Aliases for ZNF727 Gene

Aliases for ZNF727 Gene

  • Zinc Finger Protein 727 2 3 5
  • Zinc Finger Protein 727 Pseudogene 3 4
  • Putative Zinc Finger Protein 727 3 4
  • ZNF727P 3 4
  • Zinc Finger Protein 727, Pseudogene 2
  • ZNF727 5

External Ids for ZNF727 Gene

Previous HGNC Symbols for ZNF727 Gene

  • ZNF727P

Previous GeneCards Identifiers for ZNF727 Gene

  • GC00U922770
  • GC07P063104
  • GC07P063475
  • GC07P062843
  • GC07P063506
  • GC07P064047
  • GC07P064167
  • GC07P064169
  • GC07P064165
  • GC07P064376
  • GC07P064051
  • GC07P064078
  • GC07P064108
  • GC07P064135

Summaries for ZNF727 Gene

GeneCards Summary for ZNF727 Gene

ZNF727 (Zinc Finger Protein 727) is a Protein Coding gene. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF736.

UniProtKB/Swiss-Prot Summary for ZNF727 Gene

Additional gene information for ZNF727 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF727 Gene

Genomics for ZNF727 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF727 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J064312 Promoter/Enhancer 1.7 Ensembl ENCODE CraniofacialAtlas 9.7 +271.0 271025 3.6 SP1 CREB1 IKZF1 POLR2A BACH1 FOS FOXA1 DDX20 PKNOX1 REST ZNF736 ENSG00000227113 YWHAEP1 ZNF727 GUSBP6 ZNF107 SEPHS1P1 lnc-ZNF679-1 LOC105375322 lnc-ZNF736-3
GH07J063932 Enhancer 0.3 FANTOM5 4.4 -111.1 -111082 0.1 MNT SLC25A1P3 lnc-ZNF680-31 lnc-ZNF727-9 ZNF727 LOC105375318 RF00017-6203
GH07J064044 Promoter/Enhancer 0.7 Ensembl ENCODE 0.7 +2.5 2518 1.8 SP2 GABPB1 SP1 ENSG00000285544 BNIP3P11 ZNF727 piR-40295 ZNF735
GH07J063925 Promoter/Enhancer 1.2 Ensembl ENCODE 0.1 -117.1 -117078 3 CREB1 REST RFX1 SIX5 ZNF143 NR2C1 ZNF740 SP1 HDAC1 NRF1 ENSG00000227910 ENSG00000287588 LOC105375318 lnc-ZNF680-32 GUSBP6 NMD3P1 LINC02848 RF00017-6203 ZNF727
GH07J063899 Promoter/Enhancer 1.2 FANTOM5 Ensembl ENCODE 0.1 -142.5 -142493 2.2 CREB1 REST RFX1 SIX5 TARDBP FOXA1 ZNF143 ZNF341 SP2 BMI1 ENSG00000236299 BNIP3P11 LINC02848 RF00017-6203 ZNF727
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF727 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF727

Genomic Locations for ZNF727 Gene

Genomic Locations for ZNF727 Gene
42,146 bases
Plus strand
39,359 bases
Plus strand

Genomic View for ZNF727 Gene

Genes around ZNF727 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF727 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF727 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF727 Gene

Proteins for ZNF727 Gene

  • Protein details for ZNF727 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Putative zinc finger protein 727
    Protein Accession:

    Protein attributes for ZNF727 Gene

    499 amino acids
    Molecular mass:
    57972 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF727 Gene

Post-translational modifications for ZNF727 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF727 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF727 Gene

Domains & Families for ZNF727 Gene

Gene Families for ZNF727 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF727 Gene

Suggested Antigen Peptide Sequences for ZNF727 Gene

GenScript: Design optimal peptide antigens:
  • Putative zinc finger protein 727 (ZN727_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF727: view

Function for ZNF727 Gene

Molecular function for ZNF727 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF727 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IBA 21873635
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF727: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF727

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZNF727 Gene

Localization for ZNF727 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF727 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF727 gene
Compartment Confidence
nucleus 3

