Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ZNF721 Gene

Aliases for ZNF721 Gene

  • Zinc Finger Protein 721 2 3 5
  • KIAA1982 4

External Ids for ZNF721 Gene

Previous GeneCards Identifiers for ZNF721 Gene

  • GC04U900481
  • GC04M000427

Summaries for ZNF721 Gene

GeneCards Summary for ZNF721 Gene

ZNF721 (Zinc Finger Protein 721) is a Protein Coding gene. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF91.

UniProtKB/Swiss-Prot for ZNF721 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF721 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF721 Gene

Genomics for ZNF721 Gene

GeneHancer (GH) Regulatory Elements for ZNF721 Gene

Promoters and enhancers for ZNF721 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04I000498 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 561.4 -0.3 -346 2.6 HDGF PKNOX1 MLX ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 POLR2B ZNF721 PIGG GC04P000510
GH04I000472 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 577.4 +25.4 25377 2.1 HDGF PKNOX1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 POLR2B ZNF721 ABCA11P LOC100533735 PIGG CRIPAK PCGF3 GAK MAEA ENSG00000272588 ZNF718
GH04I000335 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 14.4 +161.6 161636 3.1 HDGF PKNOX1 SMAD1 NFIB RB1 SIN3A KLF5 ZBTB7B ZBTB40 RFX5 ZNF141 ENSG00000248564 ENSG00000251535 ZNF721
GH04I001267 Enhancer 0.9 Ensembl ENCODE 14.8 -768.7 -768665 1.6 CTCF PKNOX1 FOXA2 RB1 ZNF2 KLF5 RAD21 ZNF207 ZNF143 ATF7 GC04P001268 UVSSA MAEA CRIPAK ZNF721 ABCA11P ZNF732 ENSG00000251188 ZNF141 SPON2
GH04I000330 Enhancer 0.5 ENCODE 12.8 +168.9 168944 0.2 CTCF IKZF1 TRIM22 ZNF143 ZBTB33 IKZF2 ZNF721 GC04M000327 ENSG00000251535
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF721 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF721 gene promoter:

Genomic Locations for ZNF721 Gene

Genomic Locations for ZNF721 Gene
73,357 bases
Minus strand

Genomic View for ZNF721 Gene

Genes around ZNF721 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF721 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF721 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF721 Gene

Proteins for ZNF721 Gene

  • Protein details for ZNF721 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 721
    Protein Accession:
    Secondary Accessions:
    • Q69YG7

    Protein attributes for ZNF721 Gene

    911 amino acids
    Molecular mass:
    105084 Da
    Quaternary structure:
    No Data Available
    • Sequence=CAH10687.1; Type=Frameshift; Positions=246, 250, 392, 394, 401, 409, 416, 418, 426, 444, 454, 492, 500, 540, 553, 690, 779, 782; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF721 Gene


neXtProt entry for ZNF721 Gene

Post-translational modifications for ZNF721 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF721 Gene

No data available for DME Specific Peptides for ZNF721 Gene

Domains & Families for ZNF721 Gene

Gene Families for ZNF721 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF721 Gene

Suggested Antigen Peptide Sequences for ZNF721 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF721: view

Function for ZNF721 Gene

Molecular function for ZNF721 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF721 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF721: view
genes like me logo Genes that share phenotypes with ZNF721: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF721 Gene

Localization for ZNF721 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF721 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF721 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Microtubule organizing center (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF721 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF721: view

Pathways & Interactions for ZNF721 Gene

SuperPathways for ZNF721 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF721: view

Pathways by source for ZNF721 Gene

2 Reactome pathways for ZNF721 Gene

Interacting Proteins for ZNF721 Gene

Gene Ontology (GO) - Biological Process for ZNF721 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF721: view

No data available for SIGNOR curated interactions for ZNF721 Gene

Drugs & Compounds for ZNF721 Gene

No Compound Related Data Available

Transcripts for ZNF721 Gene

mRNA/cDNA for ZNF721 Gene

(1) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF721 Gene

Zinc finger protein 721:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF721 Gene

