Aliases for ZNF730 Gene

Aliases for ZNF730 Gene

  • Zinc Finger Protein 730 2 3 5
  • Putative Zinc Finger Protein 730 3 4

External Ids for ZNF730 Gene

Previous GeneCards Identifiers for ZNF730 Gene

  • GC19P023093
  • GC19P023299
  • GC19P022840
  • GC19P023248

Summaries for ZNF730 Gene

GeneCards Summary for ZNF730 Gene

ZNF730 (Zinc Finger Protein 730) is a Protein Coding gene. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF273.

UniProtKB/Swiss-Prot Summary for ZNF730 Gene

Additional gene information for ZNF730 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF730 Gene

Genomics for ZNF730 Gene

GeneHancer (GH) Regulatory Elements for ZNF730 Gene

Promoters and enhancers for ZNF730 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J023074 Promoter/Enhancer 1.3 Ensembl ENCODE CraniofacialAtlas 517.2 +0.4 391 2.4 ZBTB5 POLR2A ESRRA MXI1 MLLT1 YY1 POLR2G PHF8 MAZ TFDP1 ZNF730 ENSG00000267886 ZNF492 ZNF728 ENSG00000267924 piR-57133-314
GH19J023170 Enhancer 0.3 Ensembl ENCODE 13.7 +94.6 94591 2 ZNF730 LINC01859 ZNF492 piR-36393-254 piR-43583-259
GH19J023070 Promoter/Enhancer 0.8 Ensembl ENCODE 4.9 -4.4 -4409 2 CTCF POLR2G PTBP1 RAD21 SUZ12 POLR2A HNRNPLL ENSG00000269543 ZNF492 ZNF730 LINC01858
GH19J023003 Promoter 0.9 EPDnew Ensembl 4.1 -72.3 -72309 1.4 POLR2G GABPA GABPB1 PKNOX1 ELF1 ZNF728 LINC01859 ZNF492 ZNF730 BNIP3P36 lnc-ZNF730-9
GH19J023079 Enhancer 0.2 Ensembl 17.4 +2.8 2817 0.3 ZNF730 LINC01859 ENSG00000267886 piR-57133-314
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF730 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF730

Top Transcription factor binding sites by QIAGEN in the ZNF730 gene promoter:
  • AREB6
  • HOXA9
  • Nkx3-1
  • Nkx3-1 v1
  • Nkx3-1 v2
  • Nkx3-1 v3
  • Nkx3-1 v4
  • p53
  • SRF
  • SRF (504 AA)

Genomic Locations for ZNF730 Gene

Genomic Locations for ZNF730 Gene
chr19:23,075,210-23,147,221
(GRCh38/hg38)
Size:
72,012 bases
Orientation:
Plus strand
chr19:23,248,781-23,330,021
(GRCh37/hg19)
Size:
81,241 bases
Orientation:
Plus strand

Genomic View for ZNF730 Gene

Genes around ZNF730 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF730 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF730 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF730 Gene

Proteins for ZNF730 Gene

  • Protein details for ZNF730 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZMV8-ZN730_HUMAN
    Recommended name:
    Putative zinc finger protein 730
    Protein Accession:
    Q6ZMV8

    Protein attributes for ZNF730 Gene

    Size:
    503 amino acids
    Molecular mass:
    59040 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF730 Gene

Post-translational modifications for ZNF730 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF730 Gene

No data available for DME Specific Peptides for ZNF730 Gene

Domains & Families for ZNF730 Gene

Gene Families for ZNF730 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF730 Gene

Blocks:
  • KRAB box
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF730 Gene

GenScript: Design optimal peptide antigens:
  • Putative zinc finger protein 730 (ZN730_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q6ZMV8

UniProtKB/Swiss-Prot:

ZN730_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF730: view

Function for ZNF730 Gene

Molecular function for ZNF730 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF730 Gene

Gene Ontology (GO) - Molecular Function for ZNF730 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF730: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF730

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF730 Gene

Localization for ZNF730 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF730 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF730 gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF730 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF730: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZNF730 Gene

