735 Gene

Suggested Antigen Peptide Sequences for ZNF735 Gene

GenScript: Design optimal peptide antigens:
  • Putative zinc finger protein 735 (ZN735_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P0CB33

UniProtKB/Swiss-Prot:

ZN735_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF735: view

Function for ZNF735 Gene

Molecular function for ZNF735 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF735 Gene

Gene Ontology (GO) - Molecular Function for ZNF735 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IBA 21873635
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF735: view

Phenotypes for ZNF735 Gene

genes like me logo Genes that share phenotypes with ZNF735: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF735

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZNF735 Gene

Localization for ZNF735 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF735 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF735 gene
Compartment Confidence
nucleus 3

Gene Ontology (GO) - Cellular Components for ZNF735 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IBA 21873635
genes like me logo Genes that share ontologies with ZNF735: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZNF735 Gene

Pathways & Interactions for ZNF735 Gene

genes like me logo Genes that share pathways with ZNF735: view

Pathways by source for ZNF735 Gene

2 Reactome pathways for ZNF735 Gene
1 KEGG pathway for ZNF735 Gene

Interacting Proteins for ZNF735 Gene

Gene Ontology (GO) - Biological Process for ZNF735 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA,IBA 21873635
genes like me logo Genes that share ontologies with ZNF735: view

No data available for SIGNOR curated interactions for ZNF735 Gene

Drugs & Compounds for ZNF735 Gene

No Compound Related Data Available

Transcripts for ZNF735 Gene

mRNA/cDNA for ZNF735 Gene

1 REFSEQ mRNAs :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF735

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF735 Gene

No ASD Table

Relevant External Links for ZNF735 Gene

GeneLoc Exon Structure for
ZNF735

Expression for ZNF735 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF735 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF735

SOURCE GeneReport for Unigene cluster for ZNF735 Gene:

Hs.723116
genes like me logo Genes that share expression patterns with ZNF735: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF735 Gene

Orthologs for ZNF735 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for ZNF735 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LOC100611103 30
  • 91.99 (n)
Species where no ortholog for ZNF735 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ZNF735 Gene

ENSEMBL:
Gene Tree for ZNF735 (if available)
TreeFam:
Gene Tree for ZNF735 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF735: view image

Paralogs for ZNF735 Gene

Paralogs for ZNF735 Gene

(475) SIMAP similar genes for ZNF735 Gene using alignment to 1 proteins:

  • ZN735_HUMAN

Pseudogenes.org Pseudogenes for ZNF735 Gene

genes like me logo Genes that share paralogs with ZNF735: view

Variants for ZNF735 Gene

Additional dbSNP identifiers (rs#s) for ZNF735 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF735 Gene

Variant ID Type Subtype PubMed ID
dgv1099e201 CNV deletion 23290073
dgv11415n54 CNV loss 21841781
dgv1212e199 CNV deletion 23128226
dgv6434n100 CNV loss 25217958
esv3891132 CNV gain 25118596
nsv1016596 CNV loss 25217958
nsv1016645 CNV gain+loss 25217958
nsv1018445 CNV gain 25217958
nsv1018858 CNV loss 25217958
nsv1019909 CNV gain 25217958
nsv522412 CNV loss 19592680
nsv607304 CNV gain 21841781
nsv981495 CNV duplication 23825009

Additional Variant Information for ZNF735 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF735

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for ZNF735 Gene

Disorders for ZNF735 Gene

Additional Disease Information for ZNF735

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform

No disorders were found for ZNF735 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF735 Gene

Publications for ZNF735 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
  2. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier LW … Wilson RK (Nature 2003) 3 4
  3. The HIV-1 Tat protein recruits a ubiquitin ligase to reorganize the 7SK snRNP for transcriptional activation. (PMID: 29845934) Faust TB … Frankel AD (eLife 2018) 3
  4. KRAB zinc-finger proteins contribute to the evolution of gene regulatory networks. (PMID: 28273063) Imbeault M … Trono D (Nature 2017) 3
  5. Evolution of KRAB-containing zinc finger proteins and their roles in species evolution. (PMID: 27867147) Wang J … Tian CY (Yi chuan = Hereditas 2016) 3

Products for ZNF735 Gene

Sources for ZNF735 Gene