No ASD Table

Relevant External Links for ZNF721 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF721 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF721 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF721 Gene

Protein tissue co-expression partners for ZNF721 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF721 Gene:


SOURCE GeneReport for Unigene cluster for ZNF721 Gene:


Evidence on tissue expression from TISSUES for ZNF721 Gene

  • Nervous system(4.8)
genes like me logo Genes that share expression patterns with ZNF721: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF721 Gene

Orthologs for ZNF721 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF721 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF721 33
  • 99.46 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 53 (a)
(Mus musculus)
Mammalia Zfp458 34
  • 49 (a)
Zfp759 34
  • 48 (a)
Zfp457 34
  • 47 (a)
Zfp738 34
  • 45 (a)
A530054K11Rik 34
  • 40 (a)
Zfp748 34
  • 39 (a)
AA987161 34
  • 36 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 47 (a)
(Bos Taurus)
Mammalia -- 34
  • 46 (a)
(Canis familiaris)
Mammalia -- 34
  • 40 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101732182 33
  • 54.45 (n)
Species where no ortholog for ZNF721 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF721 Gene

Gene Tree for ZNF721 (if available)
Gene Tree for ZNF721 (if available)

Paralogs for ZNF721 Gene

(467) SIMAP similar genes for ZNF721 Gene using alignment to 4 proteins: Pseudogenes for ZNF721 Gene

genes like me logo Genes that share paralogs with ZNF721: view

Variants for ZNF721 Gene

Sequence variations from dbSNP and Humsavar for ZNF721 Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs28454778 likely-benign, benign, not provided, Mental retardation, autosomal recessive 53 500,399(-) C/A upstream_transcript_variant
rs34120878 likely-benign, benign, uncertain-significance, not provided, Mental retardation, autosomal recessive 53 500,405(-) C/A/G upstream_transcript_variant
rs551114887 uncertain-significance, Mental retardation, autosomal recessive 53 500,485(-) T/C upstream_transcript_variant
rs886041687 pathogenic, not provided 500,582(-) TT/TTT upstream_transcript_variant
rs1000031559 -- 498,967(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF721 Gene

Variant ID Type Subtype PubMed ID
dgv5077n100 CNV loss 25217958
dgv5078n100 CNV loss 25217958
dgv8875n54 CNV loss 21841781
esv2671108 CNV deletion 23128226
esv3569239 CNV loss 25503493
esv3599371 CNV loss 21293372
esv3599372 CNV loss 21293372
esv3599373 CNV loss 21293372
esv3893859 CNV gain 25118596
esv4769 OTHER complex 18987735
nsv1001899 CNV loss 25217958
nsv1006781 CNV gain 25217958
nsv1009336 CNV gain 25217958
nsv1012061 CNV loss 25217958
nsv461144 CNV loss 19166990
nsv461145 CNV gain 19166990
nsv461146 CNV gain 19166990
nsv469997 CNV gain 18288195
nsv517948 CNV loss 19592680
nsv593199 CNV loss 21841781
nsv593202 CNV gain 21841781
nsv593203 CNV loss 21841781
nsv593204 CNV gain 21841781
nsv964023 CNV duplication 23825009
nsv964024 CNV duplication 23825009

Variation tolerance for ZNF721 Gene

Residual Variation Intolerance Score: 92.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.57; 72.29% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF721 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF721 Gene

Disorders for ZNF721 Gene

Additional Disease Information for ZNF721

No disorders were found for ZNF721 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF721 Gene

Publications for ZNF721 Gene

  1. Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins. (PMID: 11853319) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2001) 2 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 58
  5. The full-ORF clone resource of the German cDNA Consortium. (PMID: 17974005) Bechtel S … Schupp I (BMC genomics 2007) 4 58

Products for ZNF721 Gene

Sources for ZNF721 Gene

Loading form....