Pathways & Interactions for ZNF730 Gene

genes like me logo Genes that share pathways with ZNF730: view

Pathways by source for ZNF730 Gene

2 Reactome pathways for ZNF730 Gene
1 KEGG pathway for ZNF730 Gene

Interacting Proteins for ZNF730 Gene

;

Gene Ontology (GO) - Biological Process for ZNF730 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF730: view

No data available for SIGNOR curated interactions for ZNF730 Gene

Drugs & Compounds for ZNF730 Gene

No Compound Related Data Available

Transcripts for ZNF730 Gene

mRNA/cDNA for ZNF730 Gene

1 REFSEQ mRNAs :
1 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF730

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF730 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c
SP1: -
SP2:
SP3: - -

Relevant External Links for ZNF730 Gene

GeneLoc Exon Structure for
ZNF730

Expression for ZNF730 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF730 Gene

mRNA differential expression in normal tissues according to GTEx for ZNF730 Gene

This gene is overexpressed in Testis (x15.3).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF730

SOURCE GeneReport for Unigene cluster for ZNF730 Gene:

Hs.427120
genes like me logo Genes that share expression patterns with ZNF730: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF730 Gene

Orthologs for ZNF730 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF730 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF730 31 30
  • 98.28 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 53 (a)
ManyToMany
-- 31
  • 35 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia -- 31
  • 51 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Rsl1 31
  • 42 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 31
  • 36 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 31
  • 49 (a)
ManyToMany
-- 31
  • 38 (a)
ManyToMany
-- 31
  • 35 (a)
ManyToMany
-- 31
  • 31 (a)
ManyToMany
-- 31
  • 29 (a)
ManyToMany
-- 31
  • 29 (a)
ManyToMany
-- 31
  • 28 (a)
ManyToMany
-- 31
  • 26 (a)
ManyToMany
Species where no ortholog for ZNF730 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF730 Gene

ENSEMBL:
Gene Tree for ZNF730 (if available)
TreeFam:
Gene Tree for ZNF730 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF730: view image

Paralogs for ZNF730 Gene

(497) SIMAP similar genes for ZNF730 Gene using alignment to 3 proteins:

  • ZN730_HUMAN
  • M0QYG2_HUMAN
  • M0QYI4_HUMAN
genes like me logo Genes that share paralogs with ZNF730: view

Variants for ZNF730 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF730 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs7247102 - p.Gly365Glu

Additional dbSNP identifiers (rs#s) for ZNF730 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF730 Gene

Variant ID Type Subtype PubMed ID
dgv138e55 CNV gain 17911159
dgv1739n106 CNV deletion 24896259
dgv511e201 CNV deletion 23290073
esv1572676 CNV deletion 17803354
esv1932531 CNV deletion 18987734
esv2436547 CNV deletion 19546169
esv2511687 CNV deletion 19546169
esv2718367 CNV deletion 23290073
esv2751784 CNV gain 17911159
esv2758750 CNV gain+loss 17122850
esv2934 CNV loss 18987735
esv3556206 CNV deletion 23714750
esv3643983 CNV loss 21293372
esv3643984 CNV gain 21293372
esv3643985 CNV loss 21293372
esv3643986 CNV gain 21293372
esv5233 OTHER inversion 18987735
esv8775 CNV loss 19470904
nsv1057420 CNV gain 25217958
nsv1060295 CNV loss 25217958
nsv1072873 CNV deletion 25765185
nsv458527 CNV loss 19166990
nsv469842 CNV gain+loss 16826518
nsv579032 CNV loss 21841781
nsv817826 CNV gain 17921354
nsv833788 CNV gain 17160897
nsv833789 CNV gain+loss 17160897
nsv956607 CNV deletion 24416366
nsv961199 CNV duplication 23825009
nsv961200 CNV duplication 23825009
nsv963031 CNV duplication 23825009
nsv9686 CNV gain+loss 18304495

Variation tolerance for ZNF730 Gene

Residual Variation Intolerance Score: 91.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.81; 58.40% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF730 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF730

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF730 Gene

Disorders for ZNF730 Gene

Additional Disease Information for ZNF730

No disorders were found for ZNF730 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF730 Gene

Publications for ZNF730 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 4 54

Products for ZNF730 Gene

Sources for ZNF730 Gene