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF727 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IBA 21873635
genes like me logo Genes that share ontologies with ZNF727: view

Pathways & Interactions for ZNF727 Gene

genes like me logo Genes that share pathways with ZNF727: view

Pathways by source for ZNF727 Gene

2 Reactome pathways for ZNF727 Gene
1 KEGG pathway for ZNF727 Gene

Interacting Proteins for ZNF727 Gene

Gene Ontology (GO) - Biological Process for ZNF727 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA,IBA 21873635
genes like me logo Genes that share ontologies with ZNF727: view

No data available for SIGNOR curated interactions for ZNF727 Gene

Drugs & Compounds for ZNF727 Gene

No Compound Related Data Available

Transcripts for ZNF727 Gene

mRNA/cDNA for ZNF727 Gene

1 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF727

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF727 Gene

No ASD Table

Relevant External Links for ZNF727 Gene

GeneLoc Exon Structure for

Expression for ZNF727 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF727 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF727

SOURCE GeneReport for Unigene cluster for ZNF727 Gene:

genes like me logo Genes that share expression patterns with ZNF727: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF727 Gene

Orthologs for ZNF727 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for ZNF727 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF727 30
  • 99.27 (n)
Species where no ortholog for ZNF727 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ZNF727 Gene

Gene Tree for ZNF727 (if available)
Gene Tree for ZNF727 (if available)
Evolutionary constrained regions (ECRs) for ZNF727: view image

Paralogs for ZNF727 Gene

Paralogs for ZNF727 Gene

(496) SIMAP similar genes for ZNF727 Gene using alignment to 1 proteins:

  • ZN727_HUMAN Pseudogenes for ZNF727 Gene

genes like me logo Genes that share paralogs with ZNF727: view

Variants for ZNF727 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF727 Gene

SNP ID Clinical significance and condition Chr 07 pos Variation AA Info Type
712646 Benign: not provided 64,077,296(+) G/A MISSENSE_VARIANT
718473 Benign: not provided 64,078,400(+) C/T MISSENSE_VARIANT
739218 Benign: not provided 64,077,773(+) GC/G FRAMESHIFT_VARIANT
746571 Likely Benign: not provided 64,077,835(+) C/G MISSENSE_VARIANT
774315 Benign: not provided 64,078,166(+) T/C MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for ZNF727 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF727 Gene

Variant ID Type Subtype PubMed ID
dgv1099e201 CNV deletion 23290073
dgv11415n54 CNV loss 21841781
dgv1212e199 CNV deletion 23128226
dgv6434n100 CNV loss 25217958
esv3891132 CNV gain 25118596
nsv1016645 CNV gain+loss 25217958
nsv1018445 CNV gain 25217958
nsv1019909 CNV gain 25217958
nsv464513 CNV gain 19166990
nsv607299 CNV gain 21841781
nsv607304 CNV gain 21841781
nsv981494 CNV duplication 23825009

Variation tolerance for ZNF727 Gene

Gene Damage Index Score: 3.47; 54.97% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF727 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF727 Gene

Disorders for ZNF727 Gene

No disorders were found for ZNF727 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF727 Gene

Publications for ZNF727 Gene

  1. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier LW … Wilson RK (Nature 2003) 3 4
  2. E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins. (PMID: 29676528) Khanna R … Parnaik VK (The FEBS journal 2018) 3
  3. A Chemical Proteomics Approach to Reveal Direct Protein-Protein Interactions in Living Cells. (PMID: 29104064) Kleiner RE … Kapoor TM (Cell chemical biology 2018) 3
  4. Evolution of KRAB-containing zinc finger proteins and their roles in species evolution. (PMID: 27867147) Wang J … Tian CY (Yi chuan = Hereditas 2016) 3
  5. Zinc fingers function cooperatively with KRAB domain for nuclear localization of KRAB-containing zinc finger proteins. (PMID: 24647005) Wang W … Li W (PloS one 2014) 3

Products for ZNF727 Gene

Sources for ZNF727 